Journal of endodontics最新文献

{"title":"Feasibility and Outcomes of Cell-based Regenerative Endodontic Therapy in Postautogenous Transplantation of a Mature Tooth: A Case Report","authors":"Noriaki Yoshihashi DDS","doi":"10.1016/j.joen.2024.11.003","DOIUrl":"10.1016/j.joen.2024.11.003","url":null,"abstract":"<div><div>Autogenous tooth transplantation (ATT) offers advantages; however, success rates depend on factors like socket formation, donor tooth manipulation, and endodontic treatment. Root canal treatment in a mature post-ATT tooth remains challenging. Cell-based regenerative endodontic therapy (RET) shows promise for regenerating the pulp-dentin complex in mature teeth. However, its application in a post-ATT tooth is unexplored. This case report demonstrates the feasibility and outcomes of cell-based RET in a post-ATT tooth. A 37-year-old male underwent ATT for a missing maxillary left first molar. The maxillary right third molar served as the donor tooth and transplanted with surgical guides. Root canal treatment began two weeks after ATT, confirming no detectable residual bacteria and fungi after 11 weeks. Dental pulp stem cells isolated from the maxillary left third molar were transplanted into the root canal 17 weeks after ATT. The ATT tooth responded positively to the electric pulp test after 1 week. Most of the periodontal ligament of the donor tooth was absent, and the ATT tooth initially showed ankylosis-like signs but regained normal mobility after 28 weeks after RET. Cone-beam computed tomography imaging showed successful outcomes with the presence of the periodontal ligament space and lamina dura, and without root resorption and ankylosis after 52 weeks. Magnetic resonance imaging revealed signal intensity of the regenerated tissue comparable to normal pulp after 60 weeks. This case report suggests the effectiveness of dental pulp stem cells in regenerating dental pulp and periodontal ligament, potentially preventing root resorption and ankylosis in the post-ATT tooth.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 1","pages":"Pages 85-93"},"PeriodicalIF":3.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regenerative Endodontic Procedures With Minced Pulp Tissue Graft in Mature Permanent Teeth: A Clinical Study","authors":"Ukseong Kim DDS ,&nbsp;Sunil Kim DDS, MSD, PhD ,&nbsp;Stephanie Myeong Choi DDS, MSD ,&nbsp;Mo K. Kang DDS, MSD, PhD ,&nbsp;Insoon Chang DDS, MSD, PhD ,&nbsp;Euiseong Kim DDS, MSD, PhD","doi":"10.1016/j.joen.2024.10.004","DOIUrl":"10.1016/j.joen.2024.10.004","url":null,"abstract":"<div><h3>Introduction</h3><div>Regenerative endodontic procedures (REPs) using cell-based approaches have emerged as novel treatment modalities. This clinical study aimed to present the outcomes and explore factors influencing REPs with minced pulp tissue (MP) grafts in a mature tooth.</div></div><div><h3>Methods</h3><div>Healthy patients requiring non-surgical root canal treatment were enrolled. MP obtained from the third molar was grafted into the instrumented, disinfected, and blood-filled root canal. After treatment, patients were evaluated clinically and radiographically.</div></div><div><h3>Results</h3><div>Follow-ups for 6 cases (male patients aged 20–27) ranged from 19 to 42 months. Radiographically, all the teeth showed favorable outcomes. Among the 6 teeth, 2 showed neither intracanal calcification nor recovery in sensibility tests, and one had no intracanal calcification with an inapplicable sensibility test evaluation. In 2 teeth, intracanal calcification was observed in the apical third; however, there was no recovery in the sensibility tests. One tooth exhibited intracanal calcification in the apical third and showed recovery in the sensibility tests. Considering these outcomes and clinical variables, the size of the apical foramen and the composition of the transplanted pulp tissue were identified as tentative influencing factors.</div></div><div><h3>Conclusions</h3><div>This exploratory clinical study on simplified cell-based REPs using autologous MP grafts for pulp/dentin regeneration in adult teeth not only enhances our understanding of REPs but also suggests its potential as an alternative treatment option to conventional endodontic treatment.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 1","pages":"Pages 43-53.e2"},"PeriodicalIF":3.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142467137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Different Separated File Retrieval Strategies on the Biomechanical Behavior of a Mandibular Molar: A Finite Element Analysis Study","authors":"Anas Sira BDS ,&nbsp;Nawar Naguib Nawar BDS, MSc, PhD ,&nbsp;Shehabeldin Mohamed Saber BDS, MSc, PhD ,&nbsp;Hyeon-Cheol Kim DDS, MS, PhD","doi":"10.1016/j.joen.2024.10.008","DOIUrl":"10.1016/j.joen.2024.10.008","url":null,"abstract":"<div><h3>Introduction</h3><div>This study evaluated the effects of retrieval strategies of separated nickel-titanium files on the biomechanical behavior of endodontically treated teeth by finite element analysis.</div></div><div><h3>Methods</h3><div>Six FE models were created: intact tooth; simulated a scenario where the apical 3 mm of a nickel-titanium file is separated and retained; TD, simulated application of a trephine drill to expose 1 mm of the separated file; simulated troughing of 180° at the inner wall of root canal for an extra 1 mm of the separated file beyond the staging platform; simulated circumferential ultrasonic troughing done for an extra 1 mm after the TD; and PM, simulated iatrogenic perforation sealed using mineral trioxide aggregate. Occlusal loading followed the occlusal fingerprint of the tooth before maximum von Mises stresses, maximum principal stresses, safety factor, and number of cycles till failure were determined. The cervical region of the teeth and mid-root sections including the separated file was chosen as the areas of interest for further analysis.</div></div><div><h3>Results</h3><div>Intact tooth recorded the highest number of cycles till failure and safety factor. Other models showed a narrow range of variation in all aspects with the PM recording the lowest number of cycles till failure. The highest von Mises stress was recorded at the mesiobuccal line angle of the PM near its cervical margin, while the lowest was found at the intact tooth.</div></div><div><h3>Conclusion</h3><div>Under the limitation of this study, various file retrieval strategies removing the surrounding root dentin within the amounts of general guidelines do not affect the biomechanical behavior of the tooth.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 1","pages":"Pages 64-70"},"PeriodicalIF":3.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibacterial Effects of Silica Nanoparticles Loading Nano-silver and Chlorhexidine in Root Canals Infected by Enterococcus faecalis","authors":"Yiyi Wang ,&nbsp;Linxin Fang ,&nbsp;Peiling Wang ,&nbsp;Lu Qin ,&nbsp;Yanmin Jia ,&nbsp;Yingchun Cai PhD ,&nbsp;Fei Liu PhD ,&nbsp;Huoxiang Zhou PhD ,&nbsp;Suping Wang PhD","doi":"10.1016/j.joen.2024.11.004","DOIUrl":"10.1016/j.joen.2024.11.004","url":null,"abstract":"<div><h3>Introduction</h3><div>The persistence of microbial infection can lead to endodontic failure. <em>Enterococcus faecalis</em> (<em>E. faecalis</em>) is acknowledged to be a closely associated bacterium. This study investigated the antimicrobial effects of mesoporous silica nanoparticles (nMS) carrying nano-silver and chlorhexidine (nMS-nAg-Chx) on <em>E. faecalis</em>.</div></div><div><h3>Methods</h3><div>Analyses were conducted to assess the antimicrobial efficacy of nMS-nAg-Chx toward planktonic <em>E. faecalis</em>, including the zone of inhibition, minimal inhibitory concentration, and growth curves. The measurement of lactic acid, scanning electron microscopy, live-dead bacteria staining, and quantitative real-time PCR were done to further investigate its anti-biofilm effect. Colony forming unit and scanning electron microscopy were used to assess its efficacy in infected root canals.</div></div><div><h3>Results</h3><div>The growth of planktonic <em>E. faecalis</em> was suppressed with a minimal inhibitory concentration value of 25 μg/mL (<em>P</em>＜.05). nMS-nAg-Chx concentration-dependently inhibited biofilm formation of <em>E. faecalis</em> with the reduction of lactic acid (<em>P</em> &lt; .05), sparse biofilm structure, reduced percentage of viable bacteria (<em>P</em> &lt; .05), and suppressed expression of <em>ebpR</em>, <em>gelE</em>, <em>ace</em>, and <em>efa</em> genes (<em>P</em> &lt; .05). The 7-day sealing of nMS-nAg-Chx resulted in a notable reduction in bacterial counts compared to the saline control group in the <em>E. faecalis</em> infected root canals (<em>P</em> &lt; .05).</div></div><div><h3>Conclusions</h3><div>nMS-nAg-Chx effectively inhibits <em>E. faecalis</em> and removes its biofilm from infected human root canals. It may be used for endodontic treatments in the control of <em>E. faecalis</em> bacteria as an intracanal medication.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 1","pages":"Pages 54-63"},"PeriodicalIF":3.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"B Cells at the Core: Immune Mechanisms and Therapeutic Potentials in Periapical Lesions","authors":"Yangqing Peng DDS, MSD ,&nbsp;Liu Liu DDS, PhD ,&nbsp;Xiangfen Li DDS, PhD ,&nbsp;Dongzhe Song DDS, PhD ,&nbsp;Dingming Huang DDS, PhD","doi":"10.1016/j.joen.2024.10.003","DOIUrl":"10.1016/j.joen.2024.10.003","url":null,"abstract":"<div><h3>Introduction</h3><div>Periapical lesions (PLs) are common inflammatory diseases primarily caused by microbial infections within root canals. These infections trigger complex immune responses in periapical tissues, with B lymphocytes playing dual roles: defending against pathogens while also contributing to tissue damage. This highlights the crucial role of B cells in the immunological processes of PLs.</div></div><div><h3>Methods</h3><div>A comprehensive review of the literature on B cells in PLs was conducted using PubMed, Web of Science, Scopus, and ScienceDirect databases.</div></div><div><h3>Results</h3><div>The review included 120 studies that examined the distribution and subtypes of B cells, their dual functions in PLs, and the potential applications of B-cell–related therapies in treating apical periodontitis.</div></div><div><h3>Conclusions</h3><div>This review enhances our understanding of the complex immune mechanisms in PLs and aids in the development of new therapeutic approaches from a B-cell perspective.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 1","pages":"Pages 4-14"},"PeriodicalIF":3.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142406467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photomechanical Investigation on the Impact of Endodontic Cavity Design on the Biomechanical Response in Mandibular Posterior Teeth","authors":"Danielle Meyerson DDS,&nbsp;Fang-Chi Li DDS, MSc, PhD,&nbsp;Anil Kishen BDS, MDS, PhD","doi":"10.1016/j.joen.2024.11.002","DOIUrl":"10.1016/j.joen.2024.11.002","url":null,"abstract":"<div><h3>Introduction</h3><div>The traditional endodontic cavity (TEC) facilitates canal preparation, but may increase susceptibility to root fracture; conservative endodontic cavities (CEC) aim to preserve tooth structure to maintain the structural integrity of root-filled teeth. The objective of this study was to evaluate the effect of access cavity design and the degree of pulp chamber root removal on the microstrain distribution patterns under different levels of functional loading using digital moiré interferometry.</div></div><div><h3>Methods</h3><div>Twelve extracted human teeth (<em>n</em> = 12) were included, comprising of mandibular premolars (<em>n</em> = 6) and mandibular first molars (<em>n</em> = 6). Specimens were subjected to physiologic levels of compressive loading ranging from 10 to 50 N for each group. Digital moiré interferometry fringe patterns were acquired three times for each pecimen: prior to endodontic cavity preparation (control group (CG)), after conservative endodontic cavity preparation (CEC), and following traditional endodontic cavity preparation (TEC). The acquired fringe patterns were used to determine the microstrain distribution at the coronal and cervical dentin. The data were analyzed qualitatively and quantitatively using one-way ANOVA and T-tests (<em>P</em> &lt; .05).</div></div><div><h3>Results</h3><div>The intact crowns of CG teeth showed significantly less microstrain, when compared to CEC and TEC with a distinct shift in coronal microstrain in both CEC and TEC groups. There were significant differences between both the coronal and cervical microstrain in the CG, CEC, and TEC groups.</div></div><div><h3>Conclusions</h3><div>The roof of the pulp chamber contributes to a distinct biomechanical response in posterior teeth. The microstrain at the coronal and cervical level increased significantly following de-roofing of the pulp chamber in both CEC and TEC groups, with the TEC resulting in higher coronal microstrain compared to CEC group.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 1","pages":"Pages 78-84"},"PeriodicalIF":3.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights Into the January 2025 Issue of the Journal of Endodontics","authors":"Anita Aminoshariae DDS, MS,&nbsp;Amir Azarpazhooh DDS, MSc, PhD, FRCD(C),&nbsp;Gerald N. Glickman DDS, MS, MBA, JD,&nbsp;Jianing He DMD, PhD,&nbsp;Sahng G. Kim DDS, MS,&nbsp;Anil Kishen BDS, MDS, PhD,&nbsp;Ariadne M. Letra DDS, MS, PhD,&nbsp;Linda Levin DDS, PhD,&nbsp;Ronald Ordinola-Zapata,&nbsp;Frank C. Setzer DMD, PhD, MS,&nbsp;Franklin R. Tay BDSc(Hons), PhD,&nbsp;Kenneth M. Hargreaves DDS, PhD","doi":"10.1016/j.joen.2024.12.005","DOIUrl":"10.1016/j.joen.2024.12.005","url":null,"abstract":"","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 1","pages":"Pages 1-3"},"PeriodicalIF":3.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Perspectives on the Adjunctive Use of Botulinum Toxin A in Endodontic Practice for Nonodontogenic Pain Management: A Web-Based Survey","authors":"Connie Y. Winegar DDS, MS ,&nbsp;Andre K. Mickel DDS, MSD, MDiv ,&nbsp;Nivine Y. El-Refai BDS, DDS, MSD ,&nbsp;Kristin A. Williams DDS, MPH","doi":"10.1016/j.joen.2024.10.012","DOIUrl":"10.1016/j.joen.2024.10.012","url":null,"abstract":"<div><h3>Introduction</h3><div>Despite the increasing use of botulinum toxin A (BoNT-A) in dentistry, there is limited research on its use in endodontics, a specialty that often receives referrals for dental pain that can coexist with nonodontogenic pain. The purpose of this study was to assess whether endodontists believe BoNT-A can be useful in an endodontic practice as an adjunctive treatment for nonodontogenic conditions overlapping with dental pain.</div></div><div><h3>Methods</h3><div>A 23-question survey was emailed to 3,979 members of the American Association of Endodontists. Descriptive statistics, bivariate analysis, and logistic regression were performed with significance at α = 0.05.</div></div><div><h3>Results</h3><div>Among the 211 respondents confirmed to be endodontists in the United States, 1 in 11 (9.14%) currently administer BoNT-A treatment. The top nonodontogenic conditions indicated for BoNT-A were myofascial orofacial pain (49.22%) and temporomandibular joint disorders (41.97%). Half of the endodontists (50.26%) believe that BoNT-A could be useful for nonodontogenic conditions overlapping with dental pain. Regression analysis identified variables significantly associated with this belief: BoNT-A can improve patient satisfaction (<em>P</em> &lt; .05), BoNT-A training should be offered in residency (<em>P</em> &lt; .05), BoNT-A would increase profitability (<em>P</em> &lt; .05), and BoNT-A will be incorporated more in the future (<em>P</em> &lt; .05).</div></div><div><h3>Conclusion</h3><div>Endodontists have split opinions on administering BoNT-A for nonodontogenic conditions overlapping with dental pain. Including BoNT-A training in residency may be key to encouraging multidisciplinary pain management in endodontics.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 1","pages":"Pages 21-27"},"PeriodicalIF":3.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guided Intentional Replantation of a Mandibular Premolar with Type IIIb Dens Invaginatus Associated with Peri-invagination Periodontitis without Root Canal Treatment: A Case Report.","authors":"Francesc Abella Sans, Marc Garcia-Font, Nandini Suresh, Paul M H Dummer, Venkateshbabu Nagendrababu","doi":"10.1016/j.joen.2024.12.017","DOIUrl":"10.1016/j.joen.2024.12.017","url":null,"abstract":"<p><p>This report highlights successful management of a rare case of a mandibular premolar with Oehler's Type IIIb Dens Invaginatus (DI) and peri-invagination periodontitis with guided intentional replantation without root canal treatment. A 22-year-old female patient reported with discomfort and a sinus tract associated with tooth number 21. Clinical examination and cone beam computed tomography revealed tooth number 21 had an Oehler's Type IIIb DI with peri-invagination periodontitis. The patient had partially healed sockets in the number 19 and number 30 regions. Thus, guided intentional replantation for tooth number 21 and guided double autotransplantation in the position of teeth number 19 and number 30 in a single visit was planned. Three-dimensional replicas of the donor teeth (numbers 16 and 32) as well as number 21 with type IIIb DI were printed based on intraoral scanning and cone beam computed tomography images. Tooth number 21 was extracted with its buccal cortical plate and root-end resection followed by root-end filling with mineral trioxide aggregate was performed. The tooth was replanted into the modified socket, and stabilized using a flexible wire-composite splint for 4 weeks. Unfortunately, the patient was lost to follow-up, but reported 2 years later when all teeth were retained without signs of disease. Two years following intentional replantation without root canal treatment, tooth number 21 with an Oehler's Type IIIb DI with peri-invagination periodontitis had no symptoms and radiographic examination revealed a reduction in the dimensions of the peri-invagination periodontitis.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Apical Periodontitis and Systemic Health: A Bibliometric Analysis of the Top 100 Most-cited Publications.","authors":"Danilo Cassiano Ferraz, Maria Eduarda Paz Dotto, Walbert A Vieira, Luiz Renato Paranhos, Camilla Christian Gomes Moura","doi":"10.1016/j.joen.2024.12.016","DOIUrl":"10.1016/j.joen.2024.12.016","url":null,"abstract":"<p><strong>Introduction: </strong>Bibliometric analysis quantitatively measures the impact of scientific articles within their respective fields, with citation counts being a key indicator of influence. This study aimed to identify the top 100 most-cited articles related to apical periodontitis and systemic health, analyzing their main characteristics.</p><p><strong>Methods: </strong>The top 100 most-cited articles were identified using Web of Science. Data on publication year, citations, title, authors, institutions, countries, journal impact factor, study design, keywords, and open access status were extracted. VOSviewer software analyzed author and keyword networks, while Power BI evaluated international collaborations, study design, and citations. Poisson regression was performed in R software (P < .05).</p><p><strong>Results: </strong>We reviewed 1,141 studies and selected the top 100 most-cited articles, totaling 4,744 citations (4,005 excluding self-citations), with an average of 47.44 citations per article. The most-cited article, a 2015 review by Segura-Egea JJ, had 187 citations. The highest publication activity was in 2017 and 2019 (n = 13). Leading institutions were the University of Sevilla and São Paulo State University. Europe accounted for 41% of publications and 2,251 citations, followed by Latin America and the United States. Cross-sectional studies were the most common (18%), with systemic diseases, particularly coronary heart disease and diabetes mellitus, as dominant topics. Most articles (69%) were published in journals with an impact factor above 3, with the Journal of Endodontics leading in number of articles.</p><p><strong>Conclusions: </strong>This bibliometric review highlights the increasing research interest in the relationship between apical periodontitis and systemic health, with most contributions coming from Europe and Latin America.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}