{"title":"Clinical Outcomes of Regenerative Endodontic Procedure: Periapical Healing, Root Development, and Intracanal Calcification.","authors":"Minju Song, Hoi In Jung, Sahng Gyoon Kim","doi":"10.1016/j.joen.2025.02.007","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>This retrospective study aimed to investigate the clinical outcomes and prognostic factors of regenerative endodontic procedure in terms of the resolution of apical periodontitis (AP), root development (RtDev), and intracanal calcification (IC).</p><p><strong>Methods: </strong>The clinical outcomes of a total of 111 cases from 94 patients who underwent regenerative endodontic procedures between 2015 and 2020 were assessed based on clinical and radiographic evaluations.</p><p><strong>Results: </strong>The cumulative survival rate was 85.15%, and RtDev was identified in 67.33% of cases. The incidence of IC has increased over time, reaching 43.45%. The median follow-up time was 1267 days (95% confidence interval, 991-∞) for AP healing and RtDev and 776 days (95% confidence interval, 563-1754) for IC. The 4th stage of RtDev and intracanal medication for less than 14 days or more than 60 days were associated with significantly lower AP healing (P < .05). Patients younger than 8 years of age, absence of a periapical lesion, 2nd and 3rd stage of RtDev, and 14-30 days of intracanal medication were associated with a higher incidence of RtDev (P < .05). Dens evaginatus was associated with a significantly higher incidence of IC (P < .05).</p><p><strong>Conclusions: </strong>The stage of RtDev and duration of intracanal medication significantly affected AP healing and RtDev. Additionally, age and the presence of a periapical lesion were found to influence RtDev, whereas etiology was identified as the only predictor of IC.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5000,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of endodontics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.joen.2025.02.007","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: This retrospective study aimed to investigate the clinical outcomes and prognostic factors of regenerative endodontic procedure in terms of the resolution of apical periodontitis (AP), root development (RtDev), and intracanal calcification (IC).
Methods: The clinical outcomes of a total of 111 cases from 94 patients who underwent regenerative endodontic procedures between 2015 and 2020 were assessed based on clinical and radiographic evaluations.
Results: The cumulative survival rate was 85.15%, and RtDev was identified in 67.33% of cases. The incidence of IC has increased over time, reaching 43.45%. The median follow-up time was 1267 days (95% confidence interval, 991-∞) for AP healing and RtDev and 776 days (95% confidence interval, 563-1754) for IC. The 4th stage of RtDev and intracanal medication for less than 14 days or more than 60 days were associated with significantly lower AP healing (P < .05). Patients younger than 8 years of age, absence of a periapical lesion, 2nd and 3rd stage of RtDev, and 14-30 days of intracanal medication were associated with a higher incidence of RtDev (P < .05). Dens evaginatus was associated with a significantly higher incidence of IC (P < .05).
Conclusions: The stage of RtDev and duration of intracanal medication significantly affected AP healing and RtDev. Additionally, age and the presence of a periapical lesion were found to influence RtDev, whereas etiology was identified as the only predictor of IC.
期刊介绍:
The Journal of Endodontics, the official journal of the American Association of Endodontists, publishes scientific articles, case reports and comparison studies evaluating materials and methods of pulp conservation and endodontic treatment. Endodontists and general dentists can learn about new concepts in root canal treatment and the latest advances in techniques and instrumentation in the one journal that helps them keep pace with rapid changes in this field.