再生根管治疗和MTA尖化后未成熟根的生物力学特征：一项临床研究。

IF 3.6 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of endodontics Pub Date : 2025-10-01 DOI:10.1016/j.joen.2025.06.018

Ali Nosrat DDS, MS, MDS , Alireza Kolahdouzan DDS, MS , Rajeshwari Hadagalu Revana Siddappa BDS, MDS, PhD , Changjun Cheng MS, PhD , Fang-Chi Li DDS, MSc, PhD , Meisam Moradi DDS, MS , Amir Hossein Khatibi DDS, MS , Davoud Jamshidi DDS, MS , Azin Parsa DDS, MSc, PhD , Jeffery B. Price DDS, MS , Anibal Diogenes DDS, MS, PhD , Yu Zou BEng, MEngDrSc , Anil Kishen BDS, MDS, PhD

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引用次数: 0

摘要

简介：本临床研究旨在确定和比较再生根管治疗（RET）和三氧化二矿骨料（MTA）尖化后未成熟根的体积、硬度和弹性模量。方法：6名年龄在9 ~ 14岁之间的志愿者，每人提供一对牙髓和尖周正常的下颌或上颌前磨牙，因正畸原因计划拔牙。全牙髓切除术后，每对患者接受MTA封闭或以血凝块为支架的RET，然后进行永久性修复。大约6.5个月后拔牙。对牙齿进行微观计算机层析成像进行体积分析，对牙根进行纳米压痕物理测试。结果：MTA组的根体积为168mm3 ~ 236mm3(202.5±31.07)，RET组的根体积为178mm3 ~ 251mm3（223±28.09）。结论：经过6.5个月的治疗后，RET组的根体积增加，根结构显示新形成的硬组织，其硬度和弹性模量低于MTA组。

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Biomechanical Characterization of Immature Roots Following Regenerative Endodontic Treatment and MTA Apexification: A Clinical Study

Introduction

This clinical investigation aims to determine and compare the volume, hardness, and elastic modulus of immature roots following regenerative endodontic treatment (RET) and mineral trioxide aggregate (MTA) apexification.

Methods

A total of six volunteers aged between 9 and 14 years participated in the study, each providing a pair of mandibular or maxillary premolars with normal pulp and periapex planned for extraction due to orthodontic reasons. After full pulpectomy, each pair received either an MTA obturation or RET using blood clot as scaffold, followed by permanent restoration. Teeth were extracted ∼6.5 months later. Micro–computed tomographic images of teeth were taken for volumetric analyses and roots were subjected to nanoindentation physical testing.

Results

Root volumes ranged from 168 mm³–236 mm³ (202.5 ± 31.07) in the MTA group and 178 mm³–251 mm³ (223 ± 28.09) in the RET group (P < .05). The median values of hardness in all regions (apical and middle) and all sites (periphery to canal lumen) ranged from 0.56–1.04 giga pascal (GPa) in the MTA group and 0.32–0.65 GPa in the RET group (P < .05). The median values of elastic modulus in all regions (apical and middle) and all sites (periphery to canal lumen) ranged from 10.4–22.9 GPa in the MTA group and 4.8–12.1 GPa in the RET groups (P < .05). Except the hardness in apical third in the MTA group, the values of hardness and elastic modulus increased from periphery towards lumen in all other regions in both groups (P < .05).

Conclusions

After a period of 6.5 months RET resulted in increased root volumes, with the root structure indicative of newly formed hard tissue, which exhibited lower hardness and elastic modulus compared to those treated with MTA apexification.

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来源期刊

Journal of endodontics 医学-牙科与口腔外科

CiteScore

8.80

自引率

9.50%

发文量

224

审稿时长

42 days

期刊介绍： The Journal of Endodontics, the official journal of the American Association of Endodontists, publishes scientific articles, case reports and comparison studies evaluating materials and methods of pulp conservation and endodontic treatment. Endodontists and general dentists can learn about new concepts in root canal treatment and the latest advances in techniques and instrumentation in the one journal that helps them keep pace with rapid changes in this field.