Jasminum-based Nano-reinforced Calcium Hydroxide Reduces Postoperative Pain in Symptomatic Apical Periodontitis: A Randomized Controlled Trial.

IF 3.6 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of endodontics Pub Date : 2025-08-01 Epub Date: 2025-06-02 DOI:10.1016/j.joen.2025.05.016

Nehal Amir, Emaan Mansoor, Nabiha Eeman, Muhammad Nouman Ahmed, Ezza Mansoor, Efrah Mansoor, Khadim Hussain, Vera Afreixo, Afsheen Mansoor, João Filipe Brochado Martins, Paulo J Palma

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引用次数: 0

Abstract

Introduction: This study evaluated the efficacy of a novel Jasminum-based titanium dioxide nano-reinforced calcium hydroxide (Ca(OH)₂) intracanal medicament in reducing postoperative pain (PP) compared to conventional Ca(OH)₂ in patients with symptomatic apical periodontitis.

Methods: A triple-blind randomized clinical trial, registered at ClinicalTrials.gov (NCT06653608, 10/19/2024) included patients with single-rooted teeth diagnosed with pulp necrosis and symptomatic AP. Patients referred for endodontic treatment fulfilling the inclusion criteria were included. The patients were grouped into nano-reinforced Ca(OH)₂ group (n = 30) and conventional-Ca(OH)₂ (n = 30). Preoperative pain and PP at 4, 24, 48, 72, and 96 hours were recorded using a visual analog scale. Data were analyzed using linear mixed-effects models (R software, version 4.3.2., R Core Team, Vienna, Austria), with significance set at P < .05.

Results: Sixty patients with comparable demographic and clinical characteristics, including preoperative pain scores, were recruited. Both groups exhibited significant pain reduction over 96 hours (P < .001). However, a significant group-time interaction was observed (P < .001), with the nano-reinforced Ca(OH)₂ group reporting consistently lower PP scores and greater reductions in PP compared to the conventional Ca(OH)₂ group at all-time points.

Conclusion: The incorporation of Jasminum-based TiO₂ nanoparticles to Ca(OH)₂ significantly improved the reduction in PP intensity and duration compared to conventional Ca(OH)₂, making it a superior option for PP management.

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茉莉基纳米增强氢氧化钙减轻症状性根尖牙周炎术后疼痛：一项随机对照试验。

简介：本研究评估了一种新型茉莉基二氧化钛（TiO2）纳米增强氢氧化钙（Ca(OH)2）管内药物在缓解症状性根尖牙周炎（AP）患者术后疼痛（PP）方面的疗效，并与传统的Ca(OH)2进行了比较。方法：在ClinicalTrials.gov注册的一项三盲随机临床试验（nct06653608,10/19/2024）纳入了诊断为髓质坏死和症状性AP的单根牙患者，纳入了符合纳入标准的根管治疗患者。将患者分为纳米增强Ca(OH)2组（n=30）和常规Ca(OH)2组（n=30）。术前4、24、48、72、96小时用视觉模拟评分法（VAS）记录疼痛和PP。数据分析采用线性混合效应模型（R软件），显著性设置为P < 0.05。结果：招募了60例具有可比人口统计学和临床特征的患者，包括术前疼痛评分。两组在96小时内均表现出明显的疼痛减轻（P < 0.001）。然而，观察到显著的组时间相互作用（P < 0.001），与常规Ca(OH)2组相比，纳米增强Ca(OH)2组在所有时间点报告的PP评分始终较低，PP下降幅度更大。结论：与常规Ca(OH)2相比，茉莉基TiO2纳米粒子掺入Ca(OH)2可显著改善PP强度和持续时间的降低，是治疗PP的一种较好的选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of endodontics 医学-牙科与口腔外科

CiteScore

8.80

自引率

9.50%

发文量

224

审稿时长

42 days

期刊介绍： The Journal of Endodontics, the official journal of the American Association of Endodontists, publishes scientific articles, case reports and comparison studies evaluating materials and methods of pulp conservation and endodontic treatment. Endodontists and general dentists can learn about new concepts in root canal treatment and the latest advances in techniques and instrumentation in the one journal that helps them keep pace with rapid changes in this field.