Jagveer Yadav, Mala Kamboj, Gopikrishnan Vijayakumar, Anjali Narwal, Anju Devi, Adarsh Kumar, R Keerthika
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引用次数: 0
Abstract
Background: Periapical lesions, often arising from polymicrobial infections, exhibit varied clinical manifestations. The role of herpes viruses, particularly Epstein-Barr virus (EBV), in the etiopathogenesis of these conditions remains underexplored despite evidence that suggests its involvement in inflammatory processes.
Objective: This systematic review and meta-analysis aimed to evaluate the presence of EBV in periapical diseases and to assess its probable role in their etiopathogenesis.
Material and methods: Literature searches were conducted across PubMed, Scopus, Web of Science, and Google Scholar until July 2024. Original research that examined the association of EBV in periapical diseases was included for review. The risk of bias for each study was assessed using the modified Newcastle-Ottawa scale and Review Manager 5.4 was used to generate the results.
Results: A total of 31 studies were included for qualitative synthesis, with 15 contributing to quantitative analysis. Findings revealed higher EBV detection rates in periapical lesions, particularly in symptomatic cases and lesions with larger sizes. Meta-analysis using random effects models also affirmed that EBV-positive transcripts significantly enhanced the risk of periapical lesions and symptomatic cases.
Conclusion: This review highlights a significant association between EBV and periapical lesions, particularly in symptomatic cases and larger lesions. The findings warrant further investigation into the mechanisms by which EBV contributes to the pathogenesis of periapical diseases and the implications for clinical management, including potential antiviral therapies.
背景：根尖周围病变通常由多种微生物感染引起，临床表现多样。尽管有证据表明疱疹病毒参与炎症过程，但疱疹病毒，特别是eb病毒（EBV）在这些疾病的发病机制中的作用仍未得到充分探讨。目的：本系统综述和荟萃分析旨在评估EBV在根尖周围疾病中的存在，并评估其在其发病机制中的可能作用。材料和方法：文献检索通过PubMed， Scopus， Web of Science和b谷歌Scholar进行，直到2024年7月。研究EBV与根尖周围疾病关联的原始研究被纳入综述。每个研究的偏倚风险采用改良的Newcastle-Ottawa量表进行评估，并使用Review Manager 5.4生成结果。结果：共纳入31项研究用于定性综合，15项研究用于定量分析。研究结果显示，EBV在根尖周围病变中的检出率较高，特别是在有症状的病例和较大的病变中。采用随机效应模型的荟萃分析也证实ebv阳性转录物显著增加根尖周病变和症状病例的风险。结论：这篇综述强调了EBV与根尖周围病变之间的显著关联，特别是在有症状的病例和较大的病变中。这一发现值得进一步研究EBV对根尖周围疾病发病机制的影响，以及对临床管理的影响，包括潜在的抗病毒治疗。普洛斯彼罗注册号：CRD4202344796。
期刊介绍：
The Journal of Endodontics, the official journal of the American Association of Endodontists, publishes scientific articles, case reports and comparison studies evaluating materials and methods of pulp conservation and endodontic treatment. Endodontists and general dentists can learn about new concepts in root canal treatment and the latest advances in techniques and instrumentation in the one journal that helps them keep pace with rapid changes in this field.
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