Journal of Dental Sciences最新文献_第5页

A scientometric study on Wnt and Notch signaling pathways in oral potentially malignant disorders and oral cancer 口腔潜在恶性疾病和口腔癌中Wnt和Notch信号通路的科学计量学研究

IF 3.1 3区医学

Journal of Dental Sciences Pub Date : 2025-06-27 DOI: 10.1016/j.jds.2025.06.015

Xiaoliang Luo , Yiwen Deng , Hao Wu

{"title":"A scientometric study on Wnt and Notch signaling pathways in oral potentially malignant disorders and oral cancer","authors":"Xiaoliang Luo , Yiwen Deng , Hao Wu","doi":"10.1016/j.jds.2025.06.015","DOIUrl":"10.1016/j.jds.2025.06.015","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Accumulating evidence indicates that aberrant activation of certain cellular signaling pathways occurs during the development and progression of oral cancer. The purpose of this study was to analyze the scientometric characteristics of Wnt and Notch pathways in oral potentially malignant disorders (OPMD) and oral squamous cell carcinoma (OSCC).</div></div><div><h3>Materials and methods</h3><div>All the papers on Wnt and Notch pathways in OPMD/OSCC were comprehensively retrieved from the Scopus database.</div></div><div><h3>Results</h3><div>A total of 301 and 169 papers on Wnt and Notch signaling pathway in the field of OPMD/OSCC were retrieved, respectively. As for Wnt pathway in OPMD/OSCC research, distinctive keywords included canonical Wnt signaling, β-catenin, CTNNB1 protein, cyclin D1, frizzled protein, Myc, Bcl-2, transcription factor, DNA methylation, long noncoding RNA, and microRNA. As for Notch pathway, distinctive keywords of bioresearch aspect included cancer stem cell, angiogenesis, genetic association, oncogene, and Jagged1. There were the same common keywords of bioresearch aspect, such as metabolism, genetics, signal transduction, apoptosis, cell proliferation, carcinogenesis, tumor marker, epithelial mesenchymal transition, protein function, drug screening, and gene mutation.</div></div><div><h3>Conclusion</h3><div>This study for the first time elucidated the scientometric characteristics of all the publications on Wnt and Notch pathways in OPMD/OSCC, and would provide new insights for researchers to delve into the mechanisms of Wnt and Notch related OPMD/OSCC and translate into clinical studies.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 4","pages":"Pages 2483-2488"},"PeriodicalIF":3.1,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145021068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accelerated senescence animal models and application in dentistry: A scoping review 加速衰老动物模型及其在牙科中的应用：综述

IF 3.1 3区医学

Journal of Dental Sciences Pub Date : 2025-06-24 DOI: 10.1016/j.jds.2025.06.010

Si-Wei Wang , Jia-Yu Mou , Jia-Rui Jiang , Qi He , Mu-Lan Qahar , Daniele De- Santis , Fang Qi , Guang-Chao Xu , Jian-Guo Liu

{"title":"Accelerated senescence animal models and application in dentistry: A scoping review","authors":"Si-Wei Wang , Jia-Yu Mou , Jia-Rui Jiang , Qi He , Mu-Lan Qahar , Daniele De- Santis , Fang Qi , Guang-Chao Xu , Jian-Guo Liu","doi":"10.1016/j.jds.2025.06.010","DOIUrl":"10.1016/j.jds.2025.06.010","url":null,"abstract":"<div><div>Accelerated senescence models are increasingly utilized in aging research; however, their application in dental studies remains relatively limited. This scoping review investigates the use of these models within oral research. A systematic search of PubMed and Web of Science was conducted, following PRISMA-ScR guidelines and registered with the Open Science Framework, to identify relevant in vivo studies published between January 2020 and March 2025. Eligible studies involved accelerated senescence animal models in oral health contexts. Data were extracted on animal types, induction methods, aging biomarkers (e.g., P53, P21, P16, SA-β-gal), and outcomes for narrative synthesis. From 377 screened articles, 29 met the inclusion criteria. Three primary types of models were identified: chemically induced, physically stress-induced, and genetically based. The majority of studies focused on periodontitis (41.4 %), followed by salivary gland dysfunction. Key aging features examined included cell cycle arrest (79.3 %), senescence-associated secretory phenotypes, oxidative stress, and lysosomal alterations. Diabetes-induced aging was employed in 37.9 % of studies, and mice were the predominant animal model used (75.9 %). The findings suggest that accelerated senescence models show promise in oral aging research, especially in periodontitis and diabetes-related conditions. Incorporating multiple biomarkers may enhance model relevance and support targeted strategies in geriatric oral care.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 4","pages":"Pages 2026-2038"},"PeriodicalIF":3.1,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145020954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the framework of professional subspecialties for dental technicians 探索牙科技师专业亚专业框架

IF 3.1 3区医学

Journal of Dental Sciences Pub Date : 2025-06-24 DOI: 10.1016/j.jds.2025.06.013

Ching-Shuen Wang , Feng-Chou Cheng , Wei-Chun Lin, Chun-Pin Chiang

引用次数: 0

Treatment of temporomandibular joint disorder with traditional Chinese medicine under the national health insurance system in Taiwan 台湾健保制度下的中医治疗颞下颌关节紊乱

IF 3.1 3区医学

Journal of Dental Sciences Pub Date : 2025-06-24 DOI: 10.1016/j.jds.2025.06.012

Feng-Chou Cheng , Ling-Hsia Wang , Wen-Chiung Chang, Chun-Pin Chiang

引用次数: 0

Career choices in graduates from the Taipei Third Girls high school in 1936 – With special emphasis on those hoping to study dentistry 1936年台北第三女子中学毕业生的职业选择——特别强调那些希望学习牙科的人

IF 3.1 3区医学

Journal of Dental Sciences Pub Date : 2025-06-23 DOI: 10.1016/j.jds.2025.06.014

Feng-Chou Cheng , Ling-Hsia Wang , Chun-Pin Chiang

引用次数: 0

Evaluating the impact of varying post angulations on the fracture resistance of maxillary incisors restored with polyethylene fiber posts 评价不同桩角对聚乙烯纤维桩修复上颌门牙抗折性的影响

IF 3.1 3区医学

Journal of Dental Sciences Pub Date : 2025-06-21 DOI: 10.1016/j.jds.2025.06.001

Christine Anastasia Rovani , Nurhayaty Natsir , Irfan Fauzy Yamin , Aries Chandra Trilaksana , Li-Rong Kuo , Bai-Hung Huang , Chung-Ming Liu

{"title":"Evaluating the impact of varying post angulations on the fracture resistance of maxillary incisors restored with polyethylene fiber posts","authors":"Christine Anastasia Rovani , Nurhayaty Natsir , Irfan Fauzy Yamin , Aries Chandra Trilaksana , Li-Rong Kuo , Bai-Hung Huang , Chung-Ming Liu","doi":"10.1016/j.jds.2025.06.001","DOIUrl":"10.1016/j.jds.2025.06.001","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Restoring anterior teeth requiring angulation correction remains clinically challenging. Polyethylene fiber posts have been introduced, offering superior adaptability within the root canal and improved aesthetics. However, the effect of varying degrees of post angulation on the fracture resistance of restored teeth has not been thoroughly investigated. This study aimed to evaluate the fracture resistance of maxillary incisors restored using polyethylene fiber posts at varying angulations.</div></div><div><h3>Materials and methods</h3><div>Thirty-two extracted incisors were selected according to the study criteria. Root canal treatment and gutta-percha removal were performed to prepare for polyethylene fiber posts. All study samples were subsequently divided into four groups of angulations: P1 (5°), P2 (10°), P3 (15°), and a control group (0°). Fracture resistance was tested, and the data were analyzed using one-way ANOVA followed by Post-Hoc comparison with the least significant difference (LSD) statistical tests.</div></div><div><h3>Results</h3><div>A statistically significant difference in fracture resistance was observed among the groups, with group P1 demonstrating the highest fracture resistance (281.29 ± 84.97 N) and the control group exhibiting the lowest (164.75 ± 41.75 N).</div></div><div><h3>Conclusion</h3><div>There was a difference in the fracture resistance of the maxillary incisors when using polyethylene fiber posts at angulation degrees of 5° and 0°, and angulation degrees of 5° and 15°. Therefore, anterior tooth restoration with angulation correction of 5°–10° can utilize polyethylene fiber posts.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 4","pages":"Pages 2231-2237"},"PeriodicalIF":3.1,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145020729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

miR-376a/Neuropilin-1 axis mediates the cancer stemness in oral squamous cell carcinoma-an in vitro study miR-376a/Neuropilin-1轴介导口腔鳞状细胞癌癌变的体外研究

IF 3.1 3区医学

Journal of Dental Sciences Pub Date : 2025-06-20 DOI: 10.1016/j.jds.2025.06.003

Yi-Wen Liao , Cheng-Chia Yu , Heng-Yi Liao , Yu-Chao Chang

{"title":"miR-376a/Neuropilin-1 axis mediates the cancer stemness in oral squamous cell carcinoma-an in vitro study","authors":"Yi-Wen Liao , Cheng-Chia Yu , Heng-Yi Liao , Yu-Chao Chang","doi":"10.1016/j.jds.2025.06.003","DOIUrl":"10.1016/j.jds.2025.06.003","url":null,"abstract":"<div><h3>Background/purpose</h3><div>The incidence of oral cancer has been steadily increased over the years. Recent researches indicated that exploring oral cancer stem cells (CSCs) characterized by self-renewal, pluripotency, and aggressiveness have emerged as a promising strategy for predicting oral squamous cell carcinoma (OSCC) recurrence and metastasis. Previous studies have demonstrated that microRNAs regulate cancer stemness. However, the mechanisms that miR-376a/neuropilin-1 (NRP1) axis influences CSC traits have not yet been fully understood. Therefore, an in-depth investigation was conducted in this study.</div></div><div><h3>Materials and methods</h3><div>miR-376a expression in CSCs derived from OSCC cell line SAS was quantified by quantitative real-time polymerase chain reaction. Aldehyde dehydrogenase 1 (ALDH1) activity and CD44 expression were assessed via flow cytometry. The CSC phenotype was characterized through self-renewal, migration, and colony formation assays. A luciferase reporter assay was used to confirm the direct interaction between miR-376a and NRP1.</div></div><div><h3>Results</h3><div>We found that miR-376a expression was downregulated in SAS-CSCs. Overexpression of miR-376a significantly reduced several CSC phenotypes including ALDH1 activity, CD44 expression, migration, and colony-forming abilities, respectively (<em>P</em> < 0.05). In addition, a luciferase reporter assay substantiated the direct binding of miR-376a to NRP1 (<em>P</em> < 0.05). Moreover, NRP1 overexpression was found to reverse miR-376a-induced the inhibition of migration and self-renewal, respectively (<em>P</em> < 0.05).</div></div><div><h3>Conclusion</h3><div>Within the limitations of our findings, miR-376a/NRP1 axis may play a crucial role in stemness of OSCC. Targeting this pathway could represent a promising strategy to inhibit OSCC progression.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 4","pages":"Pages 2238-2244"},"PeriodicalIF":3.1,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145020730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term stability of maxillary anterior tooth-implant supported fixed prostheses: A 14-year case report 上颌前牙种植体支撑固定修复体的长期稳定性：一个14年的病例报告

IF 3.1 3区医学

Journal of Dental Sciences Pub Date : 2025-06-18 DOI: 10.1016/j.jds.2025.06.006

Yuan-Yang Hsu, Shyh-Yuan Lee, Cheng-Shan Li, Chun-Yu Wang, Shing-Zeng Dung

引用次数: 0

Increased medications in the aged patients with burning mouth syndrome: A potentially overlooked risk factor 老年灼口综合征患者用药增加：一个可能被忽视的危险因素

IF 3.1 3区医学

Journal of Dental Sciences Pub Date : 2025-06-18 DOI: 10.1016/j.jds.2025.06.008

Chun-Pin Chiang , Chih-Chung Chien , Yu-Hsueh Wu

{"title":"Increased medications in the aged patients with burning mouth syndrome: A potentially overlooked risk factor","authors":"Chun-Pin Chiang , Chih-Chung Chien , Yu-Hsueh Wu","doi":"10.1016/j.jds.2025.06.008","DOIUrl":"10.1016/j.jds.2025.06.008","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Burning mouth syndrome (BMS) is a chronic oral mucosal burning and pain disorder, predominantly affecting the middle-aged and elderly women. This study aimed to explore the association between polypharmacy and BMS, with consideration of the patients’ age and sex.</div></div><div><h3>Materials and methods</h3><div>Medical data from 115 BMS patients and 115 age- and sex-matched control subjects were collected. Medications were categorized into four groups based on the number of medications taken. The chi-square test, Student's <em>t</em>-test, and binary logistic regression were performed to evaluate the association between polypharmacy and BMS, after adjustment for age and sex.</div></div><div><h3>Results</h3><div>A higher proportion of individuals with medications was observed in the BMS group than in the control group (<em>P</em> = 0.0015). Among BMS patients, the older group (≥ 65 years), especially the female BMS patients, tended to take more medications. Binary logistic regression analysis revealed a significant association between polypharmacy and increased odds of having BMS. After adjustment for age and sex, the patients in the minor polypharmacy group (1–4 medications) had significantly higher odds of having BMS compared to those in the non-pharmacy group (no medications), with an adjusted odds ratio of 5.015 (<em>P</em> < 0.001).</div></div><div><h3>Conclusion</h3><div>These findings suggest a potential association between multiple medications and the risk of having BMS and supported the need to consider polypharmacy as a contributing factor for the older BMS patient. However, future studies should be conducted to explore the exact dose–response trend and the influence of other associated factors on BMS.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 4","pages":"Pages 2245-2249"},"PeriodicalIF":3.1,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145020731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The potential effect of photobiomodulation on oral mucositis induced by head and neck radio-chemotherapy: A literature review 光生物调节对头颈部放化疗所致口腔黏膜炎的潜在作用：文献综述

IF 3.1 3区医学

Journal of Dental Sciences Pub Date : 2025-06-18 DOI: 10.1016/j.jds.2025.06.002

Rashin Bahrami , Shahriar Eftekharian , Raha Jafarieh , Maryam Pourhajibagher , Abbas Bahador

{"title":"The potential effect of photobiomodulation on oral mucositis induced by head and neck radio-chemotherapy: A literature review","authors":"Rashin Bahrami , Shahriar Eftekharian , Raha Jafarieh , Maryam Pourhajibagher , Abbas Bahador","doi":"10.1016/j.jds.2025.06.002","DOIUrl":"10.1016/j.jds.2025.06.002","url":null,"abstract":"<div><div>Oral mucositis (OM) is a common side effect of head and neck radio-chemotherapy. It manifests as painful, ulcerative lesions in the oral mucosa, significantly impairing essential functions such as eating, speaking, and maintaining oral hygiene. It finally has adverse effects on the patient's quality of life. Photobiomodulation therapy (PBMT) has emerged as a promising non-invasive modality for preventing and treating OM. Due to controversy among the results of studies, this literature review synthesizes findings from recent randomized controlled trials that evaluated the use of PBMT in adult and pediatric cancer patients. This review also highlights the mechanisms, clinical efficacy, and future challenges of integrating PBMT into routine supportive cancer care. The evidence shows that PBMT significantly reduces the severity and duration of OM, improved patient-reported outcomes, and minimized treatment-related morbidity. By utilizing low-intensity light sources—typically lasers or LEDs—PBMT enhances cellular metabolism, reduces inflammation, alleviates pain, and promotes mucosal healing. Despite its clinical potential, widespread implementation of PBMT is hindered by variability in treatment protocols and limited standardization; in brief, laser protocols — wavelengths (630–980 nm), energy densities (2–6 J/cm<sup>2</sup>), and application durations (10–125 s/point) are commonly used for preventing and treating OM induced by head and neck radio-chemotherapy. However, future studies with long-term follow-ups will be necessary to standardize PBMT protocols, as standardization is essential to integrate PBMT into routine cancer care.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 4","pages":"Pages 2039-2045"},"PeriodicalIF":3.1,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145020955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0