Journal of Dental Sciences最新文献

{"title":"Factors influencing dental career decision-making among high-achieving students in Taiwan.","authors":"Chien-Hong Yu, Mei-Huei Li, Feng-Chou Cheng, Chun-Pin Chiang","doi":"10.1016/j.jds.2025.07.3472","DOIUrl":"10.1016/j.jds.2025.07.3472","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"2014-2017"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ensemble learning for predicting periapical lesions from dental radiographs.","authors":"Fang-Yuan Liao, Ming-Jyun Jian, Abdullah Sarini, Yulianto Jesica, Yen-Kun Lin, Hsun-Yu Huang","doi":"10.1016/j.jds.2025.07.3485","DOIUrl":"10.1016/j.jds.2025.07.3485","url":null,"abstract":"<p><strong>Background/purpose: </strong>Diagnosing periapical cysts and granulomas using periapical radiographs is challenging due to subtle radiographic differences. This study aimed to develop a machine learning-based diagnostic framework to improve lesion classification through ensemble learning and dentin standardization.</p><p><strong>Materials and methods: </strong>Five models-Support Vector Classifier (SVC), Nu-SVC, K-Nearest Neighbors (KNN) and Decision Tree-were trained on 144 pre-treatment periapical radiographs (70 cysts and 74 granulomas). Dentin standardization normalized grayscale values to ensure feature consistency. A weighted soft voting strategy was employed to integrate predictions, with model weights derived from individual diagnostic performance. Model performance was evaluated via five-fold cross-validation. Statistical significance among models was assessed using the Friedman test, followed by Wilcoxon signed-rank tests for pairwise comparisons (α = 0.05).</p><p><strong>Results: </strong>The ensemble method achieved a precision of 0.83 and a sensitivity of 0.83, demonstrating robust diagnostic performance. Statistical analysis revealed significant differences among models in specificity (<i>P</i> = 0.001) and negative predictive value (<i>P</i> = 0.044), with the ensemble method reaching a peak specificity of 0.83. Although numerous improvements were observed in precision and sensitivity compared to several base models, these differences did not reach statistical significance (<i>P</i> > 0.05). Overall, the ensemble method demonstrated balanced performance across metrics, although its improvements over individual models were not statistically significant.</p><p><strong>Conclusion: </strong>By integrating dentin standardization with a weighted ensemble approach, the proposed method provides a reliable, non-invasive tool for improving radiographic differentiation of periapical cysts and granulomas. These results support the potential of intelligent diagnostic systems in dental radiology.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1583-1591"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536301/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Negative pulp sensibility responses do not necessarily indicate pulp necrosis in teeth associated with cystic or cyst-like lesions.","authors":"Le Lu, Xiang Zhang, Ya Shen, He Liu","doi":"10.1016/j.jds.2025.07.3506","DOIUrl":"10.1016/j.jds.2025.07.3506","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1988-1990"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dental age-based assessment of retromolar morphology in skeletal Class III patients: Implications for mandibular third molar development.","authors":"Thuy-Trang Thi Ho, Tu Manh Nguyen, Loc Minh Lu, Fang-Yu Fan, Ying-Sui Sun, Yang-Che Wu, Sheng-Wei Feng, Chien-Fu Tseng, Pao-Chang Chiang, I-Ta Lee","doi":"10.1016/j.jds.2025.07.3480","DOIUrl":"10.1016/j.jds.2025.07.3480","url":null,"abstract":"<p><strong>Background/purpose: </strong>In skeletal Class III malocclusion, evaluation of mandibular third molar development is clinically important for orthodontic treatment planning, particularly in relation to posterior space conditions. This study aimed to assess the association between dental age of mandibular third molars and retromolar morphological characteristics in skeletal Class III patients.</p><p><strong>Materials and methods: </strong>This retrospective cross-sectional study included panoramic radiographs from 157 patients diagnosed with skeletal Class III malocclusion based on clinical examination and lateral cephalometric analysis. Mandibular third molar development was evaluated using Demirjian mineralization stages (D-H), representing stages from crown completion to root maturation. Retromolar morphology was evaluated using retromolar space (RMS), the RMS-to-crown width ratio (Ganss ratio), and the mesiodistal angulation between the second and third molars (Beta angle). Correlations between dental age and these morphological parameters were analyzed.</p><p><strong>Results: </strong>As dental age progressed, RMS increased from 5.59 mm to 9.18 mm and the Ganss ratio from 0.45 to 0.70, whereas the Beta angle decreased from 35.82° to 24.80°. Dental age showed moderate positive associations with RMS and the Ganss ratio (<i>P</i> < 0.001), but no significant association with the Beta angle (<i>P</i> = 0.479). These findings indicate coordinated changes between third molar development and retromolar morphology in skeletal Class III patients.</p><p><strong>Conclusion: </strong>Dental age-related changes in retromolar morphology may provide useful radiographic information for describing posterior space conditions in skeletal Class III patients.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1425-1433"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual effects of 1α,25-dihydroxyvitamin D₃ on inflammation and osteogenic differentiation in lipopolysaccharide-stimulated dental pulp stem cells.","authors":"Seong Eun Song, Giyoung Yun, Cheul-Hong Kim, Ji-Young Yoon, Hee Young Kim, Hyae Jin Kim, Eun-Jung Kim","doi":"10.1016/j.jds.2025.07.3564","DOIUrl":"10.1016/j.jds.2025.07.3564","url":null,"abstract":"<p><strong>Background/purpose: </strong>Vitamin D is traditionally known for bone metabolism and also exerts immunomodulatory effects. Dental pulp stem cells (DPSCs) are essential for pulp repair but are impaired under lipopolysaccharide (LPS)-induced inflammation. Therefore, we examined the dual effects of 1α,25-dihydroxyvitamin D₃ (1α,25(OH)₂D₃) on inflammation and osteogenic differentiation in DPSCs.</p><p><strong>Materials and methods: </strong>Human DPSCs were pretreated with 1α,25(OH)₂D₃ (0.001-1 μM) and stimulated with LPS (1 μg/mL). Thereafter, cell viability was assessed using the 3-(4,5-dimethylthiazol)-2,5-diphenyl tetrazolium bromide assay. Expression of interleukin (IL)-1β, IL-8, and cyclooxygenase-2 (COX-2) was measured using real-time quantitative PCR and Western blot. Moreover, osteogenic activity was evaluated via alkaline phosphatase (ALP) staining. Mitogen-activated protein kinase signaling was analyzed via Western blot, and extracellular signal-regulated kinase (ERK)/c-Jun N-terminal kinase (JNK) inhibitors were applied to confirm mechanistic involvement.</p><p><strong>Results: </strong>The 1α,25(OH)₂D₃ did not affect DPSC viability under inflammatory conditions. However, the compound markedly suppressed LPS-induced IL-8 and COX-2 expression, with modest effects on IL-1β. LPS markedly reduced ALP activity, which was dose-dependently restored by 1α,25(OH)₂D₃. Mechanistically, 1α,25(OH)₂D₃ induced transient phosphorylation of ERK and JNK but not that of p38. Furthermore, Inhibition of ERK or JNK abrogated the osteogenic rescue, thereby confirming their essential roles.</p><p><strong>Conclusion: </strong>The 1α,25(OH)₂D₃ exerts dual actions in LPS-stimulated DPSCs by attenuating inflammatory mediators and promoting osteogenic differentiation through ERK/JNK signaling. These findings suggest its promising potential as a therapeutic adjunct in regenerative endodontics under inflamed conditions.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1948-1957"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of pneumonia and mortality after routine dental scaling in patients with moderate-to-severe cerebral palsy: A nationwide cohort study.","authors":"Li-Wei Ou-Yang, Ya-Ting Chang, Hsin-Mao Hsu, Shih-Hao Chang, Chia-Ling Wu, Hui-Ju Tsai, Yu-Tung Huang, Tsung-Chieh Yao","doi":"10.1016/j.jds.2025.07.3550","DOIUrl":"10.1016/j.jds.2025.07.3550","url":null,"abstract":"<p><strong>Background/purpose: </strong>Pulmonary infection is a major cause of hospitalization and death in individuals with cerebral palsy. The impact of routine dental scaling, a standard procedure for removing oral biofilm, on the risk of pneumonia and mortality in individuals with cerebral palsy is unknown. This study aimed to investigate the association between routine dental scaling and the risk of pneumonia and mortality in individuals with moderate-to-severe cerebral palsy.</p><p><strong>Materials and methods: </strong>This nationwide, population-based cohort study used data derived from Taiwan's National Health Insurance Research Database between 2009 and 2019. 12,853 individuals with moderate-to-severe cerebral palsy were identified. Individuals who received routine dental scaling for at least three consecutive years were compared to those without dental scaling. Propensity-score matching was applied to balance baseline characteristics. Multivariable Cox proportional hazards models and Fine-Gray competing-risks survival analyses were employed to estimate the hazard ratios (HRs) and 95 % confidence intervals (CIs) of pneumonia, pneumonia-related mortality, and all-cause mortality during 5-year follow-up period.</p><p><strong>Results: </strong>Among 2,440 matched pairs, routine dental scaling was significantly associated with reduced risks of pneumonia (HR: 0.41, 95 % CI: 0.28-0.58), pneumonia-related mortality (HR: 0.23, 95 % CI: 0.13-0.41), and all-cause mortality (HR: 0.24, 95 % CI: 0.19-0.32). These findings remained consistent across various subgroup and sensitivity analyses.</p><p><strong>Conclusion: </strong>This 11-year nationwide cohort study provides real-world evidence that routine dental scaling is associated with a substantially reduced risk of pneumonia and mortality in individuals with moderate-to-severe cerebral palsy. These findings highlight the importance of oral healthcare in preventing severe health outcomes in this vulnerable population.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1818-1826"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of condylar position displacement using various centric relation recording techniques based on maximum intercuspation position: A systematic review and meta-analysis.","authors":"Ling-Shiuan Huang, Yen-Chang Huang, I-Ting Wu, Shinn-Jyh Ding","doi":"10.1016/j.jds.2025.07.3465","DOIUrl":"10.1016/j.jds.2025.07.3465","url":null,"abstract":"<p><strong>Background/purpose: </strong>Restoring tooth defects is a key clinical task for dentists, aimed at either maintaining or reconstructing a functional occlusal dentition. This study conducted a systematic review and meta-analysis of clinical trials comparing centric relation (CR) and maximum intercuspal position (MIP) condylar positions obtained using various CR techniques, and to verify the reproducibility of these methods.</p><p><strong>Materials and methods: </strong>The PubMed, Embase, Google Scholar, and Cochrane Library databases were searched for articles published before January 2026. The single-arm meta-analysis used a random-effects model to calculate the overall effect size.</p><p><strong>Results: </strong>This study included 12 articles published between 1994 and 2024. Five different types of CR recording techniques were analyzed. Most techniques showed slight differences in CR and MIP with moderate to high heterogeneity. The chin-point guidance technique demonstrated a significant difference in the Y-axis (SMD = 1.17, <i>P</i> = 0.02), but no statistically significant differences were observed in the X and Z axes between CR and MIP. Roth's power-centric relation recording method was the only technique to show significant differences relative to MIP in all three axes. Dawson's bimanual method and Gothic arch tracer method for CR recording did not reveal any significant differences in condylar position on any axis.</p><p><strong>Conclusion: </strong>While the various methods for obtaining CR records in this study have their own advantages and disadvantages, and the CR positions obtained differed among the techniques, they all demonstrated a certain degree of reproducibility.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1347-1362"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Higher serum gastric parietal cell antibody titers are associated with increased frequencies of macrocytosis, vitamin B12 deficiency, and hyperhomocysteinemia in patients with oral lichen planus.","authors":"Yu-Hsueh Wu, Yi-Pang Lee, Julia Yu-Fong Chang, Yi-Ping Wang, Andy Sun, Chun-Pin Chiang","doi":"10.1016/j.jds.2025.07.3449","DOIUrl":"10.1016/j.jds.2025.07.3449","url":null,"abstract":"<p><strong>Background/purpose: </strong>Our previous study found 139 gastric parietal cell antibody (GPCA)-positive oral lichen planus (OLP) patients (GPCA⁺OLP patients) in a group of 588 OLP patients. This study evaluated whether higher-titer (serum GPCA titer ≥160) GPCA⁺OLP patients had greater frequencies of macrocytosis, anemia, serum iron and vitamin B12 deficiencies, and hyperhomocysteinemia than lower-titer (GPCA titer ≥80) GPCA⁺OLP patients or 588 healthy control subjects.</p><p><strong>Materials and methods: </strong>Complete blood count, serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 53 higher-titer GPCA⁺OLP patients, 86 lower-titer GPCA⁺OLP patients, and 588 healthy control subjects were measured and compared.</p><p><strong>Results: </strong>We found that 32.1%, 37.7%, 24.5%, 43.4%, and 86.8% of higher-titer GPCA⁺OLP patients and 14.0%, 24.4%, 23.3%, 19.8%, and 34.9% of 86 lower-titer GPCA⁺OLP patients were diagnosed as having macrocytosis, anemia, serum iron and vitamin B12 deficiencies, and hyperhomocysteinemia, respectively. Moreover, both 53 higher-titer and 86 lower-titer GPCA⁺OLP patients had significantly greater frequencies of macrocytosis, anemia, serum iron and vitamin B12 deficiencies, and hyperhomocysteinemia than 588 healthy control subjects (all <i>P</i>-values <i><</i>0.001). In addition, 53 higher-titer GPCA⁺OLP patients also had significantly greater frequencies of macrocytosis, serum vitamin B12 deficiency, and hyperhomocysteinemia than 86 lower-titer GPCA⁺OLP patients (all <i>P</i>-values <i><</i>0.05).</p><p><strong>Conclusion: </strong>The higher-titer GPCA⁺OLP patients have significantly greater frequencies of macrocytosis, serum vitamin B12 deficiency, and hyperhomocysteinemia than lower-titer GPCA⁺OLP patients. Thus, we conclude that higher serum GPCA titers are associated with increased frequencies of macrocytosis, vitamin B12 deficiency, and hyperhomocysteinemia in patients with oral lichen planus.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1393-1401"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluvastatin enhances healing of medication-related osteonecrosis of the jaw (MRONJ) via macrophage polarization in a rat MRONJ-like model.","authors":"Moa Tazaki, Koma Sanda, Hiroko Wada, Bin Ji, Yohei Jinno, Yasunori Ayukawa","doi":"10.1016/j.jds.2025.07.3557","DOIUrl":"10.1016/j.jds.2025.07.3557","url":null,"abstract":"<p><strong>Background/purpose: </strong>Medication-related osteonecrosis of the jaw (MRONJ), a serious adverse effect of antiresorptive agents, remains difficult to manage. Our previous studies showed that statins, widely prescribed for dyslipidemia, promote healing in MRONJ-like lesions, however, the mechanisms underlying their therapeutic effects remain unclear. This study investigated the efficacy of the therapeutic effect of fluvastatin (FS) in a rat MRONJ-like model, with particular attention to macrophage polarization.</p><p><strong>Materials and methods: </strong>Four-week-old female rats were allocated to three groups. Two groups received zoledronic acid (ZOL) and dexamethasone (DEX) for two weeks prior to extraction of maxillary first molars. After extraction, one group was treated with a single local injection of FS near the extraction site, whereas the other received saline. A control group underwent identical procedures, but received saline instead of ZOL, DEX, and FS. All animals were evaluated two weeks after treatment.</p><p><strong>Results: </strong>The control (saline) group showed complete socket healing. In contrast, ZOL/DEX-treated rats exhibited incomplete epithelial closure and exposed necrotic bone. However, local FS administration in ZOL/DEX-treated rats extensively promoted healing, resulting in smaller epithelial gaps and reduced bone exposure, and decreased areas of necrotic bone. Total macrophage numbers were significantly higher in both experimental groups compared with the control group. The ZOL/DEX group showed a predominance of pro-inflammatory M1 macrophages, whereas the FS-treated group exhibited relatively increased proportions of tissue-reparative M2 macrophages.</p><p><strong>Conclusion: </strong>Local FS administration enhances bone healing of MRONJ-like lesions by promoting macrophage polarization toward M2 phenotype.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1883-1891"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536340/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of immediate restoration on bone remodeling in the esthetic zone: A randomized clinical trial.","authors":"Hao-Dong Wang, Xin-Hai Lin, Yi-Wen Wu, Hong-Run Zhou, Tai Zhao Wei, Xi Chen, Yi-Qun Tang, Ya-Qin Zhu, Long Jiang","doi":"10.1016/j.jds.2025.07.3456","DOIUrl":"10.1016/j.jds.2025.07.3456","url":null,"abstract":"<p><strong>Background/purpose: </strong>Traumatic loss of anterior teeth creates esthetic challenges and often requires immediate rehabilitation. Although immediate implant placement and restoration (IIPR) shortens treatment time, strict primary stability limits its use. A native-crown restoration supported by fiber-reinforced composite (FRC) splints may broaden the indications of immediate restoration, but its effectiveness remains unclear. This randomized controlled trial aimed to evaluate the effects of the novel immediate restoration following IIP on peri-implant bone remodeling in anterior esthetic zone trauma during osseointegration.</p><p><strong>Materials and methods: </strong>Twenty participants undergoing IIP in the anterior maxilla were randomized into two groups. In the experimental group, immediate restorations were performed using patients' native crowns stabilized with FRC splints, while the control group received conventional delayed restorations. Peri-implant bone remodeling was quantitatively assessed through cone-beam computed tomography (CBCT) at baseline and 4-5 months postoperatively. Secondary outcomes included gingival healing and implant stability quotient (ISQ).</p><p><strong>Results: </strong>Both groups achieved 100% implant survival. Complete soft tissue closure occurred within 4-5 months in all cases, with no significant intergroup differences. Similarly, no significant intergroup differences were found in peri-implant bone changes at the implant neck (<i>P</i>= 0.878) or 2 mm apically (<i>P</i>= 0.667). Mean ISQ values (Experimental: 75.6 ± 2.4; Control: 74.1 ± 3.4) showed no significant intergroup difference (<i>P</i>= 0.271).</p><p><strong>Conclusion: </strong>The FRC-splinted immediate restoration protocol did not demonstrate additional adverse effects on early peri-implant bone remodeling or osseointegration within the observation period. It may offer an alternative option for immediate esthetic rehabilitation following IIP, particularly in cases where primary stability is limited.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1671-1678"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}