Journal of Dental Sciences最新文献_第5页

Dental students’ perceptions of two immersive reality haptic dental simulators: A pilot study 牙科学生对两种沉浸式现实触觉牙科模拟器的感知：一项初步研究

IF 3.4 3区医学

Journal of Dental Sciences Pub Date : 2025-01-03 DOI: 10.1016/j.jds.2024.12.021

Min-Hsun Hsu, Yu-Chao Chang

引用次数: 0

Diagnosis of Sjögren's syndrome via biopsy of the tongue but not the lip: An intriguing case report 通过舌头活检诊断Sjögren综合征，而不是嘴唇：一个有趣的病例报告

IF 3.4 3区医学

Journal of Dental Sciences Pub Date : 2025-01-03 DOI: 10.1016/j.jds.2024.12.022

Sak Lee

引用次数: 0

Sex differences in prognostic factors and genomic variations in oral squamous cell carcinoma: A 5-year retrospective study 口腔鳞状细胞癌预后因素和基因组变异的性别差异：一项5年回顾性研究

IF 3.4 3区医学

Journal of Dental Sciences Pub Date : 2025-01-03 DOI: 10.1016/j.jds.2024.12.014

Hui-Hsin Ko , Fang-Yu Wu , Ya-Syuan Chen , Wender Lin , Chun-Kai Fang , Chyi-Huey Bai , Hung-Ying Lin , Hsiang-Fong Kao , Shih-Jung Cheng

{"title":"Sex differences in prognostic factors and genomic variations in oral squamous cell carcinoma: A 5-year retrospective study","authors":"Hui-Hsin Ko , Fang-Yu Wu , Ya-Syuan Chen , Wender Lin , Chun-Kai Fang , Chyi-Huey Bai , Hung-Ying Lin , Hsiang-Fong Kao , Shih-Jung Cheng","doi":"10.1016/j.jds.2024.12.014","DOIUrl":"10.1016/j.jds.2024.12.014","url":null,"abstract":"<div><h3>Background/purpose</h3><div>This study examined the prognostic factors and genomic variations in oral squamous cell carcinoma (OSCC) among male and female patients, focusing on the rising incidence of OSCC in women.</div></div><div><h3>Materials and methods</h3><div>Using data from 98 OSCC cases treated at National Taiwan University Hospital between 2013 and 2018, the study analyzed the patient cohort, clinical characteristics, and genomic profiles.</div></div><div><h3>Results</h3><div>The Female patients had a higher incidence of tongue cancer, while the male patients were prone to have buccal cancer. Key prognostic factors included age over 55 years, tongue cancer, alcohol use in female patients as well as the buccal cancer, betel chewing, and smoking in male patients. Notably, women with tongue OSCC or without oral habits had poorer 5-year survival rates. Genomic analysis revealed the males with high-risk habits had elevated antigen-processing and reactive oxygen gene sets, whereas the low-risk females showed dysregulation in metabolic pathways. Immunologically, the female patients had fewer naïve B cells and higher suppressive M2 macrophages.</div></div><div><h3>Conclusion</h3><div>Our findings highlight distinct sex-related OSCC prognosis differences and suggest that personalized treatments targeting specific risk factors and genomic characteristics may improve the clinical outcomes, particularly for the female OSCC patients.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 2","pages":"Pages 1086-1094"},"PeriodicalIF":3.4,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143706233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk factors for inferior alveolar nerve injury associated with implant surgery: An observational study

IF 3.4 3区医学

Journal of Dental Sciences Pub Date : 2025-01-01 DOI: 10.1016/j.jds.2024.07.025

Jisuk Han , Jeong Joon Han

{"title":"Risk factors for inferior alveolar nerve injury associated with implant surgery: An observational study","authors":"Jisuk Han , Jeong Joon Han","doi":"10.1016/j.jds.2024.07.025","DOIUrl":"10.1016/j.jds.2024.07.025","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Inferior alveolar nerve (IAN) injury is the most serious complication associated with dental implant surgery, posing difficulties in treatment and potential for permanent disabilities. This study aimed to identify patient-related risk factors for IAN injury during implant placement and to investigate sensory disturbances depending on whether the implant was removed.</div></div><div><h3>Materials and methods</h3><div>Twenty-eight patients with implant-related IAN injury were included. To determine risk factors, patient demographics and radiographic images were analyzed. Sensory functions were evaluated and compared based on whether the implant was removed.</div></div><div><h3>Results</h3><div>IAN injury occurred more frequently in women (60.7%), with a mean age of 62.9 years. The distance from the alveolar crest to the IAN was 9.8 ± 3.0 mm, with 40.9% patients having a residual alveolar bone of 10 mm or more. The mean bone density was measured at 586.2 ± 392.5 HU, which is below the normal range for the mandible. Notably, 31.8% of the patients were found to have D4 bone. Compared to patients who did not have implants removed, those who did showed better sensory function, except pressure perception, although these differences were not statistically significant.</div></div><div><h3>Conclusion</h3><div>Older women with lower bone density were at an increased risk of IAN injury, and IAN injury occurred even in cases with sufficient alveolar ridge. The removal of implants related to the injury alone does not markedly influence the extent of sensory disturbances during follow-up period, suggesting that other aspects such as the timing of removal and severity of injury could be crucial.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 270-277"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11762662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparisons of precision and trueness of digital dental casts produced by desktop scanners and intraoral scanners

IF 3.4 3区医学

Journal of Dental Sciences Pub Date : 2025-01-01 DOI: 10.1016/j.jds.2024.09.016

Chun-Chao Chuang , Feng-Chou Cheng , Mu-Hsiung Chen , Wei-Chun Lin , Chun-Pin Chiang

{"title":"Comparisons of precision and trueness of digital dental casts produced by desktop scanners and intraoral scanners","authors":"Chun-Chao Chuang , Feng-Chou Cheng , Mu-Hsiung Chen , Wei-Chun Lin , Chun-Pin Chiang","doi":"10.1016/j.jds.2024.09.016","DOIUrl":"10.1016/j.jds.2024.09.016","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Different types of scanners are gradually used to produce digital dental casts in the current dental practice. This study tested the accuracy of the three desktop scanners and two intraoral scanners and evaluated whether the desktop scanners had higher precision than the intraoral scanners.</div></div><div><h3>Materials and methods</h3><div>This study used the three desktop and two intraoral scanners to scan a standard dental cast 5 times. The 5 digital casts produced by the same scanner were compared each other to study the precision errors of each scanner. Moreover, 5 sets of the 5 digital casts produced by the 5 different scanners were compared each other to investigate the trueness errors among these 5 different scanners.</div></div><div><h3>Results</h3><div>This study showed a significant difference in the precision error of produced digital casts made by the 5 different scanners (<em>P</em> < 0.0001). The two intraoral scanners had significantly higher precision errors of produced digital casts than the three desktop scanners. However, there were no significant differences in the precision errors among the three desktop scanners and between the two intraoral scanners. The results of the whole cast or particular tooth surface trueness analyses demonstrated that the trueness errors were concentrated at the molar regions of produced digital casts when comparisons were performed between the intraoral and desktop scanners.</div></div><div><h3>Conclusion</h3><div>We conclude that the desktop scanners can achieve a better precision than the intraoral scanners. When the intraoral scanner is used, the dentist should notice the possible model errors at the molar regions.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 137-146"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgery of impacted maxillary second premolar beneath first molar trifurcation via lateral window maxillary sinus augmentation: A case report 通过侧窗上颌窦增量手术治疗第一磨牙三叉下的上颌第二前磨牙：病例报告。

IF 3.4 3区医学

Journal of Dental Sciences Pub Date : 2025-01-01 DOI: 10.1016/j.jds.2024.09.020

Chen-Chieh Hsu, Meng-Ling Chiang, Jyh-Kwei Chen

引用次数: 0

Titanium particle-induced inflammasome in human gingival epithelial cells

IF 3.4 3区医学

Journal of Dental Sciences Pub Date : 2025-01-01 DOI: 10.1016/j.jds.2024.06.013

Shin Wakuda , Akira Hasuike , Kyoko Fujiwara , Ryo Sakai , Akhilanand Chaurasia , Toshio Uchiyama , Shuichi Sato

{"title":"Titanium particle-induced inflammasome in human gingival epithelial cells","authors":"Shin Wakuda , Akira Hasuike , Kyoko Fujiwara , Ryo Sakai , Akhilanand Chaurasia , Toshio Uchiyama , Shuichi Sato","doi":"10.1016/j.jds.2024.06.013","DOIUrl":"10.1016/j.jds.2024.06.013","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Peri-implantitis remains a substantial challenge. This study investigated the effect of titanium particles on human oral epithelial cells, focusing on the nucleotide-binding domain and leucine-rich repeat protein (NLRP) 3 inflammasome.</div></div><div><h3>Materials and methods</h3><div>The Ca9-22 human gingival epithelial cell line was subjected to incubation with titanium particles. To evaluate cell viability, the MTT assay was employed. Total RNA was extracted, and messenger RNA (mRNA) expressions of <em>COX2</em>, <em>TGF-β1</em>, <em>NLRP1</em>, <em>NLPR3</em>, <em>CASP1</em>, and <em>AIM2</em> were analyzed. The concentration of interleukin (IL)1β in cell supernatants was quantified through enzyme-linked immunosorbent assay. Intracellular reactive oxygen species (ROS) were visualized using an ROS assay Kit.</div></div><div><h3>Results</h3><div>Ca9-22 cells treated with titanium particles showed >75% cell viability across all concentrations tested, with consistent results. mRNA expressions of inflammation-related genes (<em>COX2</em> and <em>TGF-β1</em>) significantly increased in a dose-dependent manner. The mRNA expression of <em>NLRP3</em> and <em>CASP1</em>, as well as the secretion of IL1β, increased after 6-h incubation with titanium particles. Moreover, the ROS assay results showed increased production of ROS after treatment with titanium particles, whereas NLRP3 expression and IL1β secretion reduced after treatment with N-acetyl-<span>l</span>-cysteine (ROS scavenger).</div></div><div><h3>Conclusion</h3><div>Our findings indicate that titanium particles possess a distinct ability to trigger the NLRP3 inflammasome, partly by producing ROS.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 384-392"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11762583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemokine receptor-2 deficiency induced mild experimental periapical lesion in mice 趋化因子受体-2 缺乏会诱发小鼠轻度实验性根尖周病变

IF 3.4 3区医学

Journal of Dental Sciences Pub Date : 2025-01-01 DOI: 10.1016/j.jds.2024.06.005

Qiao Ling , Ai-jing Wang , Xiao-yan Wang

{"title":"Chemokine receptor-2 deficiency induced mild experimental periapical lesion in mice","authors":"Qiao Ling , Ai-jing Wang , Xiao-yan Wang","doi":"10.1016/j.jds.2024.06.005","DOIUrl":"10.1016/j.jds.2024.06.005","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Macrophages are considered to play an important role in the development of chronic apical periodontitis (CAP). However the function of tissue resident macrophages in CAP is unclear. This study aims to investigate the potential role of macrophages of different origins in CAP.</div></div><div><h3>Materials and methods</h3><div>Chemokine receptor-2 deficiency (CCR2<sup>−/−</sup>) mice and C57BL/6N mice (control group, WT mice) were used to induce apical periodontitis. The pulp of mandibular first molars of both sides were exposed to the oral environment. After 0, 7, 21, 28 days of pulp explosion, animals were sacrificed, the mandibular bones were collected and scanned with micro-CT, further processed for HE & IHC Staining to analyze the development of CAP, as well as the expression of surface markers of macrophages.</div></div><div><h3>Results</h3><div>Both CCR2<sup>−/−</sup> and WT mice exhibited CCR2 negative macrophages in normal periapical area, which indicated the presence of tissue resident macrophages. CCR2 deficiency decreased the number of macrophages in periapical lesions, the M1 type macrophages’ number as well as osteoclasts around the edge of the lesion decreased compared to wild type. Meanwhile CCR2 deficiency decreased the volume of periapical lesion significantly compared to wild type, but did not inhibite and disappeare the lesion thoroughly.</div></div><div><h3>Conclusion</h3><div>Monocyte-macrophage system derived macrophages promote the progression of periapical lesions, while tissue resident macrophages in periodontal ligament might also be involved in the progression of periapical lesion.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 402-409"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141400057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between oral health literacy and changes in self-assessment of oral health during COVID-19 口腔健康知识普及与 COVID-19 期间口腔健康自我评估变化之间的关系

IF 3.4 3区医学

Journal of Dental Sciences Pub Date : 2025-01-01 DOI: 10.1016/j.jds.2024.04.015

Yuko Hirota , Naoko Adachi , Kanade Ito , Kayoko Shinada , Yuji Kabasawa

{"title":"Relationship between oral health literacy and changes in self-assessment of oral health during COVID-19","authors":"Yuko Hirota , Naoko Adachi , Kanade Ito , Kayoko Shinada , Yuji Kabasawa","doi":"10.1016/j.jds.2024.04.015","DOIUrl":"10.1016/j.jds.2024.04.015","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Health literacy is thought to play a major role in implementing health behaviors, such as preventing coronavirus disease 2019 (COVID-19). In this study, we aimed to examine the relationship between oral health literacy (OHL), dietary literacy (DL), and changes in oral health and eating habits during the COVID-19 pandemic.</div></div><div><h3>Materials and methods</h3><div>The self-assessment questionnaire, including questions on oral and dietary conditions for each period of the COVID-19 pandemic, sources of information, OHL, DL, and frequency of COVID-19 prevention measures, was administered using a web research company. All participants were divided into low- and high-literacy groups based on the median scores: those who scored above the median in the high group and those who scored at or below the median in the low group. Comparisons were conducted between the two groups.</div></div><div><h3>Results</h3><div>The median OHL and DL scores were 16 and 17 for the 344 participants included in the study (168 males and 176 females); 160 (46.5%) participants had high OHL scores, and 157 (45.6%) had high DL scores. The group with high OHL or DL tended to collect information sent by medical professionals compared to the group with low OHL or DL, had significantly higher scores on self-assessment of oral and dietary conditions, and tended to implement infection control actions more frequently in eating situations.</div></div><div><h3>Conclusion</h3><div>The high OHL and DL groups gathered information from professionals to have attain oral and dietary conditions regardless of COVID-19 and tended to implement infection prevention measures in oral health and diet.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 569-577"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141033205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential effect of topical antibiotics administration in the oral cavity on the reduced number of bacteria entering the lower respiratory tract after oral cancer surgery 口腔局部使用抗生素对减少口腔癌手术后进入下呼吸道的细菌数量的潜在影响

IF 3.4 3区医学

Journal of Dental Sciences Pub Date : 2025-01-01 DOI: 10.1016/j.jds.2024.06.021

Akira Imakiire , Sakiko Soutome , Keiichiro Miura , Nanako Ito , Mirai Higaki , Fumitaka Obayashi , Koichi Koizumi , Souichi Yanamoto , Tomohiro Yamada , Masahiro Umeda

{"title":"Potential effect of topical antibiotics administration in the oral cavity on the reduced number of bacteria entering the lower respiratory tract after oral cancer surgery","authors":"Akira Imakiire , Sakiko Soutome , Keiichiro Miura , Nanako Ito , Mirai Higaki , Fumitaka Obayashi , Koichi Koizumi , Souichi Yanamoto , Tomohiro Yamada , Masahiro Umeda","doi":"10.1016/j.jds.2024.06.021","DOIUrl":"10.1016/j.jds.2024.06.021","url":null,"abstract":"<div><h3>Background/purpose</h3><div>One of the causes of ventilator-associated pneumonia (VAP) is aspiration of oropharyngeal fluid containing pathogenic microorganisms into the lower respiratory tract. In this study, we aimed to investigate whether antibiotic ointment applied to the oral cavity can reduce the number of bacteria in the fluid on the cuff of a tracheal cannula.</div></div><div><h3>Materials and methods</h3><div>Tetracycline ointment was applied intraorally once to a patient under endotracheal intubation by postoperative tracheostomy for oral cancer. The tetracycline concentrations in the oropharyngeal fluid and fluid on the cuff of tracheal cannula were determined by bioassay, and the total viable bacterial count was determined by delayed real-time polymerase chain reaction developed by the authors from before to 6 h after application.</div></div><div><h3>Results</h3><div>A total of seven patients were enrolled. Very high antibiotic concentrations were maintained, ranging from 481 μg/ml to 2060 μg/ml in oropharyngeal fluid and from 267 μg/ml to 858 μg/ml in fluid on the cuff from 1 h to 6 h after application. Compared to the pre-application results, the inhibition rates of viable bacteria were 80.0–97.7% for oropharyngeal fluid and 47.6%–91.9% for fluid on the cuff at 1–6 h after application, indicating that antibiotic ointment can inhibit bacteria entering the lower respiratory tract for a long period of time in intubated patients.</div></div><div><h3>Conclusion</h3><div>Oral application of antibiotic ointment reduced the number of bacteria entering the lower respiratory tract, suggesting that it may be useful in the prevention or treatment of VAP.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 319-324"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141690928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0