Journal of Dental Sciences最新文献

{"title":"The health screening measure for ionizing radiation workers under the labor insurance in Taiwan: A case study of dental assistant health management in a dental clinic","authors":"Feng-Chou Cheng , Ling-Hsia Wang , Yu-Ling Wu, Chun-Pin Chiang","doi":"10.1016/j.jds.2025.08.030","DOIUrl":"10.1016/j.jds.2025.08.030","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 1","pages":"Pages 634-636"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145903883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ferritin promotes monocyte osteoclastogenic differentiation to aggravate alveolar bone resorption in periodontitis","authors":"Wenxue Huang ,&nbsp;Jie Zhang ,&nbsp;Menglong Hu ,&nbsp;Zhaoguo Yue ,&nbsp;Ye Han ,&nbsp;Xiaochi Chang ,&nbsp;Jianxia Hou","doi":"10.1016/j.jds.2025.05.034","DOIUrl":"10.1016/j.jds.2025.05.034","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Alveolar bone resorption in periodontitis critically impairs masticatory function and tooth stability, yet the mechanistic drivers linking immune dysregulation to osteolytic pathology remain incompletely characterized. This study elucidates how ferritin-an inflammation responsive iron chaperone secreted by activated monocytes-orchestrates monocyte-to-osteoclast differentiation to exacerbate bone destruction in periodontitis.</div></div><div><h3>Materials and methods</h3><div>Using a multidisciplinary approach, we combined: Immunohistochemical profiling of cluster of differentiation 68-positive (CD68⁺) cells and cluster of differentiation 4-positive (CD4⁺) cells in human periodontal tissues (periodontitis vs. healthy controls); Murine experimental periodontitis induced by maxillary molar ligation (8-week model); <em>In vitro</em> mechanistic studies where THP-1 monocytes (human acute monocytic leukemia cell line) primed with <em>Porphyromonas gingivalis</em> lipopolysaccharide (<em>P. gingivalis</em>-LPS) were analyzed for ferritin/receptor activator of nuclear factor-κB ligand (RANKL) secretion, and RAW264.7 pre-osteoclasts (murine macrophage-like cell line) were treated with apoferritin ± RANKL to assess proliferation, osteoclast differentiation, and osteolytic gene expression.</div></div><div><h3>Results</h3><div>Inflamed periodontal tissues exhibited elevated CD68⁺ and CD4⁺ immune cells, reflecting heightened inflammatory activity. <em>P. gingivalis</em>-LPS stimulation increased ferritin and RANKL secretion in THP-1 cells. Mice with experimental periodontitis showed increased osteoclast density at alveolar bone surfaces. Apoferritin synergized with RANKL to enhance RAW264.7 proliferation, multinucleation, and expression of matrix metallopeptidase 9 (MMP-9), cathepsin K (CTSK), and tartrate-resistant acid phosphatase (TRAP) in a dose-dependent manner.</div></div><div><h3>Conclusion</h3><div>Ferritin and RANKL synergistically promote monocyte osteoclastogenesis, driving alveolar bone resorption in periodontitis. Targeting ferritin signaling may offer therapeutic potential to mitigate bone loss.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 1","pages":"Pages 206-215"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145904006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metformin alleviates the progression of oral submucous fibrosis through downregulation of metastasis associated lung adenocarcinoma transcript 1 (MALAT1)","authors":"Pei-Ling Hsieh ,&nbsp;Fang-Yu Chang ,&nbsp;Po-Hsuan Tang ,&nbsp;Yi-Wen Liao ,&nbsp;Cheng-Chia Yu ,&nbsp;Chia-Ming Liu","doi":"10.1016/j.jds.2025.07.001","DOIUrl":"10.1016/j.jds.2025.07.001","url":null,"abstract":"<div><h3>Background</h3><div><em>/purpose</em>: Emerging evidence demonstrates the anti-fibrotic properties of metformin, a first-line anti-diabetic drug; however, its inhibitory effects on oral fibrogenesis warrant further evaluation.</div></div><div><h3>Materials and methods</h3><div>The cytotoxic effects of metformin on normal and fibrotic buccal mucosal fibroblasts (fBMFs) derived from OSF tissues were evaluated using the MTT assay. Collagen gel contraction, wound healing, and transwell migration assays were carried out to assess myofibroblast features. In addition, the expression levels of alpha-1 type I collagen (COL1A1), alpha-smooth muscle actin (α-SMA) and Smad2 were measured. Moreover, RNA sequencing was performed to explore potential targets participating in the anti-fibrotic effects of metformin.</div></div><div><h3>Results</h3><div>A lower dose of metformin was sufficient to inhibit the proliferation of fBMFs without affecting normal BMFs, and to attenuate various myofibroblast characteristics, including collagen gel contraction, wound healing, transwell migration capacities, and the expression of fibrosis markers. Additionally, we showed that administration of metformin prevented the arecoline-induced myofibroblast activation. Most importantly, our results suggest that metformin may exert suppressive effects on myofibroblast activities by inhibiting ROS accumulation through the downregulation of MALAT1.</div></div><div><h3>Conclusion</h3><div>These findings indicate that metformin may serve as a preventive agent against OSF progression.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 1","pages":"Pages 133-139"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145903947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigation-guided autotransplantation: A novel technique for precise and predictable tooth placement","authors":"Yang-Chih Chou ,&nbsp;Wen-Hui Chen ,&nbsp;Hui-Na Lee ,&nbsp;Yu-Feng Chen","doi":"10.1016/j.jds.2025.08.027","DOIUrl":"10.1016/j.jds.2025.08.027","url":null,"abstract":"<div><div>Autotransplantation (AT) is a promising alternative for restoring failed teeth. However, the success rate varies due to technique sensitivity and absence of standardized protocol. We present the first documented AT protocol utilizing a dynamic navigation system, including three core innovations: (1) navigation-guided socket preparation, (2) extra-alveolar retrograde filling, and (3) digital lingual stent fixation with flowable resin. A 55-year-old Taiwanese female with a vertical root fracture in tooth 36 underwent dynamic navigation-guided AT of tooth 38. The recipient area was prepared using a 2.5 mm wide round bur under the X-Guide® navigation. The X-Mark® probe was used to detect underprepared areas, and once preparation was deemed optimal, a three-dimensional (3D) replica was used for final confirmation. Tooth 38 was extracted and underwent retrograde filling, then transplanted into the socket of tooth 36 and fixed with a lingual stent. Postoperative image demonstrated ideal tooth positioning and favorable bone remodeling.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 1","pages":"Pages 599-603"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145903936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The evolution and future prospects of ionizing radiation protection training for dentists in Taiwan","authors":"Feng-Chou Cheng ,&nbsp;Yu-Min Lin ,&nbsp;Mu-Hsiung Chen,&nbsp;Chun-Pin Chiang","doi":"10.1016/j.jds.2025.08.036","DOIUrl":"10.1016/j.jds.2025.08.036","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 1","pages":"Pages 643-645"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145904237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic evaluation of genetic polymorphisms in carcinogen metabolizing enzymes associated with the risk of oral potentially malignant disorders occurrence","authors":"Chao Lou ,&nbsp;Yuhan Zhu ,&nbsp;Linjun Shi ,&nbsp;Wei Liu","doi":"10.1016/j.jds.2025.09.010","DOIUrl":"10.1016/j.jds.2025.09.010","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Accumulated studies investigate the association of single-nucleotide polymorphisms (SNPs) in carcinogen metabolizing enzymes with oral potentially malignant disorders (OPMD) risk. However, these results were inconsistent and conflicting. The purpose of this pooled analysis was to systematically evaluate the associations of SNPs in 6 enzymes (CYP1A1, CYP2E1, GSTM1, GSTM3, GSTT1 and GSTP1) with risk of OPMD occurrence.</div></div><div><h3>Materials and methods</h3><div>A systematic evaluation was performed to identify all eligible case ndash;control studies on the association between SNPs in 6 enzymes and OPMD onset. Odds ratios (ORs) and 95 % confidence intervals (CIs) were pooled to estimate association strength.</div></div><div><h3>Results</h3><div>A significant association of CYP2E1 PstI polymorphism with OPMD was found (OR, 1.46; 95%CI, 1.07–2.00) in 430 cases and 818 health controls. A significant association of GSTM1 null genotype with OPMD, especially oral leukoplakia, was found (OR, 1.72; 95%CI, 1.24–2.37) in 2228 cases and 4425 controls. A significant association of GSTT1 null genotype with OPMD, particularly oral submucous fibrosis, was found (OR, 1.50; 95%CI, 1.01–2.22) in 1798 cases and 3934 controls. A marginally significant association of GSTM3 polymorphism with OPMD was found (OR, 1.41; 95%CI, 1.00–1.98) in 321 cases and 622 controls. There was no significant association of polymorphisms in CYP1A1, CYP2E1 RsaI variant, and GSTP1 with OPMD.</div></div><div><h3>Conclusion</h3><div>This analysis for the first time investigated SNPs in carcinogen metabolizing enzymes with OPMD, suggesting that polymorphisms in CYP2E1 PstI, GSTM1, GSTM3 and GSTT1 play roles in OPMD occurrence and highlighting their potential in risk stratification and early detection strategies.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 1","pages":"Pages 604-609"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145904243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating thymol vapor for biofilm removal and biocompatibility in curved root canal models in vitro","authors":"Maria Paulene Dee Manuel ,&nbsp;Yin-Hwa Shih ,&nbsp;Shih-Min Hsia ,&nbsp;Tong-Hong Wang ,&nbsp;Yu-Hsin Tseng ,&nbsp;Ming-Gene Tu ,&nbsp;Tzong-Ming Shieh","doi":"10.1016/j.jds.2025.09.001","DOIUrl":"10.1016/j.jds.2025.09.001","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Conventional irrigants such as chlorhexidine and sodium hypochlorite have strong antimicrobial properties but high cytotoxicity, limiting their use in regenerative endodontics. We hypothesized that thymol vapor could provide effective antibacterial activity with lower cytotoxicity.</div></div><div><h3>Materials and methods</h3><div>The antimicrobial activity of thymol in both liquid and vapor phases was tested against <em>Enterococcus faecalis</em>, <em>Streptococcus mutans</em>, and <em>Aggregatibacter actinomycetemcomitans</em> using a resin block model simulating curved root canals. The effect of thymol vapor, alone or with mechanical instrumentation, was tested on early-stage biofilms removal. Cytotoxicity was assessed using MTT assays in L-929 fibroblasts and MG-63 osteoblast-like cells, and pro-inflammatory cytokine gene expression (<em>IL-1β</em>, <em>TNF-α</em>, <em>IL-6</em>) was measured via qRT-PCR.</div></div><div><h3>Results</h3><div>Thymol exhibited minimum inhibition concentration (MIC) and minimum bactericidal concentration (MBC) values of 0.8–1.0 mg/mL in planktonic cultures. In early-stage biofilms models, 10–100 mg/mL liquid thymol and 5.0 mg/mL thymol vapor significantly reduced bacterial viability. Combining 1.0 mg/mL thymol vapor with mechanical instrumentation enhanced early-stage biofilms removal, particularly against <em>E. faecalis</em>. Direct exposure to thymol and chlorhexidine caused significant cytotoxicity, while 1.0 mg/mL vapor showed lower cytotoxic and did not significantly induce pro-inflammatory cytokine genes in L-929 cells. At higher concentrations, MG-63 cells exhibited increased cytokine expression.</div></div><div><h3>Conclusion</h3><div>This study is the first to propose thymol vapor for biofilm removal in curved root canal models and to demonstrate its antibacterial activity with lower cytotoxicity than conventional irrigants. Its potential as an adjunct in regenerative endodontics merits further investigation, particularly in relation to immunomodulatory effects.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 1","pages":"Pages 323-332"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145904050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applications and potential of ChatGPT in dentistry: Scoping review of research perspectives","authors":"Masakazu Hamada ,&nbsp;Sumire Kikuchi ,&nbsp;Tatsuya Akitomo ,&nbsp;Satoru Kusaka ,&nbsp;Yuko Iwamoto ,&nbsp;Ryota Nomura","doi":"10.1016/j.jds.2025.08.016","DOIUrl":"10.1016/j.jds.2025.08.016","url":null,"abstract":"<div><div>Since ChatGPT was released in 2022, it has been used in various settings and has rapidly been adopted worldwide. The main objective of this review was to provide a comprehensive assessment of the accuracy, reliability, usefulness, and limitations of ChatGPT in dentistry. PubMed, Scopus, and Web of Science databases were searched using the terms “ChatGPT” and “dentistry”, and 63 papers were extracted. Of the 63 records identified, medical consultation and assistance were the most common, accounting for 35 of 63 records (53.8 %), followed by study assistance and confirmation tests with 16 records (24.6 %), national and specialist dental examinations with 8 records (12.3 %), and dental research with 4 records (6.2 %). Although ChatGPT can offer many possibilities in the dental field, researchers and dentists should evaluate and use it carefully because ChatGPT answers are not always reliable, and there is a possibility of information leakage. Although its limitations need to be considered, ChatGPT has the potential to revolutionize dental diagnosis, treatment, education, and research.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 1","pages":"Pages 1-8"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145903818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Collaborative care for children's oral and holistic health among physicians and dentists in Taiwan","authors":"Feng-Chou Cheng ,&nbsp;Ling-Hsia Wang ,&nbsp;Yin-Lin Wang,&nbsp;Chun-Pin Chiang","doi":"10.1016/j.jds.2025.10.001","DOIUrl":"10.1016/j.jds.2025.10.001","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 1","pages":"Pages 659-661"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145903937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bio-obturation of a large perforated internal root resorption: A case report","authors":"Saeed Asgary","doi":"10.1016/j.jds.2025.08.043","DOIUrl":"10.1016/j.jds.2025.08.043","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 1","pages":"Pages 646-647"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145904238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}