Journal of Dental Sciences最新文献

{"title":"Strategy of allying general dentistry staffs into pre-anesthetic dental assessment reduces perioperative dental injury risk during general anesthesia.","authors":"I-Cheng Lu, Mei-Chun Chen, Po-Yang Chen, Tz-Ping Gau, Edward Chengchuan Ko, Kuang-I Cheng","doi":"10.1016/j.jds.2025.07.3551","DOIUrl":"10.1016/j.jds.2025.07.3551","url":null,"abstract":"<p><strong>Background/purpose: </strong>Perioperative dental injury remains a common complication during general anesthesia. This study aimed to evaluate whether professional dentistry intervention in pre-anesthetic assessment reduces the risk of perioperative dental injury.</p><p><strong>Materials and methods: </strong>This retrospective cohort study analyzed data from 119,656 patients who underwent general anesthesia between May 2013 and April 2021. Patients were classified into three periods based on the type of medical personnel conducting pre-anesthetic dental assessments: Period I, dental interns and registered anesthesia nurses (May 2013 to September 2016, <b>n</b> = <b>38,039</b>); Period II, postgraduate year (PGY) dental residents (October 2016 to September 2019, <b>n</b> = <b>37,750</b>); and Period III, a team of general dentistry staff (dental residents and specialists) (October 2019 to April 2021, <b>n</b> = <b>43,867</b>). The primary outcome assessed was the incidence of perioperative dental injury.</p><p><strong>Results: </strong>Intubation-related dental injuries occurred in 41 of 119,656 anesthetic cases (0.034 %). The incidence of tooth loss was significantly lower in Period III assessed by general dentistry staff (0.018 %) compared with Period I, evaluated by dental interns and registered anesthesia nurses (0.055 %) and Period II, mainly assessed by PGY dental residents (0.031 %) ( <b><i>P</i></b> = <b>0.016</b>). Male patients had a significantly higher risk of perioperative dental injury ( <b><i>P</i></b> < <b>0.05</b>). Moderate to severe tooth mobility was significantly associated with an increased risk of perioperative dental injury (all <b><i>P</i></b> < <b>0.05</b>).</p><p><strong>Conclusion: </strong>The involvement of general dentistry staff in pre-anesthetic dental assessments can reduce the incidence of perioperative dental injuries. Patients scheduled for surgery should receive not only pre-anesthesia consultations from anesthesiologists, but also routine assessments and dental care provided by general dentistry staff.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1827-1834"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral odontogenic keratocyst - A case report.","authors":"Hung-Pin Lin, Chun-Pin Chiang","doi":"10.1016/j.jds.2025.07.3467","DOIUrl":"10.1016/j.jds.2025.07.3467","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"2000-2002"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536337/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rigorous validation of machine learning models for orthodontic extraction prediction using nested cross-validation and smotenc-integrated pipelines.","authors":"Anh Thi-Ngoc Do, Hung Trong Hoang, Trang Thi-Thuy Ho, Hieu Ngoc Le","doi":"10.1016/j.jds.2025.07.3471","DOIUrl":"10.1016/j.jds.2025.07.3471","url":null,"abstract":"<p><strong>Background/purpose: </strong>Machine learning (ML) in orthodontics often suffers from optimistic bias due to data leakage and improper handling of class imbalance. This study implemented and evaluated a production-grade validation framework - nested cross-validation (CV) - for three distinct algorithm classes (logistic regression, random forest, and gradient boosting) using a consensus-labeled orthodontic dataset.</p><p><strong>Materials and methods: </strong>A retrospective dataset of 500 patients (334 non-extraction/166 extraction) was curated with 41 processed features. Two stratified split protocols (70/30 and 80/20) were evaluated to assess model robustness. To ensure methodological rigor, a 5-fold outer/3-fold inner nested cross-validation was implemented. Crucially, SMOTENC (synthetic minority over-sampling technique for nominal and continuous) was integrated inside the training pipeline to prevent data leakage.</p><p><strong>Results: </strong>All models achieved high discrimination (ROC-AUC <i>></i>0.87). XGBoost achieved the highest discrimination (ROC-AUC: 0.9177) and demonstrated the best overall balance for clinical decision support (balanced accuracy: 0.8566, F1-score: 0.8125). Logistic regression showed the highest internal stability (CV mean balanced accuracy: 0.8521 ± 0.0281) despite lower performance on the hold-out test set.</p><p><strong>Conclusion: </strong>The use of nested CV combined with pipeline-integrated SMOTENC provides a conservative and reliable estimate of model performance. While gradient boosting (XGBoost) offers superior predictive power, the framework highlights the trade-off between stability (linear models) and performance (boosting) in dentistry.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1645-1653"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic effects of biodegradable magnesium alloy and erythromycin on osteogenic activity.","authors":"Kridtapat Sirisereephap, Kitipong Pasanaphong, Thanaphum Osathanon, Patcharapit Promoppatum, Tomoki Maekawa, Viritpon Srimaneepong, Meircurius Dwi Condro Surboyo, Kamolporn Wattanasirmkit","doi":"10.1016/j.jds.2025.07.3462","DOIUrl":"10.1016/j.jds.2025.07.3462","url":null,"abstract":"<p><strong>Background/purpose: </strong>Biodegradable magnesium (Mg)-based alloys are emerging as promising alternatives to non-resorbable titanium for bone regeneration because of their favorable mechanical properties and biodegradability. However, the interaction between Mg alloys and immunomodulatory agents in promoting osteogenesis remains poorly understood. This study aimed to evaluate the osteogenic effects of an Mg alloy on pre-osteoblasts and to investigate whether erythromycin enhances Mg-induced osteogenic differentiation through regulation of developmental endothelial locus-1 (DEL-1).</p><p><strong>Materials and methods: </strong>WE43 Mg alloy disks were immersed in culture medium to produce Mg alloy-conditioned medium at concentrations of 25%, 50%, 75%, and 100%. MC3T3-E1 cells were treated with conditioned medium alone or combined with erythromycin (20 μg/mL). Cell viability was assessed using the MTT assay. Osteogenic differentiation was evaluated by Alizarin Red S staining (ARS), quantitative PCR analysis of osteogenic markers (<i>Runx2, Sp7, Bglap, Edil3</i>), and Western blot analysis of DEL-1 expression.</p><p><strong>Results: </strong>WE43 Mg alloy showed no cytotoxic effects on MC3T3-E1 cells. Treatment with Mg alloy-conditioned medium significantly enhanced osteogenic differentiation and extracellular matrix mineralization. The strongest osteogenic response was observed in cells receiving combined WE43 Mg alloy and erythromycin treatment. DEL-1 expression was significantly upregulated at both mRNA and protein levels in Mg alloy-treated groups, accompanied by increased expression of osteogenic markers. These effects were further amplified by erythromycin supplementation.</p><p><strong>Conclusion: </strong>WE43 Mg alloy promotes osteogenic differentiation of MC3T3-E1 cells, and erythromycin synergistically enhances this effect, potentially via DEL-1 upregulation. These findings support the combined use of immunomodulatory agents and Mg-based biomaterials in regenerative dentistry.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1627-1635"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A scientometric study on research trends and characteristics of tooth intentional replantation.","authors":"Yan Zhou, Simin Deng, Wenhua Xu, Wei Liu, Yibo Guo, Mingyi Zhu","doi":"10.1016/j.jds.2025.07.3451","DOIUrl":"10.1016/j.jds.2025.07.3451","url":null,"abstract":"<p><strong>Background/purpose: </strong>Intentional replantation is regarded as a final strategy to preserve natural teeth affected by inaccessible endodontic and periodontal disease. The purpose of this study was to analyze the scientometric characteristics and research trends of tooth intentional replantation.</p><p><strong>Materials and methods: </strong>All the papers on intentional replantation were comprehensively retrieved from the Scopus database. The years of publication were divided into before 2017 and after 2017 in the analysis of research trends.</p><p><strong>Results: </strong>There were 356 papers on intentional replantation, with total citations of 5562 and the <i>h</i> index of 42. The trend of bone substitutes, boron compounds, and boron derivative before 2017, has changed to aluminum compounds, aluminum derivative, and silicate after 2017. The trend of treatment keywords such as anti-bacterial agents, antiinfective agent, curettage, guided tissue regeneration, post and core technique, and retrograde obturation before 2017, has changed to apical surgery, endodontic surgery, surgical extrusion, periodontal regeneration, treatment failure, and platelet-rich fibrin after 2017. Besides, there were more systematic review and/or meta-analyses of the effectiveness and outcome of intentional replantation after 2017. There have always been common keywords such as root canal therapy, cone beam computed tomography, tooth extraction, diagnostic imaging, apicoectomy, root resorption, tooth ankylosis, tooth avulsion, periodontal ligament, periodontal pocket, auto-transplantation, alveolar bone loss, and bone regeneration.</p><p><strong>Conclusion: </strong>This scientometric study elucidated the current scenario and research trends of tooth intentional replantation, particularly the comprehensive identification and recognition of the important research topics concerned.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1983-1987"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Leeuwenhoek paradox in dental artificial intelligence: A narrative review of artificial intelligence-detected subclinical periapical changes and human-labeled false positives.","authors":"Etyene Schnurr, Mario Parra, David M Kim","doi":"10.1016/j.jds.2025.07.3498","DOIUrl":"10.1016/j.jds.2025.07.3498","url":null,"abstract":"<p><p>This narrative review explores the \"Leeuwenhoek Paradox,\" a metaphorical and conceptual challenge that arises when artificial intelligence (AI) detects subtle periapical radiological changes that are not visible to human observers. Drawing on evidence from studies using two-dimensional and cone-beam computed tomography (CBCT) imaging, this review critically examined the limitations of human-centered reference standards and recurrent discrepancies in AI-based periapical detection. The literature shows that AI systems frequently detect more periapical alterations than human experts. These findings may reflect early bone changes, as indicated by CBCT-based analyses of bone density and longitudinal observations. The paradox arises because AI identifies subclinical radiographic changes (AI-SRCs) that fall below the threshold of human visual perception, leading to their classification as false positives by humans owing to the limitations of human vision. Framed within the Leeuwenhoek Paradox, this article highlighted the constraints of equating diagnostic truth exclusively with human visual perception. Finally, the review outlined conceptual pathways for validating AISRCs, including longitudinal clinical studies, standardized visualization tools such as heatmaps, and the definition of new diagnostic thresholds, with the aim of supporting the safe integration of AI into dental diagnostics while mitigating the risks of overdiagnosis.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1385-1392"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep restriction exacerbates pulpal inflammation and impairs tissue repair following dental pulp capping: An <i>in vivo</i> animal study.","authors":"Siqi Huang, Qian Wang, Ziyu Chen, Guomiao Zhang, Ying Zheng","doi":"10.1016/j.jds.2025.07.3448","DOIUrl":"10.1016/j.jds.2025.07.3448","url":null,"abstract":"<p><p>As a fundamental physiological process, sleep is essential for maintaining systemic homeostasis. Although sleep restriction (SR) has been shown to trigger a systemic inflammatory response, its specific impact on local pulpal inflammation remains poorly understood. In this preliminary study, we investigated the effects of SR on the inflammatory response and reparative capacity of dental pulp in a rat model. Immunohistochemistry and western blotting revealed that, even in intact pulp tissue, SR upregulated the expression of interleukin-6, increased the infiltration of neutrophils, and activated the nuclear factor-kappa B signaling pathway. Subsequent investigations demonstrated that following dental pulp capping, SR provoked an exaggerated inflammatory response and impaired dental pulp repair, as evidenced by defective hard tissue formation and reduced collagen deposition. Taken together, these findings indicate that SR exacerbates the local inflammatory response within the dental pulp, thereby impairing its reparative potential.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1974-1978"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536300/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The utility of 3D nanostructured polyglycolic acid fibers for novel bone regenerative medicine.","authors":"Itsuki Hayashi, Sayaka Nakamura-Yamada, Kojiro Abe, Eiji Ito, Wataru Katagiri, Tatsuhiko Miyazaki, Yoichi Yamada","doi":"10.1016/j.jds.2025.07.3558","DOIUrl":"10.1016/j.jds.2025.07.3558","url":null,"abstract":"<p><strong>Background/purpose: </strong>Autologous and artificial bone grafts are widely applied for alveolar bone reconstruction. However, as concerns regarding invasiveness, safety, and efficacy persist, the improved novel regenerative materials are expected. This study focuses on the bone regenerative potential of three-dimensional (3D) nanofiber-based polyglycolic acid (nPGA), whose capacity for bone regeneration remains unclear.</p><p><strong>Materials and methods: </strong>Four types of 3D PGA fibrous matrices with different fiber diameters and surface densities were used. The cell affinity, proliferative capacity, and osteogenic differentiation potential of the nPGA matrices were evaluated using human dental pulp stem cells (DPSCs). The effects of nPGA on bone regeneration were also investigated using an in vivo rat calvarial bone defect model.</p><p><strong>Results: </strong>The cellular responses to the PGA matrix clearly differed depending on the structural properties of the PGA fibers. Cell engraftment was significantly enhanced in the nPGA group compared to the conventional PGA group. DPSCs exhibited a time-dependent proliferation on the nPGA matrices. Scanning electron microscopy revealed cellular extensions aligned along the 3D microfiber architecture. Moreover, the osteoinductive assays demonstrated that DPSCs possessed osteogenic differentiation potential on nPGA scaffolds. Histological evaluation revealed new bone formation in the nPGA-transplanted group. Immunohistochemical staining of CD31 demonstrated that neovascularization also occurred adjacent to the newly formed bone in this group.</p><p><strong>Conclusion: </strong>The 3D nPGA matrix characterized by finer fibers and low surface density exhibited a remarkable cell affinity and an effective scaffold function in osteogenesis, suggesting that it could be useful as a novel medical material in bone regenerative medicine.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1892-1903"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148879914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Craniofacial and dental arch morphological changes in pediatric obstructive sleep apnea syndrome following rapid maxillary expansion.","authors":"Yu-Hao Liu, Yu-Shu Huang, Yi-Jing Hwang, Cheng-Hui Lin, Shan-Shan Lee, Peng Hsu, Chung-Hsing Li, Li-Chuan Chuang","doi":"10.1016/j.jds.2025.07.3545","DOIUrl":"10.1016/j.jds.2025.07.3545","url":null,"abstract":"<p><strong>Background/purpose: </strong>Rapid maxillary expansion (RME) is a non-invasive treatment option for children with obstructive sleep apnea syndrome (OSAS). Yet, there's limited research on the effects of RME on the craniofacial, dental arch morphology and polysomnographic measures in pediatric OSAS.</p><p><strong>Materials and methods: </strong>Medical records of patients aged 4-14 years with apnea-hypopnea index (AHI) <i>></i> 1 event/hour and available cephalometric radiographs were reviewed. The Hyrax appliance was used for RME. Lateral and posterior-anterior cephalometric radiography, dental cast analysis and polysomnography (PSG) were performed before and after a six-month treatment. Statistical significance was defined as <i>P <</i> 0.05.</p><p><strong>Results: </strong>Due to data availability, 40 lateral cephalometric records, 33 posterior-anterior cephalometric images, 24 dental casts, and 40 polysomnographic records were analyzed. Significant increases were found in nasopharyngeal distances (PNS-AD1, PNS-AD2, and PNS-NPhp) and the minimal velopharyngeal distance (MinRPA). The length of the jugal process and the intermaxillary suture increased significantly. The intermaxillary suture opening in the frontal plane displayed an inverted V-shaped pattern. An inverse association was observed between the maxillary arch width and the arch length. RME also induced spontaneous dentoalveolar adaptations in the mandibular arch. The reductions in PSG measures were not statistically significant. A marked nominal decrease in AHI was seen in the moderate-to-severe obstructive sleep apnea (OSA) group compared with the mild group.</p><p><strong>Conclusion: </strong>RME treatment modifies craniofacial structure and dental arch morphology in children with OSAS. However, these anatomical improvements do not translate into statistically significant reductions in AHI. A more pronounced nominal decrease in AHI occurs in patients with moderate-to-severe OSA, compared with those with mild OSA.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1774-1784"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536419/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy outcome of the reconstruction of a total maxillectomy defect assisted by three-dimensional virtual surgical planning.","authors":"Sih-Yi Wu, Cheng-Yeu Wu, Kai-Hua Lien","doi":"10.1016/j.jds.2025.07.3455","DOIUrl":"10.1016/j.jds.2025.07.3455","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1994-1996"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}