Journal of Dental Sciences最新文献

{"title":"Development of zinc partially-stabilized cement carrying growth factor and anti-inflammatory drug for vital pulp therapy","authors":"Tsao-Li Chuang ,&nbsp;Chih-Chun Chang ,&nbsp;Chun-Liang Yeh ,&nbsp;Chun-Pin Lin","doi":"10.1016/j.jds.2025.05.029","DOIUrl":"10.1016/j.jds.2025.05.029","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Mineral trioxide aggregate (MTA) is recognized as the gold standard for vital pulp therapy. However, its clinical utility is limited by prolonged setting and poor handling characteristics. To overcome these drawbacks, the zinc-containing partially-stabilized cement (ZnPSC), a modified silicate cement, was developed. In this study, the ZnPSC was functionalized with vascular endothelial growth factor (VEGF) and aspirin to enhance its potential as an effective pulp capping material.</div></div><div><h3>Materials and methods</h3><div>The ZnPSC cements (5 %,7 %, or 10 % of Zn) were combined with poly-γ-glutamic acid (γ-PGA) 1 % or 2 % as a carrier system for VEGF and aspirin. The modified materials were evaluated for the setting time, compressive strength, biocompatibility, controlled drug release, and their ability to promote osteogenic differentiation of dental pulp stem cells (DPSC), assessed by alkaline phosphatase activity and calcium deposition staining.</div></div><div><h3>Results</h3><div>Incorporation of 1 % or 2 % γ-PGA into 5 % or 7 % ZnPSC cements significantly reduced the setting time and enhanced the compressive strength, overcoming the drawbacks associated with MTA and improving clinical workability. The modified materials exhibited excellent biocompatibility without cytotoxic effects. Furthermore, the sustained delivery of VEGF and aspirin markedly enhanced the mineralization and osteogenic differentiation of DPSCs, as evidenced by increased ALP activity and calcium deposition.</div></div><div><h3>Conclusion</h3><div>The novel ZnPSC cements functionalized with VEGF and aspirin demonstrated the superior handling properties, mechanical strength, biocompatibility, and enhanced regenerative potential, making it a promising candidate for the vital pulp therapy. Further, in vivo studies are warranted to validate its therapeutic efficacy and biosafety.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 4","pages":"Pages 2250-2257"},"PeriodicalIF":3.1,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145020732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Japanese dentist immigrant described by the writer, Chihei Nakamura, during the Japanese colonial period","authors":"Feng-Chou Cheng ,&nbsp;Ling-Hsia Wang,&nbsp;Wen-Hsun Chang,&nbsp;Chun-Pin Chiang","doi":"10.1016/j.jds.2025.05.035","DOIUrl":"10.1016/j.jds.2025.05.035","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 4","pages":"Pages 2547-2549"},"PeriodicalIF":3.1,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145020012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of an anti-snoring device featuring a Ni–Ti alloy elastic linkage in a simulated clinical environment","authors":"Ming-Sung Hsu ,&nbsp;Tung-Lin Tsai ,&nbsp;Shih-Jung Cheng ,&nbsp;Yu-Sheng Lin ,&nbsp;Li-Wen Weng ,&nbsp;Chun-Pin Lin","doi":"10.1016/j.jds.2025.05.030","DOIUrl":"10.1016/j.jds.2025.05.030","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Obstructive sleep apnea (OSA) is a common sleep-related breathing disorder that is often treated by mandibular advancement devices (MADs). However, conventional MADs are frequently associated with discomfort, rigidity, and limited patient compliance. This study aimed to design and evaluate a custom-made anti-snoring device featuring a nickel-titanium (Ni–Ti) alloy elastic connector to improve comfort, durability, and clinical performance.</div></div><div><h3>Materials and methods</h3><div>The device consisted of dual-layer upper and lower trays and was connected via Ni–Ti alloy rods. Finite element analysis (FEA) was conducted to compare the stress and deformation characteristics of three materials (Ni–Ti, stainless steel, and polycarbonate). Fatigue testing was also performed to simulate the long-term use. A clinical simulation involving seven adult participants diagnosed with mild to moderate OSA was conducted, including a seven-day trial and a post-trial questionnaire that evaluated comfort, fit, and effectiveness.</div></div><div><h3>Results</h3><div>FEA revealed that the Ni–Ti connector exhibited the most uniform stress distribution and the highest deformation capacity, indicating superior elasticity and resilience. Fatigue tests confirmed the structural stability after 5 million cycles. Subjective evaluations indicated the high user satisfaction and effective symptom relief; however, some discomfort related to oral dryness and temporomandibular joint (TMJ) pressure was reported.</div></div><div><h3>Conclusion</h3><div>The Ni–Ti-based anti-snoring device demonstrated favorable biomechanical properties and clinical usability. It offers a promising alternative to traditional MADs, potentially enhancing a long-term patient compliance and therapeutic outcomes. Further clinical validation is warranted.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 4","pages":"Pages 2258-2264"},"PeriodicalIF":3.1,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145020733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The story of a radiation technician covering dental radiology in Taiwan during the Japanese colonial period - Mr. Sakae Kawahara (1904–1943)","authors":"Feng-Chou Cheng ,&nbsp;Ling-Hsia Wang,&nbsp;Yu-Ting Hu,&nbsp;Chun-Pin Chiang","doi":"10.1016/j.jds.2025.05.036","DOIUrl":"10.1016/j.jds.2025.05.036","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 4","pages":"Pages 2550-2552"},"PeriodicalIF":3.1,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145020013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MicroRNA let-7a mitigates the progression of oral submucous fibrosis by targeting high-mobility group AT-hook 2","authors":"Hui-Wen Yang ,&nbsp;Chih-Yuan Fang ,&nbsp;Shih-Chi Chao ,&nbsp;Yi-Wen Liao ,&nbsp;Cheng-Chia Yu ,&nbsp;Yu-Wei Chiu","doi":"10.1016/j.jds.2025.05.027","DOIUrl":"10.1016/j.jds.2025.05.027","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Oral submucous fibrosis (OSF) is an irreversible fibrotic disorder of the oral cavity with a high potential for malignant transformation. MicroRNA lethal-7a (let-7a) has been recognized as a key antifibrotic regulator, but its specific role in OSF remains unknown. Therefore, this study aimed to elucidate the functional significance and the molecular mechanism of let-7a in OSF progression.</div></div><div><h3>Materials and methods</h3><div>The expression of let-7a was quantified by real-time quantitative polymerase chain reaction in fibrotic buccal mucosal fibroblasts (fBMFs) isolated from OSF lesions and patient–matched non-fibrotic BMFs (BMFs). Myofibroblastic characteristics were evaluated using collagen-gel contraction, Transwell migration, and wound-healing assays. Restoration and inhibition of let-7a expression were achieved by transfecting let-7a mimics or inhibitors, respectively. Direct binding of let-7a to high-mobility group AT-hook 2 (HMGA2) mRNA was verified using luciferase reporter assay.</div></div><div><h3>Results</h3><div>Let-7a expression was significantly down-regulated in fBMFs isolated from OSF lesions compared with patient–matched non-fibrotic BMFs. Moreover, let-7a expression declined in a dose–dependent manner during arecoline–induced myofibroblastic transdifferentiation of BMFs. Myofibroblastic characteristics, including cell contractility, cell migration, and wound-healing capacity were significantly decreased in fBMFs after transfection of let-7a mimics. Mechanistically, let-7a directly targeted the HMGA2 mRNA, leading to post-transcriptional repression of HMGA2. Importantly, silencing of HMGA2 was sufficient to diminish cell contractility and myofibroblasts marker expression in fBMFs.</div></div><div><h3>Conclusion</h3><div>The present study demonstrates that let-7a suppresses oral myofibroblast activation by directly targeting HMGA2. This finding first establishes the let-7a/HMGA2 axis as a promising therapeutic target for mitigating the progression of OSF.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 4","pages":"Pages 2265-2272"},"PeriodicalIF":3.1,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145020734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the impact of apicoectomy on autotransplantation success rates: A six-year retrospective cohort study in Taiwan","authors":"Kai-Yun Tso ,&nbsp;Wei-Chih Chiu ,&nbsp;Yu-Hsueh Wu","doi":"10.1016/j.jds.2025.05.031","DOIUrl":"10.1016/j.jds.2025.05.031","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Tooth autotransplantation is a viable surgical approach for rehabilitating edentulous areas. However, the influence of endodontic interventions, particularly apicoectomy, on outcomes of transplanting fully developed teeth remains incompletely understood. This study evaluated success and survival rates of autotransplantation in fully developed teeth and assessed the impact of various endodontic interventions on treatment outcomes in a Taiwanese population over a six-year period.</div></div><div><h3>Materials and methods</h3><div>A retrospective cohort study examined records of patients who underwent tooth autotransplantation at National Cheng Kung University Hospital, Taiwan, between 2018 and 2023. The study included 40 patients with 45 fully developed transplanted teeth. Three specialists evaluated radiographic images. Statistical analyses determined the influence of endodontic interventions on transplantation outcomes.</div></div><div><h3>Results</h3><div>The mean patient age at surgery was 35.1 ± 12.5 years and the mean follow-up period was 11.7 ± 9.9 months. Success rate at latest follow-up was 64.1 %, while survival rate reached 89.7 %. No statistically significant difference was observed between teeth that underwent apicoectomy or other endodontic interventions and those that did not (<em>P</em>-value &gt;0.05).</div></div><div><h3>Conclusion</h3><div>Despite the modest success rate, possibly due to stringent evaluation criteria, the high survival rate confirms that autotransplantation of fully developed teeth is effective when following strict protocols. Current evidence suggests endodontic interventions do not significantly influence treatment outcomes.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 4","pages":"Pages 2273-2282"},"PeriodicalIF":3.1,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145020646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vital pulp therapy of a complicated crown fracture in a child","authors":"Saeed Asgary","doi":"10.1016/j.jds.2025.05.033","DOIUrl":"10.1016/j.jds.2025.05.033","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 4","pages":"Pages 2553-2555"},"PeriodicalIF":3.1,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145020014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel surgical approach for benign deep lobe of parotid gland tumors: Utilizing the Santorini fissure","authors":"Hao Lu,&nbsp;Shengwen Liu,&nbsp;Wanlin Xu,&nbsp;Wenjun Yang","doi":"10.1016/j.jds.2025.05.019","DOIUrl":"10.1016/j.jds.2025.05.019","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 4","pages":"Pages 2556-2558"},"PeriodicalIF":3.1,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145020015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Limitations of bibliometric analysis: Evidences from trigeminocardiac reflex published in Journal of Dental Sciences","authors":"Li-Chiu Yang,&nbsp;Michelle Chao,&nbsp;Yu-Chao Chang","doi":"10.1016/j.jds.2025.05.028","DOIUrl":"10.1016/j.jds.2025.05.028","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 4","pages":"Pages 2559-2560"},"PeriodicalIF":3.1,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145020016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-cell isolation reveals 5 fluorouracil-resistant subclones in oral squamous cell carcinoma: New insights into stemness and epithelial–mesenchymal transition for targeted therapies","authors":"Wei-Chia Su ,&nbsp;Yi-Ming Chang ,&nbsp;Hsin-Hu Chen ,&nbsp;Su-Feng Chen ,&nbsp;Meng-Hua Yang ,&nbsp;Yu-Chun Lin ,&nbsp;Jian-Hong Yu","doi":"10.1016/j.jds.2025.05.032","DOIUrl":"10.1016/j.jds.2025.05.032","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Oral squamous cell carcinoma (OSCC) often recurs and has poor clinical outcomes, partly attributable to subpopulations that develop resistance to 5 fluorouracil (5FU). Elucidating how these resistant clones emerge and drive tumour aggressiveness is essential for improving OSCC treatment approaches.</div></div><div><h3>Materials and methods</h3><div>To establish 5FU-resistant cells, SCC25 cells were repeatedly exposed to 5FU, and single-cell clones were subsequently isolated using a microfluidic system. Three subclones-Holoclone, Meroclone, and Paraclone-were evaluated for their 5FU responses, expression of drug-efflux pumps (ABCB1, ABCG2), and resistance in three-dimensional (3D) cultures. Their levels of cancer stem cell (CSC) markers (OCT4, SOX2, CD44, CD133) and epithelial–mesenchymal transition (EMT) markers (E-cadherin, Vimentin, Twist) were also examined. In addition, Transwell assays were performed to assess migration and invasion.</div></div><div><h3>Results</h3><div>Compared with parental SCC25 cells, the three subclones exhibited markedly higher resistance to 5FU under 3D spheroid conditions, concurrent with upregulated ABCB1 and ABCG2 expression. All three subclones showed enhanced sphere-forming capacity and increased OCT4 and SOX2 levels, consistent with higher proportions of CD44⁺/CD133⁺ cells. Moreover, Holoclone, Meroclone, and Paraclone each displayed reduced E-cadherin alongside elevated Vimentin, and Twist, characteristic of EMT. Transwell assays confirmed increased migration and invasion, with Holoclone and Paraclone exhibiting particularly pronounced effects.</div></div><div><h3>Conclusion</h3><div>Extended 5FU treatment in OSCC selects for distinct subclones that exhibit CSC-like traits and EMT-related motility, promoting robust chemoresistance and heightened malignancy. These findings emphasise the importance of developing comprehensive therapeutic strategies that simultaneously target drug-efflux mechanisms, CSC markers, and EMT pathways to more effectively control OSCC progression.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 4","pages":"Pages 2283-2291"},"PeriodicalIF":3.1,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145020647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}