Journal of Dental Sciences最新文献

{"title":"Potential effect of topical antibiotics administration in the oral cavity on the reduced number of bacteria entering the lower respiratory tract after oral cancer surgery","authors":"Akira Imakiire ,&nbsp;Sakiko Soutome ,&nbsp;Keiichiro Miura ,&nbsp;Nanako Ito ,&nbsp;Mirai Higaki ,&nbsp;Fumitaka Obayashi ,&nbsp;Koichi Koizumi ,&nbsp;Souichi Yanamoto ,&nbsp;Tomohiro Yamada ,&nbsp;Masahiro Umeda","doi":"10.1016/j.jds.2024.06.021","DOIUrl":"10.1016/j.jds.2024.06.021","url":null,"abstract":"<div><h3>Background/purpose</h3><div>One of the causes of ventilator-associated pneumonia (VAP) is aspiration of oropharyngeal fluid containing pathogenic microorganisms into the lower respiratory tract. In this study, we aimed to investigate whether antibiotic ointment applied to the oral cavity can reduce the number of bacteria in the fluid on the cuff of a tracheal cannula.</div></div><div><h3>Materials and methods</h3><div>Tetracycline ointment was applied intraorally once to a patient under endotracheal intubation by postoperative tracheostomy for oral cancer. The tetracycline concentrations in the oropharyngeal fluid and fluid on the cuff of tracheal cannula were determined by bioassay, and the total viable bacterial count was determined by delayed real-time polymerase chain reaction developed by the authors from before to 6 h after application.</div></div><div><h3>Results</h3><div>A total of seven patients were enrolled. Very high antibiotic concentrations were maintained, ranging from 481 μg/ml to 2060 μg/ml in oropharyngeal fluid and from 267 μg/ml to 858 μg/ml in fluid on the cuff from 1 h to 6 h after application. Compared to the pre-application results, the inhibition rates of viable bacteria were 80.0–97.7% for oropharyngeal fluid and 47.6%–91.9% for fluid on the cuff at 1–6 h after application, indicating that antibiotic ointment can inhibit bacteria entering the lower respiratory tract for a long period of time in intubated patients.</div></div><div><h3>Conclusion</h3><div>Oral application of antibiotic ointment reduced the number of bacteria entering the lower respiratory tract, suggesting that it may be useful in the prevention or treatment of VAP.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 319-324"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141690928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Significant association of oral health-related quality of life with mental depression in middle-aged and older Taiwanese adults","authors":"Dun-Yu Hsu ,&nbsp;Wu-Chien Chien ,&nbsp;Da-Yo Yuh ,&nbsp;Ling-Yu Kung ,&nbsp;Yuan-Wu Chen","doi":"10.1016/j.jds.2024.07.027","DOIUrl":"10.1016/j.jds.2024.07.027","url":null,"abstract":"<div><h3>Background/purpose</h3><div>With the gradual aging of the population, oral health has emerged as a critical concern alongside mental well-being. This study endeavored to investigate the relationship between oral health-related quality of life (OHRQoL) and mental depression in middle-aged and older population.</div></div><div><h3>Materials and methods</h3><div>Based on the Taiwan Longitudinal Study on Aging in 2015, 7631 participants were enrolled. OHRQoL was assessed utilizing the Taiwan version of the Oral Health Impact Profile questionnaire, stratifying individuals into five categories (excellent, good, fair, poor, and very poor). The excellent OHRQoL group was regarded as the reference group. Depression status was evaluated using the 10-item Center for the Epidemiological Studies of Depression Short Form questionnaire. Descriptive statistics and Pearson's chi square test were applied to elucidate the demographic characteristics and the differences among the five OHRQoL groups, respectively. Multivariable logistic regression was applied to elucidate the association of OHRQoL with depression after controlling for confounding factors.</div></div><div><h3>Results</h3><div>After controlling for covariates such as age, sex, marital status, living status, residency status, religion, level of physical activity, and pressures arising from personal or familial concerns, the adjusted ORs of experiencing mental depression were 1.45 (95% CI: 1.198–1.760, <em>P</em> &lt; 0.001), 2.25 (95% CI: 1.791–2.829, <em>P</em> &lt; 0.001), 3.88 (95% CI: 2.730–5.525, <em>P</em> &lt; 0.001), and 6.87 (95% CI: 3.116–15.129, <em>P</em> &lt; 0.001) for the good, fair, poor, and very poor OHRQoL groups, respectively, which demonstrated a gradually increased relationship.</div></div><div><h3>Conclusion</h3><div>Oral health-related quality of life was negatively associated with mental depression in middle-aged and older adults.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 261-269"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11762601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periodontal ligament fibroblasts utilize isoprenoid intermediate farnesyl diphosphate for maintaining osteo/cementogenic differentiation abilities","authors":"Xiuting Wang ,&nbsp;Shigeki Suzuki ,&nbsp;Hang Yuan ,&nbsp;Shizu Hirata-Tsuchiya ,&nbsp;Rahmad Rifqi Fahreza ,&nbsp;Eiji Nemoto ,&nbsp;Hideki Shiba ,&nbsp;Satoru Yamada","doi":"10.1016/j.jds.2024.04.025","DOIUrl":"10.1016/j.jds.2024.04.025","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Peroxisome proliferator-activated receptor γ (PPARγ) is a major transcription factor of energy metabolism-associated genes, and three PPARγ isoforms have been identified in periodontal tissues and cells. When energy metabolism homeostasis is affected by PPARγ downregulation in periodontal ligament fibroblasts (PDLFs), osteo/cementogenic abilities are markedly lost. Herein, we investigated whether PPARγ agonists promote periodontal tissue regeneration, and which PPARγ isoforms and metabolic pathways are indispensable for osteo/cementogenic abilities.</div></div><div><h3>Materials and methods</h3><div>A PPARγ agonist was locally administered to regenerate murine periodontal tissue. The distinct functions of the PPARγ isoforms in PDLFs were assessed using an overexpression strategy. Candidate metabolic processes were searched using gene ontology analysis of PPARγ-knockdown PDLFs. <em>In vitro</em> differentiation assays were performed to evaluate the effects of farnesyl diphosphate (FPP) and geranylgeranyl diphosphate (GGPP), two major isoprenoid intermediates.</div></div><div><h3>Results</h3><div>PPARγ agonists accelerated periodontal tissue regeneration. Full-length PPARγ overexpression specifically enhanced the osteo/cementogenic differentiation of PPARγ agonist–induced PDLFs. The isoprenoid metabolic process was the top-ranked downregulated metabolism-associated pathway following PPARγ knockdown; FPP and GGPP enhanced and suppressed PDLFs' differentiation, respectively. Gene expression analysis of human clinical periodontal tissues revealed that <em>osteocalcin</em> correlated with <em>farnesyl pyrophosphate synthetase</em> (<em>FDPS</em>), which catalyzes FPP production, but not with two FPP conversion enzymes: <em>geranylgeranyl diphosphate synthase 1</em> (<em>GGPS1</em>) or <em>farnesyl diphosphate farnesyltransferase 1</em> (<em>FDFT1</em>).</div></div><div><h3>Conclusion</h3><div>Preferable PPARγ agonistic actions depend on the full-length PPARγ isoform. FPP increased PDLFs' osteo/cementogenic abilities. Therefore, administering FPP and precisely controlling FDPS, GGPS1, and FDFT1 activities could be a novel strategy for accelerating periodontal tissue regeneration.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 560-568"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141028542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimized design for using of double-barrel vascularized fibular flap in various types of mandibular defects","authors":"Lidong Wang ,&nbsp;Wen Ma ,&nbsp;Changbin Zhang ,&nbsp;Sihang Wang ,&nbsp;Gending Nie ,&nbsp;Ming Li","doi":"10.1016/j.jds.2024.04.022","DOIUrl":"10.1016/j.jds.2024.04.022","url":null,"abstract":"<div><h3>Background/purpose</h3><div>The functional and aesthetic reconstruction of the mandible can be achieved by using the double-barrel vascularized free fibula flap. The purpose of this study was to use multiple integrated techniques to more effectively reconstruct the mandible, some contains of our unique ideas.</div></div><div><h3>Materials and methods</h3><div>21 patients were included in this study. Computed tomography (CT) data of the patient's mandible and fibula were acquired preoperatively. Individualized surgical simulation was performed by using computer-aided surgical simulation (CASS) technology, about 6 kinds of integrated 3D design ideas were simultaneously perfectly transferred to real surgery. The accuracy of reconstruction was evaluated by superimposing the postoperative and preoperative image of mandible, measuring the linear and angular deviation of landmarks between the planned and actual outcomes.</div></div><div><h3>Results</h3><div>The mandibular reconstruction was effectively performed on all patients, and the result analysis showed that the surgical plan was precisely performed. The facial contours of the postoperative patients were harmonized and the largest mean linear and angular differences were 1.47 ± 0.31 mm and 3.97 ± 0.63°, respectively.</div></div><div><h3>Conclusion</h3><div>This study system illustrates how to select and position the fibula for reconstruction of various types of segmental mandibular defects by using double-barrel vascularized free fibula flap. It will provide valuable guidance and enhance the accessibility and efficiency of mandibular defects treatment.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 578-585"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141038694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relevance of dental management prior to radiation therapy with severe oral mucositis in head and neck cancer patients","authors":"Yutian Wang ,&nbsp;Zhou Huang ,&nbsp;Shaowen Xiao ,&nbsp;Baomin Zheng ,&nbsp;Dan Zhao ,&nbsp;Weixin Liu ,&nbsp;Xiaolong Xu ,&nbsp;Nan Wang ,&nbsp;Chao Yang ,&nbsp;Yanqun Zhang ,&nbsp;Yan Sun ,&nbsp;Hongwei Liu","doi":"10.1016/j.jds.2024.04.030","DOIUrl":"10.1016/j.jds.2024.04.030","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Dental management prior to radiotherapy is often time-critical, and there are no studies on whether manipulations such as tooth extraction influence the risk of severe radiation-induced oral mucositis (ROM) during radiotherapy. Therefore, the aim of this study was to describe the relationship between dental management and the incidence of severe ROM.</div></div><div><h3>Materials and methods</h3><div>A retrospective analysis was conducted on 144 head and neck cancer (HNC) patients who received dental management before radiotherapy at Peking University Cancer Hospital, from January 2016 to December 2017. Demographic characteristics, primary tumor features, cancer treatment characteristics, and severity of oral mucositis during radiotherapy were recorded. Univariate analysis and logistic regression analysis were used to explore factors associated with severe radiation-induced oral mucositis.</div></div><div><h3>Results</h3><div>The incidence of grade 3 mucositis was 14.5% (22/144); univariate analysis showed that the number of extracted teeth (OR = 1.313; 95%CI = 1.012–1.702; <em>P</em> = 0.040) and patients with primary oral cancer had a higher risk of developing grade 3 mucositis (OR = 3.848; 95% CI = 1.508–9.822; <em>P</em> = 0.005). No statistical correlation was found between pre-radiation therapy prophylaxis, dental restoration, endodontic treatment, and grade 3 mucositis (<em>P</em> &gt; 0.05). Logistic regression analysis showed that the number of extracted teeth (OR = 1.421, 95%CI = 1.071–1.885, <em>P</em> = 0.015) and primary tumor location in the oral cavity (compared with other head and neck cancers) (OR = 5.165, 95%CI = 1.636–16.311, <em>P</em> = 0.005) were significantly associated with grade 3 mucositis.</div></div><div><h3>Conclusion</h3><div>In HNC patients undergoing radiotherapy, the primary site located in the oral cavity and a higher number of teeth extracted are independent risk factors for the development of severe mucositis.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 522-528"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141057361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of a recurrent odontogenic keratocyst in the zygoma using piezoelectric instruments","authors":"I. Chen,&nbsp;Kwei-Jing Chen,&nbsp;Michael Yuan-Chien Chen","doi":"10.1016/j.jds.2024.11.004","DOIUrl":"10.1016/j.jds.2024.11.004","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 721-722"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11762927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preserving pulp vitality for teeth with post-vital pulp therapy symptoms by retrying pulp-preserving procedures: A retrospective clinical study","authors":"Jin-Kyu Yi ,&nbsp;Ah-Rhim Seo","doi":"10.1016/j.jds.2024.08.002","DOIUrl":"10.1016/j.jds.2024.08.002","url":null,"abstract":"<div><h3>Background/purpose</h3><div>The occurrence of post-vital pulp therapy (VPT) symptoms is perplexing for dentists, and root canal treatment (RCT) is preferred for such conditions. Furthermore, managing post-VPT symptoms, rather than performing RCT, would preserve pulp vitality and enhance VPT outcomes. This study aimed to evaluate the efficacy of VPT retrials in preserving pulp vitality and substituting RCT in teeth with post-VPT symptoms.</div></div><div><h3>Materials and methods</h3><div>VPT was performed on the exposed pulp during caries removal in symptomatic and asymptomatic teeth. VPTs were repeated in teeth with post-VPT symptoms. This study screened multi-time-practiced VPT cases from a VPT-performed data pool. The presence of vital pulp tissue after minimized pulp resection (MPR) was a prerequisite for substituting RCT with VPT retrials. A total of 22 cases from 19 patients were included in this study. MPR was introduced to maximize the preservation of the vital pulp.</div></div><div><h3>Results</h3><div>After performing VPT, post-VPT symptoms occurred in pre-VPT asymptomatic teeth, or pre-VPT symptoms were modified in teeth with pre-VPT symptoms. The rate of pre-VPT irreversible pulpitis (IP), comprising symptomatic/asymptomatic IP, was 81.68%. The most prevalent post-VPT symptom was heightened sensitivity to thermal stimuli (68.2%), followed by spontaneous pain (45.5%). The post-VPT IP was 63.6%. VPT retrials resolved 90.9% of cases with post-VPT symptoms.</div></div><div><h3>Conclusion</h3><div>VPT retrials using MPR could enhance VPT outcomes and be a viable alternative to RCT for teeth with post-VPT symptoms.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 229-237"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11762614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel transnasal technique for the removal of nasally impacted mesiodens: A case report","authors":"Yi-Kai Huang,&nbsp;Meng-Ling Chiang,&nbsp;Jyh-Kwei Chen","doi":"10.1016/j.jds.2024.09.013","DOIUrl":"10.1016/j.jds.2024.09.013","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 710-712"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody positivity in 588 patients with oral lichen planus","authors":"Yu-Hsueh Wu ,&nbsp;Julia Yu-Fong Chang ,&nbsp;Yi-Pang Lee ,&nbsp;Yi-Ping Wang ,&nbsp;Andy Sun ,&nbsp;Chun-Pin Chiang","doi":"10.1016/j.jds.2024.11.014","DOIUrl":"10.1016/j.jds.2024.11.014","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Our previous study found that 21.9 %, 13.6 %, 7.1 %, 0.3 %, and 14.8 % of 352 oral lichen planus (OLP) patients have anemia, serum iron, vitamin B12, and folic acid deficiencies, and hyperhomocysteinemia, respectively. This study mainly evaluated the anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity in a large group of 588 OLP patients.</div></div><div><h3>Materials and methods</h3><div>The blood hemoglobin (Hb) and serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 588 OLP patients were measured and compared with the corresponding levels in 588 age- and sex-matched healthy control subjects.</div></div><div><h3>Results</h3><div>We found that 148 (25.2 %), 99 (16.8 %), 60 (10.2 %), 7 (1.2 %), 124 (21.1 %), and 139 (23.6 %) OLP patients had blood Hb, serum iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity, respectively. Moreover, 588 OLP patients had significantly higher frequencies of blood Hb and serum iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity than 588 healthy control subjects (all <em>P</em>-values &lt;0.001 except <em>P</em> = 0.023 for folic acid deficiency). Of 148 anemic OLP patients, 68 had normocytic anemia, 32 had iron deficiency anemia, 19 had thalassemia trait-induced anemia, 17 had pernicious anemia, 7 had macrocytic anemia other than pernicious anemia, and 5 had microcytic anemia other than iron deficiency anemia and thalassemia trait-induced anemia.</div></div><div><h3>Conclusion</h3><div>OLP patients have significantly higher frequencies of blood Hb and serum iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity than healthy control subjects.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 660-666"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11762913/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sialolithiasis of the right submandibular gland incidentally found on the panoramic radiograph","authors":"Feng-Chou Cheng,&nbsp;Mu-Hsiung Chen,&nbsp;Chia-Hung Chang,&nbsp;Chun-Pin Chiang","doi":"10.1016/j.jds.2024.10.026","DOIUrl":"10.1016/j.jds.2024.10.026","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 683-685"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763619/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}