Chih-Wen Chi , Tze-Wen Chung , Yi-Sheng Wu , Weng-Pin Chen , Chun-Pin Lin
{"title":"Investigation of the cushioning mechanism of a novel dental implant system with composite hydrogel","authors":"Chih-Wen Chi , Tze-Wen Chung , Yi-Sheng Wu , Weng-Pin Chen , Chun-Pin Lin","doi":"10.1016/j.jds.2024.10.016","DOIUrl":"10.1016/j.jds.2024.10.016","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Dental implants can restore both function and aesthetics in edentulous areas. However, the absence of cushioning mechanical behavior in implants may limit their clinical performance and reduce the long-term survival rates. This study aimed to establish an implant cushion mechanism that mimicked the natural periodontal ligament, utilizing the properties of composite hydrogels.</div></div><div><h3>Materials and methods</h3><div>In this study, we synthesized two composite hydrogels (HS and HSP groups) using hyaluronic acid (HA) and silk fibroin. We conducted static-constrained compression, creep, and porosity tests to assess the physical properties of these composite hydrogels. Finite element analysis (FEA) was employed to examine the effects of different thicknesses, permeabilities, and compression coefficients on the deformation of the hydrogels. The composite hydrogels were then applied within a novel dental implant, and the displacement performance of the implants, along with stress distribution on the alveolar bone, was evaluated using FEA.</div></div><div><h3>Results</h3><div>Regarding the mechanical performance of the composite hydrogels, increased permeability led to quicker displacement under compression. Thicker hydrogels with larger compression moduli influenced the biphasic behavior and deformation. The novel dental implants demonstrated biphasic sinking behavior under loading and rapid repositioning during unloading. When evaluating stress distribution on the alveolar bone under oblique loading, the HS and HSP implant groups showed a stress reduction of 10.3 % and 13.6 %, respectively, compared to commercial implant groups.</div></div><div><h3>Conclusion</h3><div>This study highlights that the biphasic nature of solid and liquid phases is crucial when incorporating a cushioning mechanism into implants to replicate the characteristics of the periodontal ligament.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 61-68"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tzu-Yu Lin , Tung-Yung Huang , Hsien-Chung Chiu , Yao-Yu Chung , Wei-Chun Lin , Hung-Yun Lin , Sheng-Yang Lee
{"title":"2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside–stimulated dental pulp stem cells-derived exosomes for wound healing and bone regeneration","authors":"Tzu-Yu Lin , Tung-Yung Huang , Hsien-Chung Chiu , Yao-Yu Chung , Wei-Chun Lin , Hung-Yun Lin , Sheng-Yang Lee","doi":"10.1016/j.jds.2024.09.010","DOIUrl":"10.1016/j.jds.2024.09.010","url":null,"abstract":"<div><h3>Background/purpose</h3><div>-2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside (THSG) is a bioactive component in the Chinese herb Polygonum multiflorum, recognized for its anti-inflammatory and lipid-lowering properties. Human dental pulp stem cells (hDPSCs) have excellent capabilities in tooth regeneration, wound healing, and neural repair. The exosomes (Exo) released by hDPSCs contain bioactive molecules that influence cell proliferation, differentiation, and immune responses. Therefore, we aimed to unveil the potential of THSG-Exo and evaluate its regenerative capabilities through the <em>in vitro</em> experiment and rat bone defect model.</div></div><div><h3>Materials and methods</h3><div>The effects of hDPSC-derived exosomes, with or without THSG treatment, on repair and bone regeneration were evaluated through <em>in vitro</em> and <em>in vivo</em> studies. Finally, we conducted a proteomic analysis to meticulously compare the compositional contents of the two types of exosomes.</div></div><div><h3>Results</h3><div><em>In vitro</em> data showed that 10 and 100 μM THSG-Exo enhanced cell proliferation and osteogenic differentiation, reducing wound size to 40 % of its original size. In our maxillary bone defect rat model, THSG-Exo significantly increased bone volume, trabecular thickness, and bone density in the bone defect area. In addition, proteomic analysis of THSG-Exo revealed diverse proteins linked to bone differentiation and tissue repair, including bone morphogenetic protein-1 (BMP-1) and tumor necrosis factor (TNF)-α-stimulated gene 6 (TNFAIP6). Our searches in functional databases revealed that THSG-Exo is involved in numerous biological pathways.</div></div><div><h3>Conclusion</h3><div>THSG-Exo enhanced cell proliferation, wound healing, and osteogenesis <em>in vitro</em>, while also expediting tissue repair and bone regeneration <em>in vivo</em>. The protein diversity of THSG-Exo contributes significant value in both basic and regenerative medicine.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 154-163"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11762248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yeqiang Li , Chenxi Li , Xuemin Shen , Zhengyu Shen , Wei Liu
{"title":"A scientometric study of syphilis research by dermatologists and stomatologists: Underpinning their roles in public health","authors":"Yeqiang Li , Chenxi Li , Xuemin Shen , Zhengyu Shen , Wei Liu","doi":"10.1016/j.jds.2024.08.001","DOIUrl":"10.1016/j.jds.2024.08.001","url":null,"abstract":"<div><h3>Background/Purpose</h3><div><em>The Lancet Infectious Diseases</em> launched a call to action for dermatologists in the rise of syphilis. In practice, dermatologists and stomatologists perform early diagnoses of syphilis and refer patients to adequate treatment.</div></div><div><h3>Materials and methods</h3><div>This scientometric study aimed to investigate and compare research trends and characteristics of syphilis publications by dermatologists and stomatologists in the Scopus database, with emphasis on the analysis of the keywords that can reflect research directions and topics of concern.</div></div><div><h3>Results</h3><div>Among 18,120 papers on syphilis, 1981 (10.9%) and 201 (1.1%) were published by dermatologists and stomatologists, respectively. The total citation count was 18,629 and 2,376 with an <em>h</em> index of 52 and 25 for publications by dermatologists and stomatologists, respectively. Common keywords in papers by both dermatologists and stomatologists included male, <em>Treponema pallidum</em>, benzathine penicillin, differential diagnosis, human immunodeficiency virus, secondary syphilis, syphilis serology, cutaneous syphilis, neurosyphilis, congenital syphilis, lymphadenopathy, chancre, gonorrhea, rash, erythema, and papule. Distinctive keywords used by dermatologists included infant, pregnancy complications, lymphocytic infiltration, spirochete, and genetics. Keywords that included questionnaire, awareness, infection risk, attitude to health, sexual health, oral sex, and unprotected sex were used by stomatologists.</div></div><div><h3>Conclusion</h3><div>In the modern context, both dermatologists and stomatologists play important roles in providing early recognition and timely diagnosis of syphilis, advocating for public health campaigns aimed at increasing awareness, and improving access to care for at-risk patient populations.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 254-260"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763175/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The investigation of thermal behavior and temperature analysis of three types of contemporary gutta-percha points","authors":"Hsin-Hui Wang , Liang-Han Chiu , Yung-Hao Hsu , Sung-Chih Hsieh","doi":"10.1016/j.jds.2024.09.024","DOIUrl":"10.1016/j.jds.2024.09.024","url":null,"abstract":"<div><h3>Background/purpose</h3><div>The impact of thermal behavior on the clinical performance of gutta-percha points (GP) is unclear. This study aimed to investigate the thermal behavior of three different types of GP and their temperature changes (TC) in a simulated clinical environment.</div></div><div><h3>Materials and methods</h3><div>The GP tested were Conform Fit® Gutta-Percha Points (CF), Autofit™ Feathered Tip Gutta Percha (AF), and Gutta Percha Root Canal Points (GC). The phase transition temperatures of the samples were analyzed using differential scanning calorimetry (DSC). The TC at the tips of the GP was examined with the heat source positioned at specific distances from the tip. Additionally, the TC of the GP in the apical foramen of a simulated canal during the warm vertical compaction (WVC) technique was evaluated. Differences in the apical temperature of the GP during WVC were compared using two-way ANOVA, with statistical significance set at <em>P</em> < 0.05.</div></div><div><h3>Results</h3><div>The phase transition temperatures peaked at approximately 51 °C and 61 °C. The temperature analysis showed the maximum average temperatures of AF and CF decreased to 38 °C when the heat source was 3 mm from the tip. During WVC, the average maximum apical temperatures for AF, CF, and GC were 37.7 °C, 36.0 °C, and 35.5 °C, respectively. Both the elapsed time of WVC and the brand of GP significantly (<em>P</em> < 0.05) affected the apical temperature.</div></div><div><h3>Conclusion</h3><div>The apical temperature elevation of the GP during WVC was minimal. Neither AF nor CF reached the moldable temperatures when the heat source was 3 mm away.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 83-88"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11762960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Optimized human dedifferentiated fat cells from the buccal fat pad-derived osteoinductive extracellular vesicles promote osteoblast differentiation","authors":"Yusuke Nishiguchi , Mamoru Ueda , Hirohito Kubo , Jun-Ichiro Jo , Yoshiya Hashimoto , Toshihiko Takenobu","doi":"10.1016/j.jds.2024.07.028","DOIUrl":"10.1016/j.jds.2024.07.028","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Bone reconstruction in the maxillofacial region typically relies on autologous bone grafting, which presents challenges, including donor site complications and graft limitations. Recent advances in tissue engineering have identified highly pure and proliferative dedifferentiated fat cells (DFATs) as promising alternatives. Herein, we explored the capacity for osteoblast differentiation and the osteoinductive characteristics of extracellular vesicles derived from DFATs (DFAT-EVs).</div></div><div><h3>Materials and methods</h3><div>DFATs were isolated from human buccal fat pads, cultured to confluency, and placed in either a standard or osteogenic induction medium. After culturing for 3 days, the conditioned medium was used to generate EVs using the size-exclusion chromatography and concentration filter method.</div></div><div><h3>Results</h3><div>Characterization of DFAT-EVs revealed typical EV morphology and positive markers (CD9 and CD63), with no differences between the two groups. <em>In vitro</em> assays demonstrated that EVs derived from the osteogenic induction medium (OI-EVs) significantly increased alkaline phosphatase activity and osteogenesis-related genes (Runx2 and collagen type I) compared to control EVs. Next-generation sequencing identified differentially expressed miRNAs, and gene ontology analysis suggested pathways involved in osteoblast differentiation.</div></div><div><h3>Conclusion</h3><div>Isolating DFATs from buccal fat pads under osteogenic induction conditions offers a procedure confined to the oral cavity, eliminating the need for harvesting from other sites. Thus, DFAT-EVs hold promise for promoting bone regeneration in maxillofacial applications.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 278-285"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141969751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Developing competency-based medical education for dental education in Taiwan: A pilot study of tooth extraction entrustable professional activities","authors":"Jamie Liang-Chieh Chen , Johnson Hsin-Chung Cheng , Chia-Yu Wu , Han-Chi Chung , Chun-Cheng Chen , Cheng-Ting Hsiao , Jeng-Wen Chen","doi":"10.1016/j.jds.2024.09.032","DOIUrl":"10.1016/j.jds.2024.09.032","url":null,"abstract":"<div><h3>Background/purpose</h3><div>This study aimed to evaluate the initial implementation of competency-based medical education (CBME) through entrustable professional activities (EPAs) in Taiwan dental education, focusing on tooth extraction EPAs across undergraduate year (UGY), postgraduate year (PGY), and oral and maxillofacial surgery-residency (OS-R) levels.</div></div><div><h3>Materials and methods</h3><div>Using the Delphi method, an advisory team developed and validated three levels of trial EPAs, which were implemented through the Emyway platform. A structured questionnaire was used to evaluate teachers' and students' experiences and satisfaction with Emyway and the EPAs. Data were collected from the participants at two university-affiliated hospitals in Taiwan. Statistical analyses comparing teachers' and students’ experiences and satisfaction were conducted.</div></div><div><h3>Results</h3><div>The EQual rubric scores for the EPAs were high across all levels (UGY: 4.80, PGY: 4.78, R: 4.79) with no significant differences. The demographic characteristics and Emyway experiences were similar among 7 teachers and 17 students. No significant difference was observed in terms of satisfaction with EPA design and usage between the teachers and students. For the teachers and students, the overall Emyway satisfaction scores were 3.86 and 3.76 and the EPA content satisfaction scores were 4.00 and 3.71, respectively, with no significant differences.</div></div><div><h3>Conclusion</h3><div>The study successfully introduced EPAs into Taiwan dental education, demonstrating high EQual rubric scores and moderate satisfaction. Emyway is a convenient and effective platform for EPA implementation. Future efforts should focus on the expansion of EPAs to other dental specialties and integration of CBME into Taiwan dental education to align with international standards.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"19 ","pages":"Pages S128-S135"},"PeriodicalIF":3.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11725082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142978713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ping-Yi Lin , Yi-Hsuan Tsai , Ting-Chen Chen , Ching-Yao Hsieh , Shiu-Fong Ou , Chih-Wei Yang , Cheng-Heng Liu , Ting-Fang Lin , Chen-Ying Wang
{"title":"The virtual assessment in dental education: A narrative review","authors":"Ping-Yi Lin , Yi-Hsuan Tsai , Ting-Chen Chen , Ching-Yao Hsieh , Shiu-Fong Ou , Chih-Wei Yang , Cheng-Heng Liu , Ting-Fang Lin , Chen-Ying Wang","doi":"10.1016/j.jds.2024.10.012","DOIUrl":"10.1016/j.jds.2024.10.012","url":null,"abstract":"<div><div>The shift towards virtual assessment in dental education represents a significant advancement over traditional evaluation methods, offering new opportunities for assessing both theoretical knowledge and practical skills. This review examines the use of virtual assessment tools within the context of dental education. A narrative literature review was conducted, analyzing studies published between 2000 and 2024, sourced from PubMed, the Cochrane Library, and Embase. From the initial search, 13 studies were selected for qualitative synthesis. The results indicate that virtual assessments, facilitated by technologies such as computer-based simulations and remote objective structured clinical examinations (OSCEs), have enhanced the accuracy and comprehensiveness of dental student evaluations. These methods allow for more consistent and objective assessments of competencies, addressing some limitations of traditional practical exams. However, the integration of virtual assessments presents challenges, including the need for significant investment in technology, infrastructure, and training for faculty and students. Despite these challenges, the review concludes that virtual assessment has the potential to become a cornerstone of modern dental education, offering a scalable and adaptable solution for evaluating dental competencies in diverse learning environments.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"19 ","pages":"Pages S102-S115"},"PeriodicalIF":3.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11725131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142978722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sirida Arunjaroensuk , Thanida Yotpibulwong , Po-Sung Fu , Jen-Chyan Wang , Chun-Cheng Hung , Nikos Mattheos , Atiphan Pimkhaokham
{"title":"Implant position accuracy using dynamic computer-assisted implant surgery (CAIS) combined with augmented reality: A randomized controlled clinical trial","authors":"Sirida Arunjaroensuk , Thanida Yotpibulwong , Po-Sung Fu , Jen-Chyan Wang , Chun-Cheng Hung , Nikos Mattheos , Atiphan Pimkhaokham","doi":"10.1016/j.jds.2024.09.004","DOIUrl":"10.1016/j.jds.2024.09.004","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Computer-assisted implant surgery (CAIS) is increasingly performed to reduce deviations in implant position. Dynamic CAIS or navigation systems provide instant display of implant drilling instruments and patient positions directly on the computer monitor. Augmented reality (AR) technology allows operators to visualize real-time information projected onto the lenses of AR glasses. Although AR is being used in medical applications, there are few clinical studies on applying AR glasses to dental implants. The purpose of this randomized clinical study was to compare the accuracy of implant position using the dynamic CAIS with and without AR glasses.</div></div><div><h3>Materials and methods</h3><div>Twenty patients who needed a single dental implant were randomly divided into two groups: combined dynamic CAIS with AR glasses (AR glasses group, n = 10) and dynamic CAIS without AR glasses (non-AR glasses group, n = 10). Three-dimensional (3D) deviations of implant platform, apex and angular deviations were measured and analyzed using independent t-tests (<em>P</em> < 0.05).</div></div><div><h3>Results</h3><div>The 3D angular deviations in the AR glasses and non-AR glasses groups were 1.47 ± 1.01° and 2.42 ± 0.76°, respectively. Mean 3D entry point and apical deviations were 0.75 ± 0.45 mm and 0.87 ± 0.45 mm in the AR glasses group, whereas the non-AR glasses group were 1.11 ± 0.44 mm and 1.18 ± 0.50 mm, respectively. There was no statistically significant difference between the two groups.</div></div><div><h3>Conclusion</h3><div>Implant position accuracy using dynamic CAIS with AR glasses was similar to dynamic CAIS without AR glasses during a single implant placement.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"19 ","pages":"Pages S44-S50"},"PeriodicalIF":3.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11725068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142978880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bernadette Quah , Chee Weng Yong , Asher Ah Tong Lim , Raymond Chung Wen Wong , Sung-Kiang Chuang
{"title":"Striving for excellence in a little red dot: Exploring the evolution of oral and maxillofacial surgery training and practice in Singapore","authors":"Bernadette Quah , Chee Weng Yong , Asher Ah Tong Lim , Raymond Chung Wen Wong , Sung-Kiang Chuang","doi":"10.1016/j.jds.2024.09.026","DOIUrl":"10.1016/j.jds.2024.09.026","url":null,"abstract":"<div><div>Oral and maxillofacial surgery (OMS) is a field that straddles knowledge and clinical experience from both medical and dental specialties. In the small island nation of Singapore, the rapidly and constantly changing needs of its diverse and aging population, as well as changes in the mindsets of both students and educators have led to many developments in the local OMS program. Tied to the only dental school in the country, the curriculum of the training program has kept up with the changes in the demographics and attitudes of the local patient pool, which comprises a multicultural population with both traditional and modern mindsets. Since its inception, the training program has also shifted away from the traditional apprenticeship model of surgical specialties to include more integrated and modular learning with a heavy emphasis on evidence-based medicine, simulation training workshops, and more focus on digital planning and other technological advancements. This review explores the current scope of training and practice in the Singapore landscape, and how it has evolved and been tailored to meet the needs of its patients and future clinicians.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"19 ","pages":"Pages S10-S16"},"PeriodicalIF":3.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11725128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142978882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}