Journal of Dental Sciences最新文献

{"title":"Ethical implications and moral considerations of dental practice based on Taiwan's medical regulations","authors":"Feng-Chou Cheng, Wei-Chun Lin, Ling-Hsia Wang, Chun-Pin Chiang","doi":"10.1016/j.jds.2025.04.033","DOIUrl":"10.1016/j.jds.2025.04.033","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 3","pages":"Pages 1963-1965"},"PeriodicalIF":3.4,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe external root resorption of the right maxillary second molar caused by the pressure from an impacted wisdom tooth","authors":"Feng-Chou Cheng, Yu-Ting Hu, Chun-Pin Chiang","doi":"10.1016/j.jds.2025.04.028","DOIUrl":"10.1016/j.jds.2025.04.028","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 3","pages":"Pages 1966-1968"},"PeriodicalIF":3.4,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144364559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The dental clinic on the postcard with the theme of Taiwan street scene during the Japanese colonial period: The story of a Japanese immigrant, Dr. Akira Sugiyama","authors":"Feng-Chou Cheng, Ling-Hsia Wang, Chun-Pin Chiang","doi":"10.1016/j.jds.2025.04.029","DOIUrl":"10.1016/j.jds.2025.04.029","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 3","pages":"Pages 1969-1971"},"PeriodicalIF":3.4,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144364560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The standardization of oral health screening survey in Taiwan","authors":"Feng-Chou Cheng , Ling-Hsia Wang , Chun-Pin Chiang","doi":"10.1016/j.jds.2025.04.027","DOIUrl":"10.1016/j.jds.2025.04.027","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 3","pages":"Pages 1912-1914"},"PeriodicalIF":3.4,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3,4-methylenedioxymethamphetamine induces reactive oxygen species-mediated autophagy and thioredoxin-interactive protein/nucleotide-binding domain, leucine-rich containing family, pyrin domain-containing-3 inflammasome activation in dental pulp stem cells","authors":"Shih-Yu Lee ,&nbsp;Shang-Wen Chiu ,&nbsp;I-Hsun Li ,&nbsp;Wei-Cheng Tsai ,&nbsp;Chung-Hsing Li","doi":"10.1016/j.jds.2025.04.025","DOIUrl":"10.1016/j.jds.2025.04.025","url":null,"abstract":"<div><h3>Background/purpose</h3><div>3,4-methylenedioxymethamphetamine (MDMA) is a synthetic substituted amphetamine. Research primarily focuses on its neurotoxicity and psychological effects, while studies examining its impact on mesenchymal stem cells (MSCs) and dental pulp stem cells (DPSCs) are relatively limited. This study investigated the cytotoxicity and molecular mechanisms of MDMA in DPSCs.</div></div><div><h3>Materials and methods</h3><div>Cell viability, apoptosis, autophagy, immunophenotype, reactive oxygen species (ROS), and the related signaling pathways were analyzed using a cell counting kit, Western blot, flow cytometry, and 2′,7′-dichlorofluorescein diacetate (DCFH-DA) dye after treating DPSCs with indicated concentrations of MDMA.</div></div><div><h3>Results</h3><div>MDMA significantly decreased cell viability and increased cleaved poly adenosine diphosphate-ribose polymerase (PARP), cleaved caspase-8, cleaved caspase-3, and Bcl-2-associated X protein (Bax), while reducing B-cell lymphoma 2 (Bcl-2). Annexin V and 7-aminoactinomycin D (7-AAD) flow cytometry showed that these cells underwent early apoptosis without altering MSCs’ immunophenotypic properties. MDMA also induced ROS accumulation and nucleotide-binding domain, leucine-rich–containing family, pyrin domain–containing-3 (NLRP3) inflammasome activation. Autophagy activation was observed with adenosine monophosphate-activated protein kinase (AMPK) activation, protein kinase B (AKT) inactivation, and mammalian target of rapamycin (mTOR) suppression. Autophagy inhibitor chloroquine (CQ) attenuated MDMA-induced cell death, suggesting that excessive autophagy contributes to cell damage.</div></div><div><h3>Conclusion</h3><div>MDMA induces ROS-mediated autophagic cell death and thioredoxin-interacting protein (TXNIP)/NLRP3 inflammasome activation, causing detrimental cell damage. The historical roots of drug addiction should be considered when modifying dental approaches for patients with a history of MDMA use, as well as in the screening of DPSCs donors and patients undergoing stem cell therapy.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 3","pages":"Pages 1782-1791"},"PeriodicalIF":3.4,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144365177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychosomatic concepts in nociplastic pain: The case of burning mouth syndrome","authors":"Takayuki Suga,&nbsp;Akira Toyofuku","doi":"10.1016/j.jds.2025.04.020","DOIUrl":"10.1016/j.jds.2025.04.020","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 3","pages":"Pages 1972-1973"},"PeriodicalIF":3.4,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adenoid ameloblastoma in the maxilla","authors":"Yu-Min Lin,&nbsp;Yuk-Kwan Chen,&nbsp;Wen-Chen Wang,&nbsp;Chih-Huang Tseng","doi":"10.1016/j.jds.2025.04.013","DOIUrl":"10.1016/j.jds.2025.04.013","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 3","pages":"Pages 1974-1976"},"PeriodicalIF":3.4,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the relation among the needle insertion plane, occlusal plane, mandibular foramen, and mandibular lingula for inferior alveolar nerve block","authors":"Han-Sheng Chen ,&nbsp;Kun-Jung Hsu ,&nbsp;Pei-Jung Chen ,&nbsp;Hui-Na Lee ,&nbsp;Jen Hao Chen ,&nbsp;Chun-Ming Chen","doi":"10.1016/j.jds.2025.04.016","DOIUrl":"10.1016/j.jds.2025.04.016","url":null,"abstract":"<div><h3>Background/purpose</h3><div>The success rates and incidence of positive blood aspiration during inferior alveolar nerve blocks (IANB) vary. Understanding the relative positions of the mandibular foramen (MF), mandibular lingula (ML), and occlusal plane (OP) is crucial for the effectiveness and safety of IANB. This study evaluates the relationship among needle insertion levels, ML, and OP for IANB.</div></div><div><h3>Materials and methods</h3><div>Cone-beam computed tomography images of 90 participants were analyzed to measure ML and MF distances relative to OP. Participants were categorized into skeletal classes (I, II, and III). The distances from ML to the anesthetic needle positioned 5, 6, 7, 8, 9, and 10 mm above OP were assessed. Comparisons based on gender and skeletal classes were conducted, and correlations among variables were evaluated.</div></div><div><h3>Results</h3><div>The MF and ML were located below OP in 72 (40.0 %) and 5 (2.8 %) sides, respectively. Class II had the highest proportion of MF below OP (16.67 %), followed by Class III (13.33 %) and Class I (10 %). When the needle was inserted 5 mm and 10 mm above OP, ML was below the insertion plane in 27 (15 %) and 116 (64.4 %) sides, respectively. ML-OP distances were significantly greater in Class III (9.75 mm) and Class I (9.62 mm) than in Class II (7.29 mm).</div></div><div><h3>Conclusion</h3><div>Class II exhibited significantly smaller ML-OP and MF-OP distances than Class I and Class III. The needle should be inserted parallel to OP and positioned approximately 6–7 mm above OP for improved safety and anesthesia efficacy.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 3","pages":"Pages 1792-1801"},"PeriodicalIF":3.4,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144365180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corylin attenuates oral squamous cell carcinoma progression through c-Myc inhibition","authors":"Chin-Chuan Chen ,&nbsp;Chi-Yuan Chen ,&nbsp;Li-Fang Chou ,&nbsp;Chau-Ting Yeh ,&nbsp;Yi-Tsen Liu ,&nbsp;Yu-De Chu ,&nbsp;Hsin-Wei Lin ,&nbsp;Kai-Yin Chen ,&nbsp;Cheng-Chia Yu ,&nbsp;Tong-Hong Wang","doi":"10.1016/j.jds.2025.04.014","DOIUrl":"10.1016/j.jds.2025.04.014","url":null,"abstract":"<div><h3>Background</h3><div><em>/purpose</em>: Oral squamous cell carcinoma (OSCC) is the most prevalent malignancy of the head and neck, with current treatment options often limited by low efficacy and drug resistance. In this study, we investigated the anticancer activity and underlying mechanisms of corylin, a flavonoid extracted from Psoralea corylifolia, in OSCC.</div></div><div><h3>Materials and methods</h3><div>OSCC cell lines (SAS and OECM1) were treated with corylin, and its effects on cell proliferation, migration, and invasion were assessed using cell function assays. Flow cytometry and DiOC6/PI staining were performed to analyze cell cycle progression and apoptosis, while Western blotting was used to elucidate the molecular mechanisms of corylin's action.</div></div><div><h3>Results</h3><div>Corylin selectively inhibited OSCC cell growth, migration, and invasion while exhibiting minimal toxicity toward normal human cells. Mechanistic investigations revealed that corylin downregulated c-Myc expression, which subsequently modulated the expression of cell cycle checkpoint regulators, apoptosis-related proteins, and epithelial–mesenchymal transition (EMT)-associated markers. This led to G1 phase cell cycle arrest and enhanced apoptosis induction. Additionally, corylin significantly enhanced the anticancer efficacy of cisplatin and 5-FU in OSCC cells.</div></div><div><h3>Conclusion</h3><div>Corylin exhibits potent anticancer activity against OSCC by targeting c-Myc-mediated oncogenic pathways and may serve as a promising therapeutic candidate. Furthermore, its ability to synergize with cisplatin and 5-FU suggests its potential role in combination therapy to improve treatment efficacy.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 4","pages":"Pages 2322-2331"},"PeriodicalIF":3.1,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145020636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adenomatoid odontogenic tumor arising from a dentigerous cyst in an elderly patient: An unusual presentation","authors":"Kyu-Young Oh","doi":"10.1016/j.jds.2025.04.021","DOIUrl":"10.1016/j.jds.2025.04.021","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 3","pages":"Pages 1977-1979"},"PeriodicalIF":3.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}