Journal of Dental Sciences最新文献

{"title":"Micro-/nano-structured zirconia surface promotes osteogenic differentiation of human bone marrow mesenchymal stem cells by reducing pyroptosis under inflammatory conditions","authors":"Hui-Min Wang ,&nbsp;Qian Ding ,&nbsp;Ying Chen,&nbsp;Yao-Jun Zhang,&nbsp;Zhi-Xiao Wu,&nbsp;Xiao Zhang,&nbsp;Lei Zhang","doi":"10.1016/j.jds.2025.02.012","DOIUrl":"10.1016/j.jds.2025.02.012","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Promoting osteogenesis under inflammatory conditions holds promise for preventing and mitigating peri-implantitis. Cell pyroptosis inhibits osteoblast-mediated bone formation. Although the surface topography of implant materials influences both osteogenesis and inflammatory responses, its effects on pyroptosis and osteogenesis under inflammatory conditions have not been thoroughly investigated. The aim of this study was to investigate the effects of a porous and hydrofluoric acid-etched micro-/nano-structured zirconia (POROHF) surface on pyroptosis and osteogenesis of human bone marrow mesenchymal stem cells (hBMSCs) under inflammatory conditions.</div></div><div><h3>Materials and methods</h3><div>Lipopolysaccharide (LPS) and adenosine 5′-triphosphate (ATP) were used to induce pyroptosis in hBMSCs and evaluate the effects of pyroptosis on osteogenesis of hBMSCs. Then, using commonly used sandblasted acid-etched titanium and zirconia surfaces as controls, the effects of POROHF surface on pyroptosis and osteogenesis under inflammatory conditions simulated by LPS and ATP were evaluated. To clarify the potential mechanisms by which the surface affected pyroptosis of hBMSCs, RNA sequencing and functional verification were also performed.</div></div><div><h3>Results</h3><div>LPS and ATP induced caspase-1/GSDMD-mediated pyroptosis in hBMSCs and thereby inhibited osteogenic differentiation and angiogenic potential of hBMSCs, which could be partially reversed by inhibiting pyroptosis. The POROHF surface could reduce pyroptosis levels, thereby promoting osteogenesis of hBMSCs under inflammatory conditions. The surface reduced pyroptosis of hBMSCs by downregulating <em>EGR1</em> expression and upregulating <em>MANF</em> expression.</div></div><div><h3>Conclusion</h3><div>This study highlighted the inhibitory effects of caspase-1/GSDMD-mediated pyroptosis on osteogenesis of hBMSCs and demonstrated that micro-/nano-structured zirconia surface could promote osteogenic differentiation of hBMSCs by reducing pyroptosis under inflammatory conditions.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 3","pages":"Pages 1422-1435"},"PeriodicalIF":3.4,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144365161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contemporary approaches to orthodontic treatment in complex mixed dentition cases: A comparison of clear aligners and traditional fixed appliances","authors":"Daniel De-Shing Chen ,&nbsp;Johnson Hsin-Chung Cheng ,&nbsp;Pyi Phyo Win","doi":"10.1016/j.jds.2025.02.008","DOIUrl":"10.1016/j.jds.2025.02.008","url":null,"abstract":"<div><div>This study examined orthodontic treatment strategies for patients in the mixed dentition phase, with a focus on the advantages and limitations of clear aligners and traditional fixed appliances in addressing complex tooth movements. Herein, three cases were reported to illustrate the complementary strengths of these treatment modalities. In Case 1, presurgical orthodontics for a patient with a cleft lip and palate was performed using clear aligners, resulting in successful rotation correction and optimal alignment. In Case 2, a noninvasive approach involving a transpalatal arch and fixed appliances was used to manage a high labially impacted central incisor without the use of temporary anchorage devices (TADs). In Case 3, a combination of clear aligners and braces were used to resolve severe crowding and an impacted canine, achieving the desired outcomes without extractions. The findings underscore the ability of clear aligners to enhance oral hygiene and enable precise tooth movement through software simulations. The integration of clear aligners and fixed appliances demonstrated improved treatment efficiency and patient comfort. Additional clinical trials are warranted to refine rotation correction techniques and evaluate the efficacy of TAD-assisted traction for impacted teeth.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 2","pages":"Pages 1242-1246"},"PeriodicalIF":3.4,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143706063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-steroidal anti-inflammatory drugs (NSAIDs) regimens enhance synergistic selective anticancer efficacy of chemotherapeutic agents on cultured cells","authors":"Ming-Yung Chou ,&nbsp;Shoei-Yn Lin-Shiau","doi":"10.1016/j.jds.2025.01.019","DOIUrl":"10.1016/j.jds.2025.01.019","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Cancer incidences are rising, presenting challenges due to severe side effects and resistance of chemotherapeutic agents. To address these issues, we propose a strategy involving pharmaceutical compositions of PTM (Phytopolyphenols, Targeting drugs, Metals) regimens. This study aimed to investigate NSAIDs (Non-steroidal anti-inflammatory drugs)-PTM regimens enhancing anticancer selectivity and efficacy of chemotherapeutic agents on cultured cancer cells.</div></div><div><h3>Materials and methods</h3><div>Effects of drugs on proliferation of cultured cancer cells and pathogens was assessed using MTT assay and optical density at 600 nm (OD600) respectively. Synergistic effects of drug combinations were determined using combination index and efficacy index. ATPase activity was assayed using a colorimetric method.</div></div><div><h3>Results</h3><div>NSAIDs-PTM regimens demonstrated selective and synergistic anticancer effects. They also enhanced anticancer selectivity and efficacy of Cisplatin, 5-Fluorouracil, and Methotrexate. The most effective NSAIDs-PTM regimens increased anticancer efficacy by 16, 4, and 23 fold against oral, lung, and colon cancer cell lines, respectively. Additionally, these NSAIDs-PTM regimens enhanced selective anticancer efficacy of Cisplatin, 5-Fluorouracil, and Methotrexate by 8–21 fold on the three cancer cells. Furthermore, all regimens exhibited synergistic anti-efflux pump ATPase activity and antibacterial effects against four cultured pathogens.</div></div><div><h3>Conclusion</h3><div>The findings indicate that NSAIDs-PTM regimens not only possess synergistic and selective anticancer and antibacterial properties but also enhance anticancer selectivity and efficacy of Cisplatin, 5-Fluorouracil, and Methotrexate. Notably, all regimens exhibited anti-efflux pump ATPase, which may help overcome multidrug resistance in cancer treatment. Given that all components of PTM regimens are clinically effective and safe, further clinical studies are warranted.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 2","pages":"Pages 1175-1195"},"PeriodicalIF":3.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143706113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanical and biological properties of cellulose nanofibers as a dental biomaterial","authors":"Junduo Chen ,&nbsp;Aobo Ma ,&nbsp;Yiding Zhang ,&nbsp;Lu Sun ,&nbsp;Kunhua Yang ,&nbsp;Juan Ramón Vanegas Sáenz ,&nbsp;Guang Hong","doi":"10.1016/j.jds.2025.02.006","DOIUrl":"10.1016/j.jds.2025.02.006","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Plant-derived cellulose nanofibers (CNF) have emerged as a promising material for biomedical applications due to their diverse and exceptional properties but application in dental research remains limited. This study aimed to use CNF as barrier membranes or scaffold materials applied in guided bone regeneration (GBR) and guided tissue regeneration (GTR).</div></div><div><h3>Materials and methods</h3><div>Two different thicknesses of CNF were detected by surface morphology, roughness, hydrophilicity, mechanical properties, and degradability test, and compared with GC Membrane and Ti (titanium). Additionally, the cell compatibility and cell morphology of MC3T3-E1 and HGF-1 in different groups were also studied. The alkaline phosphatase (ALP) activity of MC3T3-E1 was also examined on the 14th and 21st days.</div></div><div><h3>Results</h3><div>Compared to the GC membrane, CNF showed better mechanical properties but remained inferior to titanium. Soaking increased their roughness and hydrophilicity while reducing mechanical strength. CNF also exhibited degradability, and good biocompatibility, with ALP expression significantly elevated at 14 and 21 days.</div></div><div><h3>Conclusion</h3><div>The results of this study on various properties of CNF indicate that CNF has the potential to become a novel dental biomaterial.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 3","pages":"Pages 1436-1446"},"PeriodicalIF":3.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Educational value of dental microphotography: Integration of art and science","authors":"Jiahe Li,&nbsp;Xian He,&nbsp;Mingxiao Liu","doi":"10.1016/j.jds.2025.02.009","DOIUrl":"10.1016/j.jds.2025.02.009","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 2","pages":"Pages 1298-1299"},"PeriodicalIF":3.4,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143705985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the applications of artificial intelligence in various commercial dental professional software","authors":"Ming-Hao Tseng,&nbsp;Pei-Rong Lin,&nbsp;Yu-Chieh Lin,&nbsp;Wei-Chun Lin","doi":"10.1016/j.jds.2025.02.004","DOIUrl":"10.1016/j.jds.2025.02.004","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 2","pages":"Pages 1300-1302"},"PeriodicalIF":3.4,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143705986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Students' perspectives on 3D-printed-simulated-caries teeth in transition to operative practice","authors":"Jiachen Lin ,&nbsp;Emma Brooke Rooney ,&nbsp;Nadia Irene Hossain ,&nbsp;Supattriya Chutinan","doi":"10.1016/j.jds.2025.01.028","DOIUrl":"10.1016/j.jds.2025.01.028","url":null,"abstract":"<div><div>The transition from pre-clinical to clinical operative dentistry requires effective training tools; however traditional typodont teeth often fall short in simulating clinical scenarios such as caries preparation. This study evaluated the perspectives of 71 third-year dental students from the classes of 2024 and 2025 at Harvard School of Dental Medicine on the use of 3D-printed caries teeth as a preparatory tool. Students participated in case-based collaborative learning and operative exercises using these models, with pre- and post-surveys capturing feedback on realism, usability, and educational impact. Statistical analysis revealed significantly increased confidence in modifying cavity preparations, understanding caries removal principles, selecting burs, using hand instruments, and differentiating carious from sound tooth structures. Students also reported improved comfort in designing cavity preparations and reduced reliance on instructors. These findings demonstrate that 3D-printed teeth effectively enhance students’ skills and confidence, making them valuable tools for pre-clinical dental education and improved learning outcomes.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 2","pages":"Pages 1247-1251"},"PeriodicalIF":3.4,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143705987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accidental ingestion or aspiration of foreign bodies in the special needs patients during the dental procedures: A retrospective study","authors":"Hsiang Yang ,&nbsp;Hsin-Yung Chen ,&nbsp;Ching-En Men ,&nbsp;Chih-Hui Shen ,&nbsp;Hsin-Ming Chen","doi":"10.1016/j.jds.2025.01.031","DOIUrl":"10.1016/j.jds.2025.01.031","url":null,"abstract":"<div><h3>Background and purpose</h3><div>Accidental ingestion or aspiration of foreign bodies (AIAOFB) is a potential complication during the routine dental procedures, particularly in the special needs patients due to disability and limited cooperation. This study aimed to analyze the prevalence and characteristics of 10 cases of AIAOFB in the special needs patients during the dental procedures from 2011 to 2024.</div></div><div><h3>Materials and methods</h3><div>This retrospective study reviewed 12 AIAOFB cases occurring either during the dental procedures or outside the dental clinic. These 12 cases were collected from the Oral Health Care Center for Special Needs at National Taiwan University Hospital from 2011 to 2024. Two cases were excluded because the possible ingested objects were not found. The analysis included the nature of ingested objects, dental procedures involved, types of impairment, practitioner experience, and subsequent treatments.</div></div><div><h3>Results</h3><div>Fortunately, no instance of foreign body aspiration into the trachea or bronchi occurred; all 10 foreign bodies were ingested into the digestive system. Thus, the prevalence of AIAOFB was 0.017 % (10/57,714). Various foreign objects, such as burs and wires, were successfully removed via endoscopic operation. Additionally, the teeth or prosthetic crowns were spontaneously passed through the digestive tract within one to two weeks without complications.</div></div><div><h3>Conclusion</h3><div>This study underscores the characteristics of 10 AIAOFB cases in the special needs patients. Vigilance is essential in preventing such incidents, and dentists must be well prepared to promptly diagnose and manage these emergencies when patients inadvertently aspirate or swallow the dental instruments or materials during the dental treatments.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 2","pages":"Pages 1196-1203"},"PeriodicalIF":3.4,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143706114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of deep pressure input on autonomic regulation during wisdom tooth extraction: From waiting room to surgery","authors":"Hsin-Yung Chen ,&nbsp;Hsiang Yang ,&nbsp;Ching-En Men ,&nbsp;Chih-Hui Shen ,&nbsp;Hsin-Ming Chen","doi":"10.1016/j.jds.2025.02.003","DOIUrl":"10.1016/j.jds.2025.02.003","url":null,"abstract":"<div><h3>Background and purpose</h3><div>Tooth extraction is a common dental procedure associated with heightened anxiety, particularly during the waiting period before treatment. This stress response is regulated by the autonomic nervous system (ANS), comprising the sympathetic nervous system (SNS), which induces excitatory responses, and the parasympathetic nervous system (PsNS), which promotes relaxation. Deep pressure input, delivered through weighted vests and blankets, has been shown to shift ANS dominance from the SNS to the PsNS, facilitating stress reduction. This study investigated the effects of deep pressure input on ANS modulation using a weighted vest during the waiting phase and a weighted blanket during the tooth extraction phase.</div></div><div><h3>Materials and methods</h3><div>Healthy adults were randomly assigned to a control group or an experimental group. The control-group subjects underwent wisdom tooth extraction without deep pressure input, while the experimental-group subjects wore a weighted vest during the waiting phase and used a weighted blanket during the tooth extraction procedure. Heart rate (HR), low-frequency heart rate variability (LF-HRV), and high-frequency heart rate variability (HF-HRV) were measured to assess ANS activity.</div></div><div><h3>Results</h3><div>The control-group subjects exhibited increased HR, elevated LF-HRV, and reduced HF-HRV, indicating the stress-induced sympathetic activation. In contrast, the experimental-group subjects showed significantly lower HR and higher HF-HRV, demonstrating the enhanced parasympathetic activation that persists throughout the tooth extraction procedure.</div></div><div><h3>Conclusion</h3><div>Deep pressure input for high-anxiety patients can effectively reduce stress and enhances the parasympathetic activation during the wisdom tooth extraction procedure. After a large-scale clinical study, it may enter clinical application for high-anxiety patients.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 2","pages":"Pages 1204-1212"},"PeriodicalIF":3.4,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143706012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polymethylmethacrylate-induced foreign body granuloma in the left lower lip","authors":"Yu-Hsueh Wu ,&nbsp;Yi-Pang Lee ,&nbsp;Andy Sun,&nbsp;Chun-Pin Chiang","doi":"10.1016/j.jds.2025.02.001","DOIUrl":"10.1016/j.jds.2025.02.001","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 2","pages":"Pages 1303-1305"},"PeriodicalIF":3.4,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143704526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}