Journal of Dental Sciences最新文献

{"title":"Profiles of peripheral B cell subsets in a cohort of primary Sjögren's syndrome patients and their potential clinical significance","authors":"Yixiao Xing ,&nbsp;Boya Li ,&nbsp;Pan Wei ,&nbsp;Hong Hua","doi":"10.1016/j.jds.2023.12.024","DOIUrl":"10.1016/j.jds.2023.12.024","url":null,"abstract":"<div><h3>Background/purpose</h3><p>Primary Sjögren's syndrome is a prototypical autoimmune disease, with B cell dysfunction as a dominant feature. Further insights into distribution of B cell subsets in primary Sjögren's syndrome are urgently required to identify the most appropriate target subpopulation. We aimed to evaluate the profiles of B lymphocyte subpopulations in primary Sjögren's syndrome patients and to investigate their clinical significance.</p></div><div><h3>Materials and methods</h3><p>Thirty primary Sjögren's syndrome patients and 15 age-and sex-matched healthy controls were recruited. Peripheral B cell subsets were analyzed by flow cytometry.</p></div><div><h3>Results</h3><p>Compared to healthy controls, circulating CD19⁺ B cells, CD19⁺CD20⁻ B cells, CD19⁺CD27⁻IgD⁺ naïve B cells, CD19⁺IgD⁺CD38^high plasmablasts, CD19⁺CD24^highCD38^high transitional B cells and CD19⁺CD20⁻CD27⁺CD38⁺ plasma cells were elevated in patients with primary Sjögren's syndrome, whereas CD19⁺CD27⁺ memory B cells, CD19⁺CD27⁻IgD^- double negative B cells and CD19⁺CD24^hiCD27⁺ Bregs were decreased. Furthermore, the percentage of circulating CD19⁺CD20⁻CD27⁺CD38⁺ plasma cells was positively correlated with serum IgG levels and the proportional area of lymphocytic infiltration of labial gland.</p></div><div><h3>Conclusion</h3><p>We identified a comprehensive B lymphocyte subset distribution profile in primary Sjögren's syndrome. Moreover, we detected a clinical significance of CD19⁺CD20⁻CD27⁺CD38⁺ plasma cells, suggesting that these cells might play a key role in disease pathology and represent potential therapeutic targets.</p></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1991790223004166/pdfft?md5=a27ddb6b5108483d288112da873c44aa&pid=1-s2.0-S1991790223004166-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139498875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel NRAS G12D mutation in extraosseous/peripheral ameloblastoma: Case report and review of mitogen-activated protein kinase pathway mutations in extraosseous/peripheral and intraosseous ameloblastomas","authors":"Kyu-Young Oh,&nbsp;Seong-Doo Hong","doi":"10.1016/j.jds.2024.05.010","DOIUrl":"10.1016/j.jds.2024.05.010","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1991790224001569/pdfft?md5=1f3172c9c6f8bf27985a263dd85b5eba&pid=1-s2.0-S1991790224001569-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141030156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastric adenocarcinoma predictive long intergenic noncoding RNA (GAPLINC) promotes oral cancer stemness by acting as a molecular sponge of miR331-3p","authors":"Kuang-Yuan Liang ,&nbsp;Ni-Yu Su ,&nbsp;Hsiu-Pin Yang ,&nbsp;Pei-Ling Hsieh ,&nbsp;Chih-Yuan Fang ,&nbsp;Lo-Lin Tsai ,&nbsp;Yi-Wen Liao ,&nbsp;Chia-Ming Liu ,&nbsp;Cheng-Chia Yu","doi":"10.1016/j.jds.2024.04.031","DOIUrl":"10.1016/j.jds.2024.04.031","url":null,"abstract":"<div><h3>Background/purpose</h3><p>Accumulating evidence has suggested that treatment failure of cancer therapy can be attributed to cancer stem cells (CSCs). Among numerous regulators of cancer stemness, non-coding RNAs (ncRNAs) have gained significant attention recently. In this study, we examined the role of gastric adenocarcinoma predictive long intergenic noncoding RNA (GAPLINC) in oral CSCs (OCSCs).</p></div><div><h3>Materials and methods</h3><p>RNA Sequencing and quantitative real-time polymerase chain reaction (qRT-PCR) were used to determine the expression of GAPLINC. Flow cytometry and sphere-forming assay were exploited to isolate OCSCs. Measurement of aldehyde dehydrogenase 1 (ALDH1) activity, CD44 expressing cells, and various phenotypic assays, such as self-renewal, migration, invasion, and colony-forming abilities, were conducted in CSCs of two types of oral cancer cells (SAS and GNM) following the knockdown of GAPLINC. A luciferase reporter was also carried out to validate the direct interaction between GAPLINC and microRNA (miR)-331-3p.</p></div><div><h3>Results</h3><p>Our results showed that GAPLINC was overexpressed in OCSCs from patient-derived and oral cancer cell lines. We demonstrated that silencing of GAPLINC in OCSCs downregulated various CSC hallmarks, such as ALDH1 activity, percentage of CD44-expressing cells, self-renewal capacity, and colony-forming ability. Moreover, our results revealed that the effect of GAPLINC on cancer stemness was mediated by direct repression of miR-331-3p.</p></div><div><h3>Conclusion</h3><p>These data have potential clinical implications in that we unraveled the aberrant upregulation of GAPLINC and demonstrated that suppression of GAPLINC may reduce cancer stemness via sequestering miR-331-3p.</p></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1991790224001466/pdfft?md5=bf20571b58ea138621dddeb7bc240cd2&pid=1-s2.0-S1991790224001466-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141044819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Soft coral Lobophytum crassum extract inhibits migration and induces apoptosis capabilities in human oral squamous cell carcinoma cells","authors":"Shih-Min Wang, Mei-Chin Lu, Yu-Ming Hsu, Chun-Chung Huang, Chih-Yuan Fang, Chuan-Hang Yu, Chueh Pin Ju, Chengen Yu, Shiao-Pieng Lee","doi":"10.1016/j.jds.2024.06.016","DOIUrl":"https://doi.org/10.1016/j.jds.2024.06.016","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141695975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential positive effect of periodontal treatment on brain function activity using functional magnetic resonance imaging analysis","authors":"Kosuke Muraoka ,&nbsp;Masafumi Oda ,&nbsp;Kenichi Yoshino ,&nbsp;Tatsurou Tanaka ,&nbsp;Masaki Morishita ,&nbsp;Taiji Nakamura ,&nbsp;Ryota Kibune ,&nbsp;Kazuo Sonoki ,&nbsp;Yasuhiro Morimoto ,&nbsp;Keisuke Nakashima ,&nbsp;Shuji Awano","doi":"10.1016/j.jds.2023.09.024","DOIUrl":"10.1016/j.jds.2023.09.024","url":null,"abstract":"<div><h3>Background/purpose</h3><p>There are reports on the relationship between periodontal treatment and the whole body. The purpose of the present study was to investigate the effect of periodontal initial treatment on brain function activity by improving periodontal tissue and the occlusal status of subjects with periodontitis.</p></div><div><h3>Materials and methods</h3><p>The subjects were 13 patients with periodontitis. Following the patient's informed written consent, the periodontal initial treatment provided to the patient included tooth brushing instruction, scaling and root planning, however, occlusal adjustment was not performed at this stage. Periodontal examination, occlusal force examination and fMRI results were also evaluated at the initial and the reevaluation examinations.</p></div><div><h3>Results</h3><p>After the periodontal initial treatment had been performed, periodontal tissue had significantly improved. In addition, cerebral blood flow in the insula and primary motor cortex was also improved, as confirmed by fMRI.</p></div><div><h3>Conclusion</h3><p>This result suggests that the periodontal ligament has recovered and the periodontal ligament neuron have been further subjected to clenching in the insula.</p></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1991790223003276/pdfft?md5=cea80ee05c6f082ad7b38d1daa724526&pid=1-s2.0-S1991790223003276-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134935830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibacterial efficacy and osteogenic potential of mineral trioxide aggregate-based retrograde filling material incorporated with silver nanoparticle and calcium fluoride","authors":"Min-Yong Lee ,&nbsp;Hi-Won Yoon ,&nbsp;Kwang-Mahn Kim ,&nbsp;Jae-Sung Kwon","doi":"10.1016/j.jds.2023.10.001","DOIUrl":"10.1016/j.jds.2023.10.001","url":null,"abstract":"<div><h3>Background/purpose</h3><p>The retrograde filling material, particularly mineral trioxide aggregate (MTA) employed in apicoectomy, should possess high antibacterial efficacy and osteogenic potential. We evaluated the antibacterial efficacy, biocompatibility, and osteogenic potential following the addition of silver nanoparticles (AgNPs) and calcium fluoride (CaF₂) in retrograde filling material of MTA.</p></div><div><h3>Materials and methods</h3><p>MTA was mixed with four different solvents. Group 1 (G1): distilled water, Group 2 (G2): 50 ppm AgNPs, Group 3 (G3): 1 wt% CaF₂, and Group 4 (G4): 50 ppm AgNPs and 1 wt% CaF₂. The pH variation of each group was monitored, while the surface roughness was measured. The antibacterial efficacy against <em>Enterococcus faecalis (E. faecalis)</em> and the viability of murine pre-osteoblast (MC3T3) were evaluated for each group using colorimetric assays. The gene expression levels of osteogenic potential marker (OCN, ALPL, and RUNX2) in MC3T3 cells for each group were quantified using real-time-qPCR. Statistical analysis was performed at α = 0.05 level of significance.</p></div><div><h3>Results</h3><p>When comparing the levels of antibacterial efficacy, the order of effectiveness was G4&gt;G2&gt;G3&gt;G1 (<em>P</em> &lt; 0.05). In the cell viability test, owing to MTA-eluted growth medium having a positive effect on MC3T3 cell proliferation, G1–4 exhibited a statistically increased cell viability compared to the control (<em>P</em> &lt; 0.05). However, G2–4 did not result in a statistically significant difference when compared to G1 (<em>P</em> &lt; 0.05). Moreover, G4 exhibited the highest gene expression among the four groups (<em>P</em> &lt; 0.05).</p></div><div><h3>Conclusion</h3><p>The addition of AgNPs and CaF₂ to MTA could be a promising option for use as a new retrograde filling material.</p></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1991790223003367/pdfft?md5=ff4fa48d97abd875da151f98409b0f6a&pid=1-s2.0-S1991790223003367-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135656858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marginal fit and retention force of zirconia resin-bonded fixed dental prostheses in the posterior region with different designs","authors":"Yue Yin ,&nbsp;Kosuke Nozaki ,&nbsp;Reina Nemoto ,&nbsp;Omnia Saleh ,&nbsp;Yayoi Oishi ,&nbsp;Mayuko Matsumura ,&nbsp;Wataru Komada ,&nbsp;Hiroyuki Miura ,&nbsp;Kenji Fueki","doi":"10.1016/j.jds.2023.12.010","DOIUrl":"10.1016/j.jds.2023.12.010","url":null,"abstract":"<div><h3>Background/purpose</h3><p>Retainer debonding of resin-bonded fixed dental prostheses (RBFDPs) is one of the major reasons for their lower survival rates than fixed dental prostheses (FDPs) with full-coverage crowns. Recent advances in milling technology have enabled the fabrication of RBFDPs with complex retainers (D-shaped designs). This study aimed to assess the marginal fit and retention force of zirconia RBFDPs with inlay-, L-, and D-shaped designs to clarify their clinical applications.</p></div><div><h3>Materials and methods</h3><p>Three abutment teeth models without maxillary second premolars were created using inlay-, L-, and D-shaped retainer designs. The zirconia RBFDPs were designed and fabricated according to the manufacturer’s instructions (n = 10). The marginal gap was measured using the silicone replica technique. Zirconia frameworks were bonded to the abutment teeth using resin cement. Tensile test was conducted after thermal cycling and dynamic loading tests. The loads during debonding or fracture were recorded. The failure pattern was analyzed by observing the fracture surface using a scanning electron microscope.</p></div><div><h3>Results</h3><p>D-shaped RBFDPs showed a significantly larger marginal gap than inlay- and L-shaped RBFDPs (<em>P</em> &lt; 0.05). However, the mean marginal values were clinically acceptable (&lt;120 μm). The D-shaped model exhibited the highest tensile strength in the tensile tests. The inlay-shaped and most of the D-shaped RBFDPs experienced debonding with cohesive failure, whereas the L-shaped RBFDPs showed fractures near the connector.</p></div><div><h3>Conclusion</h3><p>The D-shaped retainer design was superior to the inlay- and L-shaped designs with respect to the inhibition of retainer debonding. However, the marginal fitness needs to be improved.</p></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1991790223004026/pdfft?md5=df1ef492a2c695df14a02d4afa2c24b6&pid=1-s2.0-S1991790223004026-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139035432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel regimens of phytopolyphenols and celecoxib enhancing efficacy and selectivity of anticancer effects of chemotherapeutic agents on cultured cancer cells","authors":"Ming-Yung Chou ,&nbsp;Shoei-Yn Lin-Shiau","doi":"10.1016/j.jds.2024.02.013","DOIUrl":"10.1016/j.jds.2024.02.013","url":null,"abstract":"<div><h3>Background/purpose</h3><p>Explorations of novel regimens enhancing efficacy and selectivity of chemotherapeutic agents are urgent to solve the problems of cancer therapy. This study aimed to explore synergistic anticancer effects of novel regimens of phytopolyphenols [curcumin (C), tea polyphenols (G) or GC] with celecoxib (Cl) and ZnSO₄.</p></div><div><h3>Materials and methods</h3><p>Antiproliferative effects of drugs on cultured cancer cells and pathogenic biofilms were assayed by MTT and optical density (OD600) respectively; their inhibition on efflux pump (Na⁺-K⁺-ATPase) was measured by colorimetric methods. Synergistic (CI &lt; 1) anticancer effects were evaluated by the equations of combination index (CI) and efficacy index (EI).</p></div><div><h3>Results</h3><p>Both Cl and methotrexate (MTX) alone exhibited inhibitory effects not only on proliferation and efflux pump of cultured cancer cells but also pathogenic biofilm formation. Phytopolyphenols (P) and MTX potentiated these inhibitory effects of Cl. In addition, novel regimens containing Cl, memantine (Mem) or thioridazine (TRZ) further enhanced not only efficacy and selectivity of anticancer effects but also inhibition on efflux pump and pathogenic biofilm formation of four chemotherapeutic agents (MTX, cisplatin, 5-fluorouracil and doxorubicin) respectively.</p></div><div><h3>Conclusion</h3><p>In this study, novel regimens of phytopolyphenols (P), targeting drugs (T; Cl, Mem or TRZ) and metal ions (M; ZnSO₄) so called PTM regimens exerted not only by themselves but also markedly potentiated efficacy and selectivity of anticancer effects of four chemotherapeutic agents. Because of their potent inhibitions on efflux pump and pathogenic biofilm formation, these combinatorial novel regimens were expected to be able to overcome the problems of multidrug resistant cancers and merit for further clinical studies.</p></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1991790224000503/pdfft?md5=ce0041ea0cb1d80e93987c8dea6182ac&pid=1-s2.0-S1991790224000503-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140006125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carotid artery calcification detected on the panoramic radiographs","authors":"Feng-Chou Cheng,&nbsp;Shu-Yu Liu,&nbsp;Bo-Lin Liu,&nbsp;Chun-Pin Chiang","doi":"10.1016/j.jds.2024.04.005","DOIUrl":"10.1016/j.jds.2024.04.005","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S199179022400120X/pdfft?md5=7fa6524d9f0187eb651f15fede343fce&pid=1-s2.0-S199179022400120X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140759094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of low-level laser therapy on osteoclast differentiation: Clinical implications for tooth movement and bone density","authors":"Chun-Yi Huang ,&nbsp;Huynh Hoai Thuong Le ,&nbsp;Hsiao-Chi Tsai ,&nbsp;Chih-Hsin Tang ,&nbsp;Jian-Hong Yu","doi":"10.1016/j.jds.2024.03.023","DOIUrl":"10.1016/j.jds.2024.03.023","url":null,"abstract":"<div><h3>Background/purpose</h3><p>Osteoclast differentiation is crucial for orchestrating both tooth movement and the maintenance of bone density. Therefore, the current study sought to explore the impact of low-level laser therapy (LLLT) on osteoclast differentiation, functional gene expression, molecular signaling pathways, and orthodontic tooth movement in clinical settings.</p></div><div><h3>Materials and methods</h3><p>The RAW 264.7 cell line served as the precursor for osteoclasts, and these cells underwent irradiation using a 808-nm LLLT. Osteoclast differentiation was assessed through tartrate-resistant acid phosphatase (TRAP) staining. Functional gene expression levels were evaluated using real-time quantitative polymerase chain reaction (RT-qPCR) while signaling molecules were examined through Western blot analysis. In the clinical study, 12 participants were enrolled. Their tooth movement was monitored using a TRIOS desktop scanner. Bone density measurements were conducted using Mimics software, which processed cone-beam computed tomography (CBCT) images exported in Digital Imaging and Communications in Medicine (DICOM) format.</p></div><div><h3>Results</h3><p>We found that LLLT effectively promoted receptor activator of nuclear factor-κB ligand (RANKL)-dependent osteoclast differentiation and the expression of osteoclast functional genes, including matrix metallopeptidase 9 (MMP9), nuclear factor of activated T-cells cytoplasmic 1(NFATc1), tartrate-resistant acid phosphatase (TRAP) and cathepsin K (CTSK) in RAW264.7 cells. Clinically, the cumulative tooth movement over 90 days was significantly higher in the laser group than in the control group.</p></div><div><h3>Conclusion</h3><p>Our research demonstrates that LLLT not only significantly promotes osteoclast differentiation but is also a valuable adjunct in orthodontic therapy.</p></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1991790224001144/pdfft?md5=0c2e9f1bab928571c78462e4e6343254&pid=1-s2.0-S1991790224001144-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140404990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}