Journal of Dental Sciences最新文献

{"title":"The role of 27-hydroxycholesterol in hypercholesterolemia-associated exacerbation of apical periodontitis and therapeutic potential of felodipine","authors":"Cheng-Ning Yang ,&nbsp;Han-Wei Wang ,&nbsp;Hung-Ying Lin ,&nbsp;Sang-Heng Kok ,&nbsp;Chi-Yuan Hong ,&nbsp;Chia-Tung Shun ,&nbsp;Shih-Jung Cheng ,&nbsp;Fang-Yu Wu ,&nbsp;Sze-Kwan Lin","doi":"10.1016/j.jds.2024.09.027","DOIUrl":"10.1016/j.jds.2024.09.027","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Studies have demonstrated a relation between hypercholesterolemia and development of apical periodontitis (AP), but the underlying mechanism is uncertain. 27-hydroxycholesterol (27HC), produced by cytochrome P450 27A1 (CYP27A1)-catalyzed hydroxylation of cholesterol, is known to possess pro-inflammatory activity. Felodipine is an anti-hypertensive agent able to inhibit CYP27A1. The study aimed to examine the inflammatory response of macrophages to 27HC and the relation between 27HC accumulation and progression of experimental AP. The therapeutic effect of felodipine was also evaluated.</div></div><div><h3>Materials and methods</h3><div>J774 murine macrophages were used. Expressions of cyclooxygenase-2 (COX-2) and C–C motif chemokine ligand 20 (CCL20) were examined by Western blot. Concentrations of 27HC were assessed by enzyme-linked immunosorbent assay. Fluorescence assay was used to evaluate cholesterol levels. AP was induced in male rats receiving high fat/high cholesterol diet (HFHCD) or normal diet (ND). Micro-computed tomography and immunohistochemistry were employed to evaluate disease progression and therapeutic effect of felodipine.</div></div><div><h3>Results</h3><div>Cholesterol enhanced production of 27HC which in turn stimulated COX-2 and CCL20 synthesis by macrophages. HFHCD consumption significantly augmented serum and lesion tissue levels of 27HC in rats. Lesion size and infiltration of COX-2⁺ and interleukin (IL)-17⁺ cells increased in parallel with 27HC accumulation in AP. Felodipine suppressed cholesterol-induced 27HC production in macrophages. Felodipine treatment reduced serum and tissue levels of 27HC in HFHCD rats and concurrently mitigated AP propagation.</div></div><div><h3>Conclusion</h3><div>Our results suggest a pivotal role of 27HC in hypercholesterolemia-exacerbated AP. By repressing 27HC production, felodipine may have the potential to help mitigate AP in obese individuals.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 89-99"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11762924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinctive salivary oral microbiome in patients with burning mouth syndrome depending on pain intensity compared to healthy subjects","authors":"Hye-Min Ju ,&nbsp;Yong-Woo Ahn ,&nbsp;Soo-Min Ok ,&nbsp;Sung-Hee Jeong ,&nbsp;Hee-Sam Na ,&nbsp;Jin Chung","doi":"10.1016/j.jds.2024.05.022","DOIUrl":"10.1016/j.jds.2024.05.022","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Burning moouth syndrome (BMS) is a chronic pain condition similar to neuropathic pain. It is characterized by a persistent burning sensation in the oral cavity. Despite the lack of clarity regarding the etiology of BMS, recent studies have reported an association between the gut microbiome and neuropathic pain. However, few studies have investigated the association between the oral microbiome and orofacial pain, such as BMS. This study aimed to compare the oral microbial profiles of healthy controls (HC) and patients with BMS.</div></div><div><h3>Materials and methods</h3><div>The BMS group was further divided into BMS_low and BMS_high groups according to pain intensity. A total of 60 patients with BMS (BMS_low, n = 16; BMS_high, n = 44) and 30 HC provided saliva samples, which were sequenced and analyzed for the V1–V2 region of the 16S rRNA gene.</div></div><div><h3>Results</h3><div>The alpha diversity was similar among the three groups. However, a significant difference in the distribution of microbiome composition was observed between BMS_high and HC, as revealed by the Bray–Curtis distance analysis (<em>P</em> &lt; 0.01). At the genus level, <em>Prevotella</em> and <em>Alloprevotella</em> were the most abundant genera in the BMS group. Compared to HC, BMS_high exhibited a relatively higher abundance of bacterial species. Some bacteria, including <em>Prevotella</em> spp., exhibit an increasing pattern with subjective pain intensity.</div></div><div><h3>Conclusion</h3><div>These results suggest the potential involvement of oral microbiota in BMS pathogenesis. Additionally, variations in the microbiome may occur not only in the presence or absence of pain, but also with pain severity.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 462-469"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141143593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elucidating interfacial failure of cervical restorations using damage mechanics: A finite element analysis","authors":"Po-Chun Tseng ,&nbsp;Shu-Fen Chuang ,&nbsp;Ellen Schulz-Kornas ,&nbsp;Karl-Heinz Kunzelmann ,&nbsp;Andreas Kessler","doi":"10.1016/j.jds.2024.05.033","DOIUrl":"10.1016/j.jds.2024.05.033","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Although clinical studies have suggested a link between non-axial forces and reduced longevity of cervical restorations, the underlying mechanisms require further numerical investigation. This in-silico study employed a cohesive zone model (CZM) to investigate interfacial damage in a cervical restoration subjected to different load directions.</div></div><div><h3>Materials and methods</h3><div>A plane strain model of a maxillary premolar was established, with a wedge-shaped buccal cervical restoration. To simulate debonding, the restoration-tooth interface was modeled by the CZM, which defines the strain-softening damage behavior based on interfacial stress and fracture energy. Occlusal loads were applied in three different directions: (1) obliquely on the buccal triangular ridge, (2) obliquely on the palatal triangular ridge, and (3) equal magnitude axially on both ridges. Damage initiation and progression were analyzed, and stress distribution in damaged models was compared with the corresponding perfect-bond models.</div></div><div><h3>Results</h3><div>Non-axial oblique loads initiated damage at lower forces (100 N for buccal and 120 N for palatal) compared to axial loads (130 N on both ridges). After debonding, buccal oblique loading caused higher stress at the central groove (42.5 MPa at 150 N). Furthermore, buccal oblique loading resulted in more extensive debonding than that caused by the palatal oblique load (88.3% vs. 43.3% of the bonding interface at 150 N).</div></div><div><h3>Conclusion</h3><div>The study provides numerical evidence supporting the tooth flexure hypothesis, that non-axial forces are more detrimental to the bonding interface of the cervical restoration. The results highlight the necessity of damage mechanics in deriving stress distribution upon debonding.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 410-416"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141401507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automatic classification of temporomandibular joint disorders by magnetic resonance imaging and convolutional neural networks","authors":"Ting-Yi Su ,&nbsp;Jacky Chung-Hao Wu ,&nbsp;Wen-Chi Chiu ,&nbsp;Tzeng-Ji Chen ,&nbsp;Wen-Liang Lo ,&nbsp;Henry Horng-Shing Lu","doi":"10.1016/j.jds.2024.06.001","DOIUrl":"10.1016/j.jds.2024.06.001","url":null,"abstract":"<div><h3>Background/purpose</h3><div>In this study, we utilized magnetic resonance imaging data of the temporomandibular joint, collected from the Division of Oral and Maxillofacial Surgery at Taipei Veterans General Hospital. Our research focuses on the classification and severity analysis of temporomandibular joint disease using convolutional neural networks.</div></div><div><h3>Materials and methods</h3><div>In gray-scale image series, the most critical features often lie within the articular disc cartilage, situated at the junction of the temporal bone and the condyles. To identify this region efficiently, we harnessed the power of You Only Look Once deep learning technology. This technology allowed us to pinpoint and crop the articular disc cartilage area. Subsequently, we processed the image by converting it into the HSV format, eliminating surrounding noise, and storing essential image information in the V value. To simplify age and left-right ear information, we employed linear discriminant analysis and condensed this data into the S and H values.</div></div><div><h3>Results</h3><div>We developed the convolutional neural network with six categories to identify severe stages in patients with temporomandibular joint (TMJ) disease. Our model achieved an impressive prediction accuracy of 84.73%.</div></div><div><h3>Conclusion</h3><div>This technology has the potential to significantly reduce the time required for clinical imaging diagnosis, ultimately improving the quality of patient care. Furthermore, it can aid clinical specialists by automating the identification of TMJ disorders.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 393-401"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141414714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of spatial accessibility of dental institutions in Taiwan: The application of a geographical information system software","authors":"Feng-Chou Cheng,&nbsp;Chi-Hung Chen,&nbsp;Ming-Chung Lee,&nbsp;Chun-Pin Chiang","doi":"10.1016/j.jds.2024.09.014","DOIUrl":"10.1016/j.jds.2024.09.014","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 707-709"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763849/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence measurement of multi-layer tooth structures using semantic segmentation and computer vision","authors":"Yu-Chieh Lin ,&nbsp;Feng-Chou Cheng ,&nbsp;Wei-Chun Lin,&nbsp;Chun-Pin Chiang","doi":"10.1016/j.jds.2024.11.007","DOIUrl":"10.1016/j.jds.2024.11.007","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 723-725"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763839/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of autologous demineralized dentin matrix on postoperative complications and wound healing following lower third molar surgery: A split-mouth randomized clinical trial","authors":"Nhan Thanh Nguyen,&nbsp;Son Hoang Le,&nbsp;Bich-Ly Thi Nguyen","doi":"10.1016/j.jds.2024.04.026","DOIUrl":"10.1016/j.jds.2024.04.026","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Autologous dentin materials are among the most promising bone substitutes for preventing osseous defects on the distal side of the lower second molar. This study aimed to investigate the effects of autologous demineralized dentin matrix on postoperative complications and wound healing after lower third molar surgery.</div></div><div><h3>Materials and methods</h3><div>Thirteen patients with bilateral symmetrical lower third molars participated in this split-mouth randomized clinical trial. After removal surgery, one socket of the lower third molar was grafted with dentin material (demineralized dentin matrix side), and a piece of collagen sponge was used for the tooth socket of the remaining side (control side). The upper third molar on the same lateral side was extracted immediately before lower third molar surgery and used to create a demineralized dentin matrix according to the manufacturer's protocol (KometaBio). After lower third molar surgery, pain, swelling, trismus, and Inflammatory Proliferative Remodeling Scale scores were used to evaluate postoperative complications and wound healing.</div></div><div><h3>Results</h3><div>Pain, swelling, and trismus of the demineralized dentin matrix and control sides were not significantly different at any assessment time (<em>P</em> &gt; 0.05). The wound-healing scores of the demineralized dentin matrix side were better than those of the control side; however, the differences were only significant at 7th and 30th days (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Grafting autologous demineralized dentin matrix into the tooth socket did not increase the postoperative complications after lower third molar surgery. However, wound healing on the graft side was comparatively better than that on the control side.</div></div><div><h3>Clinicaltrials.gov identifier</h3><div>NCT06073639, date 10 October, 2023. This is a retrospectively registered trial.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 553-559"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141039355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic approach for the rare anterior variant of mandibular bone depression often misdiagnosed as tumorous lesions","authors":"Hak-Sun Kim","doi":"10.1016/j.jds.2024.05.002","DOIUrl":"10.1016/j.jds.2024.05.002","url":null,"abstract":"<div><h3>Background/purpose</h3><div>This study analyzed the clinical and imaging features of lingual mandibular bone depression (LMBD) in the anterior mandible, aiming to prevent misdiagnosis and unnecessary surgical procedures.</div></div><div><h3>Materials and methods</h3><div>The patients who visited a university dental hospital for painless radiolucency in the anterior mandible from January 2010 to December 2022 were retrospectively reviewed. Twelve cases of LMBD in the anterior mandible that are confirmed by biopsy or long-term follow-up were identified. Two oral and maxillofacial radiologists evaluated the imaging features. Additionally, 12 cases were manually collected from case reports published between 2001 and 2022. Clinical and histopathologic data were obtained from both groups and clinical information were compared using Fisher's exact test.</div></div><div><h3>Results</h3><div>The clinical information of the patients and that from the case reports showed no statistically significant differences, except for the clinical impression (<em>P</em> = 0.005). The imaging features of anterior LMBD included the absence of lingual cortical expansion and soft tissue bulging, a mostly round cortical border, and muscle-level attenuation, as observed on multidetector computed tomography (MDCT). Occasionally, the progression of LMBD led to thinning of the labial cortex.</div></div><div><h3>Conclusion</h3><div>If non-specific clinical features are present, MDCT is recommended to distinguish anterior LMBD from tumorous lesions that require surgical intervention.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 502-509"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141048966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment and evaluation of a deep learning-based tooth wear severity grading system using intraoral photographs","authors":"Ya-Ning Pang ,&nbsp;Zhen Yang ,&nbsp;Ling-Xiao Zhang ,&nbsp;Xiao-qiang Liu ,&nbsp;Xin-Shu Dong ,&nbsp;Xun Sheng ,&nbsp;Jian-guo Tan ,&nbsp;Xin-Yu Mao ,&nbsp;Ming-yue Liu","doi":"10.1016/j.jds.2024.05.013","DOIUrl":"10.1016/j.jds.2024.05.013","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Artificial intelligence (AI) can assist in medical diagnosis owing to its high accuracy and efficiency. This study aimed to develop a diagnostic system for automatically determining the degree of tooth wear (TW) using intraoral photographs with deep learning.</div></div><div><h3>Materials and methods</h3><div>The study included 388 intraoral photographs. A tooth segmentation model was first established using the Mask R-CNN architecture, which incorporated U-Net and SGE attention mechanisms. Subsequently, 2774 individual tooth images output from the segmentation model were included into the classification task, labeled and randomized into training, validation, and test sets with 6.0:2.0:2.0 ratio. A vision transformer model optimized using a mask mechanism was constructed for TW degree classification. The models were evaluated using the accuracy, precision, recall, and F1-score metrics. The time required for AI analysis was calculated.</div></div><div><h3>Results</h3><div>The accuracy of the tooth segmentation model was 0.95. The average accuracy, precision, recall, and F1-score in the classification task were 0.93, 0.91, 0.88, and 0.89, respectively. The F1-score differed in different grades (0.97 for grade 0, 0.90 for grade 1, 0.88 for grade 2, and 0.82 for grade 3). No significant difference was observed in the accuracy between different surfaces. The AI system reduced the time required to grade an individual tooth surface to 0.07 s, compared to the 2.67 s required by clinicians.</div></div><div><h3>Conclusion</h3><div>The developed system provides superior accuracy and efficiency in determining TW degree using intraoral photographs. It might assist clinicians in the decision-making for TW treatment and help patients perform self-assessments and disease follow-ups.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 477-486"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141130460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Membrane-free stem cell components suppress osteoclast differentiation: Implications for oral regenerative treatment","authors":"Sang-Wook Ahn ,&nbsp;Eun-Jung Kim ,&nbsp;Mi Kyoung Kim ,&nbsp;Sang-Hun Shin ,&nbsp;Jin-Ju Kwon","doi":"10.1016/j.jds.2024.08.005","DOIUrl":"10.1016/j.jds.2024.08.005","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Membrane-free stem cell components (MFSCCs) have been developed by removing cell membranes with antigens to overcome the limitations associated with cell-based therapies and isolate effective peptides. MFSCCs have been reported to have effects on oral infection sites. Chronic inflammatory diseases cause excessive bone resorption. This study investigated the effects of MFSCCs on osteoclast differentiation in the context of the high prevalence of inflammatory bone resorption.</div></div><div><h3>Materials and methods</h3><div>Bone marrow macrophages (BMMs) were treated with macrophage colony-stimulating factor and receptor activator of nuclear factor kappa-B ligand. Osteoclast differentiation was assessed based on the MFSCC concentrations. Tartrate-resistant acid phosphatase (TRAP)-stained mature osteoclasts and multinucleated cells derived from BMMs were analyzed using light microscopy. The messenger RNA (mRNA) expression levels of genes related to osteoclast differentiation were measured using real-time polymerase chain reaction (RT-PCR). The relative expression levels of the key transcription factors c-fos and nuclear factor of activated T cells (NFATc1) were determined using quantitative RT-PCR and western blotting.</div></div><div><h3>Results</h3><div>After treatment with MFSCCs, the cell viability was similar, depending on the level of BMMs. As the MFSCC concentration increased, the number of TRAP-positive cells decreased. The mRNA and protein expression of cathepsin K, TRAP, dendritic cell-specific transmembrane protein, c-fos, and NFATc1 decreased as the MFSCC concentration increased.</div></div><div><h3>Conclusion</h3><div>Our findings demonstrate that MFSCCs suppress osteoclast differentiation by downregulating transcription factors, particularly, c-fos and NFATc1. Therefore, MFSCCs may serve as a conservative treatment option for chronic inflammatory bone resorption diseases of the oral cavity by suppressing excessive bone resorption.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 212-219"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11762959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}