Journal of Dental Sciences最新文献

{"title":"Quantitative cone-beam computed tomography assessment of anterior loop safety margins using canine-guided osteotomy designs for chin bone harvesting.","authors":"Han-Sheng Chen, Kun-Jung Hsu, Hsiu-Yueh Liu, Hui-Na Lee, Chun-Ming Chen","doi":"10.1016/j.jds.2025.07.3491","DOIUrl":"10.1016/j.jds.2025.07.3491","url":null,"abstract":"<p><strong>Background: </strong>/purpose: Chin bone harvesting is a common intraoral grafting procedure but carries a risk of neurosensory complications involving the mental foramen (MF), anterior loop (AL), and mandibular incisive canal (MIC). Present study quantitatively evaluated whether the mandibular canine can serve as a safer and more reproducible landmark for chin bone harvesting.</p><p><strong>Materials and methods: </strong>Cone-beam computed tomography (CBCT) scans from 40 adults were analyzed. The mandibular canine distal angle (CDA) and canine long axis (CLA) were used as reference lines. Measurements included AL-MF length, distances from the CLA to the MF and AL, interMF distance (IntMF), interAL distance (IntAL), interCLA distance (IntCLA), and the vertical relationship between the canine apex and the MIC. Sex- and side-based comparisons were performed, and correlations with age and variables were assessed. Probability modeling estimated the likelihood of AL or MIC encounter under various osteotomy scenarios.</p><p><strong>Results: </strong>The mean AL-MF length was 1.76 ± 0.96 mm, with no significant sex or side differences. Canine-referenced measurements showed consistent horizontal safety margins, maintaining ≥2 mm from the AL in all cases. At 3 mm posterior to the CLA, the probability of avoiding AL injury exceeded 96.25%. Vertically, the MIC was often close to the canine apex, and deeper osteotomies increased risk. ANB angle demonstrated significant positive correlations with CLA-MF, CLA-AL, IntMF, and IntAL.</p><p><strong>Conclusion: </strong>The mandibular canine is a reliable landmark for horizontal osteotomy planning. This approach improves reproducibility and may reduce nerve exposure. Conservative depth control and cortical-only harvesting are recommended to minimize MIC-related complications.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1542-1550"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Daisaikoto</i> restores mitochondrial function and suppresses inflammation induced by periodontal bacteria-derived lipopolysaccharides.","authors":"Suzuka Tozawa, Kazuo Tomita, Kento Igarashi, Yoshikazu Kuwahara, Junichi Kitanaka, Nobue Kitanaka, Mehryar Habibi Roudkenar, Amaneh Mohammadi Roushandeh, Akihiro Kurimasa, Tomoaki Sato","doi":"10.1016/j.jds.2025.07.3544","DOIUrl":"10.1016/j.jds.2025.07.3544","url":null,"abstract":"<p><strong>Background/purpose: </strong>Periodontal disease affects approximately half of the world's population and is the leading cause of tooth loss. This study aimed to identify effective drug candidates for mitigating oral inflammation induced by <i>Porphyromonas gingivalis</i> lipopolysaccharide (<i>P. g</i> LPS), a major virulence factor of periodontal pathogens. We investigated <i>daisaikoto</i> (DST), known for its anti-inflammatory properties in various tissues, and compared its efficacy with <i>shosaikoto</i> (SSK) and <i>hainosankyuto</i> (HNST), both reported to have beneficial effects against periodontitis.</p><p><strong>Materials and methods: </strong>Human periodontal ligament fibroblasts were treated with DST, SSK, HNST, and their active components before and after <i>P. g</i> LPS stimulation. Anti-inflammatory effects were evaluated by quantifying <i>IL-6</i>, <i>COX2</i>, and <i>PGES2</i> gene expression using qPCR. Mitochondrial function was assessed via measurements of mitochondrial membrane potential (Ψm), Fe²⁺ content (mtFe²⁺), and reactive oxygen species (mtROS). In addition, ATP production and glycolytic gene expression were analyzed.</p><p><strong>Results: </strong>DST markedly suppressed <i>IL-6</i> and <i>PGES2</i> expression more effectively than SSK and inhibited <i>IL-6</i> more strongly than HNST. <i>P. g</i> LPS elevated mtROS and mtFe²⁺ levels while reducing Ψm; these mitochondrial impairments were reversed exclusively by DST. Moreover, DST restored ATP production diminished by <i>P. g</i> LPS exposure.</p><p><strong>Conclusion: </strong>DST exhibits superior anti-inflammatory activity compared with SSK and HNST and uniquely reverses mitochondrial dysfunction caused by <i>P. g</i> LPS. Given the association between mitochondrial dysfunction, diabetes, and periodontal disease progression, DST emerges as a promising therapeutic candidate for periodontitis.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1764-1773"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>In vitro</i> characterization of tooth-derived and dentin-derived graft particles: Comparative analysis of particle size, mineral composition, and cytotoxicity.","authors":"Vinh Quang Luu, Nhan Duc Le, Bich-Ly Thi Nguyen, Son Hoang Le","doi":"10.1016/j.jds.2025.07.3540","DOIUrl":"10.1016/j.jds.2025.07.3540","url":null,"abstract":"<p><strong>Background/purpose: </strong>Characteristics of grafting material influence its osteoconductive and osteoinductive properties. This study aimed to compare tooth-derived particles (TDPs) with dentin-derived particles (DDPs) with respect to particle size, demineralization behavior, elemental composition, and cytotoxicity.</p><p><strong>Materials and methods: </strong>TDP materials and DDP materials were cleaned, air-dried, ground using a Smart Dentin Grinder (KometaBio, Bergen, NJ, United States), and sorted by particle size. Both materials were demineralized with 10 % ethylenediaminetetraacetic acid (EDTA) at various time points and analyzed by scanning electron microscopy and energy-dispersive X-ray spectroscopy to determine the structural changes and the time required to reach 30 % residual Ca. Samples that achieved this level were subsequently evaluated for cytotoxicity according to ISO 10993-12:2021.</p><p><strong>Results: </strong>Particle size distribution was significantly different between TDPs and DDPs. The proportion of particles suitable for grafting was higher in DDPs (69.12 %) than in TDPs (55.98 %). Although the percentages of Ca and P during demineralization were slightly higher in TDPs than in DDPs, the differences were not significant. Both Ca and P contents, as well as the Ca/P ratio, decreased significantly with increasing demineralization time. Samples from both groups, adjusted to approximately 30 % residual Ca, were non-cytotoxic and met the ISO safety criteria for biological experimentation.</p><p><strong>Conclusion: </strong>DDPs have a more favorable size distribution than TDPs, requiring 17-20 min of 10 % EDTA to reach optimal 70 % Ca removal. The resulting materials are non-cytotoxic, supporting their safe and effective use as autogenous grafts.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1723-1731"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Er:YAG laser-assisted connective tissue wall technique for periodontal regeneration in a soft tissue recession combined with a furcation-involved class II subclass B molar under a microscope: A case report.","authors":"Shao-Yu Chang, Yoichi Taniguchi, Akira Aoki, Taichen Lin","doi":"10.1016/j.jds.2025.07.3457","DOIUrl":"10.1016/j.jds.2025.07.3457","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"2023-2025"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536341/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating image processing and deep learning framework for automatic supernumerary tooth detection on occlusal radiographs.","authors":"Jui-An Fu, Chia-Lin Hsu, Tsung-Yi Chen, Hung-I Wu, Tsung-Yun Cheng, Wei-Chun Lu, Chiung-An Chen, Sze-Teng Liong, Kuo-Chen Li, Ya-Yun Huang, Wei-Chen Tu, Patricia Angela R Abu, Li-Chuan Chuang","doi":"10.1016/j.jds.2025.07.3546","DOIUrl":"10.1016/j.jds.2025.07.3546","url":null,"abstract":"<p><strong>Background/purpose: </strong>Supernumerary tooth is the most common form of hyperdontia in children and is typically identified through radiographic examination. Although occlusal radiographs are recommended for assessing anterior abnormalities, anatomical superimposition and variability in pediatric imaging make early detection challenging, thereby increasing diagnostic inconsistency. Artificial intelligence has shown strong potential in dental imaging, but applications involving pediatric occlusal radiographs remain limited due to low clinical utilization and insufficient datasets. Therefore, a reliable automated tool is needed to assist clinicians in improving supernumerary tooth screening accuracy.</p><p><strong>Materials and methods: </strong>We collected 600 pediatric occlusal radiographs from children aged 6-12 years. An image-processing algorithm was developed to automatically segment the tooth-bearing region and improve feature visibility. These processed images were used to train five convolutional neural networks (CNNs) for the classification of supernumerary tooth. A fuzzy control strategy was employed to integrate the outputs of the five models, utilizing majority voting and weighted confidence scoring to generate the final diagnostic decision and mitigate model-specific bias.</p><p><strong>Results: </strong>All five CNN models achieved accuracy above 90 %. EfficientNet performed best and reached 96.12 % accuracy and 96.06 % F1 score. Statistical comparison further showed that EfficientNet achieved the highest agreement with ground truth, achieving R² with 95.73 % and the strongest agreement level, as indicated by Cohen's κ value of 0.9598.</p><p><strong>Conclusion: </strong>The proposed hybrid image-processing and deep learning framework provides accurate and interpretable supernumerary tooth detection on occlusal radiographs, offering a reliable tool to support pediatric diagnosis and improve clinical decision-making.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1785-1792"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vanadium-functionalized methyl methacrylate-based primer enhances self-curing and bonding of resin cement to polyetheretherketone restorations.","authors":"Takeru Kondo, Jun Sato, Hiroaki Kakinuma, Amal Ashry, Kulapatch Engkatanachai, Hiroshi Egusa","doi":"10.1016/j.jds.2025.07.3553","DOIUrl":"10.1016/j.jds.2025.07.3553","url":null,"abstract":"<p><strong>Background/purpose: </strong>Polyetheretherketone (PEEK) has gained considerable attention as a prosthetic material due to its favorable mechanical properties and biocompatibility. Although methyl methacrylate (MMA)-based primers are commonly used for PEEK surface pretreatment in clinical practice, a reliable method for achieving consistent bonding performance has yet to be established. This study aimed to evaluate the effects of incorporating functional components, such as 10-methacryloyloxydecyl dihydrogen phosphate (MDP), 3-(trimethoxysilyl) propyl methacrylate (TPM), and vanadium, into an MMA-based primer on the bond strength, polymerization, and mechanical properties of dual-cure resin cements bonded to PEEK.</p><p><strong>Materials and methods: </strong>PEEK specimens were sandblasted with alumina and pretreated with MMA-based primers containing various concentrations of MDP, TPM, or vanadium. Three types of dual-cure resin cements (G-CEM ONE [GO], RelyX Unicem 2 [RU], and BeautiLink SA [BS]) were used. The shear bond strength, degree of conversion (DC), and Vickers hardness were measured.</p><p><strong>Results: </strong>PEEK showed no detectable light transmittance, resulting in a significantly lower DC of the underlying resin cement. Application of the MMA-based primer improved the shear bond strength to PEEK; however, incorporation of MDP or TPM did not enhance bonding. In contrast, vanadium incorporation significantly increased the shear bond strength, DC, and Vickers hardness of all the resin cements tested.</p><p><strong>Conclusion: </strong>The incorporation of vanadium into MMA-based primers enhances both the adhesion and polymerization of dual-cure resin cements to PEEK, supporting its potential as a broadly applicable strategy for reliable bonding, particularly in clinical situations where light access is limited.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1848-1858"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148879879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The story of a Taiwanese female student studying dentistry in Japan during the Japanese colonial period: An oral history by Dr. Yueh-E Wu.","authors":"Feng-Chou Cheng, Mei-Huei Li, Chien-Chi Chu, Chun-Pin Chiang","doi":"10.1016/j.jds.2025.07.3478","DOIUrl":"10.1016/j.jds.2025.07.3478","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1991-1993"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148879949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative in vivo study of 3D-printed composite bioceramic scaffolds fabricated by distinct pre-processing methods.","authors":"Yu-Ting Li, Ju-Hsuan Yang, Yu-Hsin Chang, Hao-Hueng Chang, Kuo-Yang Tsai","doi":"10.1016/j.jds.2025.07.3555","DOIUrl":"10.1016/j.jds.2025.07.3555","url":null,"abstract":"<p><strong>Background/purpose: </strong>This study aimed to evaluate the in vivo osteoinductive potential and biocompatibility of three-dimensional (3D) printed bone substitutes composed of polylactic acid (PLA) and PLA-based bioceramic composites of hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP), fabricated using distinct pre-processing methods.</p><p><strong>Materials and methods: </strong>Pure PLA, thermally blended PLA/HA/β-TCP, and tetrahydrofuran (THF) solvent-cast PLA/HA/β-TCP (7:3w/w) were first processed into 1.75 mm filaments and subsequently fabricated into scaffolds using fused deposition modeling (FDM). These scaffolds were implanted subcutaneously in 8-week-old Sprague-Dawley (SD) rats. Histological and immunohistochemical analyses were performed at 2 and 4 weeks, as per ISO 10993-6, to evaluate inflammation, fibrous capsule formation, and osteogenic potential.</p><p><strong>Results: </strong>Semi-quantitative scoring revealed that T-MIX (tetrahydrofuran solvent-cast composite) had the lowest inflammatory scores at both 2 and 4 weeks, which were significantly lower than those of H-MIX (heat-blended composite) (<i>P</i> < 0.05). At 2 weeks, BSP (bone sialoprotein) expression in both H-MIX and T-MIX was significantly higher than in PLA (<i>P</i> < 0.05 and <i>P</i> < 0.001, respectively), with T-MIX also exceeding H-MIX (<i>P</i> < 0.05). Overall, T-MIX demonstrated superior performance in reducing inflammation and promoting osteogenesis.</p><p><strong>Conclusion: </strong>The solvent-cast T-MIX scaffold demonstrated significantly reduced inflammatory responses and enhanced osteogenic marker expression compared to both pure PLA and heat-blended composites, positioning it as a promising and standardized candidate for 3D-printed, patient-specific bone grafts in dental and craniofacial applications.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1867-1874"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Craniofacial and airway changes after skeletal Class III orthognathic surgery: A machine learning study.","authors":"Zay Yar Linn, Johnson Hsin-Chung Cheng, Sam Li-Sheng Chen, Daniel De-Shing Chen, Muhammad Izzah Abdillah","doi":"10.1016/j.jds.2025.07.3561","DOIUrl":"10.1016/j.jds.2025.07.3561","url":null,"abstract":"<p><strong>Background/purpose: </strong>Mandibular setback surgery is a common orthognathic procedure for correcting Class III malocclusion. This study aimed to evaluate posterior airway space (PAS) changes in Class III patients following mandibular setback surgery, focusing on skeletal, dental, and soft tissue alterations and their association with airway changes using conventional statistics and machine learning.</p><p><strong>Materials and methods: </strong>Fifty patients who underwent mandibular setback surgery were assessed using cephalometric radiographs taken preoperatively (T1) and postoperatively (T2). Measurements included PAS area and anteroposterior width, alongside angular and linear cephalometric parameters. Paired <i>t</i>-tests evaluated pre- and post-treatment differences. Multivariate regression, Pearson correlation and Random Forest regression were used to analyse associations between craniofacial changes and PAS alterations.</p><p><strong>Results: </strong>Significant postoperative changes were observed in most craniofacial and airway variables, except for SNA, overbite, lower lip to E-plane, and hypopharynx area. Multivariate regression showed that age, sex and several other variables influenced PAS measurements, but their effects were not uniform across all airway levels. Pearson correlation showed the strongest associations between PAS changes and SNB, ANB, mandibular body length, overjet, SN-GoGn, and Z-angle. Random forest regression demonstrated low overall predictive performance; however, the model identified SNB, nasolabial angle, overjet as the most influential predictors of airway changes.</p><p><strong>Conclusion: </strong>Mandibular setback surgery significantly reduces PAS. Skeletal changes exert the greatest influence on airway, followed by soft tissue and dental variables. Horizontal craniofacial landmarks movements are more predictive of airway changes than vertical shifts. SNB emerged as the most influential variable in both correlation and machine learning analyses.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1922-1932"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive analysis and sex-related differences in root and root canal anatomy in the Taiwanese population.","authors":"Ho-Sheng Chiang, Wei-Cheng Lee, Ying-Wu Chen, Ling-Yu Kung, Kuei-Yuan Chen, Ren-Yeong Huang, Yi-Shing Shieh, Yu-Chiao Wu","doi":"10.1016/j.jds.2025.07.3489","DOIUrl":"10.1016/j.jds.2025.07.3489","url":null,"abstract":"<p><strong>Background/purpose: </strong>Root canal morphology exhibits substantial anatomical variation influenced by ethnicity and sex, which may complicate endodontic treatment if unrecognized. This study aimed to comprehensively evaluate root and root canal configurations in a Taiwanese population using cone-beam computed tomography (CBCT) and to investigate sex-related differences in canal anatomy.</p><p><strong>Materials and methods: </strong>CBCT scans from 802 patients treated between 2022 and 2024 were retrospectively analyzed. A total of 18,578 teeth met the inclusion criteria. Root canal configurations were assessed for every root using Vertucci's classification, and C-shaped canals were further categorized based on morphology. Sex-related differences were analyzed using chisquare tests.</p><p><strong>Results: </strong>Complex canal configurations were frequently observed, particularly in molars. Distolingual roots were identified in 20.7% of mandibular first molars, and C-shaped canal configurations were present in 44.0% of mandibular second molars. Males exhibited a significantly higher prevalence of complex canals, including second mesiobuccal canals in maxillary molars and complex configurations in mandibular first premolars (<i>P</i> < 0.05). In contrast, C-shaped canals were significantly more prevalent in females (<i>P</i> < 0.05). No significant sex-related difference was observed in the prevalence of distolingual roots.</p><p><strong>Conclusion: </strong>This study presents the first large-scale CBCT-based dataset of root and root canal morphology in an East Asian population, providing a comprehensive reference for Taiwanese individuals. Analysis of more than 1000 M in each group demonstrated substantial anatomical variability and significant sex-related differences, underscoring the importance of population-and sex-specific morphological datasets.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1520-1530"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}