Fatostatin delayed lip sensory recovery after inferior alveolar nerve transection by inhibiting sterol regulatory element-binding protein 1

IF 3.4 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Dental Sciences Pub Date : 2025-05-08 DOI:10.1016/j.jds.2025.04.024

Suning Mao , Zhongkai Ma , Gaowei Zhang , Pingchuan Ma , Chunjie Li , Li Ye

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引用次数: 0

Abstract

Lipid metabolism is essential for nerve repair in damaged nerves. Fatostatin, a selective inhibitor of sterol regulatory element-binding protein 1 (SREBP1), could reduce cholesterol synthesis and disturb lipid homeostasis. However, whether fatostatin would delay lip sensory recovery after inferior alveolar nerve transection remains unclear. In this preliminary study, we investigated the effects of fatostatin on lip sensory recovery in vivo and axon growth in vitro. Fatostatin significantly delayed lip sensory recovery of mice after inferior alveolar nerve transection as evidenced by quantitative sensory testing. Fatostatin also reduced the average axon length of primary trigeminal neurons. Despite SREBP1, expressions of other lipid metabolism-related (including fatty acid synthase and ATP citrate lyase) and axon regeneration-related molecules (including activating transcription factor 3 and nerve growth factor) were also inhibited, as evidenced by the Western Blot and quantitative real-time PCR. Overall, fatostatin delayed lip sensory recovery after inferior alveolar nerve transection by inhibiting SREBP1.

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脂抑素通过抑制固醇调节元件结合蛋白1延缓下肺泡神经横断后唇部感觉恢复

脂质代谢对受损神经的修复至关重要。脂抑素（Fatostatin）是一种选择性的甾醇调节元件结合蛋白1 （SREBP1）抑制剂，可减少胆固醇合成，扰乱脂质稳态。然而，脂肪抑制素是否会延迟下肺泡神经切断后的唇部感觉恢复尚不清楚。在这项初步研究中，我们研究了脂肪抑制素对唇部感觉恢复和体外轴突生长的影响。定量感觉实验证明，脂抑素显著延缓了下肺泡神经断裂后小鼠唇部感觉的恢复。脂抑素还减少了初级三叉神经的平均轴突长度。Western Blot和实时荧光定量PCR证实，除了SREBP1外，其他脂质代谢相关分子（包括脂肪酸合成酶和ATP柠檬酸裂解酶）和轴突再生相关分子（包括激活转录因子3和神经生长因子）的表达也受到抑制。总的来说，脂肪抑制素通过抑制SREBP1延缓了下肺泡神经切断后的唇部感觉恢复。

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来源期刊

Journal of Dental Sciences 医学-牙科与口腔外科

CiteScore

5.10

自引率

14.30%

发文量

348

审稿时长

6 days

期刊介绍： he Journal of Dental Sciences (JDS), published quarterly, is the official and open access publication of the Association for Dental Sciences of the Republic of China (ADS-ROC). The precedent journal of the JDS is the Chinese Dental Journal (CDJ) which had already been covered by MEDLINE in 1988. As the CDJ continued to prove its importance in the region, the ADS-ROC decided to move to the international community by publishing an English journal. Hence, the birth of the JDS in 2006. The JDS is indexed in the SCI Expanded since 2008. It is also indexed in Scopus, and EMCare, ScienceDirect, SIIC Data Bases. The topics covered by the JDS include all fields of basic and clinical dentistry. Some manuscripts focusing on the study of certain endemic diseases such as dental caries and periodontal diseases in particular regions of any country as well as oral pre-cancers, oral cancers, and oral submucous fibrosis related to betel nut chewing habit are also considered for publication. Besides, the JDS also publishes articles about the efficacy of a new treatment modality on oral verrucous hyperplasia or early oral squamous cell carcinoma.