伴有或不伴有高同型半胱氨酸血症的口腔扁平苔藓患者的贫血、血液学缺陷和胃壁细胞抗体阳性

IF 3.4 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Dental Sciences Pub Date : 2025-05-16 DOI:10.1016/j.jds.2025.05.004

Yi-Pang Lee , Ying-Tai Jin , Julia Yu-Fong Chang , Yi-Ping Wang , Andy Sun , Chun-Pin Chiang

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引用次数: 0

摘要

背景/目的我们之前的研究发现588例口腔扁平苔藓（OLP）患者中有124例患有高同型半胱氨酸血症。本研究评估了124例高同型半胱氨酸血症的OLP患者（高同型半胱氨酸血症/OLP患者）是否比464例无高同型半胱氨酸血症的OLP患者（非高同型半胱氨酸血症/OLP患者）或588名健康对照者有明显更高的贫血、血凝缺乏症和血清胃壁细胞抗体（GPCA）阳性频率。材料与方法测定124例高同型半胱氨酸血症/OLP患者、464例非高同型半胱氨酸血症/OLP患者和588例健康对照者的血红蛋白（Hb）、血清铁、维生素B12、叶酸、同型半胱氨酸和GPCA水平。结果124例高同型半胱氨酸血症/OLP患者与588例健康对照（p值均为<；0.001）和464例非高同型半胱氨酸血症/OLP患者（p值均为<；0.001）相比，巨噬细胞增多、血Hb、血清铁和维生素B12缺乏症及血清GPCA阳性的频率显著高于对照组（p值均为<；0.001）。124例高同型半胱氨酸血症/OLP患者中有58例出现贫血，464例非高同型半胱氨酸血症/OLP患者中有90例出现贫血。124例高同型半胱氨酸血症/OLP患者中，正常细胞性贫血（22例）、恶性贫血（17例）和缺铁性贫血（10例）是3种最常见的贫血类型。此外，在464例非高同型半胱氨酸血症/OLP患者中，正常细胞性贫血（46例）、缺铁性贫血（22例）和地中海贫血特征性贫血（18例）是三种最常见的贫血类型。124例高同型半胱氨酸血症/OLP患者的大细胞性和正红细胞性贫血发生率明显高于464例非高同型半胱氨酸血症/OLP患者。结论高同型半胱氨酸血症/OLP患者巨细胞增生、贫血、血清铁和维生素B12缺乏症、血清GPCA阳性发生率明显高于健康对照组和非高同型半胱氨酸血症/OLP患者。

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Anemia, hematinic deficiencies, and gastric parietal cell antibody positivity in oral lichen planus patients with or without hyperhomocysteinemia

Background/purpose

Our previous study found that 124 of 588 oral lichen planus (OLP) patients have hyperhomocysteinemia. This study assessed whether these 124 OLP patients with hyperhomocysteinemia (hyperhomocysteinemia/OLP patients) had significantly higher frequencies of anemia, hematinic deficiencies, and serum gastric parietal cell antibody (GPCA) positivity than 464 OLP patients without hyperhomocysteinemia (non-hyperhomocysteinemia/OLP patients) or 588 healthy control subjects.

Materials and methods

The blood hemoglobin (Hb) and serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 124 hyperhomocysteinemia/OLP patients, 464 non-hyperhomocysteinemia/OLP patients, and 588 healthy control subjects were measured and compared.

Results

We found that 124 hyperhomocysteinemia/OLP patients had significantly higher frequencies of macrocytosis, blood Hb and serum iron and vitamin B12 deficiencies, and serum GPCA positivity than 588 healthy control subjects (all P-values <0.001) or 464 non-hyperhomocysteinemia/OLP patients (all P-values <0.001). Anemia was found in 58 of 124 hyperhomocysteinemia/OLP patients and in 90 of 464 non-hyperhomocysteinemia/OLP patients. Normocytic anemia (22 cases), pernicious anemia (17 cases), and iron deficiency anemia (10 cases) were the three most common types of anemia in 124 hyperhomocysteinemia/OLP patients. Moreover, normocytic anemia (46 cases), iron deficiency anemia (22 cases), and thalassemia trait-induced anemia (18 cases) were the three most common types of anemia in 464 non-hyperhomocysteinemia/OLP patients. Moreover, the 124 hyperhomocysteinemia/OLP patients had significantly higher frequencies of macrocytic and normocytic anemia than the 464 non-hyperhomocysteinemia/OLP patients.

Conclusion

Hyperhomocysteinemia/OLP patients had significantly higher frequencies of macrocytosis, anemia, serum iron and vitamin B12 deficiencies, and serum GPCA positivity than healthy control subjects or non-hyperhomocysteinemia/OLP patients.

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来源期刊

Journal of Dental Sciences 医学-牙科与口腔外科

CiteScore

5.10

自引率

14.30%

发文量

348

审稿时长

6 days

期刊介绍： he Journal of Dental Sciences (JDS), published quarterly, is the official and open access publication of the Association for Dental Sciences of the Republic of China (ADS-ROC). The precedent journal of the JDS is the Chinese Dental Journal (CDJ) which had already been covered by MEDLINE in 1988. As the CDJ continued to prove its importance in the region, the ADS-ROC decided to move to the international community by publishing an English journal. Hence, the birth of the JDS in 2006. The JDS is indexed in the SCI Expanded since 2008. It is also indexed in Scopus, and EMCare, ScienceDirect, SIIC Data Bases. The topics covered by the JDS include all fields of basic and clinical dentistry. Some manuscripts focusing on the study of certain endemic diseases such as dental caries and periodontal diseases in particular regions of any country as well as oral pre-cancers, oral cancers, and oral submucous fibrosis related to betel nut chewing habit are also considered for publication. Besides, the JDS also publishes articles about the efficacy of a new treatment modality on oral verrucous hyperplasia or early oral squamous cell carcinoma.