Journal of Dental Sciences最新文献

{"title":"Osteoclast-derived exosomes promote medication-related osteonecrosis of the jaw by delivering glycoRNA to disrupt the blood-lymphatic vascular network.","authors":"Jiankang Zhang, Junming Tao, Chengzhi Zhao, Jian Pan","doi":"10.1016/j.jds.2025.07.3549","DOIUrl":"10.1016/j.jds.2025.07.3549","url":null,"abstract":"<p><strong>Background/purpose: </strong>Medication-related osteonecrosis of the jaw (MRONJ) is a metabolic disorder of the jaw characterized by bone necrosis. Its pathogenesis remains unclear, and elucidating the underlying mechanisms and pathological changes is essential for addressing the clinical challenge of refractory jaw necrosis in MRONJ. Glycosylated RNA (glycoRNA), a recently identified class of small RNAs modified by glycosylation, plays important roles in intercellular communication, signal transduction, and autoimmunity; however, its role in the onset and progression of MRONJ has not yet been investigated.</p><p><strong>Materials and methods: </strong>Exosomes derived from zoledronate-induced osteoclasts (OC^ZA-Exosomes) were isolated by ultracentrifugation. GlycoRNA was visualized using Ac4ManNAz metabolic labeling combined with Northern blot analysis. Scratch assays, Transwell migration assays, tube-formation assays, EdU staining, and TUNEL staining were performed to evaluate the effects of OC^ZA-Exosomes on the proliferation, migration, and tube-forming capacity of human umbilical vein endothelial cells (HUVECs) and human lymphatic endothelial cells (HLECs). In MRONJ model rats, the impact of OC^ZA -Exosomes on jaw necrotic lesions was further assessed.</p><p><strong>Results: </strong>GlycoRNA was shown to undergo intercellular transfer via exosomes. In vitro, OC^ZA- Exosomes inhibited the proliferation, migration, and tube-forming abilities of HUVECs and HLECs, and induced apoptosis. In MRONJ model rats, local injection of OC^ZA-Exosomes into the tooth extraction sockets disrupted the blood-lymphatic vascular network within the jaw tissue and accelerated the progression of jaw necrosis.</p><p><strong>Conclusion: </strong>These findings reveal a previously unrecognized mechanism by which zoledronate contributes to MRONJ: exosomes-mediated intercellular transfer of glycoRNA disrupts the blood-lymphatic vascular network and promotes jaw necrosis.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1809-1817"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antisense oligonucleotides-mediated rescue of the <i>AMELX</i> splicing defects.","authors":"Eui-Sic Cho, Youn Jung Kim, Figen Seymen, Mine Koruyucu, Jan C-C Hu, James P Simmer, Jung-Wook Kim","doi":"10.1016/j.jds.2025.07.3468","DOIUrl":"10.1016/j.jds.2025.07.3468","url":null,"abstract":"<p><strong>Background/purpose: </strong>Amelogenesis imperfecta (AI) is a group of rare, inherited disorders characterized by abnormal enamel formation. While identifying the genes and mutations that cause the disease is important, understanding its molecular pathogenesis is essential to developing precision and personalized medicine, which aim to stop disease onset, slow its progression, and provide a range of treatment options. Previously, we identified mutations that affect the conserved alternative splicing of the <i>AMELX</i> gene, leading to the inclusion of normally skipped exon 4 and resulting in a characteristic AI phenotype.</p><p><strong>Materials and methods: </strong>HEK293 cells were grown on cell culture dishes for an <i>in vitro</i> splicing assay, and transiently transfected with the wild-type, c.120T>C, or c.143T>C <i>AMELX</i> expression vector. Morpholino antisense oligonucleotides (ASO) were designed and tested for correction of the altered splicing pattern. The test was performed with ASO concentrations of 1, 2 and 4 μM. Total RNA was isolated for splicing analysis, and the cells and culture media were harvested for Western blot analyses.</p><p><strong>Results: </strong>The altered splicing pattern was corrected by applying antisense oligonucleotides <i>in vitro</i>. The exon 4-included mutant mRNA was successfully eliminated, and the expression pattern of AMELX protein was restored.</p><p><strong>Conclusion: </strong>To the best of our knowledge, this is the first report to use ASO to silence mutant transcripts to correct splicing mutations confirmed to be disease-causing. This study represents a small step towards genetic interventions for AI and may serve as a basis for regulating the expression of mutant transcripts in developing teeth for future human studies.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1480-1485"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2-O-Methylmagnolol suppresses oral squamous cell carcinoma progression by targeting c-MYC signaling.","authors":"Chi-Yuan Chen, Tzong-Ming Shieh, Chin-Chuan Chen, Yann-Lii Leu, Yu-De Chu, Miaw-Jene Liou, Yi-Tsen Liu, Hsin-Wei Lin, Kai-Yin Chen, Cheng-Chia Yu, Tong-Hong Wang","doi":"10.1016/j.jds.2025.07.3483","DOIUrl":"10.1016/j.jds.2025.07.3483","url":null,"abstract":"<p><strong>Background/purpose: </strong>Oral squamous cell carcinoma (OSCC) is characterized by aggressive growth and frequent recurrence, highlighting the need for novel targeted therapies. Magnolol, a bioactive compound derived from <i>Magnolia officinalis</i>, exhibits anti-tumor activity. In this study, we synthesized a methoxylated derivative, 2-O-methylmagnolol (MM1), and evaluated the anti-OSCC efficacy and underlying mechanisms of magnolol and MM1.</p><p><strong>Materials and methods: </strong>Human OSCC cell lines (SAS and OECM1) were treated with magnolol or MM1. Cell proliferation, migration, and invasion were analyzed using functional assays. Cell-cycle distribution and apoptosis were assessed by flow cytometry and DiOC₆/PI staining. Protein expression of c-MYC and downstream regulators was examined by Western blotting. Anti-tumor efficacy was further evaluated in a xenograft mouse model.</p><p><strong>Results: </strong>Both magnolol and MM1 significantly inhibited OSCC cell proliferation, migration, and invasion, and induced G1-phase arrest and apoptosis. MM1 consistently demonstrated greater anti-tumor potency than magnolol. Mechanistically, both compounds downregulated c-MYC protein expression, accompanied by increased p21 and decreased CDC25A, CDK4, and Cyclin D1 levels, resulting in G1-S cell-cycle blockade. Epithelial-mesenchymal transition (EMT)-associated proteins were also suppressed, consistent with reduced migratory and invasive capacity. In vivo, MM1 produced stronger tumor growth inhibition without evident systemic toxicity.</p><p><strong>Conclusion: </strong>MM1 suppresses OSCC progression through coordinated inhibition of c-MYC associated oncogenic pathways and represents a promising candidate for further preclinical development.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1560-1572"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Activities of dental hygienists registered in the disaster relief system of the Japan Dental Hygienists' Association in the 2024 Noto Peninsula Earthquake.","authors":"Hitomi Suzuki, Kumiko Sugimoto, Naoko Adachi, Yuko Kuboyama, Naomi Yoshida","doi":"10.1016/j.jds.2025.07.3547","DOIUrl":"10.1016/j.jds.2025.07.3547","url":null,"abstract":"<p><strong>Background/purpose: </strong>Owing to the frequent occurrence of natural disasters in Japan, the Japan Dental Hygienists' Association established a registration system for disaster relief dental hygienists (DRDH) in 2020. Since DRDHs participated in disaster support efforts following the 2024 Noto Peninsula Earthquake, a questionnaire survey was conducted among them to clarify their activities, as well as anxieties and challenges accompanying the activities.</p><p><strong>Materials and methods: </strong>A web-based questionnaire was distributed to 141 DRDHs who participated in the relief efforts. Items included demographic information, details of relief activities, perceptions of DRDH roles, experienced anxieties, and encountered difficulties. Openended responses for perception, anxieties, and difficulties were also collected.</p><p><strong>Results: </strong>The response rate was 63.1 %, and 71.9 % of respondents were in their 50s or older. The most common activity was the shelter assessment, followed by individual counseling with evacuees. However, the activities perceived as most important were individual counseling and oral hygiene instruction, highlighting the necessity of understanding evacuees' physical and mental conditions and promoting oral health in evacuation settings. Notably, 86.5 % of participants reported pre-activity anxiety, primarily due to disaster-related environmental constraints and low self-confidence in support implementation. Furthermore, 71.9 % encountered difficulties such as disrupted transportation from damaged road conditions and challenges in providing individualized care with empathy.</p><p><strong>Conclusion: </strong>This first worldwide study documenting actual disaster relief activities of dental hygienists demonstrates their essential role in reducing disaster-related health risks. The findings underscore the need for systematic training and knowledge-sharing to enhance preparedness, self-confidence, and effectiveness of dental hygienists in future disaster responses.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1793-1800"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cephalometric and soft tissue determinants of esthetic outcomes after single-jaw mandibular setback surgery in skeletal class III patients: A retrospective study.","authors":"Chun-Te Ho, You-Ru Chen, Tsui-Hsien Huang, Jnug-Chun Yeh, Tzu-Yu Peng, Chia-Tze Kao","doi":"10.1016/j.jds.2025.07.3497","DOIUrl":"10.1016/j.jds.2025.07.3497","url":null,"abstract":"<p><strong>Background/purpose: </strong>Orthognathic surgery is an effective treatment for skeletal Class III malocclusion; however, the relative influence of skeletal and soft tissue variables on postoperative esthetic outcomes remains unclear. This study aimed to evaluate the relationships among cephalometric parameters, soft tissue changes, and esthetic outcomes following single-jaw mandibular setback surgery.</p><p><strong>Materials and methods: </strong>A retrospective study was performed on 258 adult patients with skeletal Class III malocclusion subspinale-nasion-supramentale (ANB) angle <0° who were treated between 2016 and 2021. Patients were divided into three groups: bilateral vertical ramus osteotomy (BVRO) group (n = 99), genioplasty alone group (n = 30), and BVRO plus genioplasty group. (n = 129). Cephalometric and soft tissue variables, including nasolabial angle, lip position relative to the Ricket esthetic line (E line), vertical height, and occlusal plane angle, were evaluated. Statistical analyses included multiple regression and receiver operating characteristic curve (ROC) analysis.</p><p><strong>Results: </strong>Postoperative esthetic outcomes based on the E line were achieved in approximately 47-50% of patients across groups. Significant improvements in sella turcica-nasion-subspinale (SNA) angle, sella turcica -nasion-supramentale (SNB), sella turcica -nasion-symphysis center (SND), and Wits appraisal were observed (<i>P</i> < 0.05). BVRO demonstrated the greatest mandibular setback (~11 mm). Vertical height change was a significant predictor in females, whereas upper lip position was significant in males in the BVRO plus genioplasty group. ROC analysis showed moderate predictive ability (area under curve (AUC) 0.60-0.67.</p><p><strong>Conclusion: </strong>Both skeletal and soft tissue variables influence esthetic outcomes. A multifactorial evaluation is essential for optimizing surgical planning in skeletal Class III patients.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1434-1440"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148879971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical red flags and referral strategies for odontogenic deep neck space infections: The primary care dentist's role as the first line of defense.","authors":"Sih-Yi Wu","doi":"10.1016/j.jds.2025.07.3452","DOIUrl":"10.1016/j.jds.2025.07.3452","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"2018-2019"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a risk scoring system for predicting post-extraction medication-related osteonecrosis of jaws: A derivation and validation cohort study.","authors":"Ling-Ying Wei, Ching-Ming Chiu, Sang-Heng Kok, Hung-Ying Lin, Wei-Yih Chiu, Hao-Hong Chang, Shih-Jung Cheng, Jang-Jaer Lee","doi":"10.1016/j.jds.2025.07.3445","DOIUrl":"10.1016/j.jds.2025.07.3445","url":null,"abstract":"<p><strong>Background/purpose: </strong>Although risk factors for medication-related osteonecrosis of the jaw (MRONJ) are known, clinical assessment prior to dental extraction remains largely subjective. We aimed to develop and externally validate a simple clinical risk scoring system to predict post-extraction MRONJ in osteoporotic patients receiving antiresorptive therapy (ART) and support evidence-based clinical decision-making.</p><p><strong>Materials and methods: </strong>This retrospective cohort study used a derivation cohort (N = 1067 extractions, 2003-2022) to develop a 5- to 16-point risk score system based on five predictors (age ≥75, ART duration ≥24 months, bisphosphonate use, drug interruption <i><</i>3 months, and extraction site). The model was validated in an independent cohort (N = 928 extractions, 2022-2024) using a pre-defined ≥12 cut-off. Performance metrics included the area under the curve (AUC), sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV).</p><p><strong>Results: </strong>MRONJ prevalence was lower in the validation cohort (2.2% vs. 24.5%; <i>P<</i> 0.001), reflecting stricter drug interruption adherence (90.0% vs. 71.5%). The AUC was 0.86 and 0.75 in derivation and validation cohorts, respectively. At the ≥12 cut-off, sensitivity was 65.0%, specificity 67.5%, PPV 4.2%, and NPV 98.9%.</p><p><strong>Conclusion: </strong>The model demonstrates good discrimination and excellent \"rule-out\" utility in a real-world, low-prevalence setting, identifying low-risk patients (<i><</i>12 points) for safe dental extraction, thereby facilitating evidence-based clinical decision-making.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1654-1661"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poly-ɛ-caprolactone/multi-wall carbon nanotube composites as osteoinductive scaffolds for alveolar bone regeneration.","authors":"Chien-Yang Yeh, Firdiansyah Rasyid Thaha, Yung-Kang Shen, Wei-Chun Lin","doi":"10.1016/j.jds.2025.07.3537","DOIUrl":"10.1016/j.jds.2025.07.3537","url":null,"abstract":"<p><strong>Background/purpose: </strong>Designing scaffolds to promote alveolar bone regeneration is a major challenge in dental practice. Among the desired properties of scaffolds, biocompatibility is crucial. Multi-walled carbon nanotubes (MWCNTs) possess high surface area and mechanical strength, enhancing the osteogenic properties of poly-ɛ-caprolactone (PCL). Therefore, this study evaluated the osteogenic potential of PCL/MWCNT scaffolds by incorporating varying weight percentages of MWCNTs (0.5-3 wt.%).</p><p><strong>Materials and methods: </strong>This study fabricated the scaffolds using a solvent-casting/particulate-leaching technique. Their physical and chemical properties were evaluated using contact angle (CA), porosity, pore size distribution, and Raman spectroscopy. In vitro biocompatibility was assessed via 3-(4,5-dimethylthiazole-2-Y1)-2,5-diphenyltetrazolium bromide (MTT) and alkaline phosphatase (ALP) assays using osteoblast-like cells (MG-63), and cell morphology cell morphology was observed using scanning electron microscopy (SEM).</p><p><strong>Results: </strong>The addition of MWCNTs to scaffolds improved their hydrophilicity and maintains a high porosity (>85 %) in most formulations. The Young's modulus (0.15-2.32 GPa) of PCL/MWCNT scaffolds containing different weight percentages of MWCNTs was comparable to that of human alveolar bone (1.0-3.3 GPa). PCL/MWCNT scaffolds containing 3 wt.% MWCNT exhibited the highest biocompatibility across all time points (days 1, 4, and 7). ALP activity, a marker of osteogenic differentiation, increased significantly over time, particularly at higher weight percentages MWCNT.</p><p><strong>Conclusion: </strong>The PCL/MWCNT scaffold, especially at a 3 wt.% MWCNT, demonstrated excellent biocompatibility, porosity, and osteoinductive potential, making it a promising candidate for alveolar bone tissue engineering.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1694-1703"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathogenic oral microbiota abundance is associated with reduced bite force in patients with periodontitis.","authors":"Chih-Chieh Wen, Thu Ya Linn, Ting-Yi Renn, Hui Yin Nam, Chia-Chen Hsu, Yi-Jen Lin, Yi-Fan Wu, Wei-Jen Chang","doi":"10.1016/j.jds.2025.07.3450","DOIUrl":"10.1016/j.jds.2025.07.3450","url":null,"abstract":"<p><strong>Background /purpose: </strong>Periodontitis leads to tissue destruction and functional impairment, but the interplay between microbiota, clinical parameters, and biomechanics remains unclear. This study aimed to quantitatively correlate specific oral microbial signatures and clinical inflammatory indicators with bite force in patients with periodontitis.</p><p><strong>Materials and methods: </strong>Fifteen patients with stage III-IV periodontitis and 15 periodontally healthy controls were recruited. Clinical parameters (Probing Depth, Clinical Attachment Loss, Bleeding on Probing, Plaque Index) and MBF (pressure-sensitive film) were recorded. Supragingival plaque was analyzed through 16S rRNA gene sequencing (PacBio SMRT) to determine microbial composition. Correlation analyses were performed.</p><p><strong>Results: </strong>The periodontitis group had significantly higher CAL (4.97 ± 1.18 vs. 2.49 ± 0.21 mm) and BOP (49.16 ± 17.97% vs. 14.52 ± 5.29%), and significantly lower MBF (561.17 vs. 891.46 N) (all <i>P</i>-values <i><</i>0.05). Across all subjects, Plaque Index and BOP were significantly negatively correlated with bite force. In patients, <i>Porphyromonas</i> abundance showed a significant positive correlation with BOP (ρ = 0.425), whereas <i>Streptococcus</i> showed a negative correlation (ρ = -0.381). Furthermore, higher abundances of pathogenic genera (e.g., <i>Porphyromonas</i>, <i>Capnocytophaga</i>) were significantly associated with reduced MBF.</p><p><strong>Conclusion: </strong>Bite force decline in periodontitis is directly associated with both clinical inflammation (BOP) and specific pathogenic bacterial loads (e.g., <i>Porphyromonas</i>). Microbial signatures combined with MBF may serve as a novel, integrative biomarker for assessing periodontitis severity beyond traditional clinical indices.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1636-1644"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic navigation-assisted implant placement for the jaw-in-a-day mandibular reconstruction.","authors":"Ni Lin, Min-Yi Sung, Yu-Cheng Cheng, Po-Yan Lo, Chan-Yen Kuo, Po-Chih Hsu","doi":"10.1016/j.jds.2025.07.3535","DOIUrl":"10.1016/j.jds.2025.07.3535","url":null,"abstract":"<p><strong>Background/purpose: </strong>Jaw-in-a-Day (JIAD) integrates oncologic resection, fibula free-flap reconstruction, and immediate implant-supported prosthetic rehabilitation in a single operation. This study aimed to use the dynamic navigation-assisted implant placement for the JIAD mandibular reconstruction.</p><p><strong>Materials and methods: </strong>We reported a JIAD case employing a hybrid workflow that combined conventional static guides with intraoperative dynamic navigation to enhance implant placement accuracy. Comprehensive computer-aided surgical simulation and virtual surgical planning were performed using Mimics and 3Shape software, followed by the navigation-assisted implant placement during fibula preparation.</p><p><strong>Results: </strong>The postoperative course was uneventful, and the patient was discharged three weeks after surgery. The 2-month postoperative cone-beam computed tomography demonstrated that angular deviation, platform depth deviation, and apical depth deviation were all within reported ranges for dynamic navigation-guided implant placement.</p><p><strong>Conclusion: </strong>Incorporation of dynamic navigation into the JIAD workflow provides intraoperative adaptability and improve implant accuracy and reconstructive reliability in a complex mandibular reconstruction.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1679-1682"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}