Journal of Dental Sciences最新文献

{"title":"Matrix metalloproteinase-9 upregulation in keratinocytes of oral lichen planus via c-Jun N-terminal kinase signaling pathway activation","authors":"Xinke Jiang ,&nbsp;Yiwen Deng ,&nbsp;Yirao Lai ,&nbsp;Guanhuan Du ,&nbsp;Xiye Li ,&nbsp;Xiaojie Yang ,&nbsp;Mingya Li ,&nbsp;Lei Sun ,&nbsp;Yufeng Wang ,&nbsp;Guoyao Tang","doi":"10.1016/j.jds.2024.07.010","DOIUrl":"10.1016/j.jds.2024.07.010","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Oral lichen planus (OLP) is a chronic inflammatory disorder characterized by basement membrane disruption, which plays a crucial role in its pathogenesis. Matrix metalloproteinases (MMPs), a group of proteolytic enzymes, contribute to the degradation of the basement membrane. The specific MMPs secreted by keratinocytes in OLP lesions and relevant regulatory mechanisms are not fully understood. This study aimed to investigate the involvement of MMPs in OLP pathogenesis, focusing on their expression in keratinocytes and regulatory mechanisms.</div></div><div><h3>Materials and methods</h3><div><em>MMP</em> mRNA expression in OLP epithelium was analyzed using RNA sequencing data obtained from the Gene Expression Omnibus (GEO) database. Mucosa samples from 30 OLP patients and 30 healthy controls were collected to observe the expression and regulation of MMPs in keratinocytes. The involvement of the mitogen-activated protein kinase (MAPK) pathway in MMP regulation was studied using HaCaT cells.</div></div><div><h3>Results</h3><div>RNA sequencing analysis revealed upregulation of <em>MMP1</em> and <em>MMP9</em> in OLP epithelium. MMP9 expression was predominantly observed in basal keratinocytes of OLP lesions. Elevated levels of phosphorylated c-Jun N-terminal kinase (JNK), a component of the MAPK pathway, were detected in OLP samples and co-localized with MMP9 in keratinocytes. Activation of the JNK pathway in HaCaT cells induced MMP9 expression, implicating JNK signaling in MMP9 regulation.</div></div><div><h3>Conclusion</h3><div>Keratinocytes contribute to OLP pathogenesis by secreting MMP9 through JNK pathway activation. This understanding may provide insights into targeted therapeutic interventions for this chronic recurrent disease.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 302-309"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141848711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-precision and non-invasive measurement of crestal bone level by optical coherence tomography","authors":"Wei-Ting Chang ,&nbsp;Dong-Yuan Lyu ,&nbsp;Yu-Lin Lai ,&nbsp;Jui-Ying Yen ,&nbsp;Ya-Chi Chen ,&nbsp;Shyh-Yuan Lee","doi":"10.1016/j.jds.2024.09.005","DOIUrl":"10.1016/j.jds.2024.09.005","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Identifying crestal bone level (CBL) on the buccal and lingual aspects poses challenges in conventional dental radiographs. Given that optical coherence tomography (OCT) has the capability to non-invasively provide in-depth information about the periodontium, this in vitro study aimed to assess whether OCT can effectively identify periodontal landmarks and measure CBL in the presence of gingiva.</div></div><div><h3>Materials and methods</h3><div>An in-house handheld scanning probe connected to a 1310-nm swept-source OCT (SS-OCT) system, along with self-developed algorithms were employed to measure the CBL in dental models with artificial gingiva. Markers were positioned 0.5 mm above the artificial gingival margin (SG) and the crestal bone (SC) on both the mid-buccal and mid-lingual sides of 28 plastic teeth. The distances between the paired SG and SC were measured in the OCT images after correcting for the optical path through the covering artificial gingiva. These measurements were subsequently compared to the ground truth values obtained using a 2.5D inspection system.</div></div><div><h3>Results</h3><div>The mean difference in CBL measured by SS-OCT and 2.5D was 0.008 mm (95 % CI: −0.092 to 0.108 mm). Statistical analysis using a three-way ANOVA indicated that the measurement differences were not significant across maxillary/mandible, anterior/posterior, and buccal/lingual dimensions. Furthermore, these differences were not associated with gingival thickness (α = 0.05).</div></div><div><h3>Conclusion</h3><div>The proposed SS-OCT system demonstrated its capability to accurately and non-invasively assess CBL through artificial gingiva. Moreover, it facilitated the semi-automatic delineation of critical periodontal landmarks on OCT en face images, highlighting its potential for clinical applications.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 147-153"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11762946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phosphotungstic acid-enhanced micro-computed tomography and RNA sequencing provide a new perspective on temporomandibular joint arthritis induced by complete Freund's adjuvant and collagen-induced arthritis in rat models","authors":"Ding-Han Wang ,&nbsp;Kim-Xuyen Nguyen ,&nbsp;Trang Thi-Ngoc Tran ,&nbsp;Po-Han Wu ,&nbsp;Guang Hong ,&nbsp;Yu-Min Lin ,&nbsp;Yi-Chen Hsu ,&nbsp;Cheng-Chieh Yang ,&nbsp;Yu-Cheng Lin ,&nbsp;Wun-Eng Hsu ,&nbsp;Ming-Lun Hsu ,&nbsp;Mu-Chen Yang","doi":"10.1016/j.jds.2024.08.014","DOIUrl":"10.1016/j.jds.2024.08.014","url":null,"abstract":"<div><h3>Background/Purpose</h3><div>Temporomandibular joint (TMJ) arthritis causes inflammation and degradation of the mandibular condylar cartilage and subchondral bone. Complete Freund's adjuvant (CFA) and collagen-induced arthritis (CIA) are models for studying TMJ arthritis. While micro-computed tomography (micro-CT) is crucial for three-dimensional (3D) bone analysis, it has limitations in imaging nonmineralized tissues. Phosphotungstic acid (PTA) enhances soft tissue contrast. However, research on the 3D imaging of mandibular condylar cartilage and the molecular mechanisms of CFA- and CIA-induced arthritis remains unclear. This study aimed to investigate the bone and PTA-stained cartilage in the mandibular condyle using 3D reconstruction and explore the characteristics of enriched gene ontology terms underlying CFA- and CIA-induced TMJ arthritis in rat models.</div></div><div><h3>Materials and methods</h3><div>Rat mandibular condyles were collected from control, CFA, and CIA groups. Live micro-CT created 3D bone structures, and PTA-enhanced micro-CT constructed 3D mandibular condylar cartilage. Gene ontology enrichment analysis identified enriched gene ontology terms from differentially expressed genes through RNA sequencing.</div></div><div><h3>Results</h3><div>Major deformities in cartilage volume and bone morphology were observed in the arthritis-induced groups. The CIA group exhibited significant correlations between cartilage volume and bone parameters changes. Gene ontology enrichment analysis indicated fewer terms with upregulated differentially expressed genes related to inflammation and immune response in the CIA group than in the CFA group.</div></div><div><h3>Conclusion</h3><div>This study reveals distinct responses between CFA- and CIA-induced TMJ arthritis models. The CIA group exhibited strong correlations between cartilage volume and bone parameter changes and had less pronounced inflammation and immune response than the CFA group.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 189-200"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11762256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic nomogram for proliferative verrucous leukoplakia","authors":"Yanning Zhang ,&nbsp;Xinning Zhang ,&nbsp;Zhiming Qin ,&nbsp;Jing Yan ,&nbsp;Binbin Li","doi":"10.1016/j.jds.2024.07.037","DOIUrl":"10.1016/j.jds.2024.07.037","url":null,"abstract":"<div><h3>Background</h3><div>Proliferative verrucous leukoplakia (PVL) is a special type of leukoplakia characterized by high rate of malignant transformation into oral squamous cell carcinoma (OSCC). This study aimed to analyze the canceration risk and prognostic factors of PVL and establish effective diagnostic and prognostic predictive models.</div></div><div><h3>Materials and methods</h3><div>A total of 467 patients were enrolled, including 170 cases of PVL. The independent risk and prognostic factors of PVL were analyzed by univariable and multivariable logistic regression. Nomogram models were constructed to predict the canceration risk and prognosis of PVL. The predictive power was evaluated by Hosmer–Lemeshow test, receiver operating characteristic (ROC) curve, calibration curve and decision curve analysis.</div></div><div><h3>Results</h3><div>Multivariable logistic regression analyses identified that canceration risk factors of PVL included sex, lesion sites, clinical presentation, non-smoker and oral epithelial dysplasia (OED). The independent prognostic factors of PVL were sex, clinical presentation, local irritants and OED. Diagnosis and prognostic nomogram models were constructed. The areas under the ROC curve were 0.945 and 0.893, respectively. The calibration plots showed strong agreement between the prediction and observation. Decision curve analysis indicated that the models provided significant clinical benefits for patients.</div></div><div><h3>Conclusion</h3><div>Our study established and validated the diagnosis and prognostic predictive nomogram models, which were accurate to predict the canceration risk and prognostic factors of PVL, providing individualized clinical decisions for clinical work.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 238-247"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11762630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel computer-aided design/computer-aided manufacturing guide for reduction with advancement genioplasty","authors":"Shinsuke Yamamoto,&nbsp;Keigo Maeda,&nbsp;Naoki Taniike","doi":"10.1016/j.jds.2024.10.010","DOIUrl":"10.1016/j.jds.2024.10.010","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 689-691"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A preliminary study of a dental advertisement in a Taiwan's newspaper during the Japanese colonial period","authors":"Feng-Chou Cheng ,&nbsp;Ling-Hsia Wang ,&nbsp;Yin-Lin Wang,&nbsp;Chun-Pin Chiang","doi":"10.1016/j.jds.2024.11.005","DOIUrl":"10.1016/j.jds.2024.11.005","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 718-720"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of trends and disparities in domiciliary dental care distribution in Taiwan from 2018 to 2023","authors":"Min Yee Ng ,&nbsp;Chuan-Hang Yu","doi":"10.1016/j.jds.2024.09.030","DOIUrl":"10.1016/j.jds.2024.09.030","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Domiciliary dental care (DDC) is essential for maintaining oral health in disabled and homebound patients who face barriers to accessing dental services. With Taiwan nearing super-aged society status, the demand for DDC is rising. However, comprehensive data on DDC availability and distribution across Taiwan are lacking. Hence, this study aimed to provide a comprehensive overview of the distribution of DDC across Taiwan's districts from 2018 to 2023, and to analyze the estimated ratios of disabled individuals per healthcare provider in each district.</div></div><div><h3>Materials and methods</h3><div>Data on DDC-providing hospitals and dental clinics from these years were obtained from government sources. Descriptive statistics quantified DDC facilities distribution and growth. The number of disabled individuals per district was used to estimate ratios of disabled persons to DDC facilities.</div></div><div><h3>Results</h3><div>DDC facilities increased from 47 in 2018 to 98 in 2023. Urban areas showed higher prevalence of DDC services, while some rural and offshore areas had limited or no access. Taichung and Kaohsiung had the highest numbers of DDC providers, while Penghu and Lianjiang had none. Ratios of disabled individuals to DDC facilities varied widely, with Taichung having the lowest ratio and Yunlin and Chiayi the highest. In conclusion, DDC availability in Taiwan has significantly increased, but geographical disparities persist.</div></div><div><h3>Conclusion</h3><div>These findings underscore the need for targeted policies and resource allocation to address gaps in DDC provision, particularly in underserved areas.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 77-82"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11762964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association and relevant factors between objective masticatory performance and subjective masticatory ability among community-dwelling older adults","authors":"Feng-I Chen ,&nbsp;Jen-Hao Chen ,&nbsp;Jiiang-Huei Jeng ,&nbsp;Sumio Akifusa ,&nbsp;Hsiu-Yueh Liu","doi":"10.1016/j.jds.2024.10.008","DOIUrl":"10.1016/j.jds.2024.10.008","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Dentists often focus on masticatory performance (MP) rather than masticatory ability (MA) and treatment expectations when evaluating older adults. This study aimed to determine if MA aligns with MP and to explore influencing factors.</div></div><div><h3>Materials and methods</h3><div>This cross-sectional study utilized a multi-stage stratified cluster sampling, including one thousand community-dwelling adults aged 60 and older. Participants underwent oral exams and questionnaire interviews, assessing tooth count and Eichner index (EI) levels. MP and MA were quantified using a standard gummy jelly test and a 14-food group questionnaire, respectively. Multivariable linear regressions analyzed correlations between MP, MA, and related factors.</div></div><div><h3>Results</h3><div>Approximately 25 % of participants exhibited poor MP. Factors contributing to poor MP included increased age rise, low education, number of chronic diseases, tooth loss, without the assistance of removable dentures, and being in EI group C (all <em>P</em> &lt; 0.05). Tooth count showed a significant negative correlation with MP (<em>P</em> &lt; 0.001). Participants' MP declined significantly from good to poor, with MA scores decreasing from 11.96 to 7.52 (<em>P</em> &lt; 0.001). The tooth number was a common factor influencing MA across food groups (all <em>P</em> &lt; 0.05). The decline in MA among older adults was linked to age rise, tooth loss, lack of assistance of removable dentures, and being in EI group C.</div></div><div><h3>Conclusion</h3><div>Self-rated MA in older adults effectively reflects their MP. Maintaining a high tooth count to meet occlusal support and the use of dentures to assist with tooth loss in older adults help to improve their MA.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 69-76"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Specialty education and scope of oral and maxillofacial surgery in the United States","authors":"Pooja Gangwani ,&nbsp;Sung-Kiang Chuang","doi":"10.1016/j.jds.2024.10.022","DOIUrl":"10.1016/j.jds.2024.10.022","url":null,"abstract":"<div><div>In the United States, Oral and Maxillofacial Surgery (OMS) is a specialty of dentistry that focuses on the management of injuries, diseases, and defects of the head, neck, face, and jaws. The present manuscript is an article on education and training of OMS residents in the United States. It a lso briefly describes the scope of practice of the specialty. The manuscript also sheds light upon the less practiced areas such as research and business administration aspects of the specialty. The authors also discuss gender and racial distribution of OMS residents. Descriptive information was obtained from the literature and official organization websites. Lastly, owing to the background and the arduous training required, OMS is a specialty of its own kind. It is a combination of both medical and dental sciences, with surgical and anesthesia training, and is unique in the field of medicine and dentistry. OMS play a unique role in the bridge between medicine and dentistry. Continuing education and advocacy in the hospitals, institutions, and society are crucial for increased awareness of the scope of OMS to further our specialty.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 15-19"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The establishment of pulp polyp-derived mesenchymal stem cells with normal karyotype","authors":"Ferry Sandra ,&nbsp;Eko Fibryanto ,&nbsp;Tien Suwartini ,&nbsp;Anastasia Elsa Prahasti ,&nbsp;Widya Wulandari ,&nbsp;Andri Sutanto ,&nbsp;Lyvia Juliana ,&nbsp;Kyung Hoon Lee","doi":"10.1016/j.jds.2024.08.004","DOIUrl":"10.1016/j.jds.2024.08.004","url":null,"abstract":"<div><h3>Background/Purpose</h3><div>Pulp polyp is often eliminated as dental waste. Pulp polyp cells were reported to have high proliferation activity which might be comprised of stem cells. However, little has been known on the presence of stem cells in the pulp polyp. Moreover, pulp polyp cells might contain chromosomal abnormality. The present study was conducted to investigate the presence of pulp polyp stem cells, which could later be propagated and confirmed as normal/non-pathogenic cells using karyotype analysis.</div></div><div><h3>Materials and methods</h3><div>Collected pulp polyps were minced, enzymatically digested, and cultured. Expression of mesenchymal stem cell (MSC) markers on pulp polyp cells were analyzed using flow cytometry. Multilineage differentiation capacity was assessed by culturing the cells in osteogenic, chondrogenic, and adipogenic differentiation media. Genomic stability of the cells was evaluated with G-banded and molecular karyotype analyses.</div></div><div><h3>Results</h3><div>Pulp polyp cells appeared as fibroblasts-like cells. The cells were positive for cluster of differentiation (CD)105, CD90, and CD73, and negative for CD45, CD34, CD11b, CD19, and human leukocyte antigen (HLA)-DR. The cells were capable of osteogenic, chondrogenic, and adipogenic differentiation. G-banded karyotype analysis showed that there was no abnormality in the number or structure of chromosomes in pulp polyp-derived MSCs (PP-MSCs). Molecular karyotype analysis revealed that all copy number variations identified in PP-MSCs were not pathogenic.</div></div><div><h3>Conclusion</h3><div>PP-MSCs, which fulfill the minimal criteria for MSCs and are proven to have normal karyotype, have been successfully established. PP-MSCs might be a promising and safe candidate that can be considered for pulp-dentin complex regeneration.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 220-228"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11762965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}