Journal of Dental Sciences最新文献

{"title":"A novel method for the precise second mesiobuccal canal orifice location: A combined strategy for enhanced clinical practice.","authors":"Yuhan Wang, Lingyun Li, Lu Zhang, Xiaoyan Wang","doi":"10.1016/j.jds.2025.07.3565","DOIUrl":"10.1016/j.jds.2025.07.3565","url":null,"abstract":"<p><strong>Background/purpose: </strong>Successful root canal treatment relies on thorough canal disinfection. The second mesiobuccal (MB2) canals in maxillary molars poses a significant clinical challenge due to its complex anatomy and high prevalence. The conventional perpendicular line method for MB2 canal orifice localization has notable limitations in achieving precise point identification. This study evaluates a novel combined method that integrates the perpendicular line and parallel line principles to enhance the accuracy of MB2 canal orifice localization.</p><p><strong>Materials and methods: </strong>This study analyzed 73 CBCT scans of maxillary first molars with identifiable MB2 canals. A novel combined method integrating the perpendicular line and parallel line principles was compared with the conventional perpendicular line method for MB2 canal orifice localization. Prediction accuracy was evaluated based on coordinate measurements and assessed through analysis of spatial and linear distributions.</p><p><strong>Results: </strong>The combined method demonstrated significantly higher accuracy, with data points tightly clustered near the actual MB2 canal orifice versus the scattered distribution of the perpendicular line method. The 95 % confidence ellipse area was substantially smaller for the combined method (1.63 mm² vs 2.39 mm²). Across all age and gender groups, the combined method achieved markedly lower median distance errors (<i>P <</i> 0.05), confirming its superior precision.</p><p><strong>Conclusion: </strong>The combined method, which integrates the perpendicular line and parallel line principles, demonstrated superior accuracy in MB2 canal orifice localization, providing significant clinical value for the rapid and precise localization of the MB2 canal orifice.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1958-1964"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"C-X-C motif chemokine ligand 13 and the C-X-C motif chemokine receptor 5-c-Jun N-terminal kinase-nuclear factor kappa B-matrix metalloproteinase 9 axis in oral squamous cell carcinoma metastasis.","authors":"Ju-Fang Liu, Kuan-Chou Lin, Po-Chih Hsu, Tsung-Ming Chang, Peng Chen, Ying-Sui Sun","doi":"10.1016/j.jds.2025.07.3492","DOIUrl":"10.1016/j.jds.2025.07.3492","url":null,"abstract":"<p><strong>Background/purpose: </strong>Metastasis is the leading cause of treatment failure in oral squamous cell carcinoma (OSCC). This study investigated the role of C-X-C motif chemokine ligand 13 (CXCL13) in OSCC metastasis and the underlying signaling mechanism.</p><p><strong>Materials and methods: </strong>Integrative transcriptomic analysis was performed using three independent OSCC datasets to identify metastasis-associated genes. CXCL13 expression was examined in OSCC tissues and highly migratory sublines. The effects of CXCL13 on cell migration were evaluated in vitro. Pathway analysis, pharmacological inhibitors, and receptor silencing were used to investigate the downstream signaling pathway. An orthotopic tongue xenograft model was used to evaluate the effect of CXCL13 knockdown on metastatic dissemination in vivo.</p><p><strong>Results: </strong>A total of 143 metastasis-associated genes were identified and were mainly enriched in extracellular matrix remodeling and invasion-related pathways. Among these genes, CXCL13 was identified as a central hub and was markedly upregulated in OSCC tissues and highly migratory sublines. CXCL13 significantly promoted OSCC cell migration. Mechanistically, CXCL13 activated C-X-C motif chemokine receptor 5 (CXCR5)-dependent c-Jun N-terminal kinase (JNK) signaling, which subsequently induced nuclear factor kappa B (NF-κB) activation and matrix metalloproteinase 9 (MMP9) expression. Pharmacological inhibition of JNK or NF-κB abolished CXCL13-induced migration. In vivo, CXCL13 knockdown significantly reduced metastatic dissemination without affecting primary tumor growth.</p><p><strong>Conclusion: </strong>CXCL13 acts as a metastasis-associated regulator in OSCC and promotes tumor progression through the CXCL13-CXCR5-JNK-NF-κB-MMP9 axis. This signaling pathway may serve as a potential therapeutic target for limiting metastatic progression in OSCC.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1592-1607"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delayed tooth eruption as an early clinical indicator of genetical tooth agenesis: A family-based study of cases with whole-exome sequencing.","authors":"Yu-Chen Jeng, I-Ting Chen, Hui-Ching Cheng, Hsin-Yu Huang, Chao-Kai Hsu, Yu-Fen Yen","doi":"10.1016/j.jds.2025.07.3476","DOIUrl":"10.1016/j.jds.2025.07.3476","url":null,"abstract":"<p><p>Delayed tooth eruption is frequently considered a benign developmental variation but may represent an early sign of genetically driven tooth agenesis. We evaluated a 22-month-old female presenting with markedly delayed eruption (only eight primary teeth) and a positive family history of ectodermal features. Given the inconclusive early radiographic findings, whole-exome sequencing (WES) was utilized. WES revealed the proband carried a heterozygous <i>EDARADD</i> variant (NM_080738:c.328G <i>></i> T; p. Asp110Tyr). Subsequent familial segregation analysis identified an additional heterozygous <i>WNT10A</i> variant (NM_025216:c.637G <i>></i> A; p. Gly213Ser) within the broader family. The <i>EDARADD</i> variant alone was associated with varying presentations from normal dentition to delayed eruption. Furthermore, the <i>WNT10A</i> variant alone correlated with distinct tooth agenesis, whereas their coexistence exacerbated the phenotype, resulting in severe agenesis and ectodermal features. This case demonstrates WES provides critical diagnostic insight when radiographic evaluation is inconclusive in young patients, facilitating precision dentistry.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1965-1968"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536374/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optogenetic control of odontoblastic differentiation in dental pulp stem cells (DPSC).","authors":"Francesco Torelli","doi":"10.1016/j.jds.2025.07.3543","DOIUrl":"10.1016/j.jds.2025.07.3543","url":null,"abstract":"<p><strong>Background/purpose: </strong>Dental Pulp Stem Cells (DPSC) are sensitive to ionic and electrical cues governing mineralization. We developed a photo-responsive <i>in vitro</i> model using a synthetic optogenetic construct to test whether light-gated ion flux can modulate odontoblastic differentiation without biochemical induction.</p><p><strong>Materials and methods: </strong>A commercially available, non-clinical-grade DPSC line was transfected with a modular light-gated cation channel (Opto-Ca²⁺Switch) driven by a mineralization-associated synthetic promoter. Cells were embedded in gelatin methacrylate (GelMA)-carbon-dot composites providing internal light scattering. Illumination (470 nm, 0.6 mW cm^-2, 30 min day^-1) was delivered for 14 days. Odontoblastic progression was monitored through alkaline phosphatase (ALP) activity, calcium deposition, and dentin sialophosphoprotein/dentin matrix acidic phosphoprotein 1 (DSPP/DMP1) transcription.</p><p><strong>Results: </strong>Illuminated cultures displayed a threefold increase in ALP and enhanced calcium deposition relative to dark controls. Quantitative polymerase chain reaction (qPCR) revealed significant up-regulation of DSPP (≈4.5 × ) and DMP1 (≈3.8 × ). Confocal imaging confirmed transient intracellular Ca²⁺ oscillations upon light exposure. The mineralized matrix exhibited oriented, dentin-like lamellae within the GelMA network.</p><p><strong>Conclusion: </strong>Optically gated ion channels provide a tunable strategy for light-directed odontoblastic differentiation. The system demonstrates a route toward photo-regulated biomineralization and light-responsive dental scaffolds that unify biophotonics and regenerative dentistry.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1756-1763"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dental treatment and oral care for patients with severe mental illness receiving psychiatric home-visit care: A narrative review with an illustrative case.","authors":"Takayuki Suga, Trang Thi Huyen Tu, Yuji Gamo, Takafumi Asakura, Shigeru Iida, Akira Toyofuku","doi":"10.1016/j.jds.2025.07.3505","DOIUrl":"10.1016/j.jds.2025.07.3505","url":null,"abstract":"<p><p>Patients with severe mental illness (SMI) often have untreated caries, periodontal inflammation, tooth loss, xerostomia-related risk, dental anxiety, and delayed dental attendance. This narrative review aimed to synthesize evidence relevant to dental treatment planning for patients with SMI receiving psychiatric home-visit care and to clarify when domiciliary dental assessment and repeated professional oral care may be indicated. Targeted literature searches and citation tracking were used to identify reviews, epidemiological studies, intervention studies, qualitative syntheses, and special care dentistry guidance. The evidence indicates that oral disease in SMI reflects not only limited knowledge but also avolition, cognitive impairment, psychosis, sedation, medication-induced dry mouth, shame, transport difficulty, and inability to sustain appointments. Domiciliary dental care for selected patients can include brief oral examination, identification of pain, swelling, residual roots, denture trauma and aspiration or nutritional risks, plaque and calculus removal as tolerated, topical or prescription fluoride, xerostomia and diet review, reinforcement of one feasible hygiene action, and referral for radiographs, restorations, extraction, periodontal or prosthetic treatment when clinic or special care settings become possible. In the illustrative home-visit case, severe avolition and somnolence prevented independent toothbrushing; therefore, dentists provided professional oral care every two weeks. During 7 months of follow-up, the patient had no acute dental symptoms, and no obvious clinical deterioration of carious lesions or periodontal inflammation was observed within the limits of domiciliary assessment. Home-visit dentistry should be considered for selected psychiatric home-care patients when self-care and clinic attendance are unreliable, before dental problems deteriorate into emergency-driven treatment.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1363-1368"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral health-related quality of life and diabetes outcomes: Evidence from a nationally representative U.S. sample.","authors":"Hsueh-Fen Chen, Jou-Hsun Lee, Huey-Er Lee, Ping-Shen Lin, L Joseph Su","doi":"10.1016/j.jds.2025.07.3552","DOIUrl":"10.1016/j.jds.2025.07.3552","url":null,"abstract":"<p><strong>Background/purpose: </strong>The association between self-perceived oral health-related quality of life (OHRQoL) and objective diabetes outcomes is largely unknown. This study examined six domains in Locker's framework, focusing on poor OHRQoL associated with adverse diabetes outcomes-poor glycemic control, diabetes-related complications, and polypharmacy-among U.S. adults with diabetes.</p><p><strong>Materials and methods: </strong>Data were drawn from the 2021-2023 National Health and Nutrition Examination Survey. The sample included 1179 adults aged ≥20 with diagnosed or undiagnosed diabetes (HbA1c ≥ 6.5 %), representing approximately 30.2 million U.S. adults. Six survey questions (OHQ620-OHQ680) from the Oral Health Impact Profile (OHIP) were analyzed individually to reflect Locker's conceptual domains. Outcomes included HbA1c ≥ 8 %, diabetes-related complications, and polypharmacy (defined as ≥ 5 prescribed medications). Weighted logistic regressions estimated odds ratios (OR) controlling for sociodemographic and behavioral factors.</p><p><strong>Results: </strong>Poor ratings in the domains of handicap (OHQ630), social disability (OHQ640), and psychological discomfort (OHQ680) were associated with higher odds of adverse outcomes. Specifically, individuals with poor OHQ630 and OHQ640 had greater odds of poor glycemic control (range of OR = 1.637-2.644) and diabetes-related complications (range of OR = 2.220-2.262), and poor OHQ630 and OHQ680 had greater odds of having polypharmacy (range of OR = 1.697-2.225) compared with those without poor ratings.</p><p><strong>Conclusion: </strong>Self-perceived poor OHRQoL is associated with objective diabetes outcomes, highlighting the need for integrated medical-dental care for diabetes as a public health priority. Additionally, integrating OHIP screening into community outreach programs could help identify individuals at risk for diabetes and oral health problems, facilitating early interventions.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1835-1847"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated analysis of single-cell and bulk RNA-sequence data reveal plasma dendritic cell-related diagnostic model for Sjögren's syndrome based on machine learning.","authors":"Jinhao Zhang, Chunye Zhang, Huan Shi","doi":"10.1016/j.jds.2025.07.3538","DOIUrl":"10.1016/j.jds.2025.07.3538","url":null,"abstract":"<p><strong>Background/purpose: </strong>Plasmacytoid dendritic cells (pDCs) play a critical role in linking innate and adaptive immunity in the pathogenesis of Sjögren's syndrome (SS). This study aimed to characterize pDC functional features in SS by integrating single-cell and bulk transcriptomic data and to develop a pDC-related gene signature-based diagnostic model.</p><p><strong>Materials and methods: </strong>Single-cell RNA sequencing data were analyzed using quality control, clustering, and single-cell weighted gene co-expression network analysis (scWGCNA) to identify pDC-associated gene modules. Bulk transcriptomic datasets were then used to screen diagnostic biomarkers through 204 combinations of 15 machine-learning algorithms, and a nomogram model was constructed. Cell-cell communication and drug-gene interaction analyses were subsequently performed.</p><p><strong>Results: </strong>A gene module strongly correlated with pDCs was identified, from which ten core biomarkers were selected to establish the diagnostic model. The model demonstrated excellent diagnostic performance, with AUCs of 0.999 in the training set and 0.866 in an independent validation set. Cell-cell communication analysis revealed active macrophage migration inhibitory factor (MIF) signaling between pDCs and monocyte subsets. Drug network and molecular docking analyses suggested that methotrexate and hydroxychloroquine may interact with proteins encoded by several biomarker genes.</p><p><strong>Conclusion: </strong>This study developed a robust SS diagnostic model based on pDC-related gene signatures and revealed potential pDC-monocyte interactions. The identified biomarkers and candidate drugs may facilitate auxiliary diagnosis and targeted therapeutic development for SS.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1704-1715"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Socket regeneration using a composite regenerative matrix: A simplified clinical workflow with a 5-year follow-up.","authors":"Chi-Shan Tseng, Ming-Ko Li, Cheng-Chia Yu","doi":"10.1016/j.jds.2025.07.3460","DOIUrl":"10.1016/j.jds.2025.07.3460","url":null,"abstract":"<p><p>Alveolar ridge remodeling following tooth extraction remains a clinical challenge in implant dentistry, particularly in the esthetic zone where dimensional stability of hard and soft tissues is critical for subsequent implant placement. This short communication describes a simplified clinical workflow for socket regeneration using a composite regenerative matrix (CRM) composed of concentrated growth factor (CGF), autologous fibrinogen glue (AFG), and freeze-dried bone allograft (FDBA). The technique was applied following atraumatic extraction in a single maxillary esthetic-zone case. Clinical and radiographic observations were documented for up to 5 years. Healing was uneventful, and cone-beam computed tomography performed at 3 months demonstrated qualitative socket fill and preservation of ridge contour. Implant placement was subsequently performed using a digitally guided approach. Radiographic follow-up at 1 and 5 years demonstrated stable peri-implant bone levels and maintained buccal plate morphology. The results suggest that CRM provides a simplified, biologically integrated, and predictable workflow for socket regeneration, particularly suitable for esthetic-zone applications requiring long-term dimensional stability.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1979-1982"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative effects of plasma activation and monomer infiltration on the surface characteristics and wettability of 3D-printed permanent crown resin.","authors":"Pyi Phyo Win, Szu-Yu Lai, Gannaran Narangerel, Tzu-Yu Peng, Johnson Hsin-Chung Cheng","doi":"10.1016/j.jds.2025.07.3539","DOIUrl":"10.1016/j.jds.2025.07.3539","url":null,"abstract":"<p><strong>Background/purpose: </strong>The bonding performance of 3D-printed resins (3DRs) used for permanent crowns can be challenging due to their high filler content. This study evaluated the surface characteristics and wettability of non-thermal handheld plasma (NTHP) and resin-matrix penetrating primer (RMPP) treatments in comparison with conventional airborne-particle abrasion (APA) and universal adhesive (UA) protocols.</p><p><strong>Materials and methods: </strong>Disc-shaped 3DR specimens were allocated into five surface-treatment groups: no treatment (NT), APA/UA (AU), APA/RMPP (AP), NTHP/UA (PU), and NTHP/RMPP (PP). Surface roughness and morphology were assessed. Wettability was determined by contact angle (CA) measurements using distilled water and diiodomethane, and surface energy (SE) was calculated. Data were analyzed using one-way analysis of variance (ANOVA) followed by Tukey's post-hoc test (α = 0.05).</p><p><strong>Results: </strong>APA significantly increased surface roughness (<i>P</i> < 0.001), whereas NTHP produced no significantly topographical alteration compared with the control (<i>P</i> > 0.05). SEM analysis revealed that UA formed a granular surface layer, whereas RMPP created a smoother and continuous film that reduced roughness. All treatments significantly increased SE (<i>P</i> < 0.001). The UA groups achieved the highest total SE due to enhanced hydrophilicity; however, all treated groups demonstrated similarly low CAs with diiodomethane, suggesting that both bonding agents provide sufficient dispersive energy for hydrophobic resin interaction.</p><p><strong>Conclusion: </strong>APA effectively modifies surface morphology, while NTHP activates the surface without altering its topography. Although UA yields the highest total SE, both UA and RMPP provide adequate dispersive energy to ensure favorable wetting by hydrophobic resin cements. Ultimately, the bonding agents effectively masked the mechanical topography, resulting in wettability driven primarily by the adhesive's chemical composition rather than the underlying mechanical pre-treatments.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1716-1722"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing anti-inflammatory mineral trioxide aggregate as dental implant crown cement to reduce peri-implantitis incidence.","authors":"Yung-Fu Hsu, Sea-Fue Wang, Yi-Le Liao, Chih-Sheng Lin, Ssu-Chi Chen, Sheng-Yang Lee, Wei-Chun Lin","doi":"10.1016/j.jds.2025.07.3443","DOIUrl":"10.1016/j.jds.2025.07.3443","url":null,"abstract":"<p><strong>Background/purpose: </strong>Dental resin cement residue around periodontal tissue is one of the causes of peri-implantitis. Severe cases may cause the implant to loosen or fall off. Therefore, the goal of this study was to modify mineral trioxide aggregate as an anti-inflammatory dental implant crown cement (ICC).</p><p><strong>Materials and methods: </strong>The effects of deionized water solution (Daq), hydroxyapatite solution (Haq), and calcium chloride solution (Caq) on the setting time, compressive strength, adhesion strength, and biocompatibility of ICC were evaluated. One-way analysis of variance (ANOVA) was performed for each analysis to determine differences (<i>P</i>< 0.05) between experimental groups.</p><p><strong>Results: </strong>The surface microstructure showed that the addition of Haq and Caq contributes to the binding between ICC particles. Surface element analysis showed that Haq addition increased the Ca ion content. Setting time results demonstrated that compared to Daq, Caq and Haq accelerated the final setting time by 46.5% and 34.7% respectively (<i>P</i>< 0.05). The compressive strength of Caq was 35.1% and 13.4% higher than those of Daq and Haq, respectively (<i>P</i>< 0.05). The adhesion strength results of the three ICC groups revealed that the resin cement had the same effect (<i>P</i>> 0.05). Biocompatibility and scavenging activity tests showed that ICC was superior to resin cement.</p><p><strong>Conclusion: </strong>ICC combined with Caq can shorten the setting time, improve compressive strength, increase biocompatibility, and reduce the possibility of inflammation. Therefore, the ICC system combined with Caq may serve as an alternative to dental resin cements.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1459-1468"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}