Journal of Dental Sciences最新文献

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Severe hypoplastic enamel as a primary manifestation of hypophosphatasia: A case report
IF 3.4 3区 医学
Journal of Dental Sciences Pub Date : 2025-01-01 DOI: 10.1016/j.jds.2024.10.009
Youn Jung Kim, Seon Hee Kim, Jung-Wook Kim
{"title":"Severe hypoplastic enamel as a primary manifestation of hypophosphatasia: A case report","authors":"Youn Jung Kim, Seon Hee Kim, Jung-Wook Kim","doi":"10.1016/j.jds.2024.10.009","DOIUrl":"10.1016/j.jds.2024.10.009","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 686-688"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11762665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of cortical bone thickness at the nasomaxillary and zygomaticomaxillary buttresses using cone-beam computed tomography imaging for Le Fort I osteotomy 使用锥形束计算机断层扫描成像技术评估勒堡 I 型截骨术的鼻颌和颧颌托皮质骨厚度。
IF 3.4 3区 医学
Journal of Dental Sciences Pub Date : 2025-01-01 DOI: 10.1016/j.jds.2024.10.018
Ching-Wen Chuang , Yu-Chuen Huang , I Chen , Michael Y.C. Chen , Jui-Ting Hsu
{"title":"Evaluation of cortical bone thickness at the nasomaxillary and zygomaticomaxillary buttresses using cone-beam computed tomography imaging for Le Fort I osteotomy","authors":"Ching-Wen Chuang ,&nbsp;Yu-Chuen Huang ,&nbsp;I Chen ,&nbsp;Michael Y.C. Chen ,&nbsp;Jui-Ting Hsu","doi":"10.1016/j.jds.2024.10.018","DOIUrl":"10.1016/j.jds.2024.10.018","url":null,"abstract":"<div><h3>Background/Purpose</h3><div>Studies have indicated that 50%–55% of the population have malocclusion, and approximately 5%–10% require orthognathic surgery to correct this condition. Optimal placement of plates and screws significantly affects the success rate of the surgery and postoperative stability. This study evaluates the cortical thickness of the maxillary bone in the nasomaxillary and zygomaticomaxillary buttress regions in Taiwanese patients based on cone-beam computed tomography (CBCT) images.</div></div><div><h3>Materials and methods</h3><div>128 Patients undergoing Le Fort I osteotomy were selected for this study. Their CBCT images were input into medical imaging software to simulate the placement of titanium screws and plates. The cortical bone thickness at these positions was measured to assess the thickness in the nasomaxillary buttress (surrounding the nasal opening) and the zygomaticomaxillary buttress (surrounding the maxillary zygomatic process). Associations of these thicknesses with gender, age, and screw position were analyzed.</div></div><div><h3>Results</h3><div>In the nasomaxillary region, cortical bone was thicker on the upper and lower vertical regions, with men generally having thicker bone. The zygomaticomaxillary region had increased thickness near the zygomatic end and distal region. Younger adults had significantly greater bone thickness in certain areas than those over 30 years.</div></div><div><h3>Conclusion</h3><div>The nasomaxillary region's upper and lower vertical regions and the zygomatic end in the zygomaticomaxillary region provide optimal screw placement sites. Bone thickness differences by gender and age suggest occlusal force and age-related bone resorption as influencing factors.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 36-46"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11762680/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrating digital technologies in dental technician education: A comparative study of national examination in Asian countries
IF 3.4 3区 医学
Journal of Dental Sciences Pub Date : 2025-01-01 DOI: 10.1016/j.jds.2024.10.017
Ming-Sung Hsu , Chun-Liang Yeh , Shih-Jung Cheng , Chun-Pin Lin
{"title":"Integrating digital technologies in dental technician education: A comparative study of national examination in Asian countries","authors":"Ming-Sung Hsu ,&nbsp;Chun-Liang Yeh ,&nbsp;Shih-Jung Cheng ,&nbsp;Chun-Pin Lin","doi":"10.1016/j.jds.2024.10.017","DOIUrl":"10.1016/j.jds.2024.10.017","url":null,"abstract":"<div><h3>Background/purpose</h3><div>The integration of digital technologies in dental technician education revolutionized the profession in Asian countries. Despite the growing adoption of digital methods, national examinations predominantly relied on traditional techniques. This study aimed to conduct a comparative analysis of national examination standards and digital course integration in dental technician education among 5 countries including Japan, Taiwan, South Korea, the Philippines, and China.</div></div><div><h3>Materials and methods</h3><div>Data were collected from government agencies, universities, academic organizations, professional associations, and relevant certifying institutions. The study examined the educational methodologies and regulatory frameworks in these countries, focusing on incorporating digital technologies in training and assessment.</div></div><div><h3>Results</h3><div>The findings revealed significant variations in the integration of digital technologies. Japan and South Korea made substantial progress in embedding digital education in their curricula, while the Philippines and China remained in the early stages. Taiwan showed a balanced approach with a mixture of digital and traditional methods. Practical examinations in most countries remained rooted in conventional techniques, highlighting a gap between educational advancements and examination practices.</div></div><div><h3>Conclusion</h3><div>To better prepare students for the evolving demands of the dental technology industry, it was crucial to adopt a balanced approach that combined digital learning with hands-on training. This study advocated for educational reforms that bridged the gap between traditional training methods and modern digital practices. Enhanced international cooperation and the continuous updating of training programs were essential for advancing the quality of dental technician education, which in turn improved overall oral health outcomes.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 28-35"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11762664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Calf circumference and serum albumin level are the reliable biomarkers for predicting the chewing ability and nutritional status of the elderly people
IF 3.4 3区 医学
Journal of Dental Sciences Pub Date : 2025-01-01 DOI: 10.1016/j.jds.2024.08.008
Chien-Hui Cheng , Shyh-Dye Lee , Hui-Chuen Chen , Hsin-Ming Chen
{"title":"Calf circumference and serum albumin level are the reliable biomarkers for predicting the chewing ability and nutritional status of the elderly people","authors":"Chien-Hui Cheng ,&nbsp;Shyh-Dye Lee ,&nbsp;Hui-Chuen Chen ,&nbsp;Hsin-Ming Chen","doi":"10.1016/j.jds.2024.08.008","DOIUrl":"10.1016/j.jds.2024.08.008","url":null,"abstract":"<div><h3>Background/purpose</h3><div>The relationship among chewing ability, food texture selection, and nutritional status in the elderly is well-known. This study tried to find the reliable biomarkers to predict the chewing ability and nutritional status of the elderly people.</div></div><div><h3>Materials and methods</h3><div>Sixty-eight elderly subjects (mean age, 80.38 ± 7.32 years) were enrolled in this study. Oral examinations assessed the number of total teeth, pair of antagonistic teeth, and type of dentures in participants. Sociodemographic data, dietary habits, and medical history were collected via self-reported questionnaires. Nutritional status was assessed based on the calf circumference and serum albumin level measurements.</div></div><div><h3>Results</h3><div>The elderly individuals with fewer number of total teeth, fewer pairs of antagonistic teeth, or the removable dentures preferred minced and moist food textures. These preferences were significantly associated with the smaller calf circumference (31.29 ± 4.08 cm, <em>P</em> &lt; 0.05) and lower serum albumin levels (3.52 ± 0.63 g/dL, <em>P</em> &lt; 0.001) compared to those with better chewing ability. The elderly participants with &lt;20 total teeth, &lt;10 pairs of antagonistic teeth, or the removable dentures showed significantly lower calf circumference and serum albumin levels than those with ≥20 total teeth, ≥10 pairs of antagonistic teeth, or the fixed dentures, respectively (all <em>P</em>-values &lt;0.05).</div></div><div><h3>Conclusion</h3><div>Optimal chewing ability is crucial for maintaining an adequate nutritional status in the elderly people. The calf circumference and serum albumin level are found to be the reliable biomarkers for predicting the chewing ability and nutritional status of the elderly people.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 164-169"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11762255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancement of titanium surfaces using different acid solutions at room temperature to improve bone cell responses
IF 3.4 3区 医学
Journal of Dental Sciences Pub Date : 2025-01-01 DOI: 10.1016/j.jds.2024.06.011
Thu Ya Linn , Eisner Salamanca , Chun-Yu Ho , Yi-Fan Wu , Hao-Chun Chiu , Wei-Jen Chang , Ying-Sui Sun
{"title":"Enhancement of titanium surfaces using different acid solutions at room temperature to improve bone cell responses","authors":"Thu Ya Linn ,&nbsp;Eisner Salamanca ,&nbsp;Chun-Yu Ho ,&nbsp;Yi-Fan Wu ,&nbsp;Hao-Chun Chiu ,&nbsp;Wei-Jen Chang ,&nbsp;Ying-Sui Sun","doi":"10.1016/j.jds.2024.06.011","DOIUrl":"10.1016/j.jds.2024.06.011","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Early osseointegration of titanium (Ti) dental implants relies on the surface topography. Surface modification of Ti seeks to enhance bone regeneration around implants. Acid etching is the simple, less technique sensitive and cost-effective technique for surface treatment. The purpose of this study was to elucidate the simplified acid etching technique at room temperature lies in its capacity to enhance both physical properties and biological reactions relevant to bone.</div></div><div><h3>Materials and methods</h3><div>Utilizing sulfuric acid (H<sub>2</sub>SO<sub>4</sub>) and hydrochloric acid (HCl), five distinct acid solutions were prepared, and the acid etching process was executed at five different time points at room temperature. The surface characterization of nanoscale modified titanium disks encompassed surface characteristics analysis, wettability and roughness tests. The biocompatibility evaluation involves tests that assess cell attachment, proliferation, alkaline phosphatase activity (ALP), and mineralization.</div></div><div><h3>Results</h3><div>The surface modified by HCl exhibited the most significant alterations, characterized by an elevated roughness value and reduced hydrophilicity properties. The surface treated with a mixture of HCl and H<sub>2</sub>SO<sub>4</sub> for 24 h (TH5) displayed a hydrophilic surface and high surface energy. Acid etched surfaces showed the greater cell attachment with long pseudopodia. The cell proliferation rate and ALP reaction rate of TH5 is the highest at day 7. Cells mineralization of Ti surface treated with 37% HCl for 24 h (TC5) shows the lowest and TH5 shows the greatest on day 21.</div></div><div><h3>Conclusion</h3><div>The proposed acid etching at room temperature utilizing a combination of H<sub>2</sub>SO<sub>4</sub> and HCl demonstrated improved physical properties while fostering favorable biological responses.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 373-383"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationships between orofacial pain and sleep: Analysis of UK biobank and genome-wide association studies data 口面部疼痛与睡眠之间的关系:英国生物数据库和全基因组关联研究数据分析
IF 3.4 3区 医学
Journal of Dental Sciences Pub Date : 2025-01-01 DOI: 10.1016/j.jds.2024.04.027
Yang Jiang , Xu Gong , Min Yu , Xuemei Gao
{"title":"Relationships between orofacial pain and sleep: Analysis of UK biobank and genome-wide association studies data","authors":"Yang Jiang ,&nbsp;Xu Gong ,&nbsp;Min Yu ,&nbsp;Xuemei Gao","doi":"10.1016/j.jds.2024.04.027","DOIUrl":"10.1016/j.jds.2024.04.027","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Orofacial pain is common in dental practices. This study aimed to explore relationships between orofacial pain and sleep using the UK Biobank dataset and, based on epidemiological associations, to investigate the causal association using genome-wide association studies data.</div></div><div><h3>Materials and methods</h3><div>First, a cross-sectional study was conducted with 196,490 participants from UK Biobank. Information on pain conditions and sleep traits was collected. Multivariable models were used to explore the relationships with odds ratio (OR). Second, Mendelian randomization analyses were conducted using data for orofacial pain, including temporomandibular joint disorders-related pain (n = 377,277) and atypical facial pain (n = 331,749), and sleep traits, including sleep duration (n = 446,118), short sleep (n = 411,934), long sleep (n = 339,926), snoring (n = 359,916), ease of getting up (n = 385,949), insomnia (n = 453,379), daytime dozing (n = 452,071), daytime napping (n = 452,633), and chronotype (n = 403,195).</div></div><div><h3>Results</h3><div>The cross-sectional study confirmed the bidirectionality between pain and sleep. Participants experiencing pain all over the body showed a significant association with an unhealthy sleep pattern (OR = 1.18, <em>P</em> &lt; 0.001) and other sleep traits (<em>P</em> &lt; 0.05). Risks of chronic orofacial pain were associated with sleep duration in a non-linear relationship (<em>P</em> = 0.032). The Mendelian randomization analyses indicated that long sleep was causally associated with temporomandibular joint disorders-related pain (OR = 6.77, <em>P</em> = 0.006).</div></div><div><h3>Conclusion</h3><div>The relationship between pain and sleep is bidirectional. Long sleep is found to be causally associated with chronic orofacial pain.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 529-538"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141038558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biomineralization reaction from nanosized calcium silicate: A new method for reducing dentin hypersensitivity 纳米硅酸钙的生物矿化反应:降低牙本质过敏性的新方法
IF 3.4 3区 医学
Journal of Dental Sciences Pub Date : 2025-01-01 DOI: 10.1016/j.jds.2024.05.027
Mi-Jeong Jeon , Yu-Sung Choi , Jeong-Kil Park , Jin-Soo Ahn , Yu-Chih Chiang , Deog-Gyu Seo
{"title":"Biomineralization reaction from nanosized calcium silicate: A new method for reducing dentin hypersensitivity","authors":"Mi-Jeong Jeon ,&nbsp;Yu-Sung Choi ,&nbsp;Jeong-Kil Park ,&nbsp;Jin-Soo Ahn ,&nbsp;Yu-Chih Chiang ,&nbsp;Deog-Gyu Seo","doi":"10.1016/j.jds.2024.05.027","DOIUrl":"10.1016/j.jds.2024.05.027","url":null,"abstract":"<div><h3>Background/purpose</h3><div>This study assessed the ability of experimental materials consisting of dicalcium silicate (DCS) and tricalcium silicate (TCS) with nanosized particles to form intratubular crystals under phosphate-buffered saline (PBS) and the effect on dentin permeability reduction.</div></div><div><h3>Materials and methods</h3><div>By isolating the cervical part of the extracted premolars, 195 specimens were obtained. Two experimental materials (DCS/TCS and TCS) were applied to the dentin surface by brushing and stored in PBS (n = 65). Another 65 specimens were not treated. Each group was randomly divided into five subgroups based on the PBS immersion period (1, 15, 30, 60, and 90 days, n = 10). The dentin permeability was measured, and the hydraulic conductance, Lp (%), was calculated. After acid challenge with 1 M acetic acid, Lp (%) was remeasured. Data were analyzed using two-way analysis of variance and Fisher's least significant difference test (α = 0.05). Three specimens of each subgroup were longitudinally sectioned and examined using scanning electron microscopy and a field emission-electron probe micro analyzer.</div></div><div><h3>Results</h3><div>The Lp (%) of the experimental groups gradually decreased over time (<em>P</em> &lt; 0.05). The hydroxyapatite-like crystals that grew were observed and found to have a Ca/P ratio similar to that of hydroxyapatite. The crystals remained after the acid challenge, and the Lp (%) was not significantly different from that before acid treatment.</div></div><div><h3>Conclusion</h3><div>Intratubular crystals formed from the experimental materials consisted of DCS and TCS and were resistant to acid. These crystals significantly reduced dentin permeability.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 428-436"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141408368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nucleotide-binding oligomerization domain-like receptor family caspase recruitment domain containing protein 5 affects the progression of periodontitis by regulating the function of periodontal membrane cells 核苷酸结合寡聚化结构域样受体家族 Caspase 招募结构域含蛋白 5 通过调节牙周膜细胞的功能影响牙周炎的进展
IF 3.4 3区 医学
Journal of Dental Sciences Pub Date : 2025-01-01 DOI: 10.1016/j.jds.2024.07.008
Peiying Lyu, Jianru Liu, Xiangying Ouyang, Yuanbo Wang, Wenyi Liu, Jinsheng Zhong
{"title":"Nucleotide-binding oligomerization domain-like receptor family caspase recruitment domain containing protein 5 affects the progression of periodontitis by regulating the function of periodontal membrane cells","authors":"Peiying Lyu,&nbsp;Jianru Liu,&nbsp;Xiangying Ouyang,&nbsp;Yuanbo Wang,&nbsp;Wenyi Liu,&nbsp;Jinsheng Zhong","doi":"10.1016/j.jds.2024.07.008","DOIUrl":"10.1016/j.jds.2024.07.008","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Nucleotide-binding oligomerization domain-like receptor family caspase recruitment domain containing protein 5 (NLRC5) plays a regulatory role in innate and adaptive immunity. However, its role in periodontitis remains unclear. This study investigated the effects of NLRC5 on periodontitis and the underlying mechanism.</div></div><div><h3>Materials and methods</h3><div>Experimental periodontitis models of wild-type and Nlrc5 knockout mice were established to detect alveolar bone loss. The inflammatory environment was established with <em>Porphyromonas. gingivalis</em> lipopolysaccharide (<em>P. gingivalis</em> LPS). The expression of NLRC5 in periodontal ligament stem cells (PDLSCs) were detected with P. gingivalis LPS stimulated. After knocking-down or overexpressing the NLRC5 expression level, the inflammatory cytokine level and osteogenic ability of PDLSCs were detected.</div></div><div><h3>Results</h3><div>The Nlrc5 knockout mice exhibited greater alveolar bone loss in periodontitis. In the presence of <em>P. gingivalis</em> LPS, the expression of NLRC5 decreased. Downregulating NLRC5 increased the expression of interleukin (IL)-1β, IL-6 and tumor necrosis factor-α (TNF-α). Upregulated NLRC5 inhibited nuclear factor kappa-B (NF-κB) signaling and inhibited the expression of those proinflammatory factors. NLRC5 had a positive regulatory effect on the osteogenic differentiation of PDLSCs. When NLRC5 was knocked down, the ALP activity and the number of mineralized nodules in PDLSCs decreased. Conversely, overexpression of NLRC5 enhanced the osteogenic differentiation ability of PDLSCs. Overexpression of NLRC5 increased the osteogenic differentiation of PDLSCs in inflammatory environments.</div></div><div><h3>Conclusion</h3><div>NLRC5 affects the progression of periodontitis by regulating the function of PDLSCs. NLRC5 reduced the expression of inflammatory factors by inhibiting NF-κB, and had a positive regulatory effect on the osteogenic differentiation of PDLSCs.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 325-334"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141697149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From gingiva to multiple organs in mice: The trace of Porphyromonas gingivalis via in vivo imaging 从牙龈到小鼠的多个器官:通过活体成像追踪牙龈卟啉单胞菌的踪迹
IF 3.4 3区 医学
Journal of Dental Sciences Pub Date : 2025-01-01 DOI: 10.1016/j.jds.2024.07.009
Xin-Yi Cheng, Pei-Hui Zou, Yi-Ming Ma, Yu Cai, Qiao Shi, Jia Liu, Qing-Xian Luan
{"title":"From gingiva to multiple organs in mice: The trace of Porphyromonas gingivalis via in vivo imaging","authors":"Xin-Yi Cheng,&nbsp;Pei-Hui Zou,&nbsp;Yi-Ming Ma,&nbsp;Yu Cai,&nbsp;Qiao Shi,&nbsp;Jia Liu,&nbsp;Qing-Xian Luan","doi":"10.1016/j.jds.2024.07.009","DOIUrl":"10.1016/j.jds.2024.07.009","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Periodontitis is associated with systemic health. One of the underlying mechanisms is the translocation of periodontal pathogens, among which <em>Porphyromonas gingivalis</em> (<em>Pg</em>) is the most common. Here, we aimed to illustrate the biodistribution and dynamics of <em>Pg</em> from gingiva to multiple organs through blood circulation.</div></div><div><h3>Materials and methods</h3><div><em>Pg</em> tagged by Cyanine 7 (Cy7-<em>Pg</em>) was injected into the gingiva of healthy and periodontitis mice. <em>In vivo</em> imaging system (IVIS) was applied to monitor the distribution of Cy7-<em>Pg</em> in multiple organs which were isolated at serial timepoints. Polymerase chain reaction (PCR) was conducted to determine the <em>Pg</em> DNA copies in the gingiva, blood and organs. Cy7-<em>Pg</em> in the gingiva and organs was also confirmed by frozen section staining. Furthermore, to figure out whether the bacteremia derived from oral-gut axis, mice received gavage of Cy7-<em>Pg</em>. Then the blood and organ samples were detected in the similar way as above.</div></div><div><h3>Results</h3><div>Intra-gingival injection induced larger amounts of Cy7-<em>Pg</em> accumulating in the gingiva of periodontitis mice (<em>P &lt;</em> 0.05) as confirmed by above three methods. Twenty minutes after injection, <em>Pg</em> DNA copies in the blood of periodontitis group were 36.3-fold higher than healthy group (<em>P &lt;</em> 0.05). IVIS results, combined with PCR and frozen sections, demonstrated periodontitis induced longer retention with higher amounts of Cy7-<em>Pg</em> in the periodontitis group. <em>Pg</em> was enriched more significantly in the liver for the longer duration than the kidney and pancreas.</div></div><div><h3>Conclusion</h3><div>Our study showed <em>Pg</em>, which accumulated in the gingiva, could translocate through blood circulation to multiple organs with varied duration and amounts.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 292-301"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141852540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel early vertical ridge augmentation technique
IF 3.4 3区 医学
Journal of Dental Sciences Pub Date : 2025-01-01 DOI: 10.1016/j.jds.2024.10.025
Jerry Chin-Yi Lin , Shaima O. Bahammam , David M. Kim , Wei-Jen Chang
{"title":"Novel early vertical ridge augmentation technique","authors":"Jerry Chin-Yi Lin ,&nbsp;Shaima O. Bahammam ,&nbsp;David M. Kim ,&nbsp;Wei-Jen Chang","doi":"10.1016/j.jds.2024.10.025","DOIUrl":"10.1016/j.jds.2024.10.025","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Multiple augmentation protocols are documented in the literature to rebuild the deficient alveolar ridge after tooth extraction; however, achieving adequate vertical augmentation remains the most challenging goal. This study demonstrated a novel surgical technique of early vertical ridge augmentation for post-dental extraction. This technique offers several biological and technical advantages regarding the timing of the procedure and its relative simplicity compared to other complex techniques.</div></div><div><h3>Materials and methods</h3><div>This retrospective study consisted of 50 extraction sites from 44 participants who had received early vertical ridge augmentation (VRA) procedures (6–16 weeks post-extraction in either the maxilla or the mandible). The procedures were carried out using titanium tenting screws, freeze-dried bone allografts (FDBA), and xenografts (bovine). Pre- and post-operative cone-beam computed tomography (CBCT) images were taken for all participants 6–9 months after the augmentation surgery to measure the vertical bone gained.</div></div><div><h3>Results</h3><div>A total of 44 patients were treated with early VRA 6–16 weeks post-dental extraction. The total mean vertical bone gain measured after 6–9 months of augmentation for all cases was 4.64 ± 1.76 mm with no complications encountered. About 80 % of augmented sites met or exceeded the expected vertical bone gain (EVBG). Delaying vertical ridge augmentation until after eight weeks post-extraction, particularly beyond twelve weeks, results in higher rates of EVBG and more consistent average bone gain.</div></div><div><h3>Conclusion</h3><div>This study indicates that VRA can be achieved predictably by utilizing the early VRA technique, which is relatively straightforward and is associated with a minimal complication.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 20-27"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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