Is periodontitis a potential risk factor of rhegmatogenous retinal detachment? A population-based retrospective cohort study of Taiwan

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Dental Sciences Pub Date : 2025-03-26 DOI:10.1016/j.jds.2025.03.003

Earl Fu , Yueh-Ju Tsai , Chi-Hsiang Chung , Min-Wen Fu , Yi-Jan Hsia , Wu-Chien Chien

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引用次数: 0

Abstract

Background/Purpose

Periodontitis, a common inflammatory disease, has been linked to various systemic and ocular conditions. However, its connection to rhegmatogenous retinal detachment (RRD), a vision-threatening condition, remains uncertain. This study aimed to investigate the association between periodontitis and RRD.

Materials and methods

From 2000 to 2015, 1,936,512 participants were recruited from Taiwan's National Health Insurance Research Database, including 29,970 with chronic periodontitis, defined by at least three outpatient visits within a year. A matched 1:1 comparison group was selected based on sex, age, and index year. The periodontitis group was divided into two subgroups: those who received root planing and/or surgical therapy (subgroup 1) and those who did not (subgroup 2).

Results

At the end of the follow-up, 2165 participants in the periodontitis group and 1259 in the comparison group developed RRD. The cumulative risk of RRD was increased in the periodontitis group, and the two subgroups, compared to the comparison group. After adjustment with the covariates of sociodemographic factors, systemic diseases, RRD comorbidities, and smoking/alcohol habits, the increased risk of developing RRD remained significant (adjusted hazard ratio: 1.49, 95 % CI: 1.12–1.83, P < 0.001). Subgroups 1 and 2 also had increased risks, with adjusted hazard ratios of 1.70 and 1.34, respectively. These results persisted even when excluding the first 1 or 5 years of data.

Conclusion

This nationwide retrospective study showed that patients with chronic periodontitis, regardless of whether they received periodontal treatment, had a higher risk of developing RRD, suggesting a potential association between periodontitis and RRD.

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牙周炎是孔源性视网膜脱离的潜在危险因素吗？台湾以人群为基础的回顾性队列研究

背景/目的牙周炎是一种常见的炎症性疾病，与各种全身和眼部疾病有关。然而，其与孔源性视网膜脱离（RRD）（一种视力威胁疾病）的关系仍不确定。本研究旨在探讨牙周炎与RRD之间的关系。按性别、年龄、指标年份选择匹配的1:1对照组。牙周炎组分为两个亚组：接受牙根刨平和/或手术治疗的组（亚组1）和未接受治疗的组（亚组2）。结果随访结束时，牙周炎组和对照组分别有2165人和1259人出现RRD。与对照组相比，牙周炎组和两个亚组的RRD累积风险增加。在与社会人口因素、全身性疾病、RRD合并症和吸烟/饮酒习惯等协变量进行校正后，发生RRD的风险增加仍然显著(校正风险比：1.49,95% CI: 1.12-1.83, P <；0.001)。亚组1和2的风险也增加，调整后的风险比分别为1.70和1.34。即使排除了前1年或5年的数据，这些结果仍然存在。结论：这项全国性的回顾性研究显示，慢性牙周炎患者，无论是否接受过牙周治疗，发生RRD的风险都较高，提示牙周炎与RRD之间存在潜在的关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Dental Sciences 医学-牙科与口腔外科

CiteScore

5.10

自引率

14.30%

发文量

348

审稿时长

6 days

期刊介绍： he Journal of Dental Sciences (JDS), published quarterly, is the official and open access publication of the Association for Dental Sciences of the Republic of China (ADS-ROC). The precedent journal of the JDS is the Chinese Dental Journal (CDJ) which had already been covered by MEDLINE in 1988. As the CDJ continued to prove its importance in the region, the ADS-ROC decided to move to the international community by publishing an English journal. Hence, the birth of the JDS in 2006. The JDS is indexed in the SCI Expanded since 2008. It is also indexed in Scopus, and EMCare, ScienceDirect, SIIC Data Bases. The topics covered by the JDS include all fields of basic and clinical dentistry. Some manuscripts focusing on the study of certain endemic diseases such as dental caries and periodontal diseases in particular regions of any country as well as oral pre-cancers, oral cancers, and oral submucous fibrosis related to betel nut chewing habit are also considered for publication. Besides, the JDS also publishes articles about the efficacy of a new treatment modality on oral verrucous hyperplasia or early oral squamous cell carcinoma.