Journal of Dental Sciences最新文献

{"title":"Modulation of osteoclast differentiation by epigallocatechin-3-gallate (EGCG)/type I collagen-coated titanium implant surface in vitro.","authors":"Her-Hsiung Huang, Yu-Ying Cheng, Chia-Fei Liu, Wei-Cheng Chen","doi":"10.1016/j.jds.2025.07.3474","DOIUrl":"10.1016/j.jds.2025.07.3474","url":null,"abstract":"<p><strong>Background/purpose: </strong>Implant osseointegration depends not only on osteogenesis but also on coordinated bone remodeling. Our previous study demonstrated that epigallocatechin-3-gallate (EGCG)/type I collagen-coated titanium (Ti) surfaces enhance angiogenesis and osteogenic differentiation in vitro. However, their influence on osteoclast differentiation remains unclear. This study evaluated the modulatory effects of this coating on osteoclast responses in vitro.</p><p><strong>Materials and methods: </strong>Sandblasted and acid-etched (SLA) Ti surfaces followed by alkaline treatment (SLAA) were prepared. Type I collagen was immobilized onto SLAA surfaces using the natural crosslinker EGCG (10 or 50 μg/mL). Surface morphology, roughness, hydrophilicity, and functional groups were characterized. RAW 264.7 macrophages were used to assess cell adhesion, proliferation, viability, tartrate-resistant acid phosphatase (TRAP) expression, and F-actin ring formation. Osteoclast differentiation was induced using receptor activator of nuclear factor kappa-B ligand (RANKL). Statistical analysis was performed using one-way ANOVA with Dunnett's test.</p><p><strong>Results: </strong>Surface characterization confirmed successful coating without compromising surface stability. Compared with SLA surfaces, collagen-coated surfaces with or without EGCG enhanced initial cell spreading while showing less increase in metabolic activity without cytotoxicity. EGCG- and EGCG/type I collagen-coated surfaces significantly reduced TRAP expression and F-actin ring size relative to SLA surfaces. Although the 50 μg/mL EGCG groups showed lower TRAP expression and smaller F-actin rings than the 10 μg/mL groups, the differences were not statistically significant.</p><p><strong>Conclusion: </strong>EGCG/type I collagen surface modification may modulate osteoclast-related cellular responses in RAW 264.7 cells without affecting cell viability, suggesting a potential strategy to modulate peri-implant bone resorption and support long-term implant stability.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1618-1626"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536397/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endothelin-1 drives COX-2 and prostaglandin E₂ expression in osteoblasts through MAPK/AP-1 signaling during periodontal inflammation.","authors":"Fang-Yu Fan, Thi Thuy Tien Vo, Hsuan Kuo, Chien-Fu Tseng, Wei-Ning Lin, Chia-Yu Wu, Yang-Che Wu, Chuen-Mao Yang, Li-Der Hsiao, I-Ta Lee","doi":"10.1016/j.jds.2025.07.3482","DOIUrl":"10.1016/j.jds.2025.07.3482","url":null,"abstract":"<p><strong>Background/purpose: </strong>Endothelin-1 (ET-1) has been implicated in inflammatory tissue responses, but its role in osteoblast-mediated inflammation during periodontal inflammation remains unclear. This study investigated whether ET-1 induces cyclooxygenase-2 (COX-2) expression and prostaglandin E₂ (PGE₂) release in osteoblasts and explored the underlying signaling mechanisms.</p><p><strong>Materials and methods: </strong>Murine osteoblast-like MC3T3-E1 cells were stimulated with ET-1. COX-2 protein and mRNA expression, promoter activity, and PGE₂ release were assessed by Western blotting, real-time RT-PCR, luciferase reporter assay, and ELISA, respectively. Pharmacological inhibitors and siRNA knockdown were used to examine the roles of ET_A/ET_B receptors, G_q/G_i proteins, ERK1/2, p38 MAPK, JNK1/2, and AP-1 signaling.</p><p><strong>Results: </strong>ET-1 increased COX-2 protein and mRNA expression, COX-2 promoter activity, and PGE₂ release in MC3T3-E1 cells in a time-dependent manner. Actinomycin D and cycloheximide significantly reduced ET-1-induced COX-2 expression and PGE₂ release, indicating transcriptional and translational regulation. Pharmacological blockade or knockdown of ET_A and ET_B receptors attenuated these responses. Inhibition or silencing of G_q and G_i also suppressed ET-1-induced COX-2 expression and PGE₂ release. Moreover, inhibition or knockdown of ERK1/2, p38 MAPK, or JNK1/2 reduced these effects. ET-1 also promoted c-Jun phosphorylation, nuclear accumulation, AP-1 binding activity, and COX-2 promoter transactivation, whereas AP-1 inhibition or c-Jun knockdown reduced COX-2 expression and downstream PGE₂ production.</p><p><strong>Conclusion: </strong>ET-1 drives COX-2 expression and PGE₂ release in osteoblasts through ET_A/ET_B dependent G_i/G_q, MAPK, and AP-1 signaling, supporting a potential role of ET-1 in osteoblast-associated inflammatory responses and inflammatory bone microenvironment changes under periodontal inflammatory conditions.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1411-1424"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536400/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction notice to \"MicroRNA-28-5p as a potential diagnostic biomarker for chronic periodontitis and its role in cell proliferation and inflammatory response\" [J Dental Sci 17 (2022) 1501-1509].","authors":"Pengcheng Huang, Linghui Jia","doi":"10.1016/j.jds.2025.07.3566","DOIUrl":"https://doi.org/10.1016/j.jds.2025.07.3566","url":null,"abstract":"<p><p>[This retracts the article on p. 1501 in vol. 17, PMID: 36299340.].</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"2026"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nasal polyp with ossification in the right maxillary sinus: Differential diagnosis of radiopaque lesions in maxillary sinus region.","authors":"Ssu-Li Li, Shan-Ju Chou, Yang-Che Wu, Chun-Yu Ho","doi":"10.1016/j.jds.2025.07.3453","DOIUrl":"10.1016/j.jds.2025.07.3453","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"2003-2005"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148879938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optical properties of conventional and high-translucency zirconia ceramics and their effects on resin cement polymerization.","authors":"Chia-Ling Li, Ping-Ju Chen, Jui-Che Lin, Shu-Fen Chuang","doi":"10.1016/j.jds.2025.07.3490","DOIUrl":"10.1016/j.jds.2025.07.3490","url":null,"abstract":"<p><strong>Background/purpose: </strong>Adequate polymerization of resin luting cements is essential for durable bonding in zirconia restorations. However, variations in zirconia microstructure and composition may influence translucency and light transmittance, thereby affecting resin cement polymerization. This study aimed to investigate the optical properties of conventional and high-translucency zirconia ceramics and their effects on resin cement polymerization.</p><p><strong>Materials and methods: </strong>Six zirconia ceramics were evaluated: CerconBase, CerconHT, and VitaHT (3Y-TZP); VitaST (4Y-PSZ); and CerconXT and VitaXT (5Y-PSZ). Disk specimens (0.5 and 1.0 mm thick) were fabricated and sintered. Grain size and elemental compositions were analyzed using scanning electron microscopy and energy-dispersive X-ray spectroscopy, and phase composition was assessed by X-ray diffraction. Optical properties, including light transmittance, translucency parameter (TP), and contrast ratio (CR), were measured using a UV-NIR spectrophotometer. A light-curable resin cement (Variolink N base) was polymerized through zirconia disks, and surface microhardness was measured immediately and after 24 h.</p><p><strong>Results: </strong>Two 5Y-PSZ ceramics (CerconXT, VitaXT) exhibited the highest cubic-phase fractions (48.66-54.36%), and larger grain sizes, whereas 3Y-TZP showed finer grains. Light transmittance at 468 nm was lowest for CerconBase (15.52% and 10.33% at 0.5 and 1.0 mm, respectively), while other zirconia exhibited higher and comparable values (24.63-31.41%). TP and CR followed similar trends. Although immediate microhardness values were comparable, resin cement polymerized through 1.0-mm-thick CerconBase exhibited significantly lower microhardness after 24 h.</p><p><strong>Conclusion: </strong>Optical behaviors of zirconia ceramics are governed by composition and microstructure. Opaque zirconia, particularly at greater thickness, significantly impairs post-curing polymerization of resin cement.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1531-1541"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536383/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The presence of thyroid autoantibodies is not associated with anemia, hematinic deficiencies, and hyperhomocysteinemia in oral lichen planus patients.","authors":"Yi-Pang Lee, Yu-Hsueh Wu, Julia Yu-Fong Chang, Yi-Ping Wang, Andy Sun, Chun-Pin Chiang","doi":"10.1016/j.jds.2025.07.3493","DOIUrl":"10.1016/j.jds.2025.07.3493","url":null,"abstract":"<p><strong>Background/purpose: </strong>Our previous study found that 144 of 588 oral lichen planus (OLP) patients have thyroglobulin antibody (TGA) and/or thyroid microsomal antibodies (TMA) but do not have gastric parietal cell antibody (GPCA, designated as thyroid autoantibodies-positive OLP or TA⁺OLP patients). To test the role of thyroid autoantibodies in causing microcytosis, anemia, hematinic deficiencies, and hyperhomocysteinemia in OLP patients, this study assessed whether 144 TA⁺OLP patients had significantly higher frequencies of microcytosis, anemia, hematinic deficiencies, and hyperhomocysteinemia than 588 healthy control subjects (HCSs) or 305 TGA/TMA/GPCA-negative (Abs^-) OLP patients (designated as Abs^-OLP patients).</p><p><strong>Materials and methods: </strong>The mean corpuscular volume, blood hemoglobin (Hb), and serum iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between any two of three groups of 144 TA⁺OLP patients, 305 Abs^-OLP patients, and 588 HCSs.</p><p><strong>Results: </strong>We found that both 144 TA ⁺ OLP patients and 305 Abs^-OLP patients had significantly higher frequencies of microcytosis, anemia, serum iron, vitamin B12, and folic acid deficiencies, and hyperhomocysteinemia than 588 HCSs (all <i>P</i>-values <0.05). However, there were no significant differences in the frequencies of microcytosis, anemia, serum iron, vitamin B12, and folic acid deficiencies, and hyperhomocysteinemia between 144 TA⁺OLP patients and 305 Abs^-OLP patients (all <i>P</i>-values >0.05).</p><p><strong>Conclusion: </strong>The disease of OLP itself rather than the thyroid autoantibodies plays a pivotal role in causing the significantly higher frequencies of microcytosis, anemia, serum iron, vitamin B12, and folic acid deficiencies, and hyperhomocysteinemia in TA⁺OLP patients.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1551-1559"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-perceived attractiveness of labiomental angles in Taiwanese and Caucasian males: A comparative study before and after orthodontic education among dental students.","authors":"Shih-Chieh Chen, Chun-Ming Chen, Szu-Ting Chou, Fu-Jia Syu, HisHam Mamoon, Yu-Chuan Tseng","doi":"10.1016/j.jds.2025.07.3556","DOIUrl":"10.1016/j.jds.2025.07.3556","url":null,"abstract":"<p><strong>Background/purpose: </strong>The labiomental angle plays a critical role in determining facial profile attractiveness, with aesthetic preferences influenced by ethnic background. This study investigated how variations in the labiomental angle influenced facial profile aesthetics and examined changes in dental students' understanding of facial aesthetics before and after orthodontic lectures.</p><p><strong>Materials and methods: </strong>One adult Taiwanese male and one adult Caucasian male were selected. Three-dimensional facial images were captured using a facial scanner and digitally modified to create labiomental angles ranging from 117° to 152° at 5° intervals. A total of 16 image sets, each consisting of five static images and one video, were generated. Eighty-eight dental students evaluated the images before and after orthodontic education. Attractiveness was assessed using a visual analogue scale, while acceptance was rated on a 3-point Likert scale.</p><p><strong>Results: </strong>Before the lectures, the most aesthetically preferred labiomental angle was 132° in Taiwanese males and 122° in Caucasian males. After the lectures, preferences shifted to 137° for the Caucasian male, while the Taiwanese male's preference remained at 132°. Acceptance ratings followed a similar trend, with the most accepted angle shifting from 122° to 127° for the Caucasian male, while remaining at 132° for the Taiwanese male. Dental students demonstrated a statistically significant difference in their preferences for the labiomental angle when comparing Taiwanese and Caucasian males.</p><p><strong>Conclusion: </strong>Labiomental angle preferences vary by cultural background. Orthodontic lectures can alter dental students' aesthetic preferences for Caucasian male profiles but have minimal impact on preferences for Taiwanese male profiles.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1875-1882"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536303/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isoliquiritigenin represses the pro-fibrotic TGF-β/smad2 signaling and nuclear enriched abundant transcript 1 (NEAT1) in oral submucous fibrosis.","authors":"Chi-Shan Tseng, Shih-Min Wang, Yi-Wen Liao, Her-Hsiung Huang, Cheng-Chia Yu, Yicyuan Chen","doi":"10.1016/j.jds.2025.07.3461","DOIUrl":"10.1016/j.jds.2025.07.3461","url":null,"abstract":"<p><strong>Background/purpose: </strong>Isoliquiritigenin (ISL) has shown anti-fibrotic potential in several organ systems, but its effects on oral submucous fibrosis (OSF) remain unclear. This study investigated whether ISL attenuates myofibroblast activities in buccal mucosal fibroblasts (BMFs) from OSF patients by modulating TGF-β/Smad2 signaling and the long non-coding RNA NEAT1.</p><p><strong>Materials and methods: </strong>Primary normal BMFs and fibrotic BMFs (fBMFs) were isolated from human buccal mucosa, and cell viability, collagen gel contraction, migration, and wound closure were examined after ISL treatment with or without arecoline. TGF-β1 secretion was quantified, while protein expression of phosphorylated Smad2, COL1A1, and α-SMA was analyzed, and NEAT1 expression was assessed with gain-of-function experiments.</p><p><strong>Results: </strong>ISL showed selective cytotoxicity toward fBMFs compared with normal BMFs. ISL (5 and 10 μM) significantly reduced collagen gel contraction and migration capacity of fBMFs, and reversed arecoline-induced increases in contractility and migration. ISL also decreased TGF-β1 secretion and suppressed phosphorylated Smad2, COL1A1, and α-SMA expression. Furthermore, ISL downregulated NEAT1 in fBMFs, and NEAT1 overexpression enhanced collagen gel contraction, whereas ISL partially but significantly abrogated this pro-contractile effect, suggesting that NEAT1 mediates, at least in part, ISL's anti-fibrotic actions.</p><p><strong>Conclusion: </strong>In conclusion, ISL selectively targets OSF-derived fibroblasts and attenuates myofibroblast-like phenotypes by disrupting TGF-β1/Smad2 signaling and NEAT1-driven fibrogenic activity. These findings highlight ISL as a promising candidate for adjunctive therapy in OSF.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1441-1448"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536321/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epigallocatechin gallate in dentistry: Therapeutic applications, biomaterial integration, and translational challenges.","authors":"Chloe Jui-Yun Chang, Fang-Yu Fan, Yung-Li Wang, Thi Thuy Tien Vo, Yang-Che Wu, Yu-Chia Chang, I-Ta Lee","doi":"10.1016/j.jds.2025.07.3500","DOIUrl":"10.1016/j.jds.2025.07.3500","url":null,"abstract":"<p><p>Epigallocatechin gallate (EGCG), a major bioactive catechin in green tea, has attracted increasing attention in dentistry because of its antioxidant, anti-inflammatory, antimicrobial, matrix-modulating, and regenerative properties. This narrative review summarizes current evidence on the biological mechanisms, dental applications, and translational challenges of EGCG in oral healthcare. EGCG can modulate oxidative stress and inflammatory signaling pathways, including nuclear factor-κB (NF-κB), mitogen-activated protein kinase (MAPK), nuclear factor erythroid 2-related factor 2/heme oxygenase-1 (Nrf2/HO-1), and NOD-like receptor family pyrin domain containing 3 (NLRP3)-related responses, and has activity against oral disease-associated microorganisms and biofilms. In periodontal therapy, EGCG has been investigated as an adjunct to non-surgical periodontal treatment and as a local therapeutic agent through gingival patches, injectable hydrogels, and other delivery systems. In adhesive and restorative dentistry, EGCG may improve resin-dentin interface stability through matrix metalloproteinase inhibition, dentin biomodification, and antimicrobial effects against cariogenic biofilms. In regenerative dentistry, EGCG has been reported to promote osteogenic and odontogenic differentiation, regulate immune responses, support angiogenesis, and enhance bone-related repair when incorporated into scaffolds, membranes, hydrogels, or bioactive coatings. However, most evidence remains derived from <i>in vitro</i> and preclinical studies, and clinical translation is limited by low bioavailability, chemical instability, dosage variability, delivery efficiency, material compatibility, and insufficient long-term clinical evidence. Further studies using standardized protocols, optimized delivery systems, long-term safety assessment, clinically relevant oral models, comparative biomaterial testing, mechanism- based outcome measures, and well-designed randomized clinical trials are required to determine whether EGCG can become a reliable adjunctive strategy for periodontal, restorative, and regenerative oral healthcare.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1375-1384"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A scientometric study on research trends and characteristics of diabetes-associated periodontal disease.","authors":"Man Yang, Wenxiao Shi, Yan Xiong, Mengjie Chen, Linjun Shi, Huiwen Chen","doi":"10.1016/j.jds.2025.07.3484","DOIUrl":"10.1016/j.jds.2025.07.3484","url":null,"abstract":"<p><strong>Background/purpose: </strong>Substantial evidence demonstrates that diabetes is associated with periodontal disease. The purpose of this study was to analyze the scientometric characteristics and research trends of diabetes-associated periodontal disease (DAPD).</p><p><strong>Materials and methods: </strong>All the papers on DAPD were comprehensively retrieved from the Scopus database. The years of publication were divided into before 2019 and after 2019 in the analysis of research trends.</p><p><strong>Results: </strong>There were 2466 papers on DAPD, with total citations of 73,553 and the <i>h</i> index of 120. The trend of clinical investigations has highlighted periodontal examination, bone development, micro-computed tomography, tooth brushing, cardiovascular disease, hypertension, diabetic complication, diabetic periodontitis, drug therapy, fasting blood glucose level, gingival index, and questionnaire. The trend of laboratory investigations has changed to gene expression, macrophage, signal transduction, microbiota, microflora, RNA 16s, in vitro study, immune response, antioxidant, reactive oxygen metabolite, and interleukin (IL)-17 after 2019. There have always been common keywords such as tumor necrosis factor alpha, IL-1beta, IL-6, insulin resistance, C-reactive protein, osteolysis, <i>Porphyromonas gingivalis</i>, genetics, advanced glycation end-products, oxidative stress, and saliva.</p><p><strong>Conclusion: </strong>This scientometric study elucidated the current scenario and research trends of DAPD, particularly the comprehensive identification and recognition of the important research topics concerned. A better understanding of diabetic-periodontal relationship supports interdisciplinary approaches and points toward novel preventive and therapeutic strategies.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1969-1973"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}