Journal of Dental Sciences最新文献

{"title":"Prognostic nomogram for proliferative verrucous leukoplakia","authors":"Yanning Zhang ,&nbsp;Xinning Zhang ,&nbsp;Zhiming Qin ,&nbsp;Jing Yan ,&nbsp;Binbin Li","doi":"10.1016/j.jds.2024.07.037","DOIUrl":"10.1016/j.jds.2024.07.037","url":null,"abstract":"<div><h3>Background</h3><div>Proliferative verrucous leukoplakia (PVL) is a special type of leukoplakia characterized by high rate of malignant transformation into oral squamous cell carcinoma (OSCC). This study aimed to analyze the canceration risk and prognostic factors of PVL and establish effective diagnostic and prognostic predictive models.</div></div><div><h3>Materials and methods</h3><div>A total of 467 patients were enrolled, including 170 cases of PVL. The independent risk and prognostic factors of PVL were analyzed by univariable and multivariable logistic regression. Nomogram models were constructed to predict the canceration risk and prognosis of PVL. The predictive power was evaluated by Hosmer–Lemeshow test, receiver operating characteristic (ROC) curve, calibration curve and decision curve analysis.</div></div><div><h3>Results</h3><div>Multivariable logistic regression analyses identified that canceration risk factors of PVL included sex, lesion sites, clinical presentation, non-smoker and oral epithelial dysplasia (OED). The independent prognostic factors of PVL were sex, clinical presentation, local irritants and OED. Diagnosis and prognostic nomogram models were constructed. The areas under the ROC curve were 0.945 and 0.893, respectively. The calibration plots showed strong agreement between the prediction and observation. Decision curve analysis indicated that the models provided significant clinical benefits for patients.</div></div><div><h3>Conclusion</h3><div>Our study established and validated the diagnosis and prognostic predictive nomogram models, which were accurate to predict the canceration risk and prognostic factors of PVL, providing individualized clinical decisions for clinical work.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 238-247"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11762630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel computer-aided design/computer-aided manufacturing guide for reduction with advancement genioplasty","authors":"Shinsuke Yamamoto,&nbsp;Keigo Maeda,&nbsp;Naoki Taniike","doi":"10.1016/j.jds.2024.10.010","DOIUrl":"10.1016/j.jds.2024.10.010","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 689-691"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A preliminary study of a dental advertisement in a Taiwan's newspaper during the Japanese colonial period","authors":"Feng-Chou Cheng ,&nbsp;Ling-Hsia Wang ,&nbsp;Yin-Lin Wang,&nbsp;Chun-Pin Chiang","doi":"10.1016/j.jds.2024.11.005","DOIUrl":"10.1016/j.jds.2024.11.005","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 718-720"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of trends and disparities in domiciliary dental care distribution in Taiwan from 2018 to 2023","authors":"Min Yee Ng ,&nbsp;Chuan-Hang Yu","doi":"10.1016/j.jds.2024.09.030","DOIUrl":"10.1016/j.jds.2024.09.030","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Domiciliary dental care (DDC) is essential for maintaining oral health in disabled and homebound patients who face barriers to accessing dental services. With Taiwan nearing super-aged society status, the demand for DDC is rising. However, comprehensive data on DDC availability and distribution across Taiwan are lacking. Hence, this study aimed to provide a comprehensive overview of the distribution of DDC across Taiwan's districts from 2018 to 2023, and to analyze the estimated ratios of disabled individuals per healthcare provider in each district.</div></div><div><h3>Materials and methods</h3><div>Data on DDC-providing hospitals and dental clinics from these years were obtained from government sources. Descriptive statistics quantified DDC facilities distribution and growth. The number of disabled individuals per district was used to estimate ratios of disabled persons to DDC facilities.</div></div><div><h3>Results</h3><div>DDC facilities increased from 47 in 2018 to 98 in 2023. Urban areas showed higher prevalence of DDC services, while some rural and offshore areas had limited or no access. Taichung and Kaohsiung had the highest numbers of DDC providers, while Penghu and Lianjiang had none. Ratios of disabled individuals to DDC facilities varied widely, with Taichung having the lowest ratio and Yunlin and Chiayi the highest. In conclusion, DDC availability in Taiwan has significantly increased, but geographical disparities persist.</div></div><div><h3>Conclusion</h3><div>These findings underscore the need for targeted policies and resource allocation to address gaps in DDC provision, particularly in underserved areas.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 77-82"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11762964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association and relevant factors between objective masticatory performance and subjective masticatory ability among community-dwelling older adults","authors":"Feng-I Chen ,&nbsp;Jen-Hao Chen ,&nbsp;Jiiang-Huei Jeng ,&nbsp;Sumio Akifusa ,&nbsp;Hsiu-Yueh Liu","doi":"10.1016/j.jds.2024.10.008","DOIUrl":"10.1016/j.jds.2024.10.008","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Dentists often focus on masticatory performance (MP) rather than masticatory ability (MA) and treatment expectations when evaluating older adults. This study aimed to determine if MA aligns with MP and to explore influencing factors.</div></div><div><h3>Materials and methods</h3><div>This cross-sectional study utilized a multi-stage stratified cluster sampling, including one thousand community-dwelling adults aged 60 and older. Participants underwent oral exams and questionnaire interviews, assessing tooth count and Eichner index (EI) levels. MP and MA were quantified using a standard gummy jelly test and a 14-food group questionnaire, respectively. Multivariable linear regressions analyzed correlations between MP, MA, and related factors.</div></div><div><h3>Results</h3><div>Approximately 25 % of participants exhibited poor MP. Factors contributing to poor MP included increased age rise, low education, number of chronic diseases, tooth loss, without the assistance of removable dentures, and being in EI group C (all <em>P</em> &lt; 0.05). Tooth count showed a significant negative correlation with MP (<em>P</em> &lt; 0.001). Participants' MP declined significantly from good to poor, with MA scores decreasing from 11.96 to 7.52 (<em>P</em> &lt; 0.001). The tooth number was a common factor influencing MA across food groups (all <em>P</em> &lt; 0.05). The decline in MA among older adults was linked to age rise, tooth loss, lack of assistance of removable dentures, and being in EI group C.</div></div><div><h3>Conclusion</h3><div>Self-rated MA in older adults effectively reflects their MP. Maintaining a high tooth count to meet occlusal support and the use of dentures to assist with tooth loss in older adults help to improve their MA.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 69-76"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Specialty education and scope of oral and maxillofacial surgery in the United States","authors":"Pooja Gangwani ,&nbsp;Sung-Kiang Chuang","doi":"10.1016/j.jds.2024.10.022","DOIUrl":"10.1016/j.jds.2024.10.022","url":null,"abstract":"<div><div>In the United States, Oral and Maxillofacial Surgery (OMS) is a specialty of dentistry that focuses on the management of injuries, diseases, and defects of the head, neck, face, and jaws. The present manuscript is an article on education and training of OMS residents in the United States. It a lso briefly describes the scope of practice of the specialty. The manuscript also sheds light upon the less practiced areas such as research and business administration aspects of the specialty. The authors also discuss gender and racial distribution of OMS residents. Descriptive information was obtained from the literature and official organization websites. Lastly, owing to the background and the arduous training required, OMS is a specialty of its own kind. It is a combination of both medical and dental sciences, with surgical and anesthesia training, and is unique in the field of medicine and dentistry. OMS play a unique role in the bridge between medicine and dentistry. Continuing education and advocacy in the hospitals, institutions, and society are crucial for increased awareness of the scope of OMS to further our specialty.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 15-19"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The establishment of pulp polyp-derived mesenchymal stem cells with normal karyotype","authors":"Ferry Sandra ,&nbsp;Eko Fibryanto ,&nbsp;Tien Suwartini ,&nbsp;Anastasia Elsa Prahasti ,&nbsp;Widya Wulandari ,&nbsp;Andri Sutanto ,&nbsp;Lyvia Juliana ,&nbsp;Kyung Hoon Lee","doi":"10.1016/j.jds.2024.08.004","DOIUrl":"10.1016/j.jds.2024.08.004","url":null,"abstract":"<div><h3>Background/Purpose</h3><div>Pulp polyp is often eliminated as dental waste. Pulp polyp cells were reported to have high proliferation activity which might be comprised of stem cells. However, little has been known on the presence of stem cells in the pulp polyp. Moreover, pulp polyp cells might contain chromosomal abnormality. The present study was conducted to investigate the presence of pulp polyp stem cells, which could later be propagated and confirmed as normal/non-pathogenic cells using karyotype analysis.</div></div><div><h3>Materials and methods</h3><div>Collected pulp polyps were minced, enzymatically digested, and cultured. Expression of mesenchymal stem cell (MSC) markers on pulp polyp cells were analyzed using flow cytometry. Multilineage differentiation capacity was assessed by culturing the cells in osteogenic, chondrogenic, and adipogenic differentiation media. Genomic stability of the cells was evaluated with G-banded and molecular karyotype analyses.</div></div><div><h3>Results</h3><div>Pulp polyp cells appeared as fibroblasts-like cells. The cells were positive for cluster of differentiation (CD)105, CD90, and CD73, and negative for CD45, CD34, CD11b, CD19, and human leukocyte antigen (HLA)-DR. The cells were capable of osteogenic, chondrogenic, and adipogenic differentiation. G-banded karyotype analysis showed that there was no abnormality in the number or structure of chromosomes in pulp polyp-derived MSCs (PP-MSCs). Molecular karyotype analysis revealed that all copy number variations identified in PP-MSCs were not pathogenic.</div></div><div><h3>Conclusion</h3><div>PP-MSCs, which fulfill the minimal criteria for MSCs and are proven to have normal karyotype, have been successfully established. PP-MSCs might be a promising and safe candidate that can be considered for pulp-dentin complex regeneration.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 220-228"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11762965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of 27-hydroxycholesterol in hypercholesterolemia-associated exacerbation of apical periodontitis and therapeutic potential of felodipine","authors":"Cheng-Ning Yang ,&nbsp;Han-Wei Wang ,&nbsp;Hung-Ying Lin ,&nbsp;Sang-Heng Kok ,&nbsp;Chi-Yuan Hong ,&nbsp;Chia-Tung Shun ,&nbsp;Shih-Jung Cheng ,&nbsp;Fang-Yu Wu ,&nbsp;Sze-Kwan Lin","doi":"10.1016/j.jds.2024.09.027","DOIUrl":"10.1016/j.jds.2024.09.027","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Studies have demonstrated a relation between hypercholesterolemia and development of apical periodontitis (AP), but the underlying mechanism is uncertain. 27-hydroxycholesterol (27HC), produced by cytochrome P450 27A1 (CYP27A1)-catalyzed hydroxylation of cholesterol, is known to possess pro-inflammatory activity. Felodipine is an anti-hypertensive agent able to inhibit CYP27A1. The study aimed to examine the inflammatory response of macrophages to 27HC and the relation between 27HC accumulation and progression of experimental AP. The therapeutic effect of felodipine was also evaluated.</div></div><div><h3>Materials and methods</h3><div>J774 murine macrophages were used. Expressions of cyclooxygenase-2 (COX-2) and C–C motif chemokine ligand 20 (CCL20) were examined by Western blot. Concentrations of 27HC were assessed by enzyme-linked immunosorbent assay. Fluorescence assay was used to evaluate cholesterol levels. AP was induced in male rats receiving high fat/high cholesterol diet (HFHCD) or normal diet (ND). Micro-computed tomography and immunohistochemistry were employed to evaluate disease progression and therapeutic effect of felodipine.</div></div><div><h3>Results</h3><div>Cholesterol enhanced production of 27HC which in turn stimulated COX-2 and CCL20 synthesis by macrophages. HFHCD consumption significantly augmented serum and lesion tissue levels of 27HC in rats. Lesion size and infiltration of COX-2⁺ and interleukin (IL)-17⁺ cells increased in parallel with 27HC accumulation in AP. Felodipine suppressed cholesterol-induced 27HC production in macrophages. Felodipine treatment reduced serum and tissue levels of 27HC in HFHCD rats and concurrently mitigated AP propagation.</div></div><div><h3>Conclusion</h3><div>Our results suggest a pivotal role of 27HC in hypercholesterolemia-exacerbated AP. By repressing 27HC production, felodipine may have the potential to help mitigate AP in obese individuals.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 89-99"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11762924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinctive salivary oral microbiome in patients with burning mouth syndrome depending on pain intensity compared to healthy subjects","authors":"Hye-Min Ju ,&nbsp;Yong-Woo Ahn ,&nbsp;Soo-Min Ok ,&nbsp;Sung-Hee Jeong ,&nbsp;Hee-Sam Na ,&nbsp;Jin Chung","doi":"10.1016/j.jds.2024.05.022","DOIUrl":"10.1016/j.jds.2024.05.022","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Burning moouth syndrome (BMS) is a chronic pain condition similar to neuropathic pain. It is characterized by a persistent burning sensation in the oral cavity. Despite the lack of clarity regarding the etiology of BMS, recent studies have reported an association between the gut microbiome and neuropathic pain. However, few studies have investigated the association between the oral microbiome and orofacial pain, such as BMS. This study aimed to compare the oral microbial profiles of healthy controls (HC) and patients with BMS.</div></div><div><h3>Materials and methods</h3><div>The BMS group was further divided into BMS_low and BMS_high groups according to pain intensity. A total of 60 patients with BMS (BMS_low, n = 16; BMS_high, n = 44) and 30 HC provided saliva samples, which were sequenced and analyzed for the V1–V2 region of the 16S rRNA gene.</div></div><div><h3>Results</h3><div>The alpha diversity was similar among the three groups. However, a significant difference in the distribution of microbiome composition was observed between BMS_high and HC, as revealed by the Bray–Curtis distance analysis (<em>P</em> &lt; 0.01). At the genus level, <em>Prevotella</em> and <em>Alloprevotella</em> were the most abundant genera in the BMS group. Compared to HC, BMS_high exhibited a relatively higher abundance of bacterial species. Some bacteria, including <em>Prevotella</em> spp., exhibit an increasing pattern with subjective pain intensity.</div></div><div><h3>Conclusion</h3><div>These results suggest the potential involvement of oral microbiota in BMS pathogenesis. Additionally, variations in the microbiome may occur not only in the presence or absence of pain, but also with pain severity.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 462-469"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141143593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elucidating interfacial failure of cervical restorations using damage mechanics: A finite element analysis","authors":"Po-Chun Tseng ,&nbsp;Shu-Fen Chuang ,&nbsp;Ellen Schulz-Kornas ,&nbsp;Karl-Heinz Kunzelmann ,&nbsp;Andreas Kessler","doi":"10.1016/j.jds.2024.05.033","DOIUrl":"10.1016/j.jds.2024.05.033","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Although clinical studies have suggested a link between non-axial forces and reduced longevity of cervical restorations, the underlying mechanisms require further numerical investigation. This in-silico study employed a cohesive zone model (CZM) to investigate interfacial damage in a cervical restoration subjected to different load directions.</div></div><div><h3>Materials and methods</h3><div>A plane strain model of a maxillary premolar was established, with a wedge-shaped buccal cervical restoration. To simulate debonding, the restoration-tooth interface was modeled by the CZM, which defines the strain-softening damage behavior based on interfacial stress and fracture energy. Occlusal loads were applied in three different directions: (1) obliquely on the buccal triangular ridge, (2) obliquely on the palatal triangular ridge, and (3) equal magnitude axially on both ridges. Damage initiation and progression were analyzed, and stress distribution in damaged models was compared with the corresponding perfect-bond models.</div></div><div><h3>Results</h3><div>Non-axial oblique loads initiated damage at lower forces (100 N for buccal and 120 N for palatal) compared to axial loads (130 N on both ridges). After debonding, buccal oblique loading caused higher stress at the central groove (42.5 MPa at 150 N). Furthermore, buccal oblique loading resulted in more extensive debonding than that caused by the palatal oblique load (88.3% vs. 43.3% of the bonding interface at 150 N).</div></div><div><h3>Conclusion</h3><div>The study provides numerical evidence supporting the tooth flexure hypothesis, that non-axial forces are more detrimental to the bonding interface of the cervical restoration. The results highlight the necessity of damage mechanics in deriving stress distribution upon debonding.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 1","pages":"Pages 410-416"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141401507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}