Journal of Dental Sciences最新文献

{"title":"Ubiquitin-like with phd and ring finger domains 1 as a potential therapeutic target in smoking-associated oral squamous cell carcinoma","authors":"Jia-Rong Wu ,&nbsp;Che-Ting Yeh ,&nbsp;Chu-Yen Chien ,&nbsp;Ying-Chen Chen ,&nbsp;Tsai-Wang Huang ,&nbsp;Che-Yi Lin ,&nbsp;Alexander Cheng-Ting Hsieh ,&nbsp;Yi-Jen Hung ,&nbsp;Yi-Shing Shieh","doi":"10.1016/j.jds.2025.04.011","DOIUrl":"10.1016/j.jds.2025.04.011","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Oral squamous cell carcinoma (OSCC) is a prevalent and aggressive malignancy with poor clinical outcomes. Epigenetic dysregulation, particularly involving the ubiquitin-like with phd and ring finger domains 1 (UHRF1), is increasingly recognized in cancer progression. However, the role of UHRF1 in OSCC and its regulation by cigarette smoking remains unclear. Therefore, the aim of this study was to investigate whether cigarette smoking influences UHRF1 expression in OSCC.</div></div><div><h3>Materials and methods</h3><div>UHRF1 expression was analyzed in OSCC tissues using publicly available Gene Expression Omnibus (GEO) datasets. Quantitative PCR and western blotting were employed to evaluate UHRF1 levels in OSCC cell lines. Functional assays, including colony formation, wound healing, and transwell invasion, were conducted following UHRF1 knockdown or overexpression. To investigate the impact of cigarette smoking on UHRF1 expression, cells were treated with cigarette smoke condensate (CSC) in a time-dependent manner. In vivo, a xenograft mouse model was used to assess the effect of CSC treatment on tumor growth and UHRF1 expression.</div></div><div><h3>Results</h3><div>As compared to normal tissue, UHRF1 was significantly overexpressed in OSCC tissues. Functional assays revealed that UHRF1 promotes OSCC cell proliferation, migration, and invasion. CSC treatment upregulated UHRF1 expression in vitro and enhanced tumor growth in vivo. Immunohistochemical analysis of xenograft tumors confirmed elevated UHRF1 expression following CSC exposure.</div></div><div><h3>Conclusion</h3><div>This study provides the first evidence that UHRF1 functions as an oncogenic driver in OSCC and may mediate smoking-induced tumorigenesis. These findings highlight UHRF1 as a potential biomarker and therapeutic target, particularly in smoking-associated OSCC.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 3","pages":"Pages 1772-1781"},"PeriodicalIF":3.4,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144365176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Postal Life Insurance including dental services in Taiwan during the Japanese colonial period","authors":"Feng-Chou Cheng ,&nbsp;Ling-Hsia Wang ,&nbsp;Chun-Pin Chiang","doi":"10.1016/j.jds.2025.04.019","DOIUrl":"10.1016/j.jds.2025.04.019","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 3","pages":"Pages 1915-1917"},"PeriodicalIF":3.4,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Managing limited clinical crown height with vital pulp therapy: Clinical application and outcome","authors":"Sheila May Lao Dee,&nbsp;Chun Yi Kao,&nbsp;Arturo P. de Leon,&nbsp;Tsui Hsien Huang","doi":"10.1016/j.jds.2025.04.004","DOIUrl":"10.1016/j.jds.2025.04.004","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 3","pages":"Pages 1988-1990"},"PeriodicalIF":3.4,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144364457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of various aging modes on the optical properties of zirconia with different yttria concentrations in coffee and tea","authors":"Chih-Wei Tseng ,&nbsp;Chenmin Yao ,&nbsp;Liang-Yu Wei ,&nbsp;Pei-Wen Peng ,&nbsp;Wei-Chun Lin","doi":"10.1016/j.jds.2025.04.017","DOIUrl":"10.1016/j.jds.2025.04.017","url":null,"abstract":"<div><h3>Background/purpose</h3><div>The esthetic performance of dental zirconia may be affected by both material composition and environmental exposure. This study aimed to evaluate how different aging conditions-hydrothermal aging and thermal cycling-influenced the optical properties of dental zirconia containing varying yttria concentrations (3Y-TZP, 4Y-TZP, and 5Y-TZP) in coffee and tea.</div></div><div><h3>Materials and methods</h3><div>A total of 120 zirconia specimens were prepared using three yttria concentrations. Each group was subjected to four artificial aging conditions: storage in coffee or tea at 37 °C for 1 and 6 months (hydrothermal aging), or 10,000 and 50,000 cycles of thermal cycling between 5 °C and 55 °C. Optical parameters (L∗, a∗, b∗) and color differences (ΔE₀₀) were measured using a spectrophotometer and calculated using the CIEDE2000 formula. Data were analyzed using ANOVA and Tukey's HSD test (α = 0.05).</div></div><div><h3>Results</h3><div>Zirconia with higher yttria content exhibited more pronounced color changes (<em>P</em> &lt; 0.001). Aging in tea resulted in minimal color variation regardless of yttria content or aging mode. In coffee, the ΔE₀₀ values of the HT (3Y-TZP), ST (4Y-TZP), and XT (5Y-TZP) groups ranged from 3.5, 7.0 and 8.5, respectively (<em>P</em> &lt; 0.0001). In tea, the values ranged from 1.1 for both HT and ST, and from 3.1 for XT (<em>P</em> &lt; 0.0001).</div></div><div><h3>Conclusion</h3><div>Both yttria concentration and aging conditions significantly influenced the color stability of zirconia. Hydrothermal aging had a greater impact than thermal cycling, especially in coffee. These findings suggest that material composition and exposure environment should be carefully considered when selecting zirconia for esthetic dental restorations.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 3","pages":"Pages 1764-1771"},"PeriodicalIF":3.4,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144365175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating dentinal crack formation after root canal preparation using nickel-titanium rotary file systems","authors":"Kaveh Nasiri,&nbsp;Karl-Thomas Wrbas","doi":"10.1016/j.jds.2025.04.009","DOIUrl":"10.1016/j.jds.2025.04.009","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 3","pages":"Pages 1991-1992"},"PeriodicalIF":3.4,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stomatology from the popular science reading materials of the late Qing Dynasty Imperial Family: Oral anatomical diagrams in the Li Ke Guatu (illustrations of the sciences)","authors":"Feng-Chou Cheng ,&nbsp;Ling-Hsia Wang ,&nbsp;Chun-Pin Chiang","doi":"10.1016/j.jds.2025.04.007","DOIUrl":"10.1016/j.jds.2025.04.007","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 3","pages":"Pages 1918-1920"},"PeriodicalIF":3.4,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GAS5 decreased the arecoline-induced myofibroblasts activity in buccal mucosal fibroblasts via acting as a competing endogenous RNA for miR-21","authors":"Chuan-Hang Yu ,&nbsp;Heng-Yi Liao ,&nbsp;Jung-Chun Yeh ,&nbsp;Shih-Min Wang ,&nbsp;Ming-Yi Lu ,&nbsp;Yi-Wen Liao ,&nbsp;Cheng-Chia Yu ,&nbsp;Fu-Chen Lin","doi":"10.1016/j.jds.2025.04.008","DOIUrl":"10.1016/j.jds.2025.04.008","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Oral submucous fibrosis (OSF) is recognized as a premalignant condition that increases the risk of oral cancer. Myofibroblasts are the primary cellular mediators of the pathological fibrosis characteristic of OSF. Consequently, understanding the molecular mechanisms that drive myofibroblast activation is crucial for the development of effective therapeutic interventions for this condition. Growth arrest-specific 5 (GAS5), a long non-coding RNA, represents a potential regulatory factor in OSF pathogenesis, although its specific role remains largely undefined.</div></div><div><h3>Materials and methods</h3><div>To validate the direct interaction between GAS5 and its target miR-21, a luciferase reporter assay was performed. qRT-PCR was employed to evaluate the expression levels of GAS5 in OSF tissues. Collagen gel contraction and transwell migration assays were utilized to assess myofibroblast functional activities.</div></div><div><h3>Results</h3><div>Our result validated overexpression of GAS5 inhibits TGF-β-induced myofibroblast activation, as evidenced by reduced collagen gel contraction, cell migration, and suppression of the TGF-β/Smad2 signaling pathway. GAS5 also attenuates arecoline-induced myofibroblast activation. Mechanistically, GAS5 directly interacts with and sponges miR-21, thereby modulating myofibroblast function.</div></div><div><h3>Conclusion</h3><div>Our findings suggest that GAS5 plays a crucial role in inhibiting myofibroblast activation in OSF by targeting the TGF-β/Smad2 signaling pathway and regulating the miR-21. GAS5 may represent a novel therapeutic target for the prevention and treatment of OSF.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 3","pages":"Pages 1756-1763"},"PeriodicalIF":3.4,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144365174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel combined implantoplasty and regenerative surgical approach to salvage implants: A report on two 20-year-old implants","authors":"Shing-Zeng Dung","doi":"10.1016/j.jds.2025.04.003","DOIUrl":"10.1016/j.jds.2025.04.003","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 3","pages":"Pages 1993-1995"},"PeriodicalIF":3.4,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased risk of lung cancer in Taiwanese female patients with chronic periodontitis: A nationwide population-based cohort study","authors":"Wen-Ying Shen ,&nbsp;Wei-Ju Lai ,&nbsp;Yu-Hsun Wang ,&nbsp;Yu-Chao Chang","doi":"10.1016/j.jds.2025.04.002","DOIUrl":"10.1016/j.jds.2025.04.002","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Lung cancer is the most common cause of cancer death globally. However, the association between chronic periodontitis (CP) and lung cancer risk is still not very clear. The aim of study was to investigate whether the Taiwanese female patients with CP might have increased risk of lung cancer using a nationwide registry dataset in Taiwan.</div></div><div><h3>Materials and methods</h3><div>A retrospective cohort study was conducted by using Taiwanese Longitudinal Health Insurance Database. A total of 86,886 patients who were newly diagnosed with CP from 2001 to 2012 were selected. A 1:1 propensity-matched healthy patients without any type of periodontal diseases were captured randomly from the general population. The risk of lung cancer was analyzed by Cox proportional hazards regression models between CP and non-CP cohorts.</div></div><div><h3>Results</h3><div>639 and 614 patients with newly diagnosed lung cancer were found in CP and non-CP cohorts, respectively. CP cohort exhibited a borderline significantly increased risk of lung cancer (relative risk:1.01 95 % CI: 0.90–1.12) as compared with non-CP cohort. The subgroup analysis of hazard ratio for sex difference, <em>P</em> for interaction was 0.042. The female patients with CP had a 1.23-fold higher risk of lung cancer than non-CP counterparts (95 % CI: 1.01–1.48, <em>P</em> = 0.036).</div></div><div><h3>Conclusion</h3><div>Taken together, the results of this nationwide population-based cohort study indicate that the Taiwanese female patients with CP exhibited a significantly higher risk of lung cancer than those female patients without CP.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 3","pages":"Pages 1749-1755"},"PeriodicalIF":3.4,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sialadenoma papilliferum-like intraductal papillary tumor of the mandible with BRAF V600E mutation: A rare case report","authors":"Sak Lee,&nbsp;Seong-Doo Hong,&nbsp;Jae-Il Lee,&nbsp;Hye-Jung Yoon","doi":"10.1016/j.jds.2025.03.035","DOIUrl":"10.1016/j.jds.2025.03.035","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 3","pages":"Pages 1996-1998"},"PeriodicalIF":3.4,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}