Journal of Dental Sciences最新文献

{"title":"An analysis of the relevance and proximity between maxillary posterior root apices to the maxillary sinus and the buccal cortical bone plate","authors":"Wan-Chuen Liao ,&nbsp;Shu-Hui Chang ,&nbsp;Hsiao-Hua Chang ,&nbsp;Chi-Hung Chen ,&nbsp;Yu-Hwa Pan ,&nbsp;Pei-Cheng Yeh ,&nbsp;Jiiang-Huei Jeng ,&nbsp;Mei-Chi Chang","doi":"10.1016/j.jds.2024.07.019","DOIUrl":"10.1016/j.jds.2024.07.019","url":null,"abstract":"<div><h3>Background/purpose</h3><p>Understanding the relationship between maxillary sinus and posterior root apices is critical in preventing dental treatment complications. This study aimed to analyze and showcase the relationship between the posterior root apices and the maxillary sinus floor, the distance to the buccal cortical bone, and their correlation with age, gender, and sides.</p></div><div><h3>Materials and methods</h3><p>Cone-beam computed tomography images were collected from 94 patients with a total of 478 maxillary posterior teeth and 997 roots. The shortest distance from root apices to the closest border of maxillary sinus and the outer buccal cortical bone margin were measured and grouped for statistical analysis for the differences (<em>P</em> &lt; 0.05).</p></div><div><h3>Results</h3><p>The root apices of maxillary molars and single-rooted second premolars were located closer to the maxillary sinus compared to first premolars (<em>P</em> &lt; 0.01). The buccal root of two-rooted first premolar had the shortest horizontal distance to the buccal cortical bone among all roots (<em>P</em> &lt; 0.01). The lowest position of the maxillary sinus floor was mostly located at the palatal side (<em>P</em> &lt; 0.01) and between the buccal and palatal root apices (<em>P</em> &lt; 0.01) in the maxillary premolars and molars, respectively. Increasing age would lead to longer distances between the root apices and the maxillary sinus (<em>P</em> &lt; 0.01). Additionally, male patients had thicker buccal cortical bone than female patients (<em>P</em> &lt; 0.01).</p></div><div><h3>Conclusion</h3><p>Different tooth positions, age, and gender significantly impact the relationships between root apices and the maxillary sinus and buccal cortical plates, informing patient-centered and individually tailored approaches for more effective and safer surgical endodontic treatment.</p></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"19 4","pages":"Pages 1972-1982"},"PeriodicalIF":3.4,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1991790224002393/pdfft?md5=d728ad72eb0c2d429a71b72c8077ab51&pid=1-s2.0-S1991790224002393-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141854007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictable 3D-printed surgical guide for hemisection of a double tooth with complete fusion to apex: A case report","authors":"Yong Kwon Chae ,&nbsp;Su-Bin Lee ,&nbsp;Hyun-Chang Lim,&nbsp;Ok Hyung Nam","doi":"10.1016/j.jds.2024.07.015","DOIUrl":"10.1016/j.jds.2024.07.015","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"19 4","pages":"Pages 2435-2437"},"PeriodicalIF":3.4,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1991790224002356/pdfft?md5=9a9bdf3e6e9840a82e611378f6b357f8&pid=1-s2.0-S1991790224002356-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141851466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protein inhibitor of activated signal transducer and activator of transcription 2 is an oncoprotein in oral squamous cell carcinoma and related to cigarette smoking - An in vitro study","authors":"Szu-Yu Chen ,&nbsp;Chi-Fu Chiang ,&nbsp;Yu-Fu Su ,&nbsp;Che-Yi Lin ,&nbsp;Yi-Jen Hung ,&nbsp;Tsai-Wang Huang ,&nbsp;Yi-Shing Shieh","doi":"10.1016/j.jds.2024.07.013","DOIUrl":"10.1016/j.jds.2024.07.013","url":null,"abstract":"<div><h3>Background/purpose</h3><p>Oral cancer is one of the most prevalent malignant tumors in Taiwan. Due to the heterogeneity of oral cancer cells, the five-year survival rate of patients is only 50%. Post-translational modifications contribute to protein diversity and directly influence cell functions. The protein inhibitor of activated signal transducer and activator of transcription 2 (PIAS2) is known to undergo post-translational modifications, yet its impact on oral cancer remains unclear.</p></div><div><h3>Materials and methods</h3><p>PIAS2 expression was modulated by transfecting cells with a PIAS2 expression vector or by knocking down PIAS2 using siRNA with low and high PIAS2 expression, respectively. These cells were subjected to invasion, migration, and proliferation assays to evaluate the effects of PIAS2. Changes in genotype, such as epithelial-mesenchymal transition (EMT) markers, were also examined. Additionally, the effect of cigarette smoke condensate (CSC) on PIAS2 expression in oral squamous cell carcinoma (OSCC) cells was investigated.</p></div><div><h3>Results</h3><p>Overexpression of PIAS2 significantly increased the malignant behaviors of oral cancer cells. In YD38 and SAS cells with low PIAS2 expression, overexpression of PIAS2 enhanced proliferation, invasion, and migration. PIAS2 overexpression also affected EMT gene expression, suppressing E-cadherin and increasing fibronectin expression. Conversely, PIAS2 knockdown in OECM1 and SCC25 cells suppressed malignant behaviors and reversed EMT markers, increasing E-cadherin and decreasing fibronectin expression. Furthermore, a dose-dependent increase in PIAS2 expression was observed when OSCC cells were treated with CSC.</p></div><div><h3>Conclusion</h3><p>PIAS2 functions as an oncogene in oral cancer, and cigarette smoking induces PIAS2 expression. Increased PIAS2 levels lead to enhanced malignancy in oral cancer.</p></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"19 4","pages":"Pages 1983-1990"},"PeriodicalIF":3.4,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1991790224002332/pdfft?md5=2dee05aadabd710bda6556d6d6e61eb2&pid=1-s2.0-S1991790224002332-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141842170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of antimicrobial peptide P113 oral health care products on the reduction of oral bacteria number and dental plaque formation in a randomized clinical assessment","authors":"Yi-Fan Wu ,&nbsp;Bor-Cheng Han ,&nbsp;Wen-Yi Lin ,&nbsp;Sin-Yu Wang ,&nbsp;Thu Ya Linn ,&nbsp;Hsueh- Wen Hsu ,&nbsp;Chih-Chieh Wen ,&nbsp;Hung-Yi Liu ,&nbsp;Yi-Hua Chen ,&nbsp;Wei-Jen Chang","doi":"10.1016/j.jds.2024.07.011","DOIUrl":"10.1016/j.jds.2024.07.011","url":null,"abstract":"<div><h3>Background/purpose</h3><p>Dental plaque is the main cause leading to the dental caries and periodontal diseases. The main purpose of this study was to test the efficacy of oral spray containing the antimicrobial peptide P-113 on the reduction of oral bacteria number and dental plaque formation in a randomized clinical assessment.</p></div><div><h3>Materials and methods</h3><p>This study was divided into two parts. In Part A, we investigated the user experiences with the P-113 containing oral spray. In part B, 14 subjects in the experimental group used the P-113-containing oral spray, while 14 subjects in the control group used a placebo without the P-113 in a 4-week clinical trial. Participants were asked to use the P-113-containing oral spray or placebo 3 times per day and 5 times per use. Moreover, 3 check-ups and 2 washouts were carried out to evaluate the DMFT score, dental plaque weight, dental plaque index, and gingival index.</p></div><div><h3>Results</h3><p>In part A, up to 91.8% of the subjects in the experimental group were satisfied with the use of the P-113-containing oral spray. In part B, based on our PacBio SMRT sequencing platform and DADA2 analysis, the numbers of <em>Streptococcus</em> and <em>Porphyromonas</em> in the experimental group were lower than those in the control group. In addition, decreased dental plaque weight, dental plaque index, and gingival index were all observed in the experimental group.</p></div><div><h3>Conclusion</h3><p>The P-113-containing oral spray has the potential to reduce the dental caries and periodontal disease-related bacteria and to control the dental plaque formation.</p></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"19 4","pages":"Pages 2367-2376"},"PeriodicalIF":3.4,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1991790224002319/pdfft?md5=bfe8f951301d6e9891b470d953d8c74b&pid=1-s2.0-S1991790224002319-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141844126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intramucosal nevus on the posterior hard palate","authors":"Andy Sun ,&nbsp;Ming-Jay Hwang ,&nbsp;Ying-Tai Jin,&nbsp;Chun-Pin Chiang","doi":"10.1016/j.jds.2024.07.012","DOIUrl":"10.1016/j.jds.2024.07.012","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"19 4","pages":"Pages 2438-2440"},"PeriodicalIF":3.4,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1991790224002320/pdfft?md5=e1557441c23b0b903470ba81e9dff533&pid=1-s2.0-S1991790224002320-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141841158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient considerations for orthodontists: A comparative study of university students in Malaysia and Taiwan","authors":"Tee Chi Yuo ,&nbsp;Johnson Hsin-Chung Cheng ,&nbsp;Daniel De-Shing Chen ,&nbsp;Renu Sarah Samson ,&nbsp;Eby Varghese ,&nbsp;Od Bayarsaikhan","doi":"10.1016/j.jds.2024.07.003","DOIUrl":"10.1016/j.jds.2024.07.003","url":null,"abstract":"<div><h3>Background/purpose</h3><p>Patients' considerations when choosing an orthodontist are influenced by many factors, including background, ethnicity, and location. Accordingly, this study aimed to identify factors influencing patients’ considerations when selecting an orthodontist in both Malaysia and Taiwan.</p></div><div><h3>Materials and methods</h3><p>In total, 248 dental students from Taipei Medical University and 110 dental students from Manipal University College Malaysia were selected for this study. Participants' considerations when selecting an orthodontist were assessed using a questionnaire survey. The questionnaire collected data regarding participants’ demographic characteristics and their preferences regarding clinical settings, orthodontist attributes, administrative systems, and the influence of social media. The gathered data were analyzed and compared using independent <em>t</em>-test, ANOVA, and chi-squared for both cohorts.</p></div><div><h3>Results</h3><p>The present results revealed significant differences between the Malaysian and Taiwanese participants with several variables, including orthodontist experience, recommendations, pain-free treatment procedures, treatment duration, friendly reception, sources of information about orthodontists, and preferred social media platforms. Notably, among the Taiwanese participants, “person responsible for treatment costs,” was significantly correlated with the orthodontist's age, the orthodontist's work experience, information sources, travel distance, and content posted by orthodontists on social media. By contrast, among the Malaysian participants, this variable was correlated with the work experience of orthodontists.</p></div><div><h3>Conclusion</h3><p>Significant differences were observed between the Malaysian and Taiwanese participants in terms of their considerations when choosing an orthodontist. Participant's gender significantly influenced orthodontist preferences among the Malaysian participants, whereas the individual responsible for treatment costs was identified to be the most crucial factor influencing the Taiwanese participants.</p></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"19 4","pages":"Pages 1991-1998"},"PeriodicalIF":3.4,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S199179022400223X/pdfft?md5=11b5c03d7804181890008892fa92f9ae&pid=1-s2.0-S199179022400223X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141840353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of antimicrobial photodynamic therapy on pain and oral health-related quality of life: A literature review","authors":"Rashin Bahrami ,&nbsp;Maryam Pourhajibagher ,&nbsp;Nariman Nikparto ,&nbsp;Abbas Bahador","doi":"10.1016/j.jds.2024.06.022","DOIUrl":"10.1016/j.jds.2024.06.022","url":null,"abstract":"<div><p>Antimicrobial photodynamic therapy (aPDT) is a non-invasive approach used for microbial decontamination, and it can also be beneficial as an adjunctive strategy for oral infections. The success of treatment in the long term is increasingly recognized to be influenced by patient's perception of the disease and its improvement. Recently, aPDT has been suggested as a dual approach to tissue repair, pain relief, and enhancement of oral health-related quality of life (OHRQoL). The first pathway involves the antimicrobial and anti-inflammatory effects of aPDT. It not only eliminates microorganisms but also helps regulate the immune response and reduce inflammation, leading to a faster and more effective healing process. This, in turn, provides relief from pain and associated symptoms, aiding in the management of treatment complications. The second pathway involves aPDT's ability to modulate nociception and alleviate pain. aPDT induces analgesia by releasing neurotransmitters such as β-endorphin, serotonin, and acetylcholinesterase. It also interacts with mitochondria through photoreceptors, initiating intracellular processes that alleviate pain. Furthermore, the therapy inhibits nerve fibers, reducing nerve impulse conduction and altering the pain threshold. Considering that the impact on patients' pain and OHRQoL is an important aspect of the decision-making process, this study aimed to review patient-based outcome measures during aPDT and assess its effects on pain and OHRQoL in patients. Understanding these factors will contribute to a better assessment of the overall benefits and effectiveness of aPDT as a treatment option for oral infections.</p></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"19 4","pages":"Pages 1924-1933"},"PeriodicalIF":3.4,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1991790224002198/pdfft?md5=69bb803bda6b8dc851909f83003440f3&pid=1-s2.0-S1991790224002198-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141844575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting microRNA-190a halts the persistent myofibroblast activation and oxidative stress accumulation through upregulation of Krüppel-like factor 15 in oral submucous fibrosis","authors":"Ming-Yung Chou ,&nbsp;Chia-Hsuan Lee ,&nbsp;Pei-Ling Hsieh ,&nbsp;Shih-Chi Chao ,&nbsp;Chuan-Hang Yu ,&nbsp;Yi-Wen Liao ,&nbsp;Shiao-Pieng Lee ,&nbsp;Cheng-Chia Yu ,&nbsp;Jun-Yang Fan","doi":"10.1016/j.jds.2024.07.002","DOIUrl":"10.1016/j.jds.2024.07.002","url":null,"abstract":"<div><h3>Background/purpose</h3><p>Oral submucous fibrosis (OSF) is a condition characterized by inflammation and excessive collagen deposition, which has been identified as a potentially malignant disorder. Recently, several microRNAs (miRNAs) have been shown to be implicated in various disorders associated with fibrosis. However, how these miRNAs modulate OSF development is poorly understood. Therefore, the study aimed to identify the specific miRNAs that contribute to the progression of OSF and to investigate their molecular mechanisms in promoting fibrosis.</p></div><div><h3>Materials and methods</h3><p>The expression and clinical significance of potential pro-fibrosis miRNA in the OSF cohort and primary buccal mucosal fibroblasts were confirmed through RNA sequencing and qRT–PCR. Luciferase reporter activity assay, miRNA mimic or inhibitor, and short-hairpin RNA silencing were used to elucidate the molecular mechanism of miRNA. Transwell migration, collagen contraction, and reactive oxygen species (ROS) generation detection were used to investigate the effects of this mechanism on the myofibroblast phenotype and cellular pro-fibrosis capacity.</p></div><div><h3>Results</h3><p>This study demonstrated that miR-190a was overexpressed in fibrotic buccal mucosal fibroblasts (fBMFs). Transfecting fBMFs with miR-190a inhibitor resulted in reduced cell migration, collagen gel contraction, ROS generation, and expression of fibrotic markers. Furthermore, miR-190a exerted this pro-fibrosis property by direct binding to its target, Krüppel-like factor 15 (KLF15). The results also indicated that the aberrant upregulation of miR-190a, in turn, downregulated the expression of KLF15, which resulted in the activation of myofibroblast.</p></div><div><h3>Conclusion</h3><p>Our findings demonstrated that miR-190a was involved in myofibroblast activation, suggesting that targeting the miR-190a/KLF15 axis may be a feasible approach in the therapy of OSF.</p></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"19 4","pages":"Pages 1999-2006"},"PeriodicalIF":3.4,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1991790224002228/pdfft?md5=1506873d19b98b6eaa0667d1d14d1157&pid=1-s2.0-S1991790224002228-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141705387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simple inferior border osteotomy to prevent bad split during bilateral sagittal split osteotomy","authors":"Satomi Sugiyama,&nbsp;Toshinori Iwai,&nbsp;Koji Honda,&nbsp;Kenji Mitsudo","doi":"10.1016/j.jds.2024.07.007","DOIUrl":"10.1016/j.jds.2024.07.007","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"19 4","pages":"Pages 2441-2442"},"PeriodicalIF":3.4,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1991790224002277/pdfft?md5=f4130cb9a8d354ce4a26003ea074a496&pid=1-s2.0-S1991790224002277-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141712731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lingually displaced third molar root and its salvage treatment can lead to lingual nerve damage","authors":"Kai-Chien Wang ,&nbsp;Bey-Rong Guo ,&nbsp;Aya Yoshino,&nbsp;Chih-Yuan Fang","doi":"10.1016/j.jds.2024.07.004","DOIUrl":"10.1016/j.jds.2024.07.004","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"19 4","pages":"Pages 2443-2444"},"PeriodicalIF":3.4,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1991790224002241/pdfft?md5=f36838eafedafb72792c1ad9c1d29446&pid=1-s2.0-S1991790224002241-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141701302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}