Journal of Dental Sciences最新文献

{"title":"Deciphering novel targets in salivary gland pleomorphic adenoma by integrating plasma proteomics and parotid transcriptomics analyses.","authors":"Yuchen Fan, Suning Mao, Guanru Wang, Guile Zhao, Shiyong Zhuang, Fan Yang, Liu Liu, Honglin Li, Chunjie Li, Yubin Cao","doi":"10.1016/j.jds.2025.07.3542","DOIUrl":"10.1016/j.jds.2025.07.3542","url":null,"abstract":"<p><strong>Background/purpose: </strong>Pleomorphic adenoma (PA) is the most common salivary gland benign tumor, with its molecular drivers elusive due to a lack of experimental models. This study aimed to decipher novel targets in PA by systematically integrating plasma protein quantitative trait loci (pQTL)-based Mendelian randomization (MR) with multi-omics profiling of parotid gland tissues.</p><p><strong>Materials and methods: </strong>We performed two-sample MR using 5450 plasma pQTLs and genome-wide association study summary for benign or broader salivary gland diseases from FinnGen consortium. Bulk RNA-sequencing (RNA-seq) and single-cell RNA-seq (scRNA-seq) comparing PA to normal tissue were used for transcriptomic validation. Immunohistochemistry (IHC) was applied for protein-level validation in human PA, adenoid cystic carcinoma (ACC), and murine inflammatory lesions.</p><p><strong>Results: </strong>MR identified 12 plasma proteins associated with benign salivary gland tumor risk. Transmembrane serine protease 6 (TMPRSS6) was the only protein significantly risk-increasing for both benign and broader salivary gland diseases. Strikingly, mitogen-activated protein kinase kinase 4 (MAP2K4) showed opposite MR effects between benign and all-lesion outcomes. Bulk RNA-seq showed limited concordance with MR findings, while scRNA-seq revealed a unique plastic epithelium and partially validated candidates at cellular resolution. Critically, IHC confirmed MAP2K4 protein overexpression specifically in human PA, but not in ACC or inflammatory lesions, while TMPRSS6 was downregulated in established pathologies despite its genetic risk association.</p><p><strong>Conclusion: </strong>By integrating plasma proteome-based causal inference with parotid tissue multi-omics, this study unveils MAP2K4 as a potential PA-specific driver. This integrative framework provides novel, context-specific targets for further functional investigation in salivary gland tumorigenesis.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1739-1755"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral pathogens reprogram endothelial barrier and angiotensin-converting enzyme2/endothelial nitric oxide synthase-nitric oxide signaling to promote blood pressure dysregulation.","authors":"Ming-Shou Hsieh, Tung-Nien Hsu, Chin-Sheng Huang, Ting-Yi Renn, Kuang-Tai Kuo, Kuo-Yao Lin, Wei Jen Chang","doi":"10.1016/j.jds.2025.07.3494","DOIUrl":"10.1016/j.jds.2025.07.3494","url":null,"abstract":"<p><strong>Background/purpose: </strong>Although periodontal disease is associated with an increased risk of hypertension, the endothelial mechanisms linking oral inflammation to vascular dysfunction remain unclear. We investigated whether <i>Porphyromonas gingivalis</i> lipopolysaccharide (<i>Pg</i>-LPS) can directly disturb endothelial homeostasis and whether macrophage -endothelial crosstalk further worsens endothelial injury.</p><p><strong>Materials and methods: </strong>Human umbilical vein endothelial cells (HUVECs) were exposed to <i>Pg</i>-LPS alone or co-cultured (transwell system) with <i>Pg</i>-LPS-primed human monocytic cells -derived macrophages. Endothelial dysfunction was assessed through nitric oxide (NO) production, endothelial nitric oxide synthase (eNOS) phosphorylation, inflammatory and adhesion molecule expression, as well as junctional and cytoskeletal changes. Macrophage activation was evaluated by nuclear factor kappa B (NF-κB) signaling and M1-like inflammatory polarization. Mechanistic studies were further carried out with inhibitors against toll-like receptor 4 (TLR4), rho-associated kinase (ROCK), NOS, and the angiotensin-converting enzyme 2 (ACE2) signaling axis.</p><p><strong>Results: </strong><i>Pg</i>-LPS directly triggered endothelial inflammation, with increased interleukin-6 and -8, vascular cell adhesion molecule-1/intercellular adhesion moldcule-1 expression, enhanced reactive oxygen species and endothelial permeability. <i>Pg</i>-LPS also suppressed eNOS activation and NO production, and disturbed ACE/ACE2 balance. In co-culture, <i>Pg</i>-LPS-stimulated macrophages further aggravated endothelial inflammation, barrier dysfunction, and NO-related signaling impairment. TLR4 inhibition attenuated inflammatory and barrier-disruptive responses, while modulation of the ACE/ACE2-eNOS pathway altered endothelial NO signaling.</p><p><strong>Conclusion: </strong><i>Pg</i>-LPS disrupts endothelial barrier integrity and NO signaling both directly and indirectly through inflammatory macrophage-endothelial crosstalk, involving TLR2/4-NF- κB, Rho/ROCK signaling and ACE2/eNOS imbalance. These findings provide mechanistic insight into how periodontal inflammation may contribute to vascular dysfunction relevant to blood pressure dysregulation.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1402-1410"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orthokeratinized odontogenic cyst of the mandible - A case report.","authors":"Hung-Pin Lin, Chun-Pin Chiang","doi":"10.1016/j.jds.2025.07.3459","DOIUrl":"10.1016/j.jds.2025.07.3459","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1997-1999"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative conductive hearing loss after full-arch-implantation surgery under general anesthesia in an oral submucous fibrosis patient: A case report.","authors":"Hao-Chen Wang, Fu-Chuan Tsai, Chia-Che Wu, Chih-Yuan Fang","doi":"10.1016/j.jds.2025.07.3488","DOIUrl":"10.1016/j.jds.2025.07.3488","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"2011-2013"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalences of vitamin B12 deficiency, pernicious anemia, macrocytosis, and hyperhomocysteinemia in 532 serum gastric parietal cell antibody-positive oral mucosal disease patients.","authors":"Yu-Hsueh Wu, Yi-Pang Lee, Julia Yu-Fong Chang, Yi-Ping Wang, Andy Sun, Chun-Pin Chiang","doi":"10.1016/j.jds.2025.07.3458","DOIUrl":"10.1016/j.jds.2025.07.3458","url":null,"abstract":"<p><strong>Background/purpose: </strong>Our previous studies found the serum gastric parietal cell antibody (GPCA) positivity in 12.3%-26.7% of atrophic glossitis (AG), burning mouth syndrome (BMS), and oral lichen planus (OLP) patients. This study assessed whether GPCA-positive oral mucosal disease (GPCA⁺OMD) patients (including 284 AG, 109 BMS, and 139 OLP patients) had significantly higher frequencies of microcytosis, macrocytosis, anemia, serum iron and vitamin B12 deficiencies, and hyperhomocysteinemia than healthy control subjects (HCSs) or GPCA-negative OMD (GPCA^-OMD) patients.</p><p><strong>Materials and methods: </strong>The mean corpuscular volume, blood Hb, and serum iron, vitamin B12, homocysteine, and GPCA levels were measured and compared between any two of three groups of 532 GPCA⁺OMD patients, 532 disease-, age- and sex-matched GPCA^-OMD patients, and 532 age- and sex-matched HCSs.</p><p><strong>Results: </strong>We found that 532 GPCA⁺OMD patients had significantly higher frequencies of microcytosis, macrocytosis, anemia, serum iron and vitamin B12 deficiencies, and hyperhomocysteinemia than 532 HCSs (all <i>P</i>-values <i><</i>0.001) and significantly higher frequencies of macrocytosis, macrocytic anemia including pernicious anemia (PA), serum vitamin B12 deficiency, and hyperhomocysteinemia than 532 GPCA^-OMD patients (all <i>P</i>-values <i><</i>0.001). Moreover, 532 GPCA^-OMD patients also had significantly higher frequencies of microcytosis, macrocytosis, anemia, serum iron and vitamin B12 deficiencies, and hyperhomocysteinemia than 532 HCSs (all <i>P</i>-values <i><</i>0.001). PA (39.4%) and normocytic anemia (34.3%) were the two most common types of anemia in 137 anemic GPCA⁺OMD patients.</p><p><strong>Conclusion: </strong>GPCA⁺OMD patients have significantly higher frequencies of macrocytosis, macrocytic anemia including PA, serum vitamin B12 deficiency, and hyperhomocysteinemia than HCSs or GPCA^-OMD patients.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1662-1670"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A visualized AI-assisted framework for pre-surgical evaluation of implant pathways on periapical radiographs.","authors":"Yuan-Jin Lin, Chiung-An Chen, Yi-Cheng Mao, Zi-Chun Kao, Li-Hsin Chang, Shun-Yuan Tian, Shih-Lun Chen, Wei-Chen Tu","doi":"10.1016/j.jds.2025.07.3554","DOIUrl":"10.1016/j.jds.2025.07.3554","url":null,"abstract":"<p><strong>Background/purpose: </strong>Implant pathway assessment is a crucial part of pre-operative planning before performing implant surgery at the site of a missing tooth. Dentists frequently use the periapical radiograph (PA) as a tool for preliminary evaluation of the implant pathway. However, the manual interpretation process is time-consuming and inherently subjective, making it susceptible to variations in PA-based implant pathway judgment due to the operator's experience. This study aims to establish an automated and objective framework that integrates an algorithm and deep learning to analyze the implant pathway preliminarily.</p><p><strong>Materials and methods: </strong>We analyzed 1,200 PAs containing missing teeth and reserved 120 PAs for testing. We first used segmentation model to identify the teeth adjacent to the missing tooth site. This segmentation served as the foundation for the GeoPath algorithm for visualized implant pathway. The results were compared with actual preliminary clinical assessment outcomes to evaluate feasibility.</p><p><strong>Results: </strong>The segmentation model achieved a precision of 96.73 %, a sensitivity of 97.12 %, and a specificity of 99.27 %, and obtained a Cohen's κ score of 0.93, which confirmed an agreement between the automated auxiliary detection results and the dentist's ground truth annotations. Furthermore, the angular error was only 2.79°, which confirmed a lower average root mean square error (RMSE) of 0.10433. This effectively reduced the time required for dentists' clinical PA assessment by 87.19 %.</p><p><strong>Conclusion: </strong>The automated implant pathway assessment framework for PAs can serve as an auxiliary tool for senior dentists during initial clinical diagnosis and as a method for training new dentists.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1859-1866"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence-powered chatbots' responses to orthodontic questions from the dentistry specialization examination: Accuracy and source evaluation.","authors":"Berrak Çakmak, Tevhide Sökmen, Burcu Baloş Tuncer","doi":"10.1016/j.jds.2025.07.3563","DOIUrl":"10.1016/j.jds.2025.07.3563","url":null,"abstract":"<p><strong>Background: </strong>/purpose: The use of artificial intelligence (AI) powered chatbots in dental education is becoming increasingly widespread. Evaluating their performance and the reliability of their sources is essential to understand their educational value. The aim of this study was to evaluate the performance of AI-powered chatbots in addressing orthodontic questions from the Dental Specialty Exam (DUS) and to assess the accuracy and reliability of the information sources on which they rely.</p><p><strong>Materials and methods: </strong>A total of 129 orthodontic questions from the exam administered between 2012 and 2021 were categorized according to Bloom's taxonomy. Each question was individually entered into ChatGPT-5, Claude 3.7, and Copilot, and their performances were comparatively evaluated. The sources referenced by the chatbots while generating their answers were also assessed. The data were analyzed using Pearson's chi-squared test.</p><p><strong>Results: </strong>ChatGPT-5, Claude 3.7, and Copilot achieved accuracy rates of 82.2 %, 83.7 %, and 85.3 %, respectively. Copilot performed best on scenario-based questions (100 %) but performed worst on visual analysis questions (33.3 %). Citation analysis showed that, ChatGPT-5.0 used reliable academic sources, whereas Claude cited few and less credible references, and Copilot relied mainly on moderately reliable materials.</p><p><strong>Conclusion: </strong>Chatbots exhibited strong text-based reasoning abilities but limited visual interpretation skills. While ChatGPT-5.0 provided more reliable and well-referenced responses, other models showed weaker citation practices. These underscored both the potential and the current limitations of AI-based systems in orthodontic education and clinical practice.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1942-1947"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic effect of combined cisplatin and rosmarinic acid on apoptosis and migration of head and neck cancer cell lines.","authors":"Suppanut Jongjitaree, Paopanga Kokilakanit, Pornnapas Ngamphoophunt, Than Thongsiripipat, Sittichai Koontongkaew, Kusumawadee Utispan","doi":"10.1016/j.jds.2025.07.3560","DOIUrl":"10.1016/j.jds.2025.07.3560","url":null,"abstract":"<p><strong>Background/purpose: </strong>Rosmarinic acid (RA), a phenolic compound demonstrating therapeutic effects including anticancer properties. Cisplatin, a chemotherapeutic agent, is widely employed in cancer treatment. Head and neck squamous cell carcinoma (HNSCC) exhibits high mortality rates, frequently resistance to cisplatin-based regimens. Cisplatin and RA combination enhanced cisplatin efficiency across various tumor types. This study aimed to elucidate the effects of cisplatin-RA combination on cell proliferation, apoptosis and migration in HNSCC cell lines.</p><p><strong>Materials and methods: </strong>Primary HNSCC cell lines (HN18/HN30) and metastatic HNSCC cell lines (HN17/HN31) were employed in this investigation. Cells underwent treatment with rosmarinic acid (100-1,000 μM) or cisplatin (5-40 μM) for 72 h, followed by cell viability assessment using MTT assay. The combinatorial cisplatin-RA treatment effects on cell proliferation inhibition were quantified using MTT assay, with calculation of the combination index to assess synergistic interactions. Synergistic effects of cisplatin-RA combination on apoptosis and cell migration were evaluated in HNSCC cell lines through flow cytometric analysis and scratch assay, respectively.</p><p><strong>Results: </strong>Both cisplatin and rosmarinic acid demonstrated concentration-dependent reductions in HNSCC cell viability. Combination index of cisplatin-RA interaction indicating synergistic interactions in HN17, HN30 and HN31 cells. Cisplatin (20 μM) with RA (400 μM) combination synergistically induced apoptosis in HN18 and HN17 cells, while cisplatin (20 μM) and RA (800 μM) combination demonstrated synergistic apoptotic induction in HN30 and HN31 cells. Cisplatin and RA monotherapy, but not combination significantly inhibited HNSCC cell migration.</p><p><strong>Conclusion: </strong>This study found that cisplatin-RA combination can inhibit proliferation and induce apoptosis in HNSCC cell lines.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1914-1921"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From domestic science to dental science: The hidden pathway for talented Taiwanese women during the Japanese colonial period.","authors":"Hung-Lun Pan, Mei-Huei Li, Feng-Chou Cheng, Chun-Pin Chiang","doi":"10.1016/j.jds.2025.07.3454","DOIUrl":"10.1016/j.jds.2025.07.3454","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"2020-2022"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatially resolved transcriptomics identifies epithelial-specific oncogenic signaling networks in ameloblastoma.","authors":"Chih-Huang Tseng, Shohei Yoshimoto, Kai-Feng Hung, Pei-Hsuan Lu, Yi-Ping Wang, Julia Yu-Fong Chang","doi":"10.1016/j.jds.2025.07.3487","DOIUrl":"10.1016/j.jds.2025.07.3487","url":null,"abstract":"<p><strong>Background/purpose: </strong>Ameloblastoma is a benign odontogenic tumor characterized by locally aggressive growth and a high recurrence rate. Although recurrent mutations such as <i>BRAF V600E</i> have been identified, the epithelial-specific molecular mechanisms underlying tumor initiation and invasion remain incompletely defined. Previous transcriptomic studies have been limited by stromal contamination and lack of spatial resolution.</p><p><strong>Materials and methods: </strong>An integrative transcriptomic strategy was applied, combining bulk RNA sequencing of fresh ameloblastoma and dental follicular tissues, RNA sequencing of primary cultured ameloblastoma epithelial cells and dental follicular epithelial cells, and spatial transcriptomic profiling of formalin-fixed, paraffin-embedded ameloblastoma specimens.</p><p><strong>Results: </strong>Differential expression and functional enrichment analyses identified 871 upregulated and 1464 downregulated genes in tumor tissues, and 360 upregulated and 306 downregulated genes in primary epithelial cells. Integration of these datasets defined a high-confidence set of 75 consistently dysregulated epithelial genes, including <i>BEX1</i>, <i>NOS1</i>, and <i>IRS2</i>, which were validated by quantitative RT-PCR. Pathway enrichment analyses revealed coordinated activation of Wnt/β-catenin, PI3K/AKT, MAPK, and Hedgehog signaling pathways. Spatial transcriptomic analysis further demonstrated that <i>BEX1</i>, <i>NOS1</i>, <i>IRS2</i>, Wnt ligands (<i>WNT3A</i>, <i>WNT6</i>, <i>WNT7A</i>), and Hedgehog effectors (<i>GLI1</i>, <i>GLI2</i>) were predominantly upregulated within ameloblastoma tumor epithelial compartments, confirming pathway activation in situ and minimizing stromal confounding.</p><p><strong>Conclusion: </strong>Together, these findings provide a refined molecular characterization of ameloblastoma and demonstrate spatially localized activation of multiple oncogenic signaling pathways within tumor epithelium, extending current single-pathway models of ameloblastoma pathogenesis and supporting the potential development of pathway-based or combinatorial therapeutic strategies.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1499-1510"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}