Journal of Dental Sciences最新文献

{"title":"Prevention of medication-related osteonecrosis of the jaw after tooth extraction by local administration of antibiotics and atelocollagen sponge: A preliminary study","authors":"Natsumi Nakamura ,&nbsp;Sakiko Soutome ,&nbsp;Akira Imakiire ,&nbsp;Satoshi Rokutanda ,&nbsp;Seigo Ohba ,&nbsp;Shunsuke Sawada ,&nbsp;Yuka Kojima ,&nbsp;Yuki Sakamoto ,&nbsp;Yoshiko Yamamura ,&nbsp;Madoka Funahara ,&nbsp;Mitsunobu Otsuru ,&nbsp;Masahiro Umeda","doi":"10.1016/j.jds.2024.04.006","DOIUrl":"10.1016/j.jds.2024.04.006","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Medication-related osteonecrosis of the jaw (MRONJ) often develops after extraction of a tooth with a local infection. Therefore, it is necessary to develop extraction methods that can prevent MRONJ. Before examining whether antibiotics and atelocollagen administered in the extraction socket can prevent the development of MRONJ after tooth extraction, this study was conducted to determine the appropriate antibiotics concentration and to conduct a clinical study with a small number of cases as a preliminary study.</div></div><div><h3>Materials and methods</h3><div>First, a mixture of minocycline and atelocollagen at different concentrations was implanted into the bone cavity formed in the rabbit head, and the local minocycline concentration was measured after 24 and 48 h. Next, the incidences of MRONJ after tooth extraction in patients receiving high-dose antiresorptive agents were compared between the atelocollagen and atelocollagen/minocycline mixture groups. A group that did not undergo transplantation was also compared as a historical control.</div></div><div><h3>Results</h3><div>In animal studies, a mixture of 10 mg/ml minocycline injected into collagen and implanted into the bone cavity showed sufficiently high antimicrobial concentrations, even after 48 h. Post-extraction MRONJ occurred in 3 of the 13 control groups (23.1%), 3 of the 13 atelocollagen groups (23.1%), and 1 of the 13 atelocollagen/minocycline groups (7.7%).</div></div><div><h3>Conclusion</h3><div>Atelocollagen functions as a carrier for retaining antibiotics for a certain period. Although this was a study with a limited number of cases, it suggested that the local administration of atelocollagen/minocycline in the extraction socket may reduce the risk of MRONJ following tooth extraction.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 1","pages":"Pages 579-587"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140778171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of an endodontic lesion with secondary periodontal ligament changes in an adjacent tooth following root perforation: Two-year follow-up","authors":"Saeed Asgary","doi":"10.1016/j.jds.2025.09.002","DOIUrl":"10.1016/j.jds.2025.09.002","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 1","pages":"Pages 657-658"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145903815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-related factors influencing delays in oral cancer diagnosis: Insights from Pakistan","authors":"Muhammad Usman Amanat ,&nbsp;Hutcha Sriplung ,&nbsp;Duangporn Kerdpon","doi":"10.1016/j.jds.2025.07.031","DOIUrl":"10.1016/j.jds.2025.07.031","url":null,"abstract":"<div><h3>Background/purpose</h3><div>South Asia has a high burden of oral cancer (OC); however, delays in diagnosis remain under-researched. The study investigated delay intervals in OC diagnosis and the contributing factors in rural Pakistan, considering its unique sociocultural context.</div></div><div><h3>Materials and methods</h3><div>This multi-center cross-sectional study employed a structured questionnaire to interview 152 oral squamous cell carcinoma (OSCC) patients. The diagnostic intervals were determined using the Aarhus Statement. Logistic regression assessed the association between independent factors and delay types.</div></div><div><h3>Results</h3><div>Patient delays occurred in 76.3 % of cases, mostly due to appraisal delays (65 %), while diagnostic delays appeared in 51.3 %. Median durations for patient, diagnostic, and total delays were 3, 1, and over 4 months, respectively. Appraisal delay was associated with infrequent dental visits (adjusted odds ratio [AOR]: 11.04, confidence interval [CI]: 2.29–81.53), advanced stage OSCC (AOR: 5.42, CI: 2.35–13.03), and rural residence (AOR: 3.99, CI: 1.75–9.35). Help-seeking delay was linked to use of home remedies (AOR: 5.74, CI: 2.35–14.46) and homeopathy (AOR: 4.72, CI: 1.90–11.91). Patient delay associated with advanced stage OSCC (AOR: 7.73, CI: 3.28–19.12) and rural residence (AOR: 3.91, CI: 1.62–9.69). Diagnostic delay was influenced by patients’ lack of OC knowledge (AOR: 7.33, CI: 1.30–51.74), more than two visits before biopsy (AOR: 52.88, CI: 1.50–270.88), and initial treatment with analgesics (AOR: 13.37, CI: 3.68–60.99) or antimicrobials (AOR: 3.95, CI: 1.06–18.23).</div></div><div><h3>Conclusion</h3><div>Delays in OC diagnosis arise from inadequate patient awareness, rural residence, traditional and complementary medicine use, and health system challenges. Improving healthcare access and public awareness are crucial.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 1","pages":"Pages 78-87"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145903877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No evidence supporting a causal link between orthodontic premolar extraction and obstructive sleep apnea despite radiographic airway changes","authors":"Nia Ayu Ismaniati Noerhadi,&nbsp;Tsui-Hsein Huang,&nbsp;Chun-Te Ho,&nbsp;Chia-Tze Kao","doi":"10.1016/j.jds.2025.08.033","DOIUrl":"10.1016/j.jds.2025.08.033","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 1","pages":"Pages 632-633"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145903882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"APOBEC3B/ASF1B–TGF-β signaling axis promotes epithelial–mesenchymal transition in HPV-positive oropharyngeal cancer","authors":"Ming-Shou Hsieh ,&nbsp;Chih-Chi Sheen ,&nbsp;Tung-Nien Hsu ,&nbsp;Chi-Tai Yeh ,&nbsp;Wei Jen Chang ,&nbsp;Yang-Che Wu","doi":"10.1016/j.jds.2025.10.039","DOIUrl":"10.1016/j.jds.2025.10.039","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Human papillomavirus (HPV)-positive oropharyngeal cancer (OPC) generally shows better outcomes, yet a subset of patients develops aggressive lymphatic metastasis. The molecular determinants of this divergence remain unclear. This study explored the apolipoprotein B mRNA editing enzyme catalytic subunit 3B (APOBEC3B)/anti-silencing function 1B histone chaperone (ASF1B) axis as a potential mediator linking human papillomavirus (HPV) infection, DNA damage, and transforming growth factor beta (TGF-β) signaling in OPC.</div></div><div><h3>Materials and methods</h3><div>Transcriptomic and clinical datasets from The Cancer Genome Atlas (TCGA) were analyzed to examine correlations among APOBEC3B/ASF1B expression, HPV status, and TGF-β signaling activity. Functional assays using HPV-positive and HPV-negative cell models assessed APOBEC3B/ASF1B expression, replication protein A2 (RPA2) activation, and epithelial–mesenchymal transition (EMT) markers through quantitative polymerase chain reaction (qPCR), western blotting, and immunofluorescence.</div></div><div><h3>Results</h3><div>HPV infection markedly enhanced APOBEC3B and ASF1B expression, accompanied by RPA2 upregulation and EMT features. Silencing APOBEC3B reduced RPA2 and ASF1B levels and suppressed TGF-β signaling.</div></div><div><h3>Conclusion</h3><div>These findings identify APOBEC3B/ASF1B as a central pathway through which HPV infection activates TGF-β signaling and promotes EMT, offering potential biomarkers and therapeutic targets for high-risk HPV-positive OPC.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 1","pages":"Pages 562-569"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145904233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A scientometric study on methylation modification and identification of related genes in oral potentially malignant disorders and oral cancer","authors":"Lifen Yin ,&nbsp;Xiaoliang Luo ,&nbsp;Jian Liu ,&nbsp;Wei Liu ,&nbsp;Liying Gu","doi":"10.1016/j.jds.2025.07.024","DOIUrl":"10.1016/j.jds.2025.07.024","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Accumulating evidence indicates that methylation modification alterations involve in the development and progression of oral cancer. The purpose of this study was to analyze the scientometric characteristics of methylation modification in oral potentially malignant disorders (OPMD) and oral squamous cell carcinoma (OSCC).</div></div><div><h3>Materials and methods</h3><div>All the papers on methylation research in OPMD/OSCC were comprehensively retrieved from the Scopus database with emphasis on the identification of methylation related genes.</div></div><div><h3>Results</h3><div>A total of 365 papers on methylation research in OPMD/OSCC were retrieved. The total citation count was 9998 and the <em>h</em> index was 53 for all the papers. The common keywords included prognosis, sensitivity and specificity, smoking, cohort analysis, saliva, receiver operating characteristic, follow up, risk factor, cancer diagnosis, tumor suppressor gene, biological marker. Among the 365 papers, a total of 542 methylated genes and 65 microRNAs were identified. The most common methylated gene was p16, followed by MGMT, DAPK/DAPK1, E-cadherin, RASSF1/RASSF1A, KIF1A, TIMP3, RUNX3, LINE1, CDH1, TERT, ZAP70, FLI1, GP1BB, and ZNF582. The most frequent methylation related microRNA was miR-296, followed by miR-193 and miR-137.</div></div><div><h3>Conclusion</h3><div>This study for the first time elucidated the scientometric characteristics of all the publications on methylation modification in oral carcinogenesis, and would provide new insights for researchers to comprehend the methylation specific gene profile related OPMD/OSCC.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 1","pages":"Pages 588-592"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145904240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Apoptosis-inducing factor mitochondria-associated 2 (AIFM2) promotes tumor progression and predicts poor prognosis in oral squamous cell carcinoma","authors":"Chung-Hsien Chou ,&nbsp;Kuo-Wei Chang ,&nbsp;Wan-Wen Hung ,&nbsp;Miao-An Wei ,&nbsp;Chung-Ji Liu ,&nbsp;Shu-Chun Lin","doi":"10.1016/j.jds.2025.11.007","DOIUrl":"10.1016/j.jds.2025.11.007","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Head and neck squamous cell carcinoma (HNSCC), including oral squamous cell carcinoma (OSCC), remains a major malignancy with limited therapeutic efficacy. Apoptosis-inducing factor mitochondria-associated 2 (AIFM2), also known as ferroptosis suppressor protein 1, regulates ferroptosis and tumor progression. This study investigated the oncogenic function, clinical relevance, and regulation of AIFM2 in OSCC.</div></div><div><h3>Materials and methods</h3><div>Transcriptomic data from TCGA HNSCC and in-house OSCC RNA-Seq datasets were analyzed to assess AIFM2 expression and its association with clinicopathological features and outcomes. Functional assays evaluated the effects of AIFM2 knockdown or overexpression on OSCC cell proliferation, migration, invasion, and therapeutic response. MicroRNAs targeting AIFM2 were identified through bioinformatics, luciferase reporter, and mimic assays. A Light Gradient Boosting Machine (LGBM) model was used for prognostic prediction.</div></div><div><h3>Results</h3><div>AIFM2 overexpression was associated with advanced stage, poor tumor differentiation, and unfavorable survival in HNSCC/OSCC. AIFM2 knockdown suppressed, whereas its overexpression enhanced, OSCC cell proliferation, migration, and invasion, while exerting minimal effects on cisplatin, palbociclib, or cold atmospheric plasma sensitivity. miR-32-5p and miR-432-5p directly targeted AIFM2 and were downregulated in tumors. AIFM2-associated transcripts were enriched in pathways related to oxidative stress, lipid metabolism, and E2F targets. The LGBM-derived AIFM2 gene signature demonstrated strong prognostic predictive power.</div></div><div><h3>Conclusion</h3><div>AIFM2 acts as an oncogenic driver in OSCC, regulated by tumor-suppressive miR-32-5p and miR-432-5p, and serves as a potential prognostic biomarker and therapeutic target.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 1","pages":"Pages 541-550"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145904190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of osseointegration mechanisms in a novel zirconia implant: From experimental insights to clinical comparison","authors":"Hung-Ying Lin ,&nbsp;Yu-Ting Li ,&nbsp;Ju-Hsuan Yang ,&nbsp;Cheng-Han Chou ,&nbsp;Hao-Hueng Chang ,&nbsp;Chun-Pin Lin","doi":"10.1016/j.jds.2025.08.018","DOIUrl":"10.1016/j.jds.2025.08.018","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Zirconia has been proposed as a substitutive material for the next generation of implants. This study aimed to evaluate the osseointegration of a newly developed zirconia implant and compare its clinical parameters with titanium implants.</div></div><div><h3>Materials and methods</h3><div>Beagle dog animal model were used for evaluation of two groups of zirconia implants, with one group subjected to a newly developed sandblasting surface treatment technique and the other using a commercially available zirconia implant. The implants were randomly placed in bilateral edentulous mandibular sites and evaluated at 4, 9, and 13 weeks. The bone-to-implant contact (BIC) ratio was calculated and the fluorescence labelling for evaluation of osseointegration.</div><div>Clinical trials compared the peri-implant parameters of the zirconia implants with titanium implants to assess peri-implant tissue condition.</div></div><div><h3>Results</h3><div>Animal study indicated that zirconia implant osseointegration was observed between 4 weeks and 9 weeks, accompanied by osteoid deposition. A statistically significant difference was found between the 4-week and 13-week BIC ratio (<em>P</em> = 0.045). Clinical trials revealed that zirconia implants maintained minimal plaque postoperatively for up to three months, while titanium implants accumulated more plaque. In terms of plaque index, zirconia outperformed titanium implants.</div></div><div><h3>Conclusion</h3><div>This study provides comprehensive insights into zirconia implants. During early osseointegration, bone cells exhibited affinity for the implant surface, emphasizing the role of surface treatment. Clinical trials suggest that zirconia implants may offer a slight advantage in maintaining peri-implant periodontal conditions compared to titanium implants.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 1","pages":"Pages 392-400"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145904024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral and fecal microbiota in oral lichen planus and xerostomia patients: A preliminary study","authors":"Guan-Tiing Huang ,&nbsp;Yu-Feng Huang","doi":"10.1016/j.jds.2025.09.018","DOIUrl":"10.1016/j.jds.2025.09.018","url":null,"abstract":"<div><h3>Background/purpose</h3><div>The human microbiota constitutes a dynamic community of microorganisms inhabiting the body, with the gut and oral microbiotas being the most prominent. Previous studies have shown associations between oral microbiota disruption and various oral and systemic diseases, along with the involvement of the oral–gut microbiome axis. However, further investigation into the relationship between common oral conditions and microbiota changes remains needed. This study hypothesized that the distinct immune environments in oral lichen planus (OLP) and xerostomia patients result in recognizable microbiota compositions, with additional evaluation of fecal microbiota to explore the oral–gut axis.</div></div><div><h3>Materials and methods</h3><div>Gingival and fecal samples from 8 OLP patients, 19 xerostomia patients, and 10 healthy controls were collected and analyzed using 16S rRNA sequencing with bioinformatic analysis at the phylum level. Statistical comparisons between groups were performed using Student's T-test.</div></div><div><h3>Results</h3><div>Compared with healthy controls, OLP patients showed significant increases in Campylobacterota and Fusobacteria, and decreases in Actinobacteria and Proteobacteria. Xerostomia patients demonstrated a significant increase in Firmicutes. In fecal samples, both OLP and xerostomia patients exhibited significantly reduced Bacteroidetes compared with controls.</div></div><div><h3>Conclusion</h3><div>OLP and xerostomia are associated with distinct oral microbiota patterns, which may aid in early and non-invasive diagnosis. Fecal samples of both patient groups differed significantly from controls in Bacteroidetes, supporting the oral–gut microbiome axis and providing further evidence that oral conditions can influence systemic microbial communities. A major limitation of this study is the relatively small sample size.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 1","pages":"Pages 401-409"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145904025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful non-surgical repair of a large furcal perforation using endodontic biomaterials: A case report of 30-month follow-up","authors":"Saeed Asgary","doi":"10.1016/j.jds.2025.09.006","DOIUrl":"10.1016/j.jds.2025.09.006","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 1","pages":"Pages 652-654"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145903813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}