Journal of Dental Sciences最新文献

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Integrating image processing and deep learning framework for automatic supernumerary tooth detection on occlusal radiographs. 融合图像处理和深度学习的咬合x线片多牙自动检测框架。
IF 3.6 3区 医学
Journal of Dental Sciences Pub Date : 2026-07-01 eCollection Date: 2026-01-01 DOI: 10.1016/j.jds.2025.07.3546
Jui-An Fu, Chia-Lin Hsu, Tsung-Yi Chen, Hung-I Wu, Tsung-Yun Cheng, Wei-Chun Lu, Chiung-An Chen, Sze-Teng Liong, Kuo-Chen Li, Ya-Yun Huang, Wei-Chen Tu, Patricia Angela R Abu, Li-Chuan Chuang
{"title":"Integrating image processing and deep learning framework for automatic supernumerary tooth detection on occlusal radiographs.","authors":"Jui-An Fu, Chia-Lin Hsu, Tsung-Yi Chen, Hung-I Wu, Tsung-Yun Cheng, Wei-Chun Lu, Chiung-An Chen, Sze-Teng Liong, Kuo-Chen Li, Ya-Yun Huang, Wei-Chen Tu, Patricia Angela R Abu, Li-Chuan Chuang","doi":"10.1016/j.jds.2025.07.3546","DOIUrl":"10.1016/j.jds.2025.07.3546","url":null,"abstract":"<p><strong>Background/purpose: </strong>Supernumerary tooth is the most common form of hyperdontia in children and is typically identified through radiographic examination. Although occlusal radiographs are recommended for assessing anterior abnormalities, anatomical superimposition and variability in pediatric imaging make early detection challenging, thereby increasing diagnostic inconsistency. Artificial intelligence has shown strong potential in dental imaging, but applications involving pediatric occlusal radiographs remain limited due to low clinical utilization and insufficient datasets. Therefore, a reliable automated tool is needed to assist clinicians in improving supernumerary tooth screening accuracy.</p><p><strong>Materials and methods: </strong>We collected 600 pediatric occlusal radiographs from children aged 6-12 years. An image-processing algorithm was developed to automatically segment the tooth-bearing region and improve feature visibility. These processed images were used to train five convolutional neural networks (CNNs) for the classification of supernumerary tooth. A fuzzy control strategy was employed to integrate the outputs of the five models, utilizing majority voting and weighted confidence scoring to generate the final diagnostic decision and mitigate model-specific bias.</p><p><strong>Results: </strong>All five CNN models achieved accuracy above 90 %. EfficientNet performed best and reached 96.12 % accuracy and 96.06 % F1 score. Statistical comparison further showed that EfficientNet achieved the highest agreement with ground truth, achieving R<sup>2</sup> with 95.73 % and the strongest agreement level, as indicated by Cohen's κ value of 0.9598.</p><p><strong>Conclusion: </strong>The proposed hybrid image-processing and deep learning framework provides accurate and interpretable supernumerary tooth detection on occlusal radiographs, offering a reliable tool to support pediatric diagnosis and improve clinical decision-making.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1785-1792"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vanadium-functionalized methyl methacrylate-based primer enhances self-curing and bonding of resin cement to polyetheretherketone restorations. 钒功能化甲基丙烯酸甲酯底漆增强了树脂水泥与聚醚醚酮修复体的自固化和结合。
IF 3.6 3区 医学
Journal of Dental Sciences Pub Date : 2026-07-01 eCollection Date: 2026-01-01 DOI: 10.1016/j.jds.2025.07.3553
Takeru Kondo, Jun Sato, Hiroaki Kakinuma, Amal Ashry, Kulapatch Engkatanachai, Hiroshi Egusa
{"title":"Vanadium-functionalized methyl methacrylate-based primer enhances self-curing and bonding of resin cement to polyetheretherketone restorations.","authors":"Takeru Kondo, Jun Sato, Hiroaki Kakinuma, Amal Ashry, Kulapatch Engkatanachai, Hiroshi Egusa","doi":"10.1016/j.jds.2025.07.3553","DOIUrl":"10.1016/j.jds.2025.07.3553","url":null,"abstract":"<p><strong>Background/purpose: </strong>Polyetheretherketone (PEEK) has gained considerable attention as a prosthetic material due to its favorable mechanical properties and biocompatibility. Although methyl methacrylate (MMA)-based primers are commonly used for PEEK surface pretreatment in clinical practice, a reliable method for achieving consistent bonding performance has yet to be established. This study aimed to evaluate the effects of incorporating functional components, such as 10-methacryloyloxydecyl dihydrogen phosphate (MDP), 3-(trimethoxysilyl) propyl methacrylate (TPM), and vanadium, into an MMA-based primer on the bond strength, polymerization, and mechanical properties of dual-cure resin cements bonded to PEEK.</p><p><strong>Materials and methods: </strong>PEEK specimens were sandblasted with alumina and pretreated with MMA-based primers containing various concentrations of MDP, TPM, or vanadium. Three types of dual-cure resin cements (G-CEM ONE [GO], RelyX Unicem 2 [RU], and BeautiLink SA [BS]) were used. The shear bond strength, degree of conversion (DC), and Vickers hardness were measured.</p><p><strong>Results: </strong>PEEK showed no detectable light transmittance, resulting in a significantly lower DC of the underlying resin cement. Application of the MMA-based primer improved the shear bond strength to PEEK; however, incorporation of MDP or TPM did not enhance bonding. In contrast, vanadium incorporation significantly increased the shear bond strength, DC, and Vickers hardness of all the resin cements tested.</p><p><strong>Conclusion: </strong>The incorporation of vanadium into MMA-based primers enhances both the adhesion and polymerization of dual-cure resin cements to PEEK, supporting its potential as a broadly applicable strategy for reliable bonding, particularly in clinical situations where light access is limited.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1848-1858"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148879879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The story of a Taiwanese female student studying dentistry in Japan during the Japanese colonial period: An oral history by Dr. Yueh-E Wu. 吴月娥博士口述日本殖民时期台湾女学生在日本牙科学习的故事。
IF 3.6 3区 医学
Journal of Dental Sciences Pub Date : 2026-07-01 eCollection Date: 2026-01-01 DOI: 10.1016/j.jds.2025.07.3478
Feng-Chou Cheng, Mei-Huei Li, Chien-Chi Chu, Chun-Pin Chiang
{"title":"The story of a Taiwanese female student studying dentistry in Japan during the Japanese colonial period: An oral history by Dr. Yueh-E Wu.","authors":"Feng-Chou Cheng, Mei-Huei Li, Chien-Chi Chu, Chun-Pin Chiang","doi":"10.1016/j.jds.2025.07.3478","DOIUrl":"10.1016/j.jds.2025.07.3478","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1991-1993"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148879949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative in vivo study of 3D-printed composite bioceramic scaffolds fabricated by distinct pre-processing methods. 不同预处理方法制备的3d打印复合生物陶瓷支架的体内对比研究。
IF 3.6 3区 医学
Journal of Dental Sciences Pub Date : 2026-07-01 eCollection Date: 2026-01-01 DOI: 10.1016/j.jds.2025.07.3555
Yu-Ting Li, Ju-Hsuan Yang, Yu-Hsin Chang, Hao-Hueng Chang, Kuo-Yang Tsai
{"title":"Comparative in vivo study of 3D-printed composite bioceramic scaffolds fabricated by distinct pre-processing methods.","authors":"Yu-Ting Li, Ju-Hsuan Yang, Yu-Hsin Chang, Hao-Hueng Chang, Kuo-Yang Tsai","doi":"10.1016/j.jds.2025.07.3555","DOIUrl":"10.1016/j.jds.2025.07.3555","url":null,"abstract":"<p><strong>Background/purpose: </strong>This study aimed to evaluate the in vivo osteoinductive potential and biocompatibility of three-dimensional (3D) printed bone substitutes composed of polylactic acid (PLA) and PLA-based bioceramic composites of hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP), fabricated using distinct pre-processing methods.</p><p><strong>Materials and methods: </strong>Pure PLA, thermally blended PLA/HA/β-TCP, and tetrahydrofuran (THF) solvent-cast PLA/HA/β-TCP (7:3w/w) were first processed into 1.75 mm filaments and subsequently fabricated into scaffolds using fused deposition modeling (FDM). These scaffolds were implanted subcutaneously in 8-week-old Sprague-Dawley (SD) rats. Histological and immunohistochemical analyses were performed at 2 and 4 weeks, as per ISO 10993-6, to evaluate inflammation, fibrous capsule formation, and osteogenic potential.</p><p><strong>Results: </strong>Semi-quantitative scoring revealed that T-MIX (tetrahydrofuran solvent-cast composite) had the lowest inflammatory scores at both 2 and 4 weeks, which were significantly lower than those of H-MIX (heat-blended composite) (<i>P</i> < 0.05). At 2 weeks, BSP (bone sialoprotein) expression in both H-MIX and T-MIX was significantly higher than in PLA (<i>P</i> < 0.05 and <i>P</i> < 0.001, respectively), with T-MIX also exceeding H-MIX (<i>P</i> < 0.05). Overall, T-MIX demonstrated superior performance in reducing inflammation and promoting osteogenesis.</p><p><strong>Conclusion: </strong>The solvent-cast T-MIX scaffold demonstrated significantly reduced inflammatory responses and enhanced osteogenic marker expression compared to both pure PLA and heat-blended composites, positioning it as a promising and standardized candidate for 3D-printed, patient-specific bone grafts in dental and craniofacial applications.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1867-1874"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Craniofacial and airway changes after skeletal Class III orthognathic surgery: A machine learning study. 骨骼III类正颌手术后颅面和气道的变化:一项机器学习研究。
IF 3.6 3区 医学
Journal of Dental Sciences Pub Date : 2026-07-01 eCollection Date: 2026-01-01 DOI: 10.1016/j.jds.2025.07.3561
Zay Yar Linn, Johnson Hsin-Chung Cheng, Sam Li-Sheng Chen, Daniel De-Shing Chen, Muhammad Izzah Abdillah
{"title":"Craniofacial and airway changes after skeletal Class III orthognathic surgery: A machine learning study.","authors":"Zay Yar Linn, Johnson Hsin-Chung Cheng, Sam Li-Sheng Chen, Daniel De-Shing Chen, Muhammad Izzah Abdillah","doi":"10.1016/j.jds.2025.07.3561","DOIUrl":"10.1016/j.jds.2025.07.3561","url":null,"abstract":"<p><strong>Background/purpose: </strong>Mandibular setback surgery is a common orthognathic procedure for correcting Class III malocclusion. This study aimed to evaluate posterior airway space (PAS) changes in Class III patients following mandibular setback surgery, focusing on skeletal, dental, and soft tissue alterations and their association with airway changes using conventional statistics and machine learning.</p><p><strong>Materials and methods: </strong>Fifty patients who underwent mandibular setback surgery were assessed using cephalometric radiographs taken preoperatively (T1) and postoperatively (T2). Measurements included PAS area and anteroposterior width, alongside angular and linear cephalometric parameters. Paired <i>t</i>-tests evaluated pre- and post-treatment differences. Multivariate regression, Pearson correlation and Random Forest regression were used to analyse associations between craniofacial changes and PAS alterations.</p><p><strong>Results: </strong>Significant postoperative changes were observed in most craniofacial and airway variables, except for SNA, overbite, lower lip to E-plane, and hypopharynx area. Multivariate regression showed that age, sex and several other variables influenced PAS measurements, but their effects were not uniform across all airway levels. Pearson correlation showed the strongest associations between PAS changes and SNB, ANB, mandibular body length, overjet, SN-GoGn, and Z-angle. Random forest regression demonstrated low overall predictive performance; however, the model identified SNB, nasolabial angle, overjet as the most influential predictors of airway changes.</p><p><strong>Conclusion: </strong>Mandibular setback surgery significantly reduces PAS. Skeletal changes exert the greatest influence on airway, followed by soft tissue and dental variables. Horizontal craniofacial landmarks movements are more predictive of airway changes than vertical shifts. SNB emerged as the most influential variable in both correlation and machine learning analyses.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1922-1932"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A comprehensive analysis and sex-related differences in root and root canal anatomy in the Taiwanese population. 台湾人口根与根管解剖学性别差异之综合分析。
IF 3.6 3区 医学
Journal of Dental Sciences Pub Date : 2026-07-01 eCollection Date: 2026-01-01 DOI: 10.1016/j.jds.2025.07.3489
Ho-Sheng Chiang, Wei-Cheng Lee, Ying-Wu Chen, Ling-Yu Kung, Kuei-Yuan Chen, Ren-Yeong Huang, Yi-Shing Shieh, Yu-Chiao Wu
{"title":"A comprehensive analysis and sex-related differences in root and root canal anatomy in the Taiwanese population.","authors":"Ho-Sheng Chiang, Wei-Cheng Lee, Ying-Wu Chen, Ling-Yu Kung, Kuei-Yuan Chen, Ren-Yeong Huang, Yi-Shing Shieh, Yu-Chiao Wu","doi":"10.1016/j.jds.2025.07.3489","DOIUrl":"10.1016/j.jds.2025.07.3489","url":null,"abstract":"<p><strong>Background/purpose: </strong>Root canal morphology exhibits substantial anatomical variation influenced by ethnicity and sex, which may complicate endodontic treatment if unrecognized. This study aimed to comprehensively evaluate root and root canal configurations in a Taiwanese population using cone-beam computed tomography (CBCT) and to investigate sex-related differences in canal anatomy.</p><p><strong>Materials and methods: </strong>CBCT scans from 802 patients treated between 2022 and 2024 were retrospectively analyzed. A total of 18,578 teeth met the inclusion criteria. Root canal configurations were assessed for every root using Vertucci's classification, and C-shaped canals were further categorized based on morphology. Sex-related differences were analyzed using chisquare tests.</p><p><strong>Results: </strong>Complex canal configurations were frequently observed, particularly in molars. Distolingual roots were identified in 20.7% of mandibular first molars, and C-shaped canal configurations were present in 44.0% of mandibular second molars. Males exhibited a significantly higher prevalence of complex canals, including second mesiobuccal canals in maxillary molars and complex configurations in mandibular first premolars (<i>P</i> < 0.05). In contrast, C-shaped canals were significantly more prevalent in females (<i>P</i> < 0.05). No significant sex-related difference was observed in the prevalence of distolingual roots.</p><p><strong>Conclusion: </strong>This study presents the first large-scale CBCT-based dataset of root and root canal morphology in an East Asian population, providing a comprehensive reference for Taiwanese individuals. Analysis of more than 1000 M in each group demonstrated substantial anatomical variability and significant sex-related differences, underscoring the importance of population-and sex-specific morphological datasets.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1520-1530"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
N-acetylcysteine restores osteogenesis in human periodontal ligament stem cells by attenuating HIF-1α-driven oxidative stress and glycolytic reprogramming. n -乙酰半胱氨酸通过减弱hif -1α驱动的氧化应激和糖酵解重编程来恢复人牙周韧带干细胞的成骨。
IF 3.6 3区 医学
Journal of Dental Sciences Pub Date : 2026-07-01 eCollection Date: 2026-01-01 DOI: 10.1016/j.jds.2025.07.3466
Xiaochi Chang, Yanghao Zhao, Yang Wang, Chang Shu, Yi Feng, Yichong Sun, Guangxun Zhu, Jianxia Hou
{"title":"N-acetylcysteine restores osteogenesis in human periodontal ligament stem cells by attenuating HIF-1α-driven oxidative stress and glycolytic reprogramming.","authors":"Xiaochi Chang, Yanghao Zhao, Yang Wang, Chang Shu, Yi Feng, Yichong Sun, Guangxun Zhu, Jianxia Hou","doi":"10.1016/j.jds.2025.07.3466","DOIUrl":"10.1016/j.jds.2025.07.3466","url":null,"abstract":"<p><strong>Background/purpose: </strong>Periodontitis-associated hypoxia signaling and oxidative stress severely impair the regenerative capacity of human periodontal ligament stem cells (hPDLSCs). This study investigated whether antioxidant intervention rescues hPDLSC osteogenesis under CoCl<sub>2</sub>-induced HIF-1α stabilization by modulating PI3K/Akt/HIF-1α/HO-1 signaling and glycolytic reprogramming.</p><p><strong>Materials and methods: </strong>Primary hPDLSCs isolated from healthy premolars were characterized by flow cytometry and multilineage differentiation. To simulate periodontitis-associated stress, a CoCl<sub>2</sub>-induced HIF-1α-stabilizing condition was established. Cells were treated with the antioxidant N-acetylcysteine (NAC), the glycolysis inhibitor 2-deoxy-d-glucose (2-DG), or the PI3K inhibitor LY294002. Redox balance (DCFH-DA, MDA, GPX activity), glycolysis-related markers (HK2, GLUT1, lactate), and osteogenic-related markers (RUNX2, ALP, OCN) were quantified via qRT-PCR, Western blot, and biochemical assays, alongside an analysis of the PI3K/ Akt/HIF-1α/HO-1 signaling axis.</p><p><strong>Results: </strong>CoCl<sub>2</sub> exposure triggered profound redox imbalance and significantly impaired hPDLSC osteogenesis. Crucially, NAC effectively reversed these damages and restored osteogenic capacity. Mechanistically, CoCl<sub>2</sub>-induced HIF-1α stabilization activated PI3K/Akt/HO-1 signaling, a pathological cascade attenuated by either NAC or targeted PI3K inhibition. Furthermore, CoCl<sub>2</sub> forced a pronounced glycolytic shift characterized by upregulated HK2, GLUT1, and lactate production, which was directly intercepted by ROS clearance. Functionally, targeted glycolysis inhibition via 2-DG also successfully rescued the osteogenic potential of HIF-1α-stabilized hPDLSCs.</p><p><strong>Conclusion: </strong>HIF-1α stabilization suppresses hPDLSC osteogenesis by inducing both oxidative stress and pathological glycolytic reprogramming. Targeted antioxidant intervention effectively mitigates these impairments, highlighting the ROS/PI3K/Akt/HIF-1α axis as a key link between redox imbalance and metabolic dysfunction, and suggesting a potential therapeutic target for periodontal regeneration.</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1486-1498"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mesenchymal stem cells derived from gingiva normoxic or hypoxic-preconditioning allogenous transplantation affect orthodontic tooth movement in vivo. 正常或缺氧预处理同种异体牙龈间充质干细胞移植影响正畸牙的体内运动。
IF 3.6 3区 医学
Journal of Dental Sciences Pub Date : 2026-07-01 eCollection Date: 2026-01-01 DOI: 10.1016/j.jds.2025.07.3548
Alexander Patera Nugraha, Guang Hong, Kunhua Yang, Ida Bagus Narmada, Fedik Abdul Rantam, Diah Savitri Ernawati, I Gusti Aju Wahju Ardani, Adya Pramusita, Nurul Aisyah Rizky Putranti, Naora Dewi Rahma Fadzila, Al Zayyan Shenaya Aurora, Reisya Irfanny Farizaldi, Muhammad Luthfi, Putri Cahaya Situmorang, Wibi Riawan, Kotaro Tanimoto
{"title":"Mesenchymal stem cells derived from gingiva normoxic or hypoxic-preconditioning allogenous transplantation affect orthodontic tooth movement in vivo.","authors":"Alexander Patera Nugraha, Guang Hong, Kunhua Yang, Ida Bagus Narmada, Fedik Abdul Rantam, Diah Savitri Ernawati, I Gusti Aju Wahju Ardani, Adya Pramusita, Nurul Aisyah Rizky Putranti, Naora Dewi Rahma Fadzila, Al Zayyan Shenaya Aurora, Reisya Irfanny Farizaldi, Muhammad Luthfi, Putri Cahaya Situmorang, Wibi Riawan, Kotaro Tanimoto","doi":"10.1016/j.jds.2025.07.3548","DOIUrl":"10.1016/j.jds.2025.07.3548","url":null,"abstract":"<p><strong>Background/purpose: </strong>Gingival mesenchymal stem cells (GMSC) show promising qualities in immunoregulation, immunomodulation in regeneration of periodontal tissue during orthodontic tooth movement (OTM). This study aimed to elucidate allogenous GMSC normoxia and hypoxic preconditioning transplantation in the OTM model using New Zealand rabbits (<i>Oryctolagus cuniculus</i>) by examining nuclear factor kappa beta (NF-κB), tumour necrosis factoralpha (TNF-α), nuclear factor associated T-cell-1 (NFATc1), Runt-related transcription factor 2 (RUNX2), Osteocalcin.</p><p><strong>Materials and methods: </strong>Four groups were established from forty-eight, healthy, young male rabbits divided into the following respective groups: p1: normoxic GMSC transplantation with OTM, p2: hypoxic GMSC transplantation with OTM, k2: OTM only, and K1: phosphate buffered saline (PBS) only. In order to advance the mandibular first molar mesially, a fixed orthodontic appliance was applied. The rabbit was transplanted with 10<sup>6</sup> hypoxic or normoxic GMSC in 50 μl of PBS into afflicted gingiva after one day of OTM. All experimental animals were sacrificed on days 7, 14, and 28. Furthermore, mandibular tissue was isolated for the sample to examine NFKβ, TNF-α, NFATc1, osteocalcin, RUNX2 expression, and OTM rate.</p><p><strong>Results: </strong>There was a considerable increase in OTM rate, osteocalcin and RUNX2 expression in P2 on day 28 with significantly different between groups. In contrast to other groups, the P2 group's expression of NFKβ, TNF-α, and NFATc1 was considerably lower on day 28 in the tension side of the alveolar bone (<i>P</i> ≤ 0.05).</p><p><strong>Conclusion: </strong>GMSC hypoxia-preconditioning transplantation increases the OTM rate through the RUNX2-osteocalcin-OTM rate stimulation pathway in rabbits (<i>O. cunniculus</i>).</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"1801-1808"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction notice to "MicroRNA-28-5p as a potential diagnostic biomarker for chronic periodontitis and its role in cell proliferation and inflammatory response" [J Dental Sci 17 (2022) 1501-1509]. 引用本文:“MicroRNA-28-5p在慢性牙周炎细胞增殖和炎症反应中的潜在诊断作用”[J].中华口腔医学杂志17(2022):1501-1509。
IF 3.6 3区 医学
Journal of Dental Sciences Pub Date : 2026-07-01 eCollection Date: 2026-01-01 DOI: 10.1016/j.jds.2025.07.3566
Pengcheng Huang, Linghui Jia
{"title":"Retraction notice to \"MicroRNA-28-5p as a potential diagnostic biomarker for chronic periodontitis and its role in cell proliferation and inflammatory response\" [J Dental Sci 17 (2022) 1501-1509].","authors":"Pengcheng Huang, Linghui Jia","doi":"10.1016/j.jds.2025.07.3566","DOIUrl":"https://doi.org/10.1016/j.jds.2025.07.3566","url":null,"abstract":"<p><p>[This retracts the article on p. 1501 in vol. 17, PMID: 36299340.].</p>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 3","pages":"2026"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
When two become three: Endoscope-assisted Caldwell-Luc removal of an unexpected third dental bur in the maxillary sinus. 当两个变成三个:内窥镜辅助Caldwell-Luc去除上颌窦意外的第三颗牙。
IF 3.6 3区 医学
Journal of Dental Sciences Pub Date : 2026-07-01 eCollection Date: 2026-01-01 DOI: 10.1016/j.jds.2025.07.3464
Ling-Wei Huang, Wei-Chen Huang, Sheng-Hong Wang, Ken-Chung Chen
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