Journal of Dental Sciences最新文献

{"title":"Artificial intelligence-assisted enhancement of diagnostic accuracy and efficiency in detecting cervical lymph node metastases in oral squamous cell carcinoma","authors":"Chih-Huang Tseng ,&nbsp;Chang-Wei Su ,&nbsp;Yu-Min Lin ,&nbsp;Yu-Hsun Kao ,&nbsp;Wei-Cheng Lin ,&nbsp;Hao-Tang Wang ,&nbsp;Ching-Yi Chen ,&nbsp;Wen-Chen Wang ,&nbsp;Yuk-Kwan Chen","doi":"10.1016/j.jds.2025.07.026","DOIUrl":"10.1016/j.jds.2025.07.026","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Cervical lymph node metastasis represents a critical prognostic factor in oral squamous cell carcinoma (SCC); however, early-stage or subtle metastases often pose diagnostic challenges under conventional microscopy. Recent advancements in artificial intelligence (AI) offer promising solutions to enhance diagnostic accuracy and efficiency. This study aimed to evaluate the extent to which AI-assisted tools can improve diagnostic performance and efficiency in the detection of cervical lymph node metastases.</div></div><div><h3>Materials and methods</h3><div>Sixty-six hematoxylin-eosin-stained slides containing 621 lymph nodes from oral SCC cases were digitized. Four participants (two oral pathologists, one postgraduate year (PGY) resident, one fourth-year dental student) reviewed slides with and without the AI-assistant tool. Diagnostic accuracy and interpretation time were compared.</div></div><div><h3>Results</h3><div>AI assistance significantly improved diagnostic accuracy and efficiency across different participants. False positives and false negatives decreased notably, especially for junior participants. Review time was also significantly shortened for negative and macrometastatic slides (<em>P</em> &lt; 0.0001 and <em>P</em> &lt; 0.05, respectively), with the greatest benefit seen among less-experienced participants.</div></div><div><h3>Conclusion</h3><div>The AI-assisted tool improved diagnostic accuracy and efficiency in detecting cervical lymph node metastases in oral SCC. It may serve as a preliminary screening tool and a valuable educational aid for training junior pathologists, underscoring its potential for broader application in digital pathology.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 4","pages":"Pages 2092-2097"},"PeriodicalIF":3.1,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145020870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histological insights into the nasal superficial musculoaponeurotic system implicating to oral and maxillofacial surgery – A preliminary study from cadavers","authors":"Nguyen Anh Tuan Ho ,&nbsp;Dang Khoa Tran ,&nbsp;Dang Dieu Pham ,&nbsp;Thanh Van Nguyen ,&nbsp;Yang-Che Wu ,&nbsp;Chien-Fu Tseng ,&nbsp;I-Ta Lee","doi":"10.1016/j.jds.2025.07.029","DOIUrl":"10.1016/j.jds.2025.07.029","url":null,"abstract":"<div><h3>Background/purpose</h3><div>The superficial musculoaponeurotic system (SMAS) represents a pivotal component of midfacial soft tissue architecture, with significant implications for both aesthetic and reconstructive interventions. However, the histological characteristics of the nasal SMAS remain inadequately elucidated, particularly within Asian populations. This study aimed to characterize the histological features of the nasal SMAS in adult Vietnamese cadavers and to assess its potential relevance to oral and maxillofacial surgical procedures involving the midface.</div></div><div><h3>Materials and methods</h3><div>Histological analyses were performed on eight formalin-fixed nasal tissue specimens obtained from adult Vietnamese cadavers. Sections encompassing the skin to the periosteum overlying the nasal bone were subjected to hematoxylin-eosin and Trichrome staining. Microscopic evaluation focused on the SMAS architecture, as well as associated vascular, neural, and adipose structures, assessed across five anatomical landmarks: glabella (G), nasion (N), sellion (S), kyphion (K), and rhinion (R).</div></div><div><h3>Results</h3><div>A distinct SMAS layer was identified in all specimens, exhibiting two primary fibrous configurations: vertically oriented septa at G, N, and S, and parallel-running fibers at K and R. Vascular and neural elements were consistently observed superficial to the SMAS, with variable intralayer presence. The superficial fat layer demonstrated greater thickness at G and N, whereas the deep fat layer was predominantly noted at G.</div></div><div><h3>Conclusion</h3><div>This study provides novel histological insights into the nasal SMAS, contributing to a more precise anatomical framework pertinent to oral and maxillofacial surgical planning. Understanding these structural nuances may enhance surgical safety and optimize aesthetic and functional outcomes in midfacial procedures.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 4","pages":"Pages 2098-2103"},"PeriodicalIF":3.1,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145020871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic navigation technology combined with zygomatic implants as a surgical strategy for insufficient maxillary bone volume","authors":"Han-Wei Lin ,&nbsp;Cheng-Chung Lin ,&nbsp;Wei-Shao Lin,&nbsp;Wei-Chun Lin","doi":"10.1016/j.jds.2025.07.018","DOIUrl":"10.1016/j.jds.2025.07.018","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 4","pages":"Pages 2518-2520"},"PeriodicalIF":3.1,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145018289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral soft tissue diagnosis as a novel teledentistry framework for the post-pandemic era: A systematic review","authors":"Israyani ,&nbsp;Christine Anastasia Rovani ,&nbsp;Su-Feng Chen ,&nbsp;Khanisyah Erza Gumilar ,&nbsp;Shang-Ming Wang ,&nbsp;Jian-Hong Yu ,&nbsp;Chung-Ming Liu","doi":"10.1016/j.jds.2025.07.015","DOIUrl":"10.1016/j.jds.2025.07.015","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Teledentistry has emerged as a promising alternative to conventional care. This systematic review aims to assess the effectiveness of teledentistry in diagnosing and managing oral soft tissue diseases compared to traditional consultations, explores clinical outcomes, technological challenges, and implications for future research and policy, and digitally advanced countries.</div></div><div><h3>Materials and methods</h3><div>A review registered in Prospero with CRD42024626432 used CINAHL, Embase, ProQuest, and ScienceDirect databases following PRISMA 2020 guidelines. Eligibility was based on population, intervention, comparison, outcome, and study design (PICOS) with inclusion and exclusion criteria, focusing on rural populations, teledentistry interventions for oral soft tissue conditions, comparative models, and clinical outcomes. Bias risk was assessed using the Risk of Bias Tool for Nonrandomized Studies.</div></div><div><h3>Results</h3><div>Fourteen eligible studies were included. Most demonstrated improved diagnostic accuracy of oral soft tissue lesions, patient satisfaction, and follow-up compliance in teledentistry-supported care. Modern platform diagnostics were commonly used. The comparative analyses showed that teledentistry was at least equivalent to traditional consultations.</div></div><div><h3>Conclusion</h3><div>Teledentistry shows strong potential as a cost-effective, accessible solution for managing oral soft tissue conditions. Its integration into mainstream healthcare could bridge disparities in oral health service delivery in underserved regions.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 4","pages":"Pages 2104-2117"},"PeriodicalIF":3.1,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145020872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bio-obturation in traumatized mandibular teeth: A complex case report","authors":"Saeed Asgary","doi":"10.1016/j.jds.2025.07.021","DOIUrl":"10.1016/j.jds.2025.07.021","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 4","pages":"Pages 2521-2523"},"PeriodicalIF":3.1,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145018290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anemia, hematinic deficiencies, and hyperhomocysteinemia in gastric parietal cell antibody-positive and -negative oral lichen planus patients","authors":"Yu-Hsueh Wu ,&nbsp;Julia Yu-Fong Chang ,&nbsp;Yi-Pang Lee ,&nbsp;Yi-Ping Wang ,&nbsp;Andy Sun ,&nbsp;Chun-Pin Chiang","doi":"10.1016/j.jds.2025.07.019","DOIUrl":"10.1016/j.jds.2025.07.019","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Our previous study found the serum gastric parietal cell antibody (GPCA) positivity in 23.6 % of oral lichen planus (OLP) patients. This study assessed whether GPCA-positive OLP (GPCA⁺OLP) patients had significantly higher frequencies of macrocytosis, anemia, hematinic deficiencies, and hyperhomocysteinemia than healthy control subjects or GPCA-negative OLP (GPCĀOLP) patients.</div></div><div><h3>Materials and methods</h3><div>The mean corpuscular volume, blood hemoglobin (Hb), and serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels were measured and compared between any two of three groups of 139 GPCA⁺OLP patients, 449 GPCAˉOLP patients, and 588 healthy control subjects.</div></div><div><h3>Results</h3><div>We found that 139 GPCA ⁺ OLP patients had significantly higher frequencies of macrocytosis, blood Hb and serum iron and vitamin B12 deficiencies, and hyperhomocysteinemia than 588 healthy control subjects (all <em>P</em>-values &lt;0.001) and significantly higher frequencies of macrocytosis, serum iron and vitamin B12 deficiencies, and hyperhomocysteinemia than 449 GPCAˉOLP patients (all <em>P</em>-values &lt;0.05). Moreover, 449 GPCAˉOLP patients had significantly higher frequencies of macrocytosis, blood Hb and serum iron, vitamin B12, and folic acid deficiencies, and hyperhomocysteinemia than 588 healthy control subjects (all <em>P</em>-values &lt;0.01). Pernicious anemia (41.5 %) and normocytic anemia (29.3 %) were the two most common types of anemia in 41 anemic GPCA⁺OLP patients. Moreover, normocytic anemia (52.3 %), iron deficiency anemia (21.5 %), and thalassemia trait-induced anemia (16.8 %) were the three most common types of anemia in 107 anemic GPCĀOLP patients.</div></div><div><h3>Conclusion</h3><div>GPCA ⁺ OLP patients have significantly higher frequencies of macrocytosis, serum iron and vitamin B12 deficiencies, and hyperhomocysteinemia than healthy control subjects or GPCĀOLP patients.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 4","pages":"Pages 2118-2126"},"PeriodicalIF":3.1,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145020873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sugar-sweetened beverages and oral health in Taiwan: An emerging public health challenge","authors":"Hui-Chieh Yu ,&nbsp;Tsung-Po Chen ,&nbsp;Yu-Chao Chang","doi":"10.1016/j.jds.2025.07.023","DOIUrl":"10.1016/j.jds.2025.07.023","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 4","pages":"Pages 2492-2493"},"PeriodicalIF":3.1,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145021070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential diagnosis of a painful swelling lesion in the facial region: A case report of Merkel cell carcinoma","authors":"Yan-Zhi Wang ,&nbsp;Pei-Hui Chen ,&nbsp;Yang-Che Wu,&nbsp;Chih-Yuan Fang","doi":"10.1016/j.jds.2025.07.014","DOIUrl":"10.1016/j.jds.2025.07.014","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 4","pages":"Pages 2524-2526"},"PeriodicalIF":3.1,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145018291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the diagnostic value and prospects of genomic and mutational sequencing in malignant transformation of oral leukoplakia","authors":"Jian Yuan ,&nbsp;Yuhan Zhu ,&nbsp;Zirui Wang ,&nbsp;Zhongjing Lv ,&nbsp;Wei Liu","doi":"10.1016/j.jds.2025.07.016","DOIUrl":"10.1016/j.jds.2025.07.016","url":null,"abstract":"<div><div>Genomic and mutational sequencing in malignant transformation of oral leukoplakia (OLK) has emergingly gained momentum. In this short communication, we identified 5 retrospective follow-up studies and 5 cross-section comparative studies on this issue using formalin-fixed paraffin-embedded tissues. Copy number alteration (CNA) was demonstrated to increase with the grade of oral dysplasia. CNA-based algorithms showed better prediction performances than histological grade in assessing the risk of OLK malignant transformation. Importantly, we conducted a pooled-analysis on the mutation frequencies of the common oral cancer driver genes extracted from individual studies. The most common mutation gene was found to be <em>TP53</em> (26.26 %; 95 % confidence intervals (CI), 20.61–32.82 %), followed by <em>NOTCH1</em> (23.23 %; 95%CI, 17.87–29.61 %), <em>FAT1</em> (16.67 %; 95%CI, 12.08–22.52 %), and <em>CDKN2A</em> (10.61 %; 95%CI, 6.98–15.73 %). Collectively, it is promising to establish molecular subtyping and risk stratification of OLK patients using genomic and mutational sequencing. We recommend the well-designed studies with a larger OLK patient population with clinical endpoints using fresh or frozen tissues and matched optimal samples as controls in further investigations.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 4","pages":"Pages 2472-2478"},"PeriodicalIF":3.1,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145021067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flammulina velutipes polysaccharides exhibit potent antioxidant and anti-pyroptotic properties in diabetes-associated periodontitis: A preliminary in vitro study","authors":"Chun-Cheng Chen ,&nbsp;Ni-Yu Su ,&nbsp;Szu-Han Chen ,&nbsp;Yi-Wen Liao ,&nbsp;Chang-Wei Hsieh ,&nbsp;Cheng-Chia Yu","doi":"10.1016/j.jds.2025.07.017","DOIUrl":"10.1016/j.jds.2025.07.017","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Diabetes-associated periodontitis (DAP) is a complicated illness characterized by elevated oxidative stress and a pro-inflammatory response. There is a bidirectional relationship between diabetes and periodontitis. Although <em>Flammulina velutipes</em> polysaccharides (FVP) has demonstrated anti-inflammatory properties, its specific role in DAP remains uncertain. The purpose of our study was to seek the protective effects and the underlying mechanism of FVP against advanced glycation end products (AGEs) and lipopolysaccharide (LPS)-induced damage in human gingival fibroblasts (HGFs).</div></div><div><h3>Materials and methods</h3><div>Our study used HGFs treated with AGEs and LPS to mimic the in vitro environment of DAP. MTT assay was utilized to seek the various concentrations of FVP (a component of <em>Flammulina velutipes</em>) affected cell survival, migration, reactive oxygen species (ROS) generation, and cell senescence. Western blotting was used to evaluate the expression of pyroptosis pathway-related proteins, while ELISA was used to detect proinflammatory cytokines interleukin (IL)-6 and IL-8 levels.</div></div><div><h3>Results</h3><div>Our study discovered that FVP exhibited minimal cytotoxicity to HGFs at the dosages examined. Co-treatment with AGEs and LPS dramatically reduced HGFs cell survival and migratory capacity, while considerably increasing intracellular ROS levels and expression of the cell senescence marker p16. However, the treatment of FVP restore these AGE and LPS-induced adverse effects, as evidenced by the restoration of cell survival and wound healing capacity, ROS production, and decrease the protein expression of p16. FVP inhibits AGEs and LPS-induced cell pyroptosis by lowering pyroptosis markers (apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), NLR family pyrin domain containing 3 (NLRP3), caspase-1, gasdermin D (GSDMD), and IL-1β. Furthermore, FVP dramatically decreased proinflammatory cytokine production levels, including IL-6 and IL-8.</div></div><div><h3>Conclusion</h3><div>The results of our study demonstrated that FVP had a significant protective effect on human gingival fibroblast damage caused by AGEs and LPS. The addition of FVP can reverse pathological processes such as cellular oxidative stress, poor wound healing, inflammaging, and pyroptosis caused by AGEs and LPS. These findings suggest that FVP could be effective as a therapeutic or adjuvant treatment for DAP.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 4","pages":"Pages 2127-2134"},"PeriodicalIF":3.1,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145020874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}