Journal of Dental Sciences最新文献

{"title":"Anemia, hematinic deficiencies, and gastric parietal cell antibody positivity in oral lichen planus patients with or without hyperhomocysteinemia","authors":"Yi-Pang Lee ,&nbsp;Ying-Tai Jin ,&nbsp;Julia Yu-Fong Chang ,&nbsp;Yi-Ping Wang ,&nbsp;Andy Sun ,&nbsp;Chun-Pin Chiang","doi":"10.1016/j.jds.2025.05.004","DOIUrl":"10.1016/j.jds.2025.05.004","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Our previous study found that 124 of 588 oral lichen planus (OLP) patients have hyperhomocysteinemia. This study assessed whether these 124 OLP patients with hyperhomocysteinemia (hyperhomocysteinemia/OLP patients) had significantly higher frequencies of anemia, hematinic deficiencies, and serum gastric parietal cell antibody (GPCA) positivity than 464 OLP patients without hyperhomocysteinemia (non-hyperhomocysteinemia/OLP patients) or 588 healthy control subjects.</div></div><div><h3>Materials and methods</h3><div>The blood hemoglobin (Hb) and serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 124 hyperhomocysteinemia/OLP patients, 464 non-hyperhomocysteinemia/OLP patients, and 588 healthy control subjects were measured and compared.</div></div><div><h3>Results</h3><div>We found that 124 hyperhomocysteinemia/OLP patients had significantly higher frequencies of macrocytosis, blood Hb and serum iron and vitamin B12 deficiencies, and serum GPCA positivity than 588 healthy control subjects (all <em>P</em>-values &lt;0.001) or 464 non-hyperhomocysteinemia/OLP patients (all <em>P</em>-values &lt;0.001). Anemia was found in 58 of 124 hyperhomocysteinemia/OLP patients and in 90 of 464 non-hyperhomocysteinemia/OLP patients. Normocytic anemia (22 cases), pernicious anemia (17 cases), and iron deficiency anemia (10 cases) were the three most common types of anemia in 124 hyperhomocysteinemia/OLP patients. Moreover, normocytic anemia (46 cases), iron deficiency anemia (22 cases), and thalassemia trait-induced anemia (18 cases) were the three most common types of anemia in 464 non-hyperhomocysteinemia/OLP patients. Moreover, the 124 hyperhomocysteinemia/OLP patients had significantly higher frequencies of macrocytic and normocytic anemia than the 464 non-hyperhomocysteinemia/OLP patients.</div></div><div><h3>Conclusion</h3><div>Hyperhomocysteinemia/OLP patients had significantly higher frequencies of macrocytosis, anemia, serum iron and vitamin B12 deficiencies, and serum GPCA positivity than healthy control subjects or non-hyperhomocysteinemia/OLP patients.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 3","pages":"Pages 1802-1809"},"PeriodicalIF":3.4,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organoid in dentistry: Models for oral biology and disease","authors":"Tomomi Sano ,&nbsp;Ting-Yi Renn ,&nbsp;Takashi Kanematsu ,&nbsp;Ming-Shou Hsieh ,&nbsp;Chia-Chen Hsu ,&nbsp;Wei-Jen Chang","doi":"10.1016/j.jds.2025.05.002","DOIUrl":"10.1016/j.jds.2025.05.002","url":null,"abstract":"<div><div>Cell lines and animal models have long been used as essential tools in studies targeting the oral cavity, offering valuable insights into various oral diseases. Each of these research models provides its advantages, such as ease of manipulation in cell lines and the ability to replicate whole–organ interactions in animal models. However, conventional models often have limited native phenotypic features, which do not fully capture the complexity of the human oral cavity. In response to these limitations, organoid technologies have recently been developed and emerged as a promising alternative. Organoids, which are widely applied to mimic the complexity of oral tissues, such as tongue (including taste buds), tooth germs, teeth, salivary glands, periodontal ligament, bone, and oral squamous cell carcinoma, offer a more proper model for studying oral biology and disease. Key signaling pathways, including Wnt/β-catenin, transforming growth factor beta (TGF-β) (bone morphogenetic protein (BMP), and fibroblast growth factor (FGF), have been demonstrated to play important roles in expansion and differentiation of oral organoids. These advancements have opened new avenues for understanding the development and pathology of oral cavity. Therefore, we summarize current novel oral organoid culture strategies and their application, providing a deeper understanding of the biology of the oral cavity and the pathophysiology of oral diseases.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 3","pages":"Pages 1816-1823"},"PeriodicalIF":3.4,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histologic and micro-computed tomography confirmation of cementogenesis over calcium-enriched mixture cement in a human permanent tooth","authors":"Saeed Asgary ,&nbsp;Nafise Shamloo","doi":"10.1016/j.jds.2025.04.035","DOIUrl":"10.1016/j.jds.2025.04.035","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 3","pages":"Pages 1955-1957"},"PeriodicalIF":3.4,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic contrast-enhanced magnetic resonance imaging of masticatory muscles in patients with idiopathic condylar resorption","authors":"Yu-Chen Wang ,&nbsp;Hsiao-Chiao Yeh ,&nbsp;Yunn-Jy Chen ,&nbsp;Tiffany Ting-Fang Shih","doi":"10.1016/j.jds.2025.04.031","DOIUrl":"10.1016/j.jds.2025.04.031","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Idiopathic condylar resorption (ICR), a subset of temporomandibular disorders (TMDs), presents an unclear relationship between structural changes in the mandibular condyle and alterations in masticatory muscle perfusion. This study aimed to investigate the correlation between mandibular condyle structural changes and masticatory muscle perfusion in patients with ICR using dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI).</div></div><div><h3>Materials and methods</h3><div>From July 2018 to August 2022, patients with ICR from hospital-based TMD clinics underwent conventional and DCE MRI examinations. The patients were categorized on the basis of the degree of temporomandibular joint (TMJ) condylar resorption into grade 0 (normal), grade 1 (mild to moderate), and grade 2 (severe). DCE MRI parameters of masticatory muscles responsible for mouth closing (masseter [MA] and medial pterygoid [MP]) and opening (lateral pterygoid [LP]) were examined.</div></div><div><h3>Results</h3><div>Among 79 patients (158 TMJs), 41 % were assigned to the grade 0 group, 29 % were assigned to the grade 1 group, and 30 % were assigned to the grade 2 group. No significant differences in demographic or physical parameters were observed between the groups. In cases of severe condylar resorption (grade 2), the LP muscle exhibited a marked increase in plasma volume; none of the other muscles exhibited significant variations in plasma volume.</div></div><div><h3>Conclusion</h3><div>Increased plasma volume perfusion of the LP muscle is correlated with the severity of TMJ condylar resorption, indicating a specific correlation between muscle function and ICR severity. DCE MRI is useful for exploring muscular adaptation in patients with ICR and TMDs.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 3","pages":"Pages 1824-1831"},"PeriodicalIF":3.4,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Migration of submandibular gland sialolith into the subcutaneous tissue","authors":"Toshinori Iwai,&nbsp;Satomi Sugiyama,&nbsp;Hiroaki Kitajima,&nbsp;Kenji Mitsudo","doi":"10.1016/j.jds.2025.05.006","DOIUrl":"10.1016/j.jds.2025.05.006","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 3","pages":"Pages 1958-1959"},"PeriodicalIF":3.4,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multi-participation model of oral health care for the students at the outlying island schools: A case study of Kinmen County Jin-Hu Junior High School","authors":"Feng-Chou Cheng ,&nbsp;Kung-Chieh Wu ,&nbsp;Ming-Chung Lee,&nbsp;Chun-Pin Chiang","doi":"10.1016/j.jds.2025.05.001","DOIUrl":"10.1016/j.jds.2025.05.001","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 3","pages":"Pages 1960-1962"},"PeriodicalIF":3.4,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring gender-specific prognostic factors and survival outcomes in oral squamous cell carcinoma: Insights from a Taiwanese cohort","authors":"Hui-Hsin Ko ,&nbsp;Fang-Yu Wu ,&nbsp;Hsiang-Fong Kao ,&nbsp;Wender Lin ,&nbsp;Ya-Syuan Chen ,&nbsp;Shih-Jung Cheng","doi":"10.1016/j.jds.2025.04.026","DOIUrl":"10.1016/j.jds.2025.04.026","url":null,"abstract":"<div><h3>Background</h3><div>/purpose: Oral squamous cell carcinoma (OSCC) is a prevalent malignancy in Taiwan, with sex-specific variations in risk factors, clinical presentation, and prognosis. This study aimed to evaluate the clinicopathological characteristics and survival outcomes of a larger cohort of male and female OSCC patients treated at National Taiwan University Hospital (NTUH) between 2012 and 2022.</div></div><div><h3>Materials and methods</h3><div>A retrospective review of 240 de-identified, sex- and age-matched OSCC patients was conducted, analyzing clinicopathological characteristics, lifestyle habits (alcohol, betel quid, smoking), and survival outcomes.</div></div><div><h3>Results</h3><div>Gender differences were observed in tumor location, with males more likely to have buccal mucosa cancer and females more frequently diagnosed with tongue cancer. Survival analysis showed no significant sex differences in overall survival (OS), but oral habits, oral ulcer, xerostomia and menopause significantly influenced female prognosis. Multivariate analysis identified age, tumor location, and oral habits as independent factors affecting survival.</div></div><div><h3>Conclusion</h3><div>Sex-specific factors, including age, lifestyle, and oral health conditions, contribute to OSCC prognosis. Tailored therapeutic strategies are necessary to address these gender-based disparities and improve survival outcomes for all OSCC patients.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 3","pages":"Pages 1832-1842"},"PeriodicalIF":3.4,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatostatin delayed lip sensory recovery after inferior alveolar nerve transection by inhibiting sterol regulatory element-binding protein 1","authors":"Suning Mao ,&nbsp;Zhongkai Ma ,&nbsp;Gaowei Zhang ,&nbsp;Pingchuan Ma ,&nbsp;Chunjie Li ,&nbsp;Li Ye","doi":"10.1016/j.jds.2025.04.024","DOIUrl":"10.1016/j.jds.2025.04.024","url":null,"abstract":"<div><div>Lipid metabolism is essential for nerve repair in damaged nerves. Fatostatin, a selective inhibitor of sterol regulatory element-binding protein 1 (SREBP1), could reduce cholesterol synthesis and disturb lipid homeostasis. However, whether fatostatin would delay lip sensory recovery after inferior alveolar nerve transection remains unclear. In this preliminary study, we investigated the effects of fatostatin on lip sensory recovery <em>in vivo</em> and axon growth <em>in vitro</em>. Fatostatin significantly delayed lip sensory recovery of mice after inferior alveolar nerve transection as evidenced by quantitative sensory testing. Fatostatin also reduced the average axon length of primary trigeminal neurons. Despite SREBP1, expressions of other lipid metabolism-related (including fatty acid synthase and ATP citrate lyase) and axon regeneration-related molecules (including activating transcription factor 3 and nerve growth factor) were also inhibited, as evidenced by the Western Blot and quantitative real-time PCR. Overall, fatostatin delayed lip sensory recovery after inferior alveolar nerve transection by inhibiting SREBP1.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 3","pages":"Pages 1885-1889"},"PeriodicalIF":3.4,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethical implications and moral considerations of dental practice based on Taiwan's medical regulations","authors":"Feng-Chou Cheng,&nbsp;Wei-Chun Lin,&nbsp;Ling-Hsia Wang,&nbsp;Chun-Pin Chiang","doi":"10.1016/j.jds.2025.04.033","DOIUrl":"10.1016/j.jds.2025.04.033","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 3","pages":"Pages 1963-1965"},"PeriodicalIF":3.4,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe external root resorption of the right maxillary second molar caused by the pressure from an impacted wisdom tooth","authors":"Feng-Chou Cheng,&nbsp;Yu-Ting Hu,&nbsp;Chun-Pin Chiang","doi":"10.1016/j.jds.2025.04.028","DOIUrl":"10.1016/j.jds.2025.04.028","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 3","pages":"Pages 1966-1968"},"PeriodicalIF":3.4,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144364559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}