台湾女性慢性牙周炎患者肺癌风险增加:一项全国性人群队列研究

IF 3.1 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
Wen-Ying Shen , Wei-Ju Lai , Yu-Hsun Wang , Yu-Chao Chang
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引用次数: 0

摘要

背景/目的肺癌是全球最常见的癌症死亡原因。然而,慢性牙周炎(CP)与肺癌风险之间的关系尚不清楚。本研究的目的是利用台湾的全国登记数据,探讨台湾女性CP患者是否可能增加肺癌的风险。材料与方法采用台湾健康保险纵向数据库进行回顾性队列研究。选取2001 - 2012年新诊断的CP患者86886例。从普通人群中随机捕获无任何牙周病的健康患者,其倾向匹配率为1:1。采用Cox比例风险回归模型分析肺癌和非肺癌队列之间的风险。结果CP组和非CP组分别有639例和614例新发肺癌患者。与非CP组相比,CP组肺癌风险显著增加(相对风险:1.01 95% CI: 0.90-1.12)。亚组分析性别差异的风险比,交互作用的P为0.042。女性CP患者患肺癌的风险比非CP患者高1.23倍(95% CI: 1.01-1.48, P = 0.036)。结论本研究结果显示,台湾女性CP患者罹患肺癌的风险明显高于非CP女性患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Increased risk of lung cancer in Taiwanese female patients with chronic periodontitis: A nationwide population-based cohort study

Background/purpose

Lung cancer is the most common cause of cancer death globally. However, the association between chronic periodontitis (CP) and lung cancer risk is still not very clear. The aim of study was to investigate whether the Taiwanese female patients with CP might have increased risk of lung cancer using a nationwide registry dataset in Taiwan.

Materials and methods

A retrospective cohort study was conducted by using Taiwanese Longitudinal Health Insurance Database. A total of 86,886 patients who were newly diagnosed with CP from 2001 to 2012 were selected. A 1:1 propensity-matched healthy patients without any type of periodontal diseases were captured randomly from the general population. The risk of lung cancer was analyzed by Cox proportional hazards regression models between CP and non-CP cohorts.

Results

639 and 614 patients with newly diagnosed lung cancer were found in CP and non-CP cohorts, respectively. CP cohort exhibited a borderline significantly increased risk of lung cancer (relative risk:1.01 95 % CI: 0.90–1.12) as compared with non-CP cohort. The subgroup analysis of hazard ratio for sex difference, P for interaction was 0.042. The female patients with CP had a 1.23-fold higher risk of lung cancer than non-CP counterparts (95 % CI: 1.01–1.48, P = 0.036).

Conclusion

Taken together, the results of this nationwide population-based cohort study indicate that the Taiwanese female patients with CP exhibited a significantly higher risk of lung cancer than those female patients without CP.
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来源期刊
Journal of Dental Sciences
Journal of Dental Sciences 医学-牙科与口腔外科
CiteScore
5.10
自引率
14.30%
发文量
348
审稿时长
6 days
期刊介绍: he Journal of Dental Sciences (JDS), published quarterly, is the official and open access publication of the Association for Dental Sciences of the Republic of China (ADS-ROC). The precedent journal of the JDS is the Chinese Dental Journal (CDJ) which had already been covered by MEDLINE in 1988. As the CDJ continued to prove its importance in the region, the ADS-ROC decided to move to the international community by publishing an English journal. Hence, the birth of the JDS in 2006. The JDS is indexed in the SCI Expanded since 2008. It is also indexed in Scopus, and EMCare, ScienceDirect, SIIC Data Bases. The topics covered by the JDS include all fields of basic and clinical dentistry. Some manuscripts focusing on the study of certain endemic diseases such as dental caries and periodontal diseases in particular regions of any country as well as oral pre-cancers, oral cancers, and oral submucous fibrosis related to betel nut chewing habit are also considered for publication. Besides, the JDS also publishes articles about the efficacy of a new treatment modality on oral verrucous hyperplasia or early oral squamous cell carcinoma.
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