Wen-Ying Shen , Wei-Ju Lai , Yu-Hsun Wang , Yu-Chao Chang
{"title":"台湾女性慢性牙周炎患者肺癌风险增加:一项全国性人群队列研究","authors":"Wen-Ying Shen , Wei-Ju Lai , Yu-Hsun Wang , Yu-Chao Chang","doi":"10.1016/j.jds.2025.04.002","DOIUrl":null,"url":null,"abstract":"<div><h3>Background/purpose</h3><div>Lung cancer is the most common cause of cancer death globally. However, the association between chronic periodontitis (CP) and lung cancer risk is still not very clear. The aim of study was to investigate whether the Taiwanese female patients with CP might have increased risk of lung cancer using a nationwide registry dataset in Taiwan.</div></div><div><h3>Materials and methods</h3><div>A retrospective cohort study was conducted by using Taiwanese Longitudinal Health Insurance Database. A total of 86,886 patients who were newly diagnosed with CP from 2001 to 2012 were selected. A 1:1 propensity-matched healthy patients without any type of periodontal diseases were captured randomly from the general population. The risk of lung cancer was analyzed by Cox proportional hazards regression models between CP and non-CP cohorts.</div></div><div><h3>Results</h3><div>639 and 614 patients with newly diagnosed lung cancer were found in CP and non-CP cohorts, respectively. CP cohort exhibited a borderline significantly increased risk of lung cancer (relative risk:1.01 95 % CI: 0.90–1.12) as compared with non-CP cohort. The subgroup analysis of hazard ratio for sex difference, <em>P</em> for interaction was 0.042. The female patients with CP had a 1.23-fold higher risk of lung cancer than non-CP counterparts (95 % CI: 1.01–1.48, <em>P</em> = 0.036).</div></div><div><h3>Conclusion</h3><div>Taken together, the results of this nationwide population-based cohort study indicate that the Taiwanese female patients with CP exhibited a significantly higher risk of lung cancer than those female patients without CP.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"20 3","pages":"Pages 1749-1755"},"PeriodicalIF":3.1000,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Increased risk of lung cancer in Taiwanese female patients with chronic periodontitis: A nationwide population-based cohort study\",\"authors\":\"Wen-Ying Shen , Wei-Ju Lai , Yu-Hsun Wang , Yu-Chao Chang\",\"doi\":\"10.1016/j.jds.2025.04.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background/purpose</h3><div>Lung cancer is the most common cause of cancer death globally. However, the association between chronic periodontitis (CP) and lung cancer risk is still not very clear. The aim of study was to investigate whether the Taiwanese female patients with CP might have increased risk of lung cancer using a nationwide registry dataset in Taiwan.</div></div><div><h3>Materials and methods</h3><div>A retrospective cohort study was conducted by using Taiwanese Longitudinal Health Insurance Database. A total of 86,886 patients who were newly diagnosed with CP from 2001 to 2012 were selected. A 1:1 propensity-matched healthy patients without any type of periodontal diseases were captured randomly from the general population. The risk of lung cancer was analyzed by Cox proportional hazards regression models between CP and non-CP cohorts.</div></div><div><h3>Results</h3><div>639 and 614 patients with newly diagnosed lung cancer were found in CP and non-CP cohorts, respectively. CP cohort exhibited a borderline significantly increased risk of lung cancer (relative risk:1.01 95 % CI: 0.90–1.12) as compared with non-CP cohort. The subgroup analysis of hazard ratio for sex difference, <em>P</em> for interaction was 0.042. The female patients with CP had a 1.23-fold higher risk of lung cancer than non-CP counterparts (95 % CI: 1.01–1.48, <em>P</em> = 0.036).</div></div><div><h3>Conclusion</h3><div>Taken together, the results of this nationwide population-based cohort study indicate that the Taiwanese female patients with CP exhibited a significantly higher risk of lung cancer than those female patients without CP.</div></div>\",\"PeriodicalId\":15583,\"journal\":{\"name\":\"Journal of Dental Sciences\",\"volume\":\"20 3\",\"pages\":\"Pages 1749-1755\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2025-04-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Dental Sciences\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1991790225001151\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Dental Sciences","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1991790225001151","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
Increased risk of lung cancer in Taiwanese female patients with chronic periodontitis: A nationwide population-based cohort study
Background/purpose
Lung cancer is the most common cause of cancer death globally. However, the association between chronic periodontitis (CP) and lung cancer risk is still not very clear. The aim of study was to investigate whether the Taiwanese female patients with CP might have increased risk of lung cancer using a nationwide registry dataset in Taiwan.
Materials and methods
A retrospective cohort study was conducted by using Taiwanese Longitudinal Health Insurance Database. A total of 86,886 patients who were newly diagnosed with CP from 2001 to 2012 were selected. A 1:1 propensity-matched healthy patients without any type of periodontal diseases were captured randomly from the general population. The risk of lung cancer was analyzed by Cox proportional hazards regression models between CP and non-CP cohorts.
Results
639 and 614 patients with newly diagnosed lung cancer were found in CP and non-CP cohorts, respectively. CP cohort exhibited a borderline significantly increased risk of lung cancer (relative risk:1.01 95 % CI: 0.90–1.12) as compared with non-CP cohort. The subgroup analysis of hazard ratio for sex difference, P for interaction was 0.042. The female patients with CP had a 1.23-fold higher risk of lung cancer than non-CP counterparts (95 % CI: 1.01–1.48, P = 0.036).
Conclusion
Taken together, the results of this nationwide population-based cohort study indicate that the Taiwanese female patients with CP exhibited a significantly higher risk of lung cancer than those female patients without CP.
期刊介绍:
he Journal of Dental Sciences (JDS), published quarterly, is the official and open access publication of the Association for Dental Sciences of the Republic of China (ADS-ROC). The precedent journal of the JDS is the Chinese Dental Journal (CDJ) which had already been covered by MEDLINE in 1988. As the CDJ continued to prove its importance in the region, the ADS-ROC decided to move to the international community by publishing an English journal. Hence, the birth of the JDS in 2006. The JDS is indexed in the SCI Expanded since 2008. It is also indexed in Scopus, and EMCare, ScienceDirect, SIIC Data Bases.
The topics covered by the JDS include all fields of basic and clinical dentistry. Some manuscripts focusing on the study of certain endemic diseases such as dental caries and periodontal diseases in particular regions of any country as well as oral pre-cancers, oral cancers, and oral submucous fibrosis related to betel nut chewing habit are also considered for publication. Besides, the JDS also publishes articles about the efficacy of a new treatment modality on oral verrucous hyperplasia or early oral squamous cell carcinoma.