Journal of Diabetes Research最新文献

{"title":"Diagnostic Accuracy of Screening Tests for Diabetic Peripheral Neuropathy: An Umbrella Review.","authors":"María Mogilevskaya, Mariana Gaviria-Carrillo, John Edwin Feliciano-Alfonso, Ana M Barragan, Carlos A Calderon-Ospina, Mauricio O Nava-Mesa","doi":"10.1155/jdr/5902036","DOIUrl":"10.1155/jdr/5902036","url":null,"abstract":"<p><p>Peripheral neuropathy is a common cause of morbidity in diabetes. Despite recent advancements in early diagnosis methods, there is a need for practical, highly sensitive, and cost-effective screening methods in clinical practice. This study summarizes evidence from systematic reviews and meta-analyses on the diagnostic accuracy of validated screening methods for diabetic peripheral neuropathy. Two independent reviewers assessed methodological quality and bias using AMSTAR and ROBIS tools. Seven reviews with 19,531 participants were included. The monofilament test showed inconsistent sensitivity (<i>S</i>: 0.53-0.93) and specificity (Sp: 0.64-1.00), along with high variability in its application. Neuropad exhibited high <i>S</i> (86%, 95% CI 79-91). However, variations in the interpretation of results across the included studies may have impacted its Sp (65%, 95% CI 51-76). The Ipswich touch test exhibited adequate diagnostic accuracy (<i>S</i>: 0.77, Sp: 0.96, DOR: 75.24) but lacked comparison with gold standard tests. In vibration perception studies, the biothesiometer outperformed the tuning fork (<i>S</i>: 0.61-0.80 vs. 0.10-0.46). In general, heterogeneity was observed due to varied reference tests, thresholds, and patient differences. The development of automated analysis methods, as well as determination of predictive value of the combination of screening tools, is needed for further studies. Based on the study results, we suggest that clinicians should select screening tools tailored to their patient population, clinical setting, and available resources, as no single test can be universally recommended for all clinical scenarios.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2024 ","pages":"5902036"},"PeriodicalIF":3.6,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11634407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of a Circuit Training Program on Myokine Levels in Insulin-Resistant Women: A Randomised Controlled Trial.","authors":"Joanna Karolkiewicz, Monika Krzywicka, Monika Szulińska, Katarzyna Musialik, Dominka Musiałowska, Jacek Zieliński, Agnieszka Bilska, Marzena Ratajczak","doi":"10.1155/jdr/6624919","DOIUrl":"10.1155/jdr/6624919","url":null,"abstract":"<p><p><b>Introduction:</b> Circuit training is a form of body conditioning with endurance and resistance components. Given the function of skeletal muscle as an endocrine organ secreting various myokines involved in maintaining glucose metabolism homeostasis, our study focused on estimating the impact of the implemented training program on the direction of changes in myokines such as interleukin (IL)-6, IL-10, fibroblast growth factor 21 (FGF21), and irisin in women newly diagnosed with insulin resistance. <b>Methods:</b> This prospective controlled trial randomly divided 42 women into two groups. The training group performed circuit training combining strength (50%-80% of one-repetition maximum) and endurance (50%-75% of heart rate reserve) exercises for 3 months, three 33-min sessions weekly. Exercises were performed on five weight and two cardio machines. The control nontraining group did not change their previous activity. Body composition indicators and IL-6, IL-10, FGF21, and irisin levels were measured before and after the intervention. The data for 27 patients were analysed using two-way repeated measures analyses of variance. <b>Results:</b> The pattern of change in serum IL-6 levels over time differed significantly between the groups (<i>p</i> < 0.05). The patterns of change did not differ significantly between groups for IL-10, FGF21, and irisin. <b>Conclusion:</b> The circuit training program implemented in women newly diagnosed with insulin resistance significantly increased their serum IL-6 and not their IL-10, FGF21, and irisin levels. <b>Trial Registration:</b> ClinicalTrials.gov: NCT04528693.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2024 ","pages":"6624919"},"PeriodicalIF":3.6,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11620807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Jiedu Tongluo Therapy for Diabetic Kidney Disease Treatment: A Systematic Review and Meta-Analysis.","authors":"Yuxin Liu, Xiaoling Shang, Hongliang Wu, Ze He","doi":"10.1155/jdr/4180944","DOIUrl":"10.1155/jdr/4180944","url":null,"abstract":"<p><p><b>Background:</b> No comprehensive meta-analysis has evaluated the efficacy and safety of the protective effect of Jiedu Tongluo Therapy on the kidney of DKD until now. This meta-analysis covers this gap in knowledge. <b>Methods:</b> We have conducted an extensive search of databases, including CNKI, Wanfang, PubMed, and Web of Science. The selection was based on conventional treatment, including information and education on DKD, blood glucose, hypertension control methods, and lifestyle. The control group was composed of conventional western medicine or proprietary Chinese medicine, and the experimental group was composed of Jiedu Tongluo therapy controlled trials (RCTs) between 2003 and 2023. R 4.1.0 software was used to perform statistical analysis. <b>Results:</b> A total of 1871 patients from 19 RCTs were analyzed. Meta-analysis results showed that the Jiedu Tongluo therapy was effective in improving clinical efficacy (OR = 2.47, 95% CI [1.94, 3.15], <i>I</i> ² = 0%), and these trials were more effective in reducing Scr (MD = -19.81, 95% CI [-27.64, -11.97], <i>p</i> < 0.01), BUN (MD = -0.70, 95% CI [-1.13, -0.27], <i>p</i> < 0.01), UAER (MD = -29.97, 95% CI [-37.33, -22.61], <i>p</i> < 0.01), FBG (MD = -0.85, 95% CI [-1.22, -0.47], <i>p</i> < 0.01), and certain medication safety (OR = 0.75, 95% CI [0.27, 2.11]). <b>Conclusions:</b> For treating diabetic kidney disease, TCM-based Jiedu Tongluo therapy showed optimal clinical efficacy and safety. However, further rational experiments are needed to validate the above conclusions.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2024 ","pages":"4180944"},"PeriodicalIF":3.6,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11614504/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Influencing Factors Related to Health Literacy of Diabetic Patients: A Survey Based on DHLEIS.","authors":"Yalan Chen, Zepeng Wang, Fangyuan Jiang, Junyi Shi, Kui Jiang","doi":"10.1155/jdr/5110867","DOIUrl":"https://doi.org/10.1155/jdr/5110867","url":null,"abstract":"<p><p><b>Purpose:</b> This study is aimed at investigating health literacy (HL) among diabetes mellitus (DM) patients using a comprehensive, scientific, feasible, and suitable HL assessment indicator system tailored for the diabetic population in mainland China and systematically analyzing the factors influencing HL in this population. <b>Methods:</b> The Delphi expert consultation method was employed to initially draft and refine the Diabetes Health Literacy Evaluation Indicator System (DHLEIS). The reliability and representativeness of the indicator system were tested through metrics including the active coefficient, authority degree, and coordination degree. A HL survey questionnaire for diabetic patients was developed based on DHLEIS and administered to diabetic patients across five hospitals in Nantong and Yancheng cities, Jiangsu Province. The random forest method was utilized to deeply analyze the impact of various factors on HL and its four dimensions and to identify the core influencing factors. <b>Results:</b> Analysis of 707 questionnaires based on the DHLEIS revealed that nine factors-age, sex, body shape, income, exercise, education level, duration of DM, whether insulin is injected, and the number of cohabitants-significantly impact the HL levels. Among these, age, duration of DM, education level, and number of cohabitants were particularly influential across the four dimensions of health knowledge, awareness, behavior, and skills. Factors related to health knowledge and skills were the most significant contributors to overall HL. <b>Conclusions:</b> The multidimensional analysis of factors influencing HL offers valuable insights into characterizing varying levels of HL among diabetic patients. This approach supports targeted cognitive improvements and the effective enhancement of health skills, ultimately leading to better health outcomes.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2024 ","pages":"5110867"},"PeriodicalIF":3.6,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11611418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetic Cardiomyopathy Uncovered: Transcriptomics, NLRP3, and Carvedilol Mechanisms.","authors":"Alimujiang Abudoureyimu, Alimu Aihaiti, Nuliman Abudoujilili, Mayila Tuergong, Guzainuer Adili, Maihebubaimu Maimaiti, Dilinuer Mohetaer, Yimamumaimaiti Maiamaitishawuti","doi":"10.1155/2024/9378405","DOIUrl":"https://doi.org/10.1155/2024/9378405","url":null,"abstract":"<p><p><b>Background:</b> This study investigates the impact of a high-sugar environment on H9C2 cardiomyocytes and explores the protective effects of carvedilol in the context of diabetic cardiomyopathy (Dia-CM). Transcriptomic analysis identified 21,655 differentially expressed genes associated with Dia-CM, demonstrating significant separation among samples. <b>Methods:</b> H9C2 cardiomyocytes were cultured in a high-sugar environment to simulate Dia-CM conditions. Cell viability, cytokine levels, and protein expression were assessed using CCK-8 assays, ELISA, and Western blot techniques. Intervention experiments with NLRP3, caspase-1, and ROS inhibitors were conducted to evaluate their protective effects. The therapeutic potential of carvedilol was assessed by examining its impact on cell viability, cytokine levels, and key biomarkers. An in-depth analysis of carvedilol's regulatory effects on ROS and key proteins in H9C2 cells was also conducted. <b>Results:</b> In vitro, a high-sugar environment significantly reduced H9C2 cell survival, increased ROS levels, activated inflammatory responses, and upregulated NLRP3, caspase-1, and GSDMD-N proteins. Inhibitors of NLRP3, caspase-1, and ROS ameliorated these effects. Carvedilol treatment improved cell activity, reduced inflammatory cytokine levels, suppressed ROS production, and downregulated NLRP3, pro-caspase-1, GSDMD-N, and p-NF-<i>κ</i>B proteins. Moderate-dose carvedilol exhibited optimal intervention effects. <b>Conclusions:</b> A high-sugar environment induces cardiomyocyte damage through ROS production and NLRP3 inflammasome activation. Inhibitors of NLRP3, caspase-1, and ROS provide effective protection. Carvedilol significantly mitigates the detrimental effects of a high-sugar environment on H9C2 cardiomyocytes, potentially through inhibiting the NLRP3-ASC inflammasome and caspase-1/GSDMD-dependent signaling pathway-mediated pyroptosis. These findings offer insights into Dia-CM mechanisms and highlight carvedilol as a promising therapeutic intervention.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2024 ","pages":"9378405"},"PeriodicalIF":3.6,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ABHD1 Facilitates Intermediate Filament-Mediated Endothelial Cell Chemotaxis by Regulating KRT1 and KRT2 in Diabetic Retinopathy.","authors":"Xinyi Liu, Junwei Fang, Tian Niu, Xindan Xing, Xin Shi, Yu Xiao, Yuan Qu, Yan Jiang, Kangjia Lv, Tianyu Dou, Qian Zhu, Hancong Wan, Xiaoxin Liu, Hanying Wang, Kun Liu","doi":"10.1155/jdr/5513165","DOIUrl":"https://doi.org/10.1155/jdr/5513165","url":null,"abstract":"<p><p>Diabetic retinopathy (DR) is one of the most common complications of diabetes and induces severe visual impairment worldwide. Endothelial cell dysfunction plays an important role in the pathogenesis of DR. Here, we keep a watchful eye on <i>α</i>/<i>β</i>-hydrolase domain-containing 1 (ABHD1), a potential regulator in lipid metabolism and neovascularization. Results revealed that ABHD1 expression increased both in retina tissues of DR patients and in high-glucose-treated human retina endothelial cells. Inhibition of ABHD1 remitted endothelial cell proliferation and migration. And GSEA uncovered that ABHD1 knockdown remits endothelial cell chemotaxis and intermediate filament (IF) might be mediated in the progress by regulating keratin 1 (KRT1) and keratin 2 (KRT2). Therefore, we assume that ABHD1 is concerned with endothelial cell proliferation and migration in DR, consequently leading to pathological neovascularization. The findings may provide a potential therapeutic target for DR.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2024 ","pages":"5513165"},"PeriodicalIF":3.6,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11606687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding Experiences of Diabetes Distress: A Systematic Review and Thematic Synthesis.","authors":"Louise Anne Morales-Brown, Guillermo Perez Algorta, Yakubu Salifu","doi":"10.1155/2024/3946553","DOIUrl":"10.1155/2024/3946553","url":null,"abstract":"<p><p><b>Background:</b> Diabetes distress is a common emotional issue for those living with diabetes, which has the potential to negatively impact well-being, management behaviors, and HbA1c levels. These implications have led to diabetes distress becoming an important consideration in diabetes healthcare and management. Nonetheless, discussions remain ongoing on how to best conceptualize this experience. Recent research has attempted to enhance conceptualization by considering the underlying emotional mechanisms that may underpin the highly contextualized experience of diabetes distress. Qualitative insights can further add to these understandings; however, the research in this remit is yet to be systematically reviewed. This review therefore sought to add to the growing body of literature attempting to better conceptualize diabetes distress and the underlying mechanisms that may contribute to this experience. A secondary aim was to leverage this understanding to consider ways to improve patient-healthcare interactions. <b>Methods:</b> A qualitative systematic review and thematic synthesis was undertaken. Eligible studies were identified through PsycINFO, MEDLINE, CINAHL, and EMBASE databases from November 2020 to May 2021. Study quality was assessed using the McMaster Critical Review Form. <b>Results:</b> Nineteen papers were included in the review. The analysis resulted in seven descriptive themes which contributed to three analytical themes: (1) threatened autonomy, (2) sense of helplessness, and (3) negative sense of self. These results highlight that a major area underpinning experiences of diabetes distress is not feeling in control. <b>Conclusions:</b> Consideration should be given to how psychological factors, such as locus of control and learned helplessness, may constitute underlying mechanisms impacting emotional regulation in those experiencing diabetes distress. Clinicians should consider including and leading discussions around distress during appointments, as well as using approaches that promote patient autonomy and empowerment.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2024 ","pages":"3946553"},"PeriodicalIF":3.6,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11581805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Total Water-Soluble Flavonoids From <i>Lithocarpus litseifolius</i> (Hance) Chun (Sweet Tea) Improve Glucose Homeostasis Through Multitarget Signalling in GDM Mice.","authors":"Junfei Xu, Fenfang Zhang, Huanhuan Li, Pan Li, Junying Zeng, Xianjin Wu, Rong Zhou, Chunyan Yang, Juzuo Zhang","doi":"10.1155/2024/1518080","DOIUrl":"10.1155/2024/1518080","url":null,"abstract":"<p><p><b>Background:</b> The oral safety of <i>Lithocarpus litseifolius</i> (Hance) Chun (sweet tea) that has antihyperglycemic potential has been verified. However, its specific application and action mechanism in the treatment of gestational diabetes mellitus (GDM) are still unclear. <b>Methods:</b> Total water-soluble flavonoids extracted from <i>L. litseifolius</i> (Hance) Chun (sweet tea) were applied to GDM mice. The glucose tolerance, insulin sensitivity, and histopathology of the GDM mice were evaluated through an intraperitoneal glucose tolerance test (IPGTT), an intraperitoneal insulin tolerance test (IPITT), and histochemistry. The possible mechanism was analysed through network pharmacology. <b>Results:</b> Compared with those in GDM model mice (MD group), blood glucose levels indicating both glucose tolerance and insulin sensitivity were improved in GDM mice treated with total water-soluble flavonoids (LLHC group) but were greater than those in normal control mice (NC group). The number of apoptotic liver cells was significantly lower in the LLHC group than in the MD group, but greater than that in the NC group. Multiple targets and signalling pathways that were acted by eight main active ingredients were involved in the process by which total water-soluble flavonoids protect against GDM. The main mechanism involved quercetin (10 targets) and luteolin (8 targets), which acted on the effector target of GAA through six main signalling pathways around the AKT1 core axis. <b>Conclusion:</b> Oral administration of total water-soluble flavonoids can alleviate glucose intolerance and insulin resistance via the inhibition of liver cell apoptosis. The main active ingredients act on GAA through the signalling pathways of the AKT1 core axis.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2024 ","pages":"1518080"},"PeriodicalIF":3.6,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11578658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Hypertension and Its Clinical and Psychological Factors in Type 2 Diabetes Patients in Ghana: A Secondary Analysis of a Cross-Sectional Study.","authors":"V Boima, E Yorke, V Ganu, L Twumasi, G Ekem-Ferguson, D Dey, I A Kretchy, K Agyabeng, C C Mate-Kole","doi":"10.1155/2024/9286774","DOIUrl":"10.1155/2024/9286774","url":null,"abstract":"<p><p><b>Background:</b> Hypertension (HTN) is common in patients with type 2 diabetes mellitus (T2DM). Patients with both T2DM and HTN have a higher risk of heart disease, kidney disorders, and mortality than those with either HTN or T2DM alone. Patients' psychological well-being plays a significant role in the optimum management of these chronic conditions. This study is aimed at determining the current prevalence of HTN and its related clinical and psychological factors in patients with T2DM. <b>Methods:</b> This cross-sectional study was conducted at the Korle-Bu Teaching Hospital with 156 patients diagnosed with T2DM. A structured questionnaire was used to obtain information on sociodemographic and clinical characteristics. In addition, the following information was obtained from the patients' clinical files: blood pressure, height, weight, waist circumference, serum creatinine, and urine protein. Depression, resilience, and coping skills of the participants were measured using the Brief Symptom Inventory-18, Resilience Scale for Adults, and Brief COPE Inventory, respectively. Data were analyzed using STATA version 18, with a significance level of <i>p</i> < 0.05. <b>Results:</b> The median age of respondents was 62.0 (IQR: 51.50, 67.00) years. The majority was female (76.3%). The prevalence of HTN among the patients with T2DM was 79.9% (95% CI: 72.7-85.9). The average body mass index (BMI) of the patients was 28871kg/m² with 34.8% and 36.2% being overweight and obese, respectively. The average HBA1C level was 8.6 ± 2.1 with 71.8% of the patients having poor glycemic control. Increasing age, caregiver, and personal resilience were factors significantly associated with HTN (<i>p</i> value of <0.05) among patients with T2DM. <b>Conclusion:</b> The prevalence of HTN among T2DM patients was high; age, caregiver, and personal resilience significantly predicted HTN among T2DM patients. These findings have implications for healthcare providers in implementing strategies to reduce central obesity and incorporating resilience as an important factor in improving treatment outcomes in patients with T2DM.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2024 ","pages":"9286774"},"PeriodicalIF":3.6,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11578660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visceral Adiposity as an Independent Risk Factor for Diabetic Peripheral Neuropathy in Type 2 Diabetes Mellitus: A Retrospective Study.","authors":"Rui-Ling Wu, Niyao Chen, Yanni Chen, Xiaohong Wu, Chih-Yuan Ko, Xiao-Yu Chen","doi":"10.1155/2024/9912907","DOIUrl":"10.1155/2024/9912907","url":null,"abstract":"<p><p><b>Background:</b> Diabetic peripheral neuropathy (DPN) impacts approximately 50% of individuals with Type 2 diabetes mellitus (T2DM), leading to severe complications such as foot ulcers and amputations. Notably, visceral adiposity is increasingly recognized as a pivotal factor in augmenting the risk of DPN. We aim to evaluate the correlation between obesity-related body composition, particularly visceral fat, and DPN to facilitate early identification of high-risk patients with T2DM. <b>Methods:</b> This cross-sectional analysis encompassed 113 T2DM patients from the Department of Endocrinology and Metabolism at the Second Affiliated Hospital of Fujian Medical University, conducted between September 2020 and January 2021. Patients were categorized into two cohorts: those with DPN (DPN group) and those without (NDPN group). We utilized bioelectrical impedance analysis (BIA) to determine body measurements, such as weight and visceral fat area, in addition to collecting clinical and biochemical data. Logistic regression was employed to analyze the data. <b>Results:</b> The study uncovered a statistically significant difference in the visceral fat area between the DPN and NDPN groups (<i>p</i> = 0.048). Through multivariate logistic regression analysis, the visceral fat area was identified as an independent risk factor for DPN among T2DM patients (OR 1.027; 95% CI 1.004-1.051, <i>p</i> = 0.022). Other significant risk factors included the duration of diabetes and the presence of diabetic retinopathy. <b>Conclusion:</b> The visceral fat area serves as an independent risk factor for DPN in individuals with T2DM. Implementing measures to assess and manage visceral obesity could be vital in the prevention and management of DPN. This underscores the value of technologies such as BIA in clinical and community settings for early intervention.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2024 ","pages":"9912907"},"PeriodicalIF":3.6,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11573447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}