Journal of Diabetes Research最新文献

{"title":"Network Pharmacology and Serum Nontargeted Metabolomics Reveal the Protective Effects of Propionate Against Liver Damage Induced by a High-Fat and AGE-Rich Diet in Diabetic Mice.","authors":"Liang Wu, Jiajun Tan, Wen Sun, Xueyun Dong, Jiayuan He, Asmaa Ali, Min Chen, Leilei Zhang, Pingping Wang","doi":"10.1155/jdr/3955893","DOIUrl":"10.1155/jdr/3955893","url":null,"abstract":"<p><p>Diabetic liver injury is a leading cause of mortality in diabetes, with no specific treatment available. Sodium propionate (NaP) has anti-inflammatory and antioxidant properties, but its effectiveness in treating diabetic liver injury is still lacking research. The study employed network pharmacology to identify potential targets of NaP for Type 2 diabetes treatment, using oleic acid (OA) and advanced glycation end products (AGEs) to induce diabetic liver injury in HepG2 cells <i>in vitro</i>. Post-NaP intervention, Oil Red O staining assessed cellular lipid deposition, while Western blotting analyzed protein expression associated with oxidative stress, autophagy, and bile acid synthesis. NaP was administered to mice with diabetic liver injury induced by a high-fat and AGEs diet, and qPCR analysis was conducted to assess the expression of genes associated with inflammation, oxidative stress, and bile acid synthesis in the liver. HE staining was used to observe the liver injury, and nontargeted metabolomics analysis was used to analyze the effect of NaP on serum metabolic pathways. Network pharmacology analysis showed that NaP has anti-inflammatory and antioxidant effects, mainly involving multiple targets such as mitochondrial function, insulin resistance, and glucose metabolism. Experimental results in cells and animals demonstrated that NaP reduces lipid accumulation and inflammation in liver cells; decreases inflammatory markers like NLRP3, IL-1<i>β</i>, and TNF-<i>α</i>; enhances antioxidant factors such as serum SOD and liver Nrf2; increases the expression of the bile acid synthesis enzyme CYP7A1; and upregulates autophagy in liver cells. Serum nontargeted metabolomics indicated that NaP enhances anti-inflammatory and antioxidant metabolites, including proline and N-Acetyl-L-leucine, in diabetic liver injury mice. It potentially influences purine metabolism, amino acid synthesis (e.g., arginine, tryptophan, and tyrosine), and steroid hormone biosynthesis. This study indicates that NaP may serve as a preventive and therapeutic agent for diabetic liver injury.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"3955893"},"PeriodicalIF":3.6,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12240661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Thyroid Function Parameters and Plasma Branched-Chain Amino and Keto Acids in Patients With Euthyroid Type 2 Diabetes Mellitus.","authors":"Xinghua Cai, Yuanying Xu, Jie Gao, Huihui Zhang, Jun Lu, Tao Lei","doi":"10.1155/jdr/2540444","DOIUrl":"10.1155/jdr/2540444","url":null,"abstract":"<p><p><b>Objectives:</b> The objective of the study is to determine the association between thyroid function parameters and plasma levels of branched-chain amino acids (BCAAs) and their metabolites, branched-chain keto acids (BCKAs), in patients with euthyroid Type 2 diabetes mellitus (T2DM). <b>Methods:</b> We conducted a cross-sectional study among 357 participants with euthyroid T2DM. Plasma BCAAs and BCKAs were measured using enzyme-linked immunosorbent assay (ELISA), while four thyroid function parameters, including triiodothyronine (T3), thyroxine (T4), free triiodothyronine (FT3), and free thyroxine (FT4), were determined by an automatic biochemical analyzer. The variance inflation factor (VIF) was used to investigate variable collinearity. Pearson correlation and multivariate linear regression analysis were used to establish the relationship between BCAAs or BCKAs and thyroid function parameters. <b>Results:</b> The means of T3, T4, FT3, and FT4 were different among the three groups divided by BCAA tertiles (all <i>p</i> < 0.05), and the means of T3 and FT3 were different among the three groups divided by BCKA tertiles (all <i>p</i> < 0.01). Pearson correlation analysis indicated a positive relationship between all the thyroid function parameters and BCAA levels (<i>p</i> < 0.05), while a statistically significant inverse relationship was established between T3 and FT3 levels and BCKA levels (<i>p</i> < 0.01). Collinearity analysis demonstrated no collinearity among the variables (tolerance: 0.501~0.922; VIF: 1.084~1.995). Multivariate linear regression analysis showed that thyroid function parameters were significantly associated with BCAAs (coefficients: 0.042 to 4.614, <i>p</i> < 0.05) and BCKAs (coefficients: -0.200 to -0.156, <i>p</i> < 0.01) after adjusting for other potential confounding factors. <b>Conclusions:</b> Thyroid function parameters positively correlated with plasma BCAAs but negatively correlated with plasma BCKAs in patients with euthyroid T2DM. However, further prospective studies are needed to explore potential causal relationships and verify these findings.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"2540444"},"PeriodicalIF":3.6,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12240655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Albuminuria and Renal Dysfunction on the Anemia-Improving Effect of SGLT2 Inhibitors in Patients With Type 2 Diabetes: A Real-World Observational Study.","authors":"Ayami Kajiwara-Morita, Kentaro Oniki, Akira Yoshida, Noboru Kurinami, Tomoko Suzuki, Fumio Miyamoto, Kunio Hieshima, Seigo Sugiyama, Keizo Kajiwara, Katsunori Jinnouchi, Junji Saruwatari, Hideaki Jinnouchi","doi":"10.1155/jdr/5399360","DOIUrl":"10.1155/jdr/5399360","url":null,"abstract":"<p><p><b>Aim:</b> Sodium-glucose cotransporter 2 (SGLT2) inhibitors have been reported to increase hemoglobin levels; however, little is known about the magnitude of their anemia-improving effect in patients with advanced chronic kidney disease. We aimed to determine the influence of albuminuria and renal dysfunction on the anemia-improving effects of SGLT2 inhibitors in patients with Type 2 diabetes (T2D). <b>Materials and Methods:</b> In this clinically based retrospective longitudinal study, the records of 4664 consecutive patients with T2D were reviewed. We investigated the effects of albuminuria and eGFR at baseline on change in hemoglobin after 3 months of SGLT2 inhibitor treatment by a multivariable linear regression analysis with calculation of the unstandardized partial regression coefficient (<i>B</i>). <b>Results:</b> Among the patients with T2D, 230 patients (male, <i>n</i> = 170; female, <i>n</i> = 60; age, 67.0 ± 11.5 years) were eligible for the analysis. Patients with macroalbuminuria (urine albumin-to-creatinine ratio (uACR) > 300 mg/g or urine protein-to-creatinine ratio (uPCR) > 500 mg/g) exhibited a significantly smaller increase in hemoglobin after the initiation of SGLT2 inhibitor treatment (<i>B</i> -5.923 g/L, <i>p</i> = 0.003) compared to patients with normoalbuminuria (uACR < 30 mg/g or uPCR < 150 mg/g). Furthermore, almost all patients with proteinuria in the \"nephrotic range,\" defined as uPCR > 3500 mg/g, did not experience increased hemoglobin from SGLT2 inhibitor treatment. However, we could not find a significant association between the eGFR at baseline (including eGFR ≤ 15 mL/min/1.73 m²) and change in hemoglobin with SGLT2 inhibitor treatment. <b>Conclusions:</b> Our findings indicate that severely increased albuminuria attenuates the anemia-improving effect of SGLT2 inhibitors for at least 3 months after their administration.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"5399360"},"PeriodicalIF":3.6,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12228570/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mogrosides Protect Against Diabetic Kidney Injury via Inhibiting Macrophage Activation in a Mouse Model.","authors":"Fangyi Jiang, Xiaoli Huang, Man Yan, Jiajun Tan, Xueyun Dong, Xianhai Liu, Jiayuan He, Asmaa Ali, Min Chen, Leilei Zhang, Liang Wu, Pingping Wang","doi":"10.1155/jdr/5291562","DOIUrl":"10.1155/jdr/5291562","url":null,"abstract":"<p><p>Diabetic kidney injury is an almost unavoidable complication in diabetic patients. The activation of macrophages with high glucose in the patient's body is a key factor in triggering diabetic kidney disease (DKD). Mogrosides are commonly used sweeteners, but their effects on diabetic kidney injury are still unclear. This study used THP-1 cell models and diabetic mouse models to examine the impacts and pathways of mogrosides in inhibiting hyperglycemia-activated macrophages and alleviating kidney damage. This study used high glucose (33.3 mmol/L) to induce activation of macrophage-like THP-1 cells for studying the anti-inflammatory mechanism of mogrosides. At the same time, a diabetic mouse model was prepared using a high-fat diet and intraperitoneal injection of streptozotocin in order to further study the effects of mogrosides on alleviating symptoms of DKD. Mogrosides can suppress the activation of macrophages and kidney damage in diabetic mice, and this anti-inflammatory effect seems to be mediated through the NF-<i>κ</i>B/NLRP3/Caspase-1 axis in macrophages. Moreover, the metabolomic results revealed that the anti-inflammatory properties of mogrosides were associated with the modulation of glutamate metabolism and glycerophospholipid metabolism in macrophages. Our results indicated that supplementing diabetic patients with mogrosides may help inhibit inflammatory responses and prevent kidney damage.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"5291562"},"PeriodicalIF":3.6,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12213039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Improvements in Glycemic Control and Risk of Pregnancy Complications in Patients With Diabetes Mellitus: Metaregression Analysis of Randomized Controlled Trials of Intensive Glucose Management.","authors":"Satoru Kodama, Kazuya Fujihara, Noriko Yagyuuda, Yoko Yachi, Chika Horikawa, Yasunaga Takeda, Sakiko Yoshizawa Morikawa, Takaho Yamada, Kiminori Kato, Yoshimi Nakagawa, Shiro Tanaka, Hitoshi Shimano, Hirohito Sone","doi":"10.1155/jdr/3490884","DOIUrl":"10.1155/jdr/3490884","url":null,"abstract":"<p><p><b>Background:</b> It remains unknown whether improvements in prognosis of pregnancy in patients with diabetes mellitus are dependent on glycemic control (GC). This metaregression analysis was aimed at exploring the relationships between the improvements in GC. <b>Methods:</b> Using Embase and MEDLINE (from Jan. 1, 1950, to Apr. 29, 2024), we searched for randomized controlled trials of intensive glucose management in pregnant women with gestational, pregestational, or overt diabetes mellitus, in which the blood glucose level using any GC indicator and the incidence of any adverse maternal and/or fetal outcome were compared between two groups with different intensities of glucose management. Relative risks (RRs) of individual adverse outcomes were regressed on the reductions in individual GC indicators. <b>Results:</b> We examined the dose-response relationship between reductions in four GC indicators (hemoglobin A1c (A1C), fasting plasma glucose (FPG), 2-h postprandial glucose, and mean blood glucose) and 14 adverse pregnancy outcomes in 62 eligible trials. Reductions in FPG were associated with the reduced risk of 10/14 adverse outcomes, with the exceptions being cesarean section, small for gestational age, premature rupture of membranes, and congenital malformation. Reductions in A1C were strongly associated with the reduced risk of cesarean section (<i>r</i> = 0.67, <i>p</i> < 0.001), indicating that the RR (95% confidence interval) for a 1% incremental decrease in A1C was 0.63 (0.49-0.80). <b>Conclusions:</b> Risk reductions in the majority of pregnancy complications in those with diabetes depend on the improvement of GC induced by intensive glucose management.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"3490884"},"PeriodicalIF":3.6,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12208766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Diabetic Polyneuropathy Prevalence in Hospitalized Patients: A Comparative Study Using the Michigan Self-Report Questionnaire and Physical Examination Methods.","authors":"Parastoo EsnaAshari, Elaheh Mianehsaz, Maryam Afarini, Mohammad Javad Azadchehr","doi":"10.1155/jdr/7027972","DOIUrl":"10.1155/jdr/7027972","url":null,"abstract":"<p><p><b>Background:</b> Chronic complications of diabetes, such as diabetic polyneuropathy (DPN), are major contributors to disability and mortality among diabetic patients. Effective screening for DPN is crucial to prevent severe complications, including limb amputation. This study was aimed at assessing the prevalence of DPN among hospitalized diabetic patients using both self-report (Michigan questionnaire) and physical examination methods and at evaluating the level of agreement between these two screening approaches. <b>Methods:</b> This cross-sectional study included 158 adult diabetic patients admitted to Shahid Beheshti Hospital in Kashan, Iran, between April and September 2023. Patients were screened for DPN using the Michigan self-report questionnaire and physical examination. Sociodemographic and clinical data were collected through patient interviews and medical records. Random sampling was used to ensure representativeness. Data analysis was conducted using SPSS Version 26, applying descriptive and inferential statistics. Cohen's kappa statistic was used to assess the level of agreement between the two screening methods. The validity and reliability of the assessment tools were confirmed through previous studies. <b>Results:</b> The study found a moderate agreement between the physical examination and the Michigan self-report questionnaire in diagnosing DPN (<i>κ</i> = 0.486, <i>p</i> < 0.001). The overall prevalence of DPN, based on the agreement of both methods, was 64.6%. The prevalence was 75.9% based on physical examination and 72.8% based on the questionnaire. <b>Conclusions:</b> This study found a high prevalence of DPN among hospitalized diabetic patients, highlighting the urgent need for effective screening methods. The moderate agreement between the Michigan questionnaire and physical examination suggests that the questionnaire could serve as a simple, cost-effective tool for early DPN detection. Further research and wider implementation of these screening tools may enhance early diagnosis and help reduce the risk of severe complications, such as limb amputation.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"7027972"},"PeriodicalIF":3.6,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12168654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"sFlt-1/PlGF Ratio in the Prediction of Preeclampsia in Pregnant Women With Diabetic Kidney Disease.","authors":"Jakub Kornacki, Ewa Wender-Ozegowska, Daniel Boroń, Urszula Mantaj, Przemysław Wirstlein, Paweł Gutaj","doi":"10.1155/jdr/3987453","DOIUrl":"10.1155/jdr/3987453","url":null,"abstract":"<p><p><b>Objectives:</b> The objective of the study is to evaluate the potential role of the sFlt-1/PlGF ratio in predicting preeclampsia (PE) in pregnant women with diabetic kidney disease (DKD) during the second and third trimesters of pregnancy. <b>Study Design:</b> This study included 102 patients with DKD. All participants had a history of pregestational diabetes of at least 20 years' duration and/or onset before the age of 10 or pregestational diabetes complicated by hypertension or diabetic retinopathy (classified as D, R, or F according to White's classification). All patients exhibited elevated urinary protein loss (30-299 mg/24 h) or overt proteinuria (≥ 300 mg/24 h) during the first trimester of pregnancy. All participants were treated with intensive insulin therapy, either via multiple daily insulin injections (MDIs) or continuous subcutaneous insulin infusion (CSII). Serum levels of sFlt-1, PlGF, and the sFlt-1/PlGF ratio were assessed at both the 20th and 30th weeks of gestation. <b>Main Outcome Measures:</b> The serum levels of sFlt-1, PlGF, and the sFlt-1/PlGF ratio during the second and third trimesters were compared between women who developed PE and a control group without PE. <b>Results:</b> In DKD patients who developed PE, serum sFlt-1 levels were significantly higher, while PlGF levels were significantly lower, compared to those who did not develop PE. The sFlt-1/PlGF ratio was also markedly elevated in the PE group compared to controls during both the second and third trimesters. Increased sFlt-1 levels, decreased PlGF levels, and an elevated sFlt-1/PlGF ratio were significant predictors of PE development at both 20 and 30 weeks of gestation. The sFlt-1/PlGF ratio demonstrated a sensitivity of 72.7% and specificity of 75.7% at 20 weeks (sFlt-1/PlGF cut-off > 10.1) and a sensitivity of 84.6% and specificity of 82.0% at 30 weeks for predicting PE (sFlt-1/PlGF cut-off > 37). The positive predictive values were 47.1% and 50.0%, while the negative predictive values were 90.3% and 96.0% at 20 and 30 weeks, respectively. <b>Conclusions:</b> The assessment of antiangiogenic and proangiogenic markers, particularly the sFlt-1/PlGF ratio, appears to be a valuable tool for predicting PE in patients with long-lasting diabetes complicated by DKD.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"3987453"},"PeriodicalIF":3.6,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12165755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Glycemic Control of Pay-for-Performance Program for Psychiatric Patients With Diabetes in Real World: A Retrospective Quasiexperimental Study.","authors":"Chin-Chou Yang, Wen-Chen Ouyang, Tsuo-Hung Lan, Yee-Yung Ng, Shiao-Chi Wu","doi":"10.1155/jdr/9660739","DOIUrl":"10.1155/jdr/9660739","url":null,"abstract":"<p><p><b>Background:</b> Psychiatric patients with Type 2 diabetes often experience suboptimal care and poor health outcomes. <b>Aims:</b> This study is aimed at investigating the impact of a diabetes pay-for-performance (P4P) program on glycemic control in psychiatric patients with diabetes by comparing two regional psychiatric hospitals, one with the P4P program and one without. <b>Methods:</b> We conducted a retrospective quasiexperimental study. A total of 149 psychiatric outpatients with Type 2 diabetes were enrolled in the P4P group, and 129 patients were in the non-P4P group. Hemoglobin A1c (HbA1c) values in the fourth quarter of 2018 served as baseline (before P4P implementation in either hospital). Follow-up HbA1c levels were collected at 3, 6, 9, and 12 months in 2019. Propensity score matching was performed based on baseline HbA1c to create comparable groups. Changes in HbA1c over 1 year were analyzed using paired and independent <i>t</i>-tests and a generalized estimating equation (GEE) model. <b>Result:</b> The mean HbA1c level in the P4P group decreased progressively over 12 months (from 6.97% at baseline to 6.60%), whereas the non-P4P group showed an increase (from 7.00% to 7.12%). By the fourth quarter, the P4P group had a significantly lower mean HbA1c than the non-P4P group (<i>p</i> < 0.05). Subgroup analysis showed a greater HbA1c reduction in P4P participants who were male or had schizophrenia (<i>p</i> = 0.01 and <i>p</i> = 0.04, respectively). <b>Conclusions:</b> The P4P program was associated with significantly improved glycemic control in psychiatric patients with diabetes compared to usual care. This integrated care model may be an effective strategy to improve diabetes outcomes in psychiatric populations.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"9660739"},"PeriodicalIF":3.6,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12158592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patients With Type 2 Diabetes Are at Greater Risk of Developing New Hypertension and Chronic Kidney Disease Following COVID-19.","authors":"Justin Y Lu, Shiv Mehrotra-Varma, Stephen H Wang, Montek Singh Boparai, Sonya Henry, Jai Mehrotra-Varma, Tim Q Duong","doi":"10.1155/jdr/8816198","DOIUrl":"10.1155/jdr/8816198","url":null,"abstract":"<p><p><b>Background:</b> The purpose of this study was to test the hypothesis that COVID-19 status increases the incidence of new hypertension (HTN) and chronic kidney disease (CKD) in patients with Type 2 diabetes (T2D). <b>Methods:</b> This retrospective study consisted of 46,448 patients with T2D from the Montefiore Health System in the Bronx (3/01/2020-7/01/2023), of which 13,801 had a positive COVID-19 test on record. Contemporary controls included those hospitalized for other lower respiratory tract infections (LRTIs) (<i>n</i> = 1638) and nonhospitalized patients without COVID-19 or LRTI (<i>n</i> = 31009). Outcomes were assessed at follow-up (2 months to 3 years) relative to baseline. Adjusted hazards ratios (aHRs) with 95% confidence interval (CI) were computed. <b>Results:</b> The cumulative incidences of HTN (22.32% vs. 9.13%, <i>p</i> < 0.001) and CKD (6.20% vs. 2.03%, p <0.001) were significantly higher in nonhospitalized COVID-19 compared to non-COVID-19 patients, but not between patients hospitalized for COVID-19 and LRTI (<i>p</i> > 0.05). Nonhospitalized COVID-19 patients had higher risk of developing HTN compared to non-COVID patients during all follow-up (aHR 1.99, 95% CI [1.54, 2.57], <i>p</i> < 0.001), but hospitalized COVID-19 patients had similar risk of developing HTN relative to patients hospitalized for LRTI (aHR 1.26 [0.70, 2.27], <i>p</i> = 0.441). Nonhospitalized COVID-19 patients had higher risk of developing CKD compared to non-COVID patients during all follow-up (aHR 2.09 [1.69, 2.76], <i>p</i> < 0.001), but hospitalized COVID-19 patients had similar risk of developing CKD relative to patients hospitalized for LRTI (aHR 0.96 [0.79, 1.36], <i>p</i> = 0.131). <b>Conclusions:</b> T2D patients with COVID-19 were at higher risk of developing new disorders compared with COVID-19-negative controls and were at similar risk compared with those hospitalized for other LRTIs.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"8816198"},"PeriodicalIF":3.6,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12158568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Heart Rate Variability in People With Diabetes-Related Neuropathic Foot to Their Counterparts Without a Foot Ulcer History: A Propensity Score Matching Study.","authors":"Murong Wu, Shuang Lin, Yan Liu, Dawei Chen, Xingwu Ran, Chun Wang, Lihong Chen, Sen He, Donge Yan, Mingxin Bai, Yingying Dong, Wen Wang, Zhiyi Lei, Yun Gao","doi":"10.1155/jdr/3349391","DOIUrl":"10.1155/jdr/3349391","url":null,"abstract":"<p><p><b>Background:</b> The reasons that individuals with diabetic foot ulceration (DFU) have higher cardiovascular mortality than those with Type 2 diabetes mellitus (T2DM) but without DFU remain controversial. We aimed to compare the differences in cardiac autonomic function between individuals with neuropathic DFU and their counterparts without DFU. <b>Methods:</b> Three hundred and sixty-two participants with T2DM (181 with DFU and 181 without DFU) who were free of peripheral artery disease (PAD) were included in the final analysis after propensity score matching (PSM). All individuals underwent a 24-h ECG Holter and used the following indices of heart rate variability (HRV) to assess cardiac autonomic function: the standard deviation of the normal sinus interval (SDNN), the root mean square of successive RR interval differences (rMSSD), the standard deviation of the 5-min average RR intervals (SDANN), the percentage of normal adjacent RR interval difference > 50 ms (PNN50), the low-frequency power (LF), the high-frequency power (HF), and the LF/HF ratio. <b>Results:</b> Individuals with DFU had lower SDNN, LF/HF, PNN50, rMSSD, HF, SDANN, and LF than their counterparts without DFU (all <i>p</i> < 0.05). Individuals with DFU had a 2.5-fold increase in severe impairment of cardiac autonomic modulation (i.e., SDNN < 50 ms) compared to those without DFU (21.6% vs. 8.8%, <i>p</i> < 0.001). DFU was independently and negatively associated with all the abovementioned HRV measures (all <i>p</i> < 0.05). <b>Conclusion:</b> Among people with neuropathic diabetic foot only, cardiac autonomic function was still more severely impaired in individuals with DFU than in their counterparts without DFU. <b>Trial Registration:</b> CHiCTR2300076628.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"3349391"},"PeriodicalIF":3.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12143952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}