Journal of Diabetes Research最新文献

{"title":"HbA1c and the Risk of Lower Limb Ulcers Among Diabetic Patients: An Observational and Genetics Study.","authors":"Guojun Guo, Yunlong Guan, Yuhuan Chen, Yuge Ye, Zeyu Gan, Xi Cao, Zhenbing Chen, Xingjie Hao","doi":"10.1155/jdr/4744194","DOIUrl":"10.1155/jdr/4744194","url":null,"abstract":"<p><p><b>Aims:</b> A lower limb ulcer is a serious complication of diabetes. The association between glycated hemoglobin (HbA1c) and lower limb ulcers needs further clarification. We aimed to comprehensively evaluate the relationship between HbA1c and lower limb ulcer risk in diabetic patients through multivariable-adjusted observational analyses and Mendelian randomization (MR) approaches. <b>Methods:</b> This prospective cohort study included 23,434 individuals with prevalent diabetes in the UK Biobank. The Cox proportional hazard model was used to evaluate the association between HbA1c levels and lower limb ulcer risk. Furthermore, a one-sample MR analysis was conducted to explore the potential causal effect. <b>Results:</b>Over a follow-up period of 290,677 person-years (median length: 13.3 years), 1101 lower limb ulcers cases were documented. The multivariable-adjusted hazard ratios across categories of HbA1c of ≤ 42, 42-53, 53-64, 64-75, 75-86, and > 86 mmol/mol were 0.93 (0.76-1.15), 1.00, 1.24 (1.05-1.46), 1.98 (1.65-2.39), 2.68 (2.13-3.37), and 4.52 (3.62-5.65), respectively. The restrictive cubic spline model showed that lower limb ulcer risk increased steeply when HbA1c concentration exceeded 53 mmol/mol. One-sample linear and nonlinear MR analyses provided a positive but not significant association between genetically proxied HbA1c and lower limb ulcer risk among diabetic patients. <b>Conclusions:</b> High HbA1c levels increase the risk of lower limb ulcers in diabetic patients. MR analyses validated the positive but not significant association between genetically proxied HbA1c levels and lower limb ulcer risk. The results recommended an HbA1c goal of < 53 mmol/mol to decrease the incidence of diabetic ulcers.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"4744194"},"PeriodicalIF":3.6,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11972128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health-Related Quality of Life Among Type 2 Diabetes Patients With Depressive Symptoms in Vietnam.","authors":"Nguyen Tran Kien, Nguyen Phuong Hoa, Ha Huu Tung, Kris Van den Broeck, Johan Wens","doi":"10.1155/jdr/6992121","DOIUrl":"10.1155/jdr/6992121","url":null,"abstract":"<p><p><b>Background:</b> This study investigates the impact of Type 2 diabetes mellitus (T2DM) and depressive symptoms on the health-related quality of life (HRQoL) among patients at the Agricultural General Hospital in Hanoi, Vietnam. The research explores the interconnections between chronic physical conditions and mental health within a resource-constrained healthcare environment. <b>Methods:</b> A cross-sectional survey was conducted with 516 T2DM patients using the SF-36 to assess HRQoL and the PHQ-9 to measure depressive symptoms. The study examined the prevalence of depressive symptoms and their correlation with various HRQoL components. <b>Results:</b> Among the participants, 45.2% exhibited depressive symptoms from mild to severe levels. Significant disparities in HRQoL scores were observed, particularly in physical composite and overall quality of life scores between T2DM with and without depressive symptoms. Statistical analysis highlighted that depressive symptoms significantly diminish HRQoL, with the PHQ-9 scores serving as a robust predictor. <b>Conclusion:</b> The findings underscore the critical need for integrated care approaches that include mental health support for T2DM patients. Routine screening for depressive symptoms should be a component of diabetes management protocols to improve overall patient outcomes. Further longitudinal research is needed to confirm these findings and develop effective interventions.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"6992121"},"PeriodicalIF":3.6,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11971502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of a Health Literacy and Diabetes Self-Management Education (DSME) Improvement Program for People With Type 2 Diabetes Mellitus: A Community-Based Quasiexperimental Study in Thailand.","authors":"Fatima Ibrahim Abdulsalam, Sribud Srichaijaroonpong, Natthida Phoosuwan, Nitikorn Phoosuwan","doi":"10.1155/jdr/2640702","DOIUrl":"10.1155/jdr/2640702","url":null,"abstract":"<p><p><b>Background:</b> This community-based randomised controlled study was aimed at evaluating a health literacy (HL) and diabetes self-management education (DSME) improvement program (HL-DSME program) among people with Type 2 diabetes mellitus. <b>Methods</b>: The program conducted in Sakonnakhon Province in northeastern Thailand comprised 1 day of theory and a 4-week period of follow-up. There were 72 participants (36 participants for each intervention and control group) in the program. Independent <i>t</i>-tests, one-way analysis of variance and, paired-sample <i>T</i>-tests were used to predict HL and self-management scores. <b>Results</b>: The participants in the intervention group increased their total HL score and four dimensions of the HL score significantly in comparison to those in the control group. Total self-management score and the score related to the dimension of exercise behaviour among the participants in the intervention group improved significantly in comparison to those in the control group. <b>Conclusion</b>: The HL-DSME program could increase the total score of HL, scores of four dimensions of HL, the total score of self-management, and the score related to exercise behaviour. Healthcare providers who try to enhance diabetes patients' self-management practices should consider diabetes patients' HL and provide health education regularly. Diabetes management approach should be scalable, efficacious, sustainable, and affordable for patients. <b>Trial Registration:</b> Thai Registry of Clinical Trials: TCTR20241120002.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"2640702"},"PeriodicalIF":3.6,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11957850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Empagliflozin on Serum Ferritin and Its Relationship With Inflammatory Markers in Prediabetic and Diabetic Patients.","authors":"Mojgan Sanjari, Narges Sadeghi, Azade Ramezannezhad, Zohre Safi, Ahmad Naghibzadeh-Tahami, Ladan Amirkhosravi","doi":"10.1155/jdr/8835829","DOIUrl":"10.1155/jdr/8835829","url":null,"abstract":"<p><p><b>Background:</b> This research is aimed at evaluating the effects of the SGLT2 inhibitor empagliflozin on inflammatory markers, some iron metabolism markers, and their interrelationships before and after using empagliflozin. <b>Methods:</b> A quasiexperimental study was conducted on 44 prediabetic and Type 2 diabetic patients aged 18-65 years. The participants were among those treated at the clinic affiliated with Kerman Medical Sciences University between 2022 and 2023. The study included diabetic patients with HbA1c levels of 0.5%-1% higher than the therapeutic target who were not using blood sugar control medication. Each patient received a daily dose of 10 mg of empagliflozin for 3 months. Changes in serum levels of iron, total iron-binding capacity (TIBC), ferritin, transferrin saturation, inflammatory markers IL-6, C-reactive protein (CRP), and uric acid were measured before and 3 months after commencing empagliflozin. <b>Results:</b> Three months after starting empagliflozin, the mean FPG and Hb A1c levels showed a drop (<i>p</i> < 0.05). The serum ferritin level decreased, and TIBC increased significantly (<i>p</i> < 0.05) following empagliflozin treatment. Additionally, the serum levels of CRP (<i>p</i> < 0.05), IL-6 (<i>p</i> < 0.001), and uric acid (<i>p</i> < 0.001) declined. Analysis of the correlation between serum ferritin level and IL-6 and uric acid before and after empagliflozin use revealed a positive correlation between serum ferritin and IL-6 (<i>p</i> = 0.04) and uric acid (<i>p</i> = 0.03). However, no significant correlation was observed between the change in ferritin and CRP levels (<i>p</i> = 0.22). <b>Conclusion:</b> Following empagliflozin treatment, serum levels of ferritin and inflammatory markers interleukin-6, CRP, and uric acid declined, indicating a significant relationship between SGLT2 inhibition, inflammation, and iron metabolism. Furthermore, the correlation between ferritin and inflammatory markers suggests that reduced ferritin levels may result from reduced inflammation. <b>Trial Registration:</b> ClinicalTrials.gov identifier: IRCT20090317001774N10.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"8835829"},"PeriodicalIF":3.6,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application and Progression of Single-Cell RNA Sequencing in Diabetes Mellitus and Diabetes Complications.","authors":"Jiajing Hong, Shiqi Lu, Guohui Shan, Yaoran Yang, Bailin Li, Dongyu Yang","doi":"10.1155/jdr/3248350","DOIUrl":"10.1155/jdr/3248350","url":null,"abstract":"<p><p>Diabetes is a systemic metabolic disorder primarily caused by insulin deficiency and insulin resistance, leading to chronic hyperglycemia. Prolonged diabetes can result in metabolic damage to multiple organs, including the heart, brain, liver, muscles, and adipose tissue, thereby causing various chronic fatal complications such as diabetic retinopathy, diabetic cardiomyopathy, and diabetic nephropathy. Single-cell RNA sequencing (scRNA-seq) has emerged as a valuable tool for investigating the cell diversity and pathogenesis of diabetes and identifying potential therapeutic targets in diabetes or diabetes complications. This review provides a comprehensive overview of recent applications of scRNA-seq in diabetes-related researches and highlights novel biomarkers and immunotherapy targets with cell-type information for diabetes and its associated complications.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"3248350"},"PeriodicalIF":3.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipid Profile Abnormalities in Type 2 Diabetes Mellitus Patients at Mbeya Zonal Referral Hospital, Tanzania: A Retrospective Study.","authors":"Justine Mlonga, Donath Damian","doi":"10.1155/jdr/9966933","DOIUrl":"10.1155/jdr/9966933","url":null,"abstract":"<p><p><b>Introduction:</b> Type 2 diabetes mellitus poses global health challenges due to insulin resistance and hyperglycaemia. Understanding demographic characteristics and lipid profiles among diabetic patients is crucial for effective management and risk reduction. This study analyzes demographic distribution, gender representation, and lipid profile variations among Type 2 diabetes patients at the Mbeya Zonal Referral Hospital, aiming at informing tailored interventions to improve outcomes and mitigate cardiovascular risks associated with dyslipidemia. <b>Methods:</b> This retrospective study analyzed data from 311 Type 2 diabetes patients at the Mbeya Zonal Referral Hospital. Demographic data including age and gender were recorded, and lipid profiles (triglycerides, high-density lipoprotein, and low-density lipoprotein) were assessed using standard clinical measurements. Statistical analyses determined frequency distributions of age groups, gender proportions, and lipid profile categories. Associations between lipid profiles and demographic factors were also examined. <b>Results:</b> The study cohort predominantly consisted of patients aged 60-69 years (35.05%), with females slightly outnumbering males (54.02% vs. 45.98%). Triglyceride levels ≥ 150 mg/dL were observed in 43% of patients, primarily in older age groups. While 72% of patients had high - density lipoprotein levels ≥ 35 mg/dL, this percentage declined with age. Low - density lipoprotein levels ≥ 130 mg/dL were prevalent in 41.77% of patients, indicating a notable proportion with elevated low-density lipoprotein cholesterol. Higher levels of high-density lipoprotein were associated with better glycemic control, as indicated by lower glycated hemoglobin levels (< 6.5%), although the relationship between high-density lipoprotein and cardiovascular outcomes remains unclear. <b>Conclusion:</b> This study reveals significant demographic and lipid profile variations among Type 2 diabetes patients at the Mbeya Zonal Referral Hospital, influenced by aging. Tailored management strategies considering age- and gender-specific trends in lipid profiles could optimize glycemic control and reduce cardiovascular risks associated with Type 2 diabetes, thereby enhancing overall patient outcomes and quality of life.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"9966933"},"PeriodicalIF":3.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetes Screening in the Emergency Department: Development of a Predictive Model for Elevated Hemoglobin A1c.","authors":"Mary H Smart, Janet Y Lin, Brian T Layden, Yuval Eisenberg, A Simon Pickard, Lisa K Sharp, Kirstie K Danielson, Angela Kong","doi":"10.1155/jdr/8830658","DOIUrl":"10.1155/jdr/8830658","url":null,"abstract":"<p><p><b>Aims:</b> We developed a prediction model for elevated hemoglobin A1c (HbA1c) among patients presenting to the emergency department (ED) at risk for diabetes to identify important factors that may influence follow-up patient care. <b>Methods:</b> Retrospective electronic health records data among patients screened for diabetes at the ED in May 2021 was used. The primary outcome was elevated HbA1c (≥ 5.7%). The data was divided into a derivation set (80%) and a test set (20%) stratified by elevated HbA1c. In the derivation set, we estimated the optimal significance level for backward elimination using a 10-fold cross-validation method. A final model was derived using the entire derivation set and validated on the test set. Performance statistics included C-statistic, sensitivity, specificity, predictive values, Hosmer-Lemeshow test, and Brier score. <b>Results:</b> There were 590 ED patients screened for diabetes in May 2021. The final model included nine variables: age, race/ethnicity, insurance, chief complaints of back pain and fever/chills, and a past medical history of obesity, hyperlipidemia, chronic obstructive pulmonary disease, and substance misuse. Adequate model discrimination (C-statistic = 0.75; sensitivity, specificity, and predictive values > 0.70), no evidence of model ill fit (Hosmer-Lemeshow test = 0.29), and moderate Brier score (0.21) suggest acceptable model performance. <b>Conclusion:</b> In addition to age, obesity, and hyperlipidemia, a history of substance misuse was identified as an important predictor of elevated HbA1c levels among patients screened for diabetes in the ED. Our findings suggest that substance misuse may be an important factor to consider when facilitating follow-up care for patients identified with prediabetes or diabetes in the ED and warrants further investigation. Future research efforts should also include external validation in larger samples of ED patients.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"8830658"},"PeriodicalIF":3.6,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11922610/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delving Into the Interaction Between Exercise and Diabetes on Methylation of the FKBP5 Gene.","authors":"Teng-Chi Yang, Jen Pi Tsai, Honda Hsu, Yen-Chung Chen, Yi-Chia Liaw, Shu Yi Hsu, Hao Jan Yang, Yung-Po Liaw","doi":"10.1155/jdr/1162708","DOIUrl":"10.1155/jdr/1162708","url":null,"abstract":"<p><p><b>Objective:</b> FKBP5 is a critical gene involved in regulating the hypothalamic-pituitary-adrenal (HPA) axis and stress response. Aberrant DNA methylation at FKBP5 cytosine-phosphate-guanine (CpG) sites, such as cg22363520 and cg00862770, has been implicated in mental health disorders and metabolic diseases, including Type 2 diabetes. Exercise is a modulator of DNA methylation and metabolic health. This study investigates the interaction between exercise, diabetes, and FKBP5 methylation at cg22363520 and cg00862770 and explores their implications for mental health and disease development. <b>Materials and Methods:</b> FKBP5 methylation levels at cg22363520 and cg00862770 were analyzed in a cohort stratified by diabetes and exercise. Multiple linear regression models assessed the main effects and interactions of exercise and diabetes on FKBP5 methylation, with further stratified analyses for site-specific effects. <b>Results:</b> Exercise and diabetes showed significant and site-specific effects on FKBP5 methylation at cg22363520 and cg00862770. At cg22363520, exercise significantly reduced methylation levels in nondiabetic participants (<i>β</i> = -0.00195, <i>p</i> = 0.0157), while no significant effect was observed in diabetic individuals. Conversely, at cg00862770, exercise significantly decreased methylation levels in diabetic participants (<i>β</i> = -0.00611, <i>p</i> = 0.0081), with no significant effect in the nondiabetic group. Diabetes itself was associated with increased FKBP5 methylation at both sites, particularly in individuals without regular exercise. Additionally, significant interaction effects between exercise and diabetes were identified for both cg22363520 (<i>p</i> = 0.0336) and cg00862770 (<i>p</i> = 0.0021), highlighting the interplay between metabolic status and physical activity in regulating FKBP5 methylation. <b>Conclusion:</b> This study demonstrates that the effects of exercise on FKBP5 methylation are site-specific and influenced by diabetes status. Exercise reduces methylation at cg22363520 in nondiabetics and at cg00862770 in diabetics, indicating its role in modulating epigenetic regulation of stress and metabolic pathways. These findings underscore the interplay between exercise, diabetes, and FKBP5 methylation, with potential implications for improving mental health and metabolic outcomes.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"1162708"},"PeriodicalIF":3.6,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11865466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Value of Glycemic Gap for Predicting Mortality in ICU in Patients With and Without Diabetes.","authors":"Ran Lou, Li Jiang, Meiping Wang, Tingting Wang, Quan Si, Weixue Su, Nan Wang, Yuyan Liu, Ting Chen, Qi Jiang, Bo Zhu","doi":"10.1155/jdr/4563928","DOIUrl":"10.1155/jdr/4563928","url":null,"abstract":"<p><p><b>Objective:</b> Dysglycemia is associated with poor outcomes; the actual status of dysglycemia of critically ill patients with diabetes should refer to background glycemia. We investigated the effect of difference between mean blood glucose and basic blood glucose upon outcomes. <b>Methods:</b> Glycated hemoglobin A1c (HbA1c) was detected within the first 24 h and converted to A1C-derived average glucose (ADAG) by the equation ADAG = [(HbA1c∗28.7) - 46.7]∗18^-1; blood glucose measurements were fourth per day during the first 7 days after admission; the mean blood glucose level (Mean), standard deviation (SD), and coefficient of variation (CV) were calculated. GAP were calculated as admission blood glucose and Mean minus ADAG, respectively. <b>Results:</b> Six hundred forty-nine patients were recruited and 428 survived at 28 days; 302 patients with diabetes had greater ADAG, blood glucose at admission (BG_adm), Mean, SD, CV, GAP, and hypoglycemia incidences. The GAP between Mean and ADAG had superior predictive power, which was decreased in patients with diabetes and increased in patients without diabetes. GAP7 was related to 28-day mortality; the death risk was decreased in patients with diabetes. Patients with lower GAP tended to survive. Nonsurvivors with diabetes suffered higher rate of hypoglycemia than survivors which was the opposite in patients without diabetes. <b>Conclusion:</b> The glycemic GAP between the mean level of blood glucose within the first 7 days in ICU and ADAG was independently associated with 28-day mortality of critically ill patients, which was different between patients with and without diabetes. Hypoglycemia in patients with diabetes should be a concern.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"4563928"},"PeriodicalIF":3.6,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Should I Take Prediabetes Seriously or Not: A Qualitative Study on People's Perceptions of Prediabetes.","authors":"Katri Harcke, Marit Graue, Timothy Charles Skinner, Christina B Olsson, Dan Grabowski, Nouha Saleh-Stattin","doi":"10.1155/jdr/8063481","DOIUrl":"10.1155/jdr/8063481","url":null,"abstract":"<p><p>It is critical to ensure that lifestyle change programs are tailored to the person with prediabetes needs and wishes. However, programs that are carried out in research settings to delay or prevent Type 2 diabetes in people with prediabetes do not translate easily to everyday settings. There is a need to explore further the perceptions of people with prediabetes about the condition and their role in self-management to better balance the content of intervention programs for prediabetes with the participants' life context and experience. For this purpose, we invited 21 persons with prediabetes from four primary healthcare centers in Region Stockholm, Sweden, for individual interviews. Transcripts were analyzed with qualitative content analysis. Two main themes were identified, <i>prediabetes: a condition between health and disease</i> and <i>I must manage prediabetes myself but need support</i>. This in-between state has a serious impact on the decisions that people with prediabetes make concerning self-management and behavioral changes. One of the main findings of this study highlights the importance of communicating the diagnosis of prediabetes clearly and the importance of preventive actions as this can trigger behavioral change. People with prediabetes in our study shed light on different needs for support to make and maintain behavioral change which requires a person-centered approach. This support was described internally, from family and peers, or externally from healthcare professionals. These results will be used in a codesign study where healthcare professionals and persons with prediabetes discuss the components of a person-centered model for a behavioral change intervention in primary healthcare.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"8063481"},"PeriodicalIF":3.6,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11839257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}