Journal of Diabetes Research最新文献

{"title":"Assessing Diabetic Polyneuropathy Prevalence in Hospitalized Patients: A Comparative Study Using the Michigan Self-Report Questionnaire and Physical Examination Methods.","authors":"Parastoo EsnaAshari, Elaheh Mianehsaz, Maryam Afarini, Mohammad Javad Azadchehr","doi":"10.1155/jdr/7027972","DOIUrl":"10.1155/jdr/7027972","url":null,"abstract":"<p><p><b>Background:</b> Chronic complications of diabetes, such as diabetic polyneuropathy (DPN), are major contributors to disability and mortality among diabetic patients. Effective screening for DPN is crucial to prevent severe complications, including limb amputation. This study was aimed at assessing the prevalence of DPN among hospitalized diabetic patients using both self-report (Michigan questionnaire) and physical examination methods and at evaluating the level of agreement between these two screening approaches. <b>Methods:</b> This cross-sectional study included 158 adult diabetic patients admitted to Shahid Beheshti Hospital in Kashan, Iran, between April and September 2023. Patients were screened for DPN using the Michigan self-report questionnaire and physical examination. Sociodemographic and clinical data were collected through patient interviews and medical records. Random sampling was used to ensure representativeness. Data analysis was conducted using SPSS Version 26, applying descriptive and inferential statistics. Cohen's kappa statistic was used to assess the level of agreement between the two screening methods. The validity and reliability of the assessment tools were confirmed through previous studies. <b>Results:</b> The study found a moderate agreement between the physical examination and the Michigan self-report questionnaire in diagnosing DPN (<i>κ</i> = 0.486, <i>p</i> < 0.001). The overall prevalence of DPN, based on the agreement of both methods, was 64.6%. The prevalence was 75.9% based on physical examination and 72.8% based on the questionnaire. <b>Conclusions:</b> This study found a high prevalence of DPN among hospitalized diabetic patients, highlighting the urgent need for effective screening methods. The moderate agreement between the Michigan questionnaire and physical examination suggests that the questionnaire could serve as a simple, cost-effective tool for early DPN detection. Further research and wider implementation of these screening tools may enhance early diagnosis and help reduce the risk of severe complications, such as limb amputation.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"7027972"},"PeriodicalIF":3.6,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12168654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"sFlt-1/PlGF Ratio in the Prediction of Preeclampsia in Pregnant Women With Diabetic Kidney Disease.","authors":"Jakub Kornacki, Ewa Wender-Ozegowska, Daniel Boroń, Urszula Mantaj, Przemysław Wirstlein, Paweł Gutaj","doi":"10.1155/jdr/3987453","DOIUrl":"10.1155/jdr/3987453","url":null,"abstract":"<p><p><b>Objectives:</b> The objective of the study is to evaluate the potential role of the sFlt-1/PlGF ratio in predicting preeclampsia (PE) in pregnant women with diabetic kidney disease (DKD) during the second and third trimesters of pregnancy. <b>Study Design:</b> This study included 102 patients with DKD. All participants had a history of pregestational diabetes of at least 20 years' duration and/or onset before the age of 10 or pregestational diabetes complicated by hypertension or diabetic retinopathy (classified as D, R, or F according to White's classification). All patients exhibited elevated urinary protein loss (30-299 mg/24 h) or overt proteinuria (≥ 300 mg/24 h) during the first trimester of pregnancy. All participants were treated with intensive insulin therapy, either via multiple daily insulin injections (MDIs) or continuous subcutaneous insulin infusion (CSII). Serum levels of sFlt-1, PlGF, and the sFlt-1/PlGF ratio were assessed at both the 20th and 30th weeks of gestation. <b>Main Outcome Measures:</b> The serum levels of sFlt-1, PlGF, and the sFlt-1/PlGF ratio during the second and third trimesters were compared between women who developed PE and a control group without PE. <b>Results:</b> In DKD patients who developed PE, serum sFlt-1 levels were significantly higher, while PlGF levels were significantly lower, compared to those who did not develop PE. The sFlt-1/PlGF ratio was also markedly elevated in the PE group compared to controls during both the second and third trimesters. Increased sFlt-1 levels, decreased PlGF levels, and an elevated sFlt-1/PlGF ratio were significant predictors of PE development at both 20 and 30 weeks of gestation. The sFlt-1/PlGF ratio demonstrated a sensitivity of 72.7% and specificity of 75.7% at 20 weeks (sFlt-1/PlGF cut-off > 10.1) and a sensitivity of 84.6% and specificity of 82.0% at 30 weeks for predicting PE (sFlt-1/PlGF cut-off > 37). The positive predictive values were 47.1% and 50.0%, while the negative predictive values were 90.3% and 96.0% at 20 and 30 weeks, respectively. <b>Conclusions:</b> The assessment of antiangiogenic and proangiogenic markers, particularly the sFlt-1/PlGF ratio, appears to be a valuable tool for predicting PE in patients with long-lasting diabetes complicated by DKD.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"3987453"},"PeriodicalIF":3.6,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12165755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Glycemic Control of Pay-for-Performance Program for Psychiatric Patients With Diabetes in Real World: A Retrospective Quasiexperimental Study.","authors":"Chin-Chou Yang, Wen-Chen Ouyang, Tsuo-Hung Lan, Yee-Yung Ng, Shiao-Chi Wu","doi":"10.1155/jdr/9660739","DOIUrl":"10.1155/jdr/9660739","url":null,"abstract":"<p><p><b>Background:</b> Psychiatric patients with Type 2 diabetes often experience suboptimal care and poor health outcomes. <b>Aims:</b> This study is aimed at investigating the impact of a diabetes pay-for-performance (P4P) program on glycemic control in psychiatric patients with diabetes by comparing two regional psychiatric hospitals, one with the P4P program and one without. <b>Methods:</b> We conducted a retrospective quasiexperimental study. A total of 149 psychiatric outpatients with Type 2 diabetes were enrolled in the P4P group, and 129 patients were in the non-P4P group. Hemoglobin A1c (HbA1c) values in the fourth quarter of 2018 served as baseline (before P4P implementation in either hospital). Follow-up HbA1c levels were collected at 3, 6, 9, and 12 months in 2019. Propensity score matching was performed based on baseline HbA1c to create comparable groups. Changes in HbA1c over 1 year were analyzed using paired and independent <i>t</i>-tests and a generalized estimating equation (GEE) model. <b>Result:</b> The mean HbA1c level in the P4P group decreased progressively over 12 months (from 6.97% at baseline to 6.60%), whereas the non-P4P group showed an increase (from 7.00% to 7.12%). By the fourth quarter, the P4P group had a significantly lower mean HbA1c than the non-P4P group (<i>p</i> < 0.05). Subgroup analysis showed a greater HbA1c reduction in P4P participants who were male or had schizophrenia (<i>p</i> = 0.01 and <i>p</i> = 0.04, respectively). <b>Conclusions:</b> The P4P program was associated with significantly improved glycemic control in psychiatric patients with diabetes compared to usual care. This integrated care model may be an effective strategy to improve diabetes outcomes in psychiatric populations.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"9660739"},"PeriodicalIF":3.6,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12158592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patients With Type 2 Diabetes Are at Greater Risk of Developing New Hypertension and Chronic Kidney Disease Following COVID-19.","authors":"Justin Y Lu, Shiv Mehrotra-Varma, Stephen H Wang, Montek Singh Boparai, Sonya Henry, Jai Mehrotra-Varma, Tim Q Duong","doi":"10.1155/jdr/8816198","DOIUrl":"10.1155/jdr/8816198","url":null,"abstract":"<p><p><b>Background:</b> The purpose of this study was to test the hypothesis that COVID-19 status increases the incidence of new hypertension (HTN) and chronic kidney disease (CKD) in patients with Type 2 diabetes (T2D). <b>Methods:</b> This retrospective study consisted of 46,448 patients with T2D from the Montefiore Health System in the Bronx (3/01/2020-7/01/2023), of which 13,801 had a positive COVID-19 test on record. Contemporary controls included those hospitalized for other lower respiratory tract infections (LRTIs) (<i>n</i> = 1638) and nonhospitalized patients without COVID-19 or LRTI (<i>n</i> = 31009). Outcomes were assessed at follow-up (2 months to 3 years) relative to baseline. Adjusted hazards ratios (aHRs) with 95% confidence interval (CI) were computed. <b>Results:</b> The cumulative incidences of HTN (22.32% vs. 9.13%, <i>p</i> < 0.001) and CKD (6.20% vs. 2.03%, p <0.001) were significantly higher in nonhospitalized COVID-19 compared to non-COVID-19 patients, but not between patients hospitalized for COVID-19 and LRTI (<i>p</i> > 0.05). Nonhospitalized COVID-19 patients had higher risk of developing HTN compared to non-COVID patients during all follow-up (aHR 1.99, 95% CI [1.54, 2.57], <i>p</i> < 0.001), but hospitalized COVID-19 patients had similar risk of developing HTN relative to patients hospitalized for LRTI (aHR 1.26 [0.70, 2.27], <i>p</i> = 0.441). Nonhospitalized COVID-19 patients had higher risk of developing CKD compared to non-COVID patients during all follow-up (aHR 2.09 [1.69, 2.76], <i>p</i> < 0.001), but hospitalized COVID-19 patients had similar risk of developing CKD relative to patients hospitalized for LRTI (aHR 0.96 [0.79, 1.36], <i>p</i> = 0.131). <b>Conclusions:</b> T2D patients with COVID-19 were at higher risk of developing new disorders compared with COVID-19-negative controls and were at similar risk compared with those hospitalized for other LRTIs.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"8816198"},"PeriodicalIF":3.6,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12158568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Heart Rate Variability in People With Diabetes-Related Neuropathic Foot to Their Counterparts Without a Foot Ulcer History: A Propensity Score Matching Study.","authors":"Murong Wu, Shuang Lin, Yan Liu, Dawei Chen, Xingwu Ran, Chun Wang, Lihong Chen, Sen He, Donge Yan, Mingxin Bai, Yingying Dong, Wen Wang, Zhiyi Lei, Yun Gao","doi":"10.1155/jdr/3349391","DOIUrl":"10.1155/jdr/3349391","url":null,"abstract":"<p><p><b>Background:</b> The reasons that individuals with diabetic foot ulceration (DFU) have higher cardiovascular mortality than those with Type 2 diabetes mellitus (T2DM) but without DFU remain controversial. We aimed to compare the differences in cardiac autonomic function between individuals with neuropathic DFU and their counterparts without DFU. <b>Methods:</b> Three hundred and sixty-two participants with T2DM (181 with DFU and 181 without DFU) who were free of peripheral artery disease (PAD) were included in the final analysis after propensity score matching (PSM). All individuals underwent a 24-h ECG Holter and used the following indices of heart rate variability (HRV) to assess cardiac autonomic function: the standard deviation of the normal sinus interval (SDNN), the root mean square of successive RR interval differences (rMSSD), the standard deviation of the 5-min average RR intervals (SDANN), the percentage of normal adjacent RR interval difference > 50 ms (PNN50), the low-frequency power (LF), the high-frequency power (HF), and the LF/HF ratio. <b>Results:</b> Individuals with DFU had lower SDNN, LF/HF, PNN50, rMSSD, HF, SDANN, and LF than their counterparts without DFU (all <i>p</i> < 0.05). Individuals with DFU had a 2.5-fold increase in severe impairment of cardiac autonomic modulation (i.e., SDNN < 50 ms) compared to those without DFU (21.6% vs. 8.8%, <i>p</i> < 0.001). DFU was independently and negatively associated with all the abovementioned HRV measures (all <i>p</i> < 0.05). <b>Conclusion:</b> Among people with neuropathic diabetic foot only, cardiac autonomic function was still more severely impaired in individuals with DFU than in their counterparts without DFU. <b>Trial Registration:</b> CHiCTR2300076628.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"3349391"},"PeriodicalIF":3.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12143952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychosocial Factors Associated With Medication Burden Among Patients With Type 2 Diabetes Mellitus: A Cross-Sectional Study.","authors":"Minh Hoang Le, Ngoc Diem Le, Thi Thuy Nhu Le, Minh Cuong Nguyen, Van De Tran","doi":"10.1155/jdr/8885209","DOIUrl":"10.1155/jdr/8885209","url":null,"abstract":"<p><p><b>Background:</b> Previous research has focused largely on sociodemographic, clinical, and medication-use characteristics, overlooking the critical role psychosocial factors may play in influencing the medication-related burden among patients with Type 2 diabetes mellitus. <b>Objectives:</b> The aim of this study was to explore the psychosocial factors associated with medication burden among patients with Type 2 diabetes mellitus. <b>Methods:</b> A cross-sectional study was performed on 261 patients with Type 2 diabetes from four community health stations in Can Tho, Vietnam. Linear regression models were used to identify demographic and health factors, as well as psychosocial factors, including medication self-efficacy, medication social support, satisfaction with medication treatments, depression, and medication beliefs that are related to medication burden. <b>Results:</b> The presence of dyslipidemia (<i>β</i> = 0.15, <i>p</i> = 0.002) and depression (<i>β</i> = 0.21, <i>p</i> < 0.001) and a stronger belief in the necessity of medication (<i>β</i> = 0.41, <i>p</i> < 0.001) were significantly associated with increased medication-related burden. Conversely, higher education (<i>β</i> = -0.16, <i>p</i> = 0.002), a greater number of family members (<i>β</i> = -0.25, <i>p</i> < 0.001), and higher medication self-efficacy (<i>β</i> = -0.21, <i>p</i> < 0.001) were significantly associated with a reduction in medication-related burden. <b>Conclusion:</b> Psychosocial factors were found to be associated with medication burden among patients with Type 2 diabetes. These findings highlight the importance of psychosocial factors in managing medication burden. Future interventions should focus on these factors to reduce the medication burden and improve the quality of life for patients with Type 2 diabetes.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"8885209"},"PeriodicalIF":3.6,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12140820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Type 2 Diabetes in Taiwan: Unmasking Influential Factors Through Advanced Predictive Modeling.","authors":"Shih-Tsung Chang, Ying-Hsiang Chou, Oswald Ndi Nfor, Ji-Han Zhong, Chien-Ning Huang, Yung-Po Liaw","doi":"10.1155/jdr/5531934","DOIUrl":"10.1155/jdr/5531934","url":null,"abstract":"<p><p><b>Background:</b> Type 2 diabetes (T2D) is influenced by lifestyle, genetics, and environmental conditions. By utilizing machine learning techniques, we can enhance the precision of T2D risk prediction by analyzing the complex interactions among these variables. This study was aimed at identifying and predicting key variables linked to T2D within the Taiwanese population. <b>Methods:</b> The study included 3623 individuals with T2D and 14,492 without. Data on lifestyle and anthropometric measures were obtained from the Taiwan Biobank. Statistical analyses were performed using Base SAS software and SAS Viya. <b>Results:</b> Traditional models identified body mass index (BMI) and waist-hip ratio (WHR) as significant risk factors for T2D, with odds ratios (OR) of 1.10 (95% confidence interval (CI) 1.09-1.12) and 1.10 (95% CI 1.09-1.11), respectively. These variables remained crucial in predictive models, with the WHR being the most influential. In the overall population, BMI's relative importance was 0.57, differing by gender (0.23 in men and 0.62 in women). While cigarette smoking and certain genetic variants (<i>CDKAL1</i>, <i>SLC30A8</i>, <i>CDKN2B</i>, <i>KCNQ1</i>, <i>HHEX</i>, <i>and TCF7L2</i>) were significant in traditional models, their importance decreased in predictive models. <b>Conclusions:</b> Among various factors, the WHR emerged as the most critical attribute for T2D, underscoring the complexity of T2D etiology. Overall, the random forest and ensemble classifiers emerge as the most effective models, especially in mixed and female categories, highlighting their robustness in predictive performance.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"5531934"},"PeriodicalIF":3.6,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12133368/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations Between Self-Stigma and Health Promotion Behaviors in Overweight/Obese Patients With Type 2 Diabetes: A Cross-Sectional Study.","authors":"Shilian Niu, Rao Li, Li Yuan, Dan Huang","doi":"10.1155/jdr/9142949","DOIUrl":"10.1155/jdr/9142949","url":null,"abstract":"<p><p><b>Background:</b> Patients experiencing stigma are more prone to engage in unhealthy behaviors. The correlation between stigma and health-promoting behaviors in overweight/obese T2DM patients is unclear. Therefore, this study aimed to investigate the association between the two in this particular population. <b>Methods:</b> This cross-sectional study, conducted from July 2022 to July 2023 at the Department of Endocrinology and Metabolism of a tertiary general hospital in Chengdu, Sichuan Province, China, used convenience sampling to enroll overweight/obese T2DM patients. A structured questionnaire was used to obtain information on sociodemographic and clinical characteristics. Respondents were assessed for stigma and health-promoting behaviors using the SSCI and T2DHPS scales. Data were analyzed using SPSS version 27.0, with a significance level of <i>p</i> < 0.05. <b>Results:</b> The majority was males (64%). The average BMI of patients was 27.27 ± 3.11 (kg/m²), and the average HbA1c was 8.36 ± 1.81 (mmol/mol). The overall stigma score of overweight/obese T2DM patients was 4.19 ± 8.69, and the overall health-promoting behaviors score was 87.75 ± 16.75. Pearson correlation analysis revealed a significant correlation between stigma and the overall score of health promotion behaviors (<i>r</i> = -0.144, <i>p</i> < 0.05). The multiple linear regression analysis showed that the hypoglycemia incidence, patient origin, GLP-1RA use, and stress management explained 23.9% of the patients' feelings of stigma. <b>Conclusions:</b> This study found that there was a correlation between the level of stigma and health-promoting behaviors in overweight/obese patients with T2DM. Hypoglycemia, inpatient, GLP-1RA treatment, and stress management significantly predicted stigma among overweight/obese patients. These findings have implications for healthcare providers, as they can develop intervention strategies by assessing the levels of stigma and stress management in overweight/obese patients with T2DM, to help reduce stigma and promote healthy behaviors among these patients.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"9142949"},"PeriodicalIF":3.6,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12129618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do the Interactions Between Type 1 Diabetes and Work Support Self-Management? A Best-Evidence Synthesis.","authors":"Emma Victoria Shiel, Kim Burton, Steve Hemingway","doi":"10.1155/jdr/5523829","DOIUrl":"10.1155/jdr/5523829","url":null,"abstract":"<p><p>Work can be challenging for people with Type 1 diabetes, in part due to difficulties around workplace self-management. What is unclear is the level of accommodation needed, and the type of support required, for effective self-management. To understand the interactions between work and Type 1 diabetes, a best-evidence synthesis of the available grey and peer-reviewed literature was conducted. Twenty-eight articles were included for thematic analysis. Three themes were formulated: (1) How work can be challenging for people with T1D, (2) how work can be beneficial for people with T1D, and (3) influence of policy and legislation. The interactions between Type 1 diabetes and work can hinder self-management. Work-related diabetes distress, concealment, stigma, lack of action space, and work-related intentional hyperglycaemia were reported concerns. Legislation and workplace policy around sickness and disability seem to be relatively inflexible and do not readily accommodate the needs of people with Type 1 diabetes. Conversely, work has acknowledged benefits for health and well-being, indicating a need to facilitate workplace accommodation for people with Type 1 diabetes. Current workplaces do not provide optimal support and accommodation for self-management of Type 1 diabetes. Future research should explore interventions that engage workers in their diabetes management, emphasising individual differences and empowerment. Moving forward, fostering collaborative approaches between the key actors, including managers, human resources, occupational health, and workers with Type 1 diabetes, could be important.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"5523829"},"PeriodicalIF":3.6,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Role of CD99 Signaling Pathway in Schwann Cell Dysfunction in Diabetic Foot Ulcers Based on Single-Cell Transcriptome Analysis.","authors":"Yannan Zhou, Yaxin Zhou, Haohan Chen, Li Zhang, Siwei Bi","doi":"10.1155/jdr/9935400","DOIUrl":"10.1155/jdr/9935400","url":null,"abstract":"<p><p><b>Background:</b> Schwann cell (SC) dysfunction contributes to the delayed healing of diabetic foot ulcers (DFUs). However, the underlying molecular mechanism regarding the unregulated SC function is poorly understood. Thus, we examined the single-cell transcriptome data from different DFU states focusing on SC characteristics. <b>Methods:</b> The single-cell RNA sequencing (scRNA-seq) data of DFU was obtained from the Gene Expression Omnibus (GEO) database, covering foot skin samples from nondiabetic patients, diabetic patients without DFU, DFU healers, and DFU nonhealers. After scRNA-seq data processing, downscaling, and cell cluster identification, cell communication analysis was performed by the CellChat package. Furthermore, we subclustered SC populations and ran the trajectory inference and pseudotime analysis to investigate the dynamic changes in SC. Finally, the significant pathways were validated with a <i>db/db</i> mouse wound model. <b>Results:</b> scRNA-seq analysis revealed different SC percentages and gene markers across the DFU groups. We identified that the CD99 signaling pathway was upregulated in the DFU nonhealer group. In the <i>db/db</i> mouse wound model, we observed that CD99 was highly expressed in the demyelinated area of the peripheral nerve fibers. <b>Conclusion:</b> Our study elucidated that the CD99 pathway activation may play a crucial role in SC dysfunction of DFU, providing insights into the peripheral glia regulation mechanism and potential therapeutic target of DFU.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"9935400"},"PeriodicalIF":3.6,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}