Correlation Between Blood Glucose Variability Indices Using Continuous Glucose Monitoring in Gestational Diabetes Patients and Abnormal Glucose Levels 42 Days Postpartum.

IF 3.4 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Journal of Diabetes Research Pub Date : 2025-07-14 eCollection Date: 2025-01-01 DOI:10.1155/jdr/1021066
Rui Wang, Yuping Zhang, Huiqian Zeng, Jinyan Xiao, Mingming Qi, Lei Bao, Ruifen Jiao, Jing Liu, Yichun Li, Shuli He, Yunlong Li, Rui Li, Fan Ping, Yanping Liu
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Abstract

Objective: This study was aimed at analyzing the impact of blood glucose variability (GV) in gestational diabetes mellitus (GDM) patients on glucose outcomes 42 days postpartum and pregnancy outcomes. Additionally, it explored differences between various GV indices and evaluated their predictive values. Methods: This retrospective study included 75 pregnant women diagnosed with GDM. Continuous glucose monitoring (CGM) was initiated postdiagnosis, and outcomes were followed up. Oral glucose tolerance tests (OGTTs) were conducted 42 days postpartum to assess glucose response. Results: A total of 75 patients were included, among whom 8 (10.67%) exhibited impaired fasting glucose (IFG) and 7 (9.33%) impaired glucose tolerance (IGT) in the 42-day postpartum OGTT. No cases of diabetes were diagnosed. The results of the postpartum OGTT were significantly correlated with various GV indexes. In multivariate analysis, LBGI (OR: 1.437; 95% CI: 1.015-2.035; p = 0.041), M value (OR: 1.215; 95% CI: 1.030-1.434; p = 0.021), and TBR% (OR: 1.138; 95% CI: 1.020-1.271; p = 0.021) independently influenced IFG. Receiver operating characteristic (ROC) analysis indicated areas under the curve (AUCs) of 0.877 (95% CI: 0.760~0.994), 0.853 (95% CI: 0.730~0.975), 0.869 (95% CI: 0.748~0.991), and 0.793 (95% CI: 0.622~0.963) of IFG prediction model performance of TBR%, LBGI, M value, and HbA1c% combined with age, BMI, and family history of diabetes, respectively. Conclusion: Blood GV is an independent factor influencing IFG 42 days postpartum in GDM women, especially with hypoglycemia. It can increase the predictive efficiency of the postpartum abnormal blood glucose prediction model. Trial Registration: Chinese Clinical Trial Registry number: ChiCTR2100054833.

妊娠期糖尿病患者连续血糖监测血糖变异性指标与产后42天血糖异常的相关性
目的:本研究旨在分析妊娠期糖尿病(GDM)患者血糖变异性(GV)对产后42天血糖结局及妊娠结局的影响。此外,还探讨了各种GV指数之间的差异,并评价了它们的预测价值。方法:本回顾性研究纳入75例诊断为GDM的孕妇。诊断后开始持续血糖监测(CGM),并随访结果。产后42天进行口服葡萄糖耐量试验(ogtt)以评估血糖反应。结果:共纳入75例患者,其中8例(10.67%)在产后42天OGTT中出现空腹血糖(IFG)受损,7例(9.33%)出现糖耐量(IGT)受损。没有诊断出糖尿病病例。产后OGTT结果与GV各项指标均有显著相关。在多变量分析中,LBGI (OR: 1.437;95% ci: 1.015-2.035;p = 0.041), M值(OR: 1.215;95% ci: 1.030-1.434;p = 0.021), TBR% (OR: 1.138;95% ci: 1.020-1.271;p = 0.021)独立影响IFG。受试者工作特征(ROC)分析显示,结合年龄、BMI、糖尿病家族史,TBR%、LBGI、M值、HbA1c%的IFG预测模型性能曲线下面积(aus)分别为0.877 (95% CI: 0.760~0.994)、0.853 (95% CI: 0.730~0.975)、0.869 (95% CI: 0.748~0.991)、0.793 (95% CI: 0.622~0.963)。结论:血GV是影响GDM妇女产后42天IFG的独立因素,尤其是低血糖患者。可提高产后血糖异常预测模型的预测效率。试验注册:中国临床试验注册号:ChiCTR2100054833。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Diabetes Research
Journal of Diabetes Research ENDOCRINOLOGY & METABOLISM-MEDICINE, RESEARCH & EXPERIMENTAL
CiteScore
8.40
自引率
2.30%
发文量
152
审稿时长
14 weeks
期刊介绍: Journal of Diabetes Research is a peer-reviewed, Open Access journal that publishes research articles, review articles, and clinical studies related to type 1 and type 2 diabetes. The journal welcomes submissions focusing on the epidemiology, etiology, pathogenesis, management, and prevention of diabetes, as well as associated complications, such as diabetic retinopathy, neuropathy and nephropathy.
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