Journal of Diabetes Research最新文献

{"title":"Study on the Correlation Between GDF-15 Levels and a Diagnostic Model for Diabetic Retinopathy.","authors":"Xue-Nan Lian, Xian-Ling Zheng, Ming-Ming Zhu, Zong-Hu Li","doi":"10.1155/jdr/6959604","DOIUrl":"10.1155/jdr/6959604","url":null,"abstract":"<p><p><b>Background and Purpose:</b> Diabetic retinopathy (DR) is a chronic complication that affects approximately one-third of individuals with diabetes and represents a serious threat to vision. In recent years, increasing attention has been given to biomarkers and cytokines related to inflammation for their roles in disease mechanisms. This study is aimed at investigating the association between growth differentiation factor-15 (GDF-15) and the risk of DR in Handan, China, and developing a predictive model based on patients' clinical characteristics. <b>Methods:</b> Between January and July 2024, patients with Type 2 diabetes mellitus (T2DM) treated at Handan Central Hospital were enrolled and classified into two groups: 74 patients without DR (NDR) and 79 with DR. Stepwise regression was used to select variables, and a logistic regression model was constructed to predict the risk of DR. Additionally, 17 healthy individuals (control group, CG) were included to explore GDF-15 distribution across different populations. <b>Results:</b> Compared to the NDR group, patients with DR showed significantly lower levels of HB, ALB, CO₂, and 2h-CP and considerably higher levels of DvT, UREA, HDL-C, ApoA-1, and GDF-15. A logistic regression model incorporating six key variables-ALB, ApoA-1, CO₂, DvT, 2h-CP, and GDF-15-was developed, yielding an accuracy of 0.936 (95% CI: [0.786, 0.992]), which outperformed the model based solely on GDF-15. Comparison among the three groups showed that GDF-15 levels were highest in the DR group and increased progressively with diabetes severity. <b>Conclusion:</b> GDF-15 levels are significantly associated with the presence and progression of DR. The logistic regression model demonstrates high predictive value, suggesting that GDF-15 may serve as a promising biomarker for the early diagnosis and intervention of DR.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"6959604"},"PeriodicalIF":3.4,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12463507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of the Online Interactive Podcast Program \"Living With Type 1 Diabetes to Grown-Up\": A Two-Arm Randomized Controlled Trial Protocol.","authors":"Yueh-Tao Chiang, Fu-Sung Lo, Hsing-Yi Yu, Chi-Wen Chen, Philip Moons","doi":"10.1155/jdr/4866975","DOIUrl":"10.1155/jdr/4866975","url":null,"abstract":"<p><p><b>Aim:</b> The aim was to design a study protocol for evaluating the efficacy of an interactive podcast program to assist Type 1 diabetes patients transitioning from adolescence to young adulthood. <b>Design:</b> The study design is a parallel 1:1 two-arm randomized controlled trial emphasizing treatment fidelity through standardized interventions and improved adherence to reduce biases in outcomes. <b>Methods:</b> This theoretical-based study will be conducted at two medical centers in northern Taiwan, enrolling 88 participants. Participants will be randomly assigned to either the experimental group, receiving the interactive podcast program \"Living With Type 1 Diabetes to Grown-Up,\" or the active control group, receiving the e-book \"Transitioning from Adolescence to Early Adulthood: The Ins and Outs of Type 1 Diabetes.\" The 3-month intervention will release 36 podcast episodes at a rate of three per week. Data will be collected at baseline, postintervention, and at 3 and 6 months postintervention to evaluate the efficacy of the intervention on disease control outcomes, emotional distress, diabetes knowledge, self-care behaviors, self-management confidence, interpersonal distress, and family conflict. <b>Conclusion:</b> This first evidence-based, rigorously designed podcast program will offer valuable guidelines for future interventions aimed at helping adolescents with Type 1 diabetes transition to adulthood. <b>Impact:</b> This study's positive findings could support podcasts as an innovative tool for helping adolescents with Type 1 diabetes transition to young adulthood. Additionally, it may provide valuable insights for future research and health policymakers, potentially transforming diabetes management approaches. <b>Reporting Method:</b> The authors adhered to CONSORT guidelines to ensure transparency and reliability. <b>Patient or Public Contribution:</b> There is no patient or public contribution. <b>This Paper Contributes to the Wider Global Clinical Community:</b> This paper provides an evidence-based framework for using podcasts to support self-management and well-being in adolescents with Type 1 diabetes and offers insights for future digital health strategies. <b>Trial Registration:</b> ClinicalTrials.gov identifier: NCT06464640.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"4866975"},"PeriodicalIF":3.4,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12450109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of HbA1c and OGTT Results in Obese and Morbidly Obese Patients: A Single-Center Evaluation From an Obesity Clinic.","authors":"Banu Açmaz, Sami Bahçebaşı, Erdem Aydın, Şeyma Yıldız, İrem Biçer","doi":"10.1155/jdr/9933219","DOIUrl":"10.1155/jdr/9933219","url":null,"abstract":"<p><p><b>Introduction:</b> Obesity, particularly morbid obesity, is associated with significant metabolic alterations such as insulin resistance and compensatory hyperinsulinemia. These pathophysiological changes may influence the performance and interpretation of glycemic diagnostic tools, including the oral glucose tolerance test (OGTT) and glycated hemoglobin (HbA1c). This study is aimed at comparing the diagnostic profiles of OGTT and HbA1c across BMI categories, with a specific focus on morbid obesity and the potential role of elevated insulin levels in test discrepancies. <b>Materials and Methods:</b> This retrospective study included 1031 patients who were classified into nonobese, obese, and morbidly obese groups based on body mass index (BMI). All participants underwent assessment of glycemic status, lipid profile, and related metabolic parameters. <b>Results:</b> Of the study population, 86.8% were female. Based on BMI classification, 56.5% were obese, 35.8% morbidly obese, and 7.8% nonobese. The prevalence of dysglycemia (prediabetes + diabetes) was 43.1% according to HbA1c and 30.9% according to OGTT. Dysglycemia was significantly more frequent in the morbidly obese group by HbA1c (<i>p</i> < 0.001), while OGTT showed no significant intergroup difference (<i>p</i> = 0.117). The agreement between methods was low (<i>κ</i> = 0.326). HbA1c, insulin, HOMA-IR, CRP, and triglyceride levels increased with BMI. Insulin-related parameters were higher among HbA1c-defined dysglycemic individuals. <b>Discussion:</b> HbA1c may be more sensitive in identifying early metabolic disturbances, particularly during the compensatory phase involving hyperinsulinemia. Elevated insulin levels may attenuate glucose response during OGTT, potentially reducing its diagnostic sensitivity.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"9933219"},"PeriodicalIF":3.4,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12425632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Body Roundness Index and Diabetic Kidney Disease in Patients With Type 2 Diabetes Mellitus: A Population-Based Study.","authors":"Mengdie Chen, Yiyun Wang, Ping Feng, Qidong Zheng, Qiao Liu, Mimi Chen, Chaoyin Lu, Lijing Wu","doi":"10.1155/jdr/1854458","DOIUrl":"10.1155/jdr/1854458","url":null,"abstract":"<p><p><b>Background:</b> Considering the reported link between obesity and diabetic kidney disease (DKD), this study investigated the association between body roundness index (BRI) and DKD. <b>Methods:</b> Cross-sectional data were obtained from the National Metabolic Management Center (MMC) of Yuhuan Second People's Hospital and Taizhou Central Hospital (Taizhou University Hospital) between September 2017 and May 2024. BRI was calculated using waist circumference (WC) and height. BRI was analyzed as a continuous and categorical variable to examine its association with DKD. Multivariate logistic regression and restricted cubic spline (RCS) analyses of the interplay between the BRI and DKD were conducted. Subgroup analysis was also performed. <b>Results:</b> Among 12,231 analyzed individuals, 5020 (41.0%) exhibited DKD. The BRI of individuals with DKD was higher than that of those without (<i>p</i> < 0.001). Compared with those in the first BRI tertile (T1), those in T2 or T3 showed higher DKD prevalence rates (T1 33.4% vs. T2 41.3% vs. T3 48.3%, <i>p</i> < 0.001). Compared with individuals in T1, those in T2 and T3 exhibited fully adjusted odds ratios for the relationship between BRI and DKD of 1.25 (95% confidence interval [CI]: 1.13-1.37, <i>p</i> < 0.001) and 1.42 (95% CI: 1.28-1.57, <i>p</i> < 0.001), respectively. A significant trend across BRI tertiles for DKD odds was observed (<i>p</i> for trend < 0.001). RCS regression with three knots at clinically relevant percentiles (5th, 50th, and 95th) confirmed a dose-response relationship between BRI and DKD, demonstrating positive linearity (<i>p</i> for nonlinearity = 0.628). <b>Conclusion:</b> BRI demonstrated significant positive associations with DKD, supporting its utility as a clinical risk indicator for early identification of high-risk individuals. Prospective cohort studies are warranted to evaluate BRI's predictive capacity for incident DKD.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"1854458"},"PeriodicalIF":3.4,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12422861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myristoylated Cathelicidin-DM Fused With ANG1-7: A Novel Self-Assembling Antimicrobial Peptide for the Treatment and Mechanism of Diabetic Infected Wounds.","authors":"Rongqin Feng, Peng Wang, Li Fan, He Lu, Danna Yao, Panpan Sun, Zhonghua Liu, Fu Han, Xiaozhi Bai, Xuekang Yang, Juntao Han","doi":"10.1155/jdr/9601959","DOIUrl":"10.1155/jdr/9601959","url":null,"abstract":"<p><p>Diabetic wounds, due to severe vascular dysfunction, persistent inflammatory responses, and susceptibility to microbial infections, exhibit delayed healing and pose a significant challenge to human health. Diabetic wounds face delayed healing and significant health challenges due to vascular dysfunction, persistent inflammation, and infection susceptibility. Therefore, the development of drugs with antibacterial capabilities, as well as the ability to effectively regulate inflammation and promote angiogenesis, is of great importance. In this study, a novel antibacterial peptide (named MYR-DM-ANG1-7) was designed. It is composed of the coassembly of myristoylated antibacterial peptide cathelicidin-DM and angiotensin 1-7 (ANG 1-7). This novel antibacterial peptide demonstrates antibacterial activity against both <i>Escherichia coli</i> and <i>Staphylococcus aureus</i> bacteria and can even effectively inhibit the formation of biofilms. In vitro experiments confirmed that MYR-DM-ANG1-7 can promote the proliferation, migration, and angiogenesis of human umbilical vein endothelial cells (HUVECs), reduce the level of oxidative stress, alleviate the increase in mitochondrial membrane potential caused by high glucose (HG) and lipopolysaccharide (LPS), and decrease the expression of proinflammatory cytokines IL-6 and TNF-<i>α</i>. Western blot experiments confirmed that MYR-DM-ANG1-7 activates PI3K by targeting the membrane receptor Mas, thereby activating AKT, which ultimately promotes the activation of eNOS to produce nitric oxide (NO), thereby enhancing the angiogenic capacity of HUVECs. In vivo experiments showed that the local application of MYR-DM-ANG1-7 significantly improved the healing of infected diabetic wounds in mice, including increased wound healing rate, reduced inflammatory cell infiltration, and promoted collagen fiber and blood vessel formation. In summary, this study successfully constructed a multifunctional novel self-assembling antibacterial peptide that can effectively regulate oxidative stress, inflammation, and angiogenesis to promote the repair of diabetic infected wounds. This research provides a brand new self-assembling lipopeptide therapeutic strategy for the treatment of diabetic infected wounds.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"9601959"},"PeriodicalIF":3.4,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12419922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health-Related Quality of Life and Psychosocial Outcomes in Patients With Type 2 Diabetes Mellitus: A Bibliometric Analysis.","authors":"Guojun Liu, Tianjiao Li, Chaofan Chen, Ningkun Xiao","doi":"10.1155/jdr/5164503","DOIUrl":"10.1155/jdr/5164503","url":null,"abstract":"<p><p><b>Background:</b> Health-related quality of life (HRQoL) has become a critical focus in managing Type 2 diabetes mellitus (T2DM), emphasizing the need to integrate physiological, psychological, and social dimensions into clinical practice. Despite the growing prevalence of T2DM worldwide, particularly in low- and middle-income countries, the global research landscape of HRQoL remains unevenly distributed. <b>Objectives:</b> This study is aimed at systematically analyzing the global research trends, key contributors, and influencing factors of HRQoL in patients with T2DM using bibliometric methods, providing insights to guide future research and targeted interventions. <b>Methods:</b> A total of 6470 articles published before October 31, 2024, were retrieved from the Web of Science Core Collection (WoSCC). We analyzed publication trends, national and institutional contributions, author impact, journal distribution, and keyword co-occurrence using bibliometric tools. Factors influencing HRQoL were identified through a comprehensive literature review, focusing on physiological, psychological, and social determinants. <b>Results:</b> The number of publications in the field has grown rapidly since 2000, with 40.03% of all articles published in the past 5 years. The United States led global research output with 1620 articles and 98,354 citations, followed by China (622 articles) and the United Kingdom (529 articles). However, China's average citations per article (15.50) lagged significantly behind developed countries such as the United Kingdom (62.70) and the United States (60.70). Key factors influencing HRQoL included psychological health (e.g., depression and anxiety), sleep disturbances, socioeconomic status, lifestyle, and diabetes-related complications. Early research focused on metabolic control and complications, whereas recent studies have increasingly emphasized integrating psychosocial factors and patient-centered management strategies. <b>Conclusions:</b> HRQoL research in T2DM reflects a shift toward holistic, patient-centered approaches that address the complex interplay of clinical, psychological, and social factors. Future research should prioritize addressing disparities in low- and middle-income countries, leveraging international collaboration, and utilizing advanced digital health technologies to enhance HRQoL monitoring and interventions. These efforts will be critical in improving the overall well-being and long-term outcomes of patients with T2DM globally.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"5164503"},"PeriodicalIF":3.4,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12411053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Nonalcoholic Fatty Liver Disease in Type 2 Diabetes Patients at a Tertiary Hospital, Addis Ababa, Ethiopia.","authors":"Edomias Adyamseged Berhe, Rediet Ambachew Sema, Yididya Mehari Tesfaye, Abel Andargie Berhane, Mikale Dawit, Ephrem Mamo Gebrehiwot, Subah Abderehim Yesuf","doi":"10.1155/jdr/5555842","DOIUrl":"10.1155/jdr/5555842","url":null,"abstract":"<p><p><b>Background:</b> Nonalcoholic fatty liver disease (NAFLD) is an emerging global health concern that commonly occurs in patients with Type 2 diabetes mellitus (T2DM). However, there is limited literature on the epidemiology of NAFLD among adults with T2DM in Ethiopia. Therefore, this study is aimed at assessing the prevalence of NAFLD and its associated factors in patients with T2DM attending Yekatit 12 Hospital Medical College in Addis Ababa, Ethiopia. <b>Methods:</b> An institution-based, cross-sectional study was conducted. Data were collected using a pretested, structured data collection tool. All eligible consecutive patients diagnosed with T2DM were enrolled in this study. Data were entered into Microsoft Excel 2016 and analyzed using the Statistical Package for the Social Sciences (SPSS) Version 26. Descriptive statistics were used to summarize the data. Multivariable logistic regression was performed to identify associations between dependent and independent variables by calculating odds ratios with corresponding 95% confidence intervals. A <i>p</i> value of < 0.05 was considered statistically significant. <b>Results:</b> A total of 211 patients were enrolled in the study. Females (108; 51.2%) slightly predominated, and the mean (standard deviation) age of patients was 56.2 (11.0) years. Fatty liver was detected in 102 patients, representing a prevalence of 48.3% (95% CI: 42%-55%). Mild, moderate, and severe NAFLD accounted for 19.0%, 24.6%, and 4.7%, respectively. Female sex (AOR = 2.27 [95% CI: 1.17, 4.41]), obesity (AOR = 6.13 [95% CI: 2.15, 17.46]), borderline serum triglyceride levels (AOR = 3.22 [95% CI: 1.36, 7.58]), and high serum triglyceride levels (AOR = 2.29 [95% CI: 1.03, 5.10]) were significantly associated with the presence of NAFLD. <b>Conclusions:</b> NAFLD is highly prevalent among patients with T2DM in this Ethiopian cohort. Female sex, obesity, and elevated serum triglyceride levels are significant risk factors. These findings highlight the urgent need to address the silent epidemic of NAFLD among adults with T2DM in Ethiopia and emphasize the importance of educating patients on adopting healthy lifestyles to reduce the incidence of this condition.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"5555842"},"PeriodicalIF":3.4,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12398411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparative Multicenter Cross-Sectional Study on Hypoglycemia in Young Adults and Older Adults With Type 2 Diabetes Mellitus in an Outpatient Setting in Sri Lanka.","authors":"Priyamali Thusharika Jayasekera, Thamarasi Senaratne, Dilusha Lamabadusuriya, Harsha Sathischandra, Anne Thushara Matthias, Pubudu Jayasekera, Mettananda Herath, Warsha Dilani De Zoysa, Ganaka Senaratne, Manoji Pathirage, Kumuduni Jayasinghe, Shashi Karunaratne, Ponnuthurai Sudarshan, Vathulan Sujanitha, Nalayni Rajaratnam, Deeptha Wickramaratne, Maheshwaran Umakanth, Bandusiri Ratnayake, Lalith Rasnayake, Roshan Liyanage, Jagath Pushpakumara, Thushari Wanigarathne, Prasad Siriwardhane, Yapa Udaya Kumara, Shanil Kuruppu, Deepthi Edirisinghe, Namal Wijesinghe","doi":"10.1155/jdr/4412070","DOIUrl":"10.1155/jdr/4412070","url":null,"abstract":"<p><p><b>Background:</b> Hypoglycemia has been an often-neglected complication of diabetes therapy. Mild hypoglycemia reduces quality of life, while severe hypoglycemia is life-threatening and can precipitate major cardiovascular and cerebrovascular events. <b>Methods:</b> A multicenter cross-sectional study was conducted on hypoglycemia among adults with diabetes attending 19 medical clinics in government hospitals in Sri Lanka using an interviewer-administered questionnaire. <b>Results:</b> There were 2005 participants, and 1110 (55.4%) were < 65 years of age and 895 (44.6%) were > 65 years of age; the mean age was 62.12 ± 11.94 years (58.1% female). The median duration of diabetes was 8 (IQR11) years. Among them, 808 (43%), 757 (37.8%), and 376 (18.8%) had neuropathy, retinopathy, and nephropathy, respectively, while 415 (20.7%), 50 (2.5%), and 22 (1%) had ischemic heart disease, strokes, and peripheral vascular disease, respectively. One thousand three hundred forty-nine (67.3%) experienced at least one episode of hypoglycemia, and 462 (34.2%) had hospital admissions (9 (0.7%) intensive care admissions) over the past year. Older adults (<i>n</i> = 584) experienced significantly more symptomatic hypoglycemia compared to the younger population (<i>p</i> ≤ 0.001). Their mean CBS during hypoglycemic episodes was 57.04 ± 18.15 mg/dL. Among them, 1552 (77.4%) were on oral hypoglycemic medications, 453 (22.6%) were on insulin, and 126 (6.3%) were on both. The most typical reasons for hypoglycemia were skipping meals while taking regular medications (511, 37.9%), consumption of sugar-reducing native food items (203, 15%) and taking higher doses of insulin (112, 8.3%) and oral medication (74, 5.5%) than prescribed. To self-manage hypoglycemia, 1070 (79.3%) took sugary drinks, food, or glucose, and 279 (20.7%) did not do anything. There were 304 (34%) frail older adults, and 238 (78.3%) got hypoglycemia. They were taking similar prescriptions as young adults. They displayed significant hypoglycemic symptoms such as dizziness, irritability, nausea, speech impediment, and blurred vision compared to nonfrail elders (<i>p</i> ≤ 0.01). There were 485 diabetic patients who either drove or rode in a vehicle; 51 (10.5%) of them had experienced hypoglycemia during driving or riding. <b>Conclusion:</b> Hypoglycemia is a significant issue which needs to be addressed. There is no difference in prescription medication in age categories and frail patients. Driving and hypoglycemia are also a concerning issue. Patients need advice on the prevention and treatment of hypoglycemia.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"4412070"},"PeriodicalIF":3.4,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12396914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fall Risk Factors and Other Geriatric Syndromes in Older Adults With Diabetes: Experience of a Multidisciplinary Fall Consultation.","authors":"Aurélie Mailliez, Yaohua Chen, Rachel Litke, Stéphanie Gloria, Hacène Chekroud, Dominique Huvent-Grelle, Liubinka Mirakovska, Cédric Gaxatte, François Puisieux","doi":"10.1155/jdr/6145818","DOIUrl":"10.1155/jdr/6145818","url":null,"abstract":"<p><p><b>Aims:</b> The aim of this study is to assess the prevalence of diabetes in patients attending a multidisciplinary consultation for fall risk assessment and to compare fall risk factors and the prevalence of other geriatric syndromes in patients with and without diabetes. <b>Materials and Methods:</b> A single-center retrospective cohort study was conducted at the Lille University Hospital Geriatrics Department, France. Inclusion criteria were any patients aged 65 years and over consulting for fall risk assessment between January 2, 2005, and January 2, 2015. A comprehensive multidisciplinary clinical evaluation was carried out to establish a personalized assessment of the patient's risk of falling. <b>Results:</b>One thousand five hundred and twenty patients were included. Mean age was 81.4 ± 6.4 years; 72.2% were female, and 20% had diabetes. While patients with diabetes were younger than patients without diabetes (mean age: 79.4 ± 6.1 years vs. 81.9 ± 6.4 years, <i>p</i> < 0.001), they were more likely to have had at least two falls in the previous 6 months (65.5% vs. 56.2%; <i>p</i> = 0.004), had more balance and gait disorders (respectively, 77.4% vs. 69.7%, <i>p</i> = 0.009, and 88% vs. 82%, <i>p</i> = 0.012), and had more cognitive decline, urinary disorders, functional dependency, and polypharmacy than patients without diabetes (<i>p</i> < 0.0001 for all). <b>Conclusions:</b> Patients with diabetes have more geriatric syndromes and comorbidities, leading to a higher risk of adverse events compared to patients without diabetes even if they are younger. Preventing falls and other geriatric syndromes should therefore be a concern for all healthcare professionals who care for people with diabetes.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"6145818"},"PeriodicalIF":3.4,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12393927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective Study on Self-Calibrating Continuous Glucose Monitoring Practicality and Accuracy in Noncritically Ill COVID-19 Hospitalized Patients.","authors":"Choompunuj Sakjirapapong, Sirinart Sirinvaravong, Lukana Preechasuk, Nuntakorn Thongtang","doi":"10.1155/jdr/7538573","DOIUrl":"10.1155/jdr/7538573","url":null,"abstract":"<p><p><b>Aims:</b> This study is aimed at evaluating the accuracy and feasibility of real-time continuous glucose monitoring (rt-CGM) in non-ICU hospitalized adult COVID-19 patients who had hyperglycemia requiring insulin therapy during admission. <b>Materials and Methods:</b> Medtronic Guardian Sensor 3 and transmitter were placed on the patient's abdomen. The patient performed a self-calibration of CGM via the application installed in the smartphone. Paired CBG and sensor glucose values were analyzed for accuracy of CGM using mean absolute relative difference (MARD) and Clarke error grid analysis (CEGA). <b>Results:</b> Fifteen patients were enrolled. Mean age was 48.6 ± 17.9 years; 53.3% were female. Thirteen patients (86.7%) had pre-existing diabetes. Mean HbA1c was 10.6 ± 3.6%. Mean duration of CGM use was 6 ± 1.2 days, and mean calibration was 2.6 ± 0.7 times/day. There were 253 paired CBG and CGM measurements. The overall MARD was 9.9 ± 9.3%. The lowest MARD was observed in the CBG range of 70-180 mg/dL (9.6 ± 9.0%) and on Day 3 of sensor wear (8.0 ± 4.6%). The percentages of glucose readings within 15/15%, 20/20%, and 30/30% were 81.0%, 89.7%, and 95.3%, respectively. A total of 99.2% of the data points were in Zones A and B of CEGA, and none were in Zone E. CGM reduced POC testing by approximately 30%. <b>Conclusions:</b> Rt-CGM use in hospitalized patients with COVID-19 infection demonstrates high accuracy, reduces the frequency of CBG testing, and preserves medical resources. The patient's self-calibration of rt-CGM in this setting is feasible. Although the COVID-19 pandemic tends to improve, our research could be applied to new emerging infectious diseases. <b>Trial Registration:</b> Thai Clinical Trials Registry: TCTR20230426007.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"7538573"},"PeriodicalIF":3.4,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12393932/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}