{"title":"Relationship Between Body Roundness Index and Diabetic Kidney Disease in Patients With Type 2 Diabetes Mellitus: A Population-Based Study.","authors":"Mengdie Chen, Yiyun Wang, Ping Feng, Qidong Zheng, Qiao Liu, Mimi Chen, Chaoyin Lu, Lijing Wu","doi":"10.1155/jdr/1854458","DOIUrl":null,"url":null,"abstract":"<p><p><b>Background:</b> Considering the reported link between obesity and diabetic kidney disease (DKD), this study investigated the association between body roundness index (BRI) and DKD. <b>Methods:</b> Cross-sectional data were obtained from the National Metabolic Management Center (MMC) of Yuhuan Second People's Hospital and Taizhou Central Hospital (Taizhou University Hospital) between September 2017 and May 2024. BRI was calculated using waist circumference (WC) and height. BRI was analyzed as a continuous and categorical variable to examine its association with DKD. Multivariate logistic regression and restricted cubic spline (RCS) analyses of the interplay between the BRI and DKD were conducted. Subgroup analysis was also performed. <b>Results:</b> Among 12,231 analyzed individuals, 5020 (41.0%) exhibited DKD. The BRI of individuals with DKD was higher than that of those without (<i>p</i> < 0.001). Compared with those in the first BRI tertile (T1), those in T2 or T3 showed higher DKD prevalence rates (T1 33.4% vs. T2 41.3% vs. T3 48.3%, <i>p</i> < 0.001). Compared with individuals in T1, those in T2 and T3 exhibited fully adjusted odds ratios for the relationship between BRI and DKD of 1.25 (95% confidence interval [CI]: 1.13-1.37, <i>p</i> < 0.001) and 1.42 (95% CI: 1.28-1.57, <i>p</i> < 0.001), respectively. A significant trend across BRI tertiles for DKD odds was observed (<i>p</i> for trend < 0.001). RCS regression with three knots at clinically relevant percentiles (5th, 50th, and 95th) confirmed a dose-response relationship between BRI and DKD, demonstrating positive linearity (<i>p</i> for nonlinearity = 0.628). <b>Conclusion:</b> BRI demonstrated significant positive associations with DKD, supporting its utility as a clinical risk indicator for early identification of high-risk individuals. Prospective cohort studies are warranted to evaluate BRI's predictive capacity for incident DKD.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"1854458"},"PeriodicalIF":3.4000,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12422861/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Diabetes Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1155/jdr/1854458","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Considering the reported link between obesity and diabetic kidney disease (DKD), this study investigated the association between body roundness index (BRI) and DKD. Methods: Cross-sectional data were obtained from the National Metabolic Management Center (MMC) of Yuhuan Second People's Hospital and Taizhou Central Hospital (Taizhou University Hospital) between September 2017 and May 2024. BRI was calculated using waist circumference (WC) and height. BRI was analyzed as a continuous and categorical variable to examine its association with DKD. Multivariate logistic regression and restricted cubic spline (RCS) analyses of the interplay between the BRI and DKD were conducted. Subgroup analysis was also performed. Results: Among 12,231 analyzed individuals, 5020 (41.0%) exhibited DKD. The BRI of individuals with DKD was higher than that of those without (p < 0.001). Compared with those in the first BRI tertile (T1), those in T2 or T3 showed higher DKD prevalence rates (T1 33.4% vs. T2 41.3% vs. T3 48.3%, p < 0.001). Compared with individuals in T1, those in T2 and T3 exhibited fully adjusted odds ratios for the relationship between BRI and DKD of 1.25 (95% confidence interval [CI]: 1.13-1.37, p < 0.001) and 1.42 (95% CI: 1.28-1.57, p < 0.001), respectively. A significant trend across BRI tertiles for DKD odds was observed (p for trend < 0.001). RCS regression with three knots at clinically relevant percentiles (5th, 50th, and 95th) confirmed a dose-response relationship between BRI and DKD, demonstrating positive linearity (p for nonlinearity = 0.628). Conclusion: BRI demonstrated significant positive associations with DKD, supporting its utility as a clinical risk indicator for early identification of high-risk individuals. Prospective cohort studies are warranted to evaluate BRI's predictive capacity for incident DKD.
背景：考虑到肥胖与糖尿病肾病（DKD）之间的联系，本研究调查了身体圆度指数（BRI）与糖尿病肾病（DKD）之间的关系。方法：收集2017年9月- 2024年5月玉环第二人民医院国家代谢管理中心（MMC）和台州中心医院（台州学院医院）的横断面数据。BRI采用腰围（WC）和身高计算。BRI作为一个连续和分类变量进行分析，以检验其与DKD的关系。对BRI和DKD之间的相互作用进行了多元逻辑回归和限制三次样条（RCS）分析。并进行亚组分析。结果：在12231例分析个体中，5020例（41.0%）表现为DKD。有DKD个体的BRI高于无DKD个体（p < 0.001）。T2或T3患者的DKD患病率高于T1 （33.4% vs. T2 41.3% vs. T3 48.3%, p < 0.001）。与T1期患者相比，T2期和T3期患者BRI与DKD关系的完全校正比值比分别为1.25（95%可信区间[CI]: 1.13-1.37, p < 0.001）和1.42 （95% CI: 1.28-1.57, p < 0.001）。在BRI中观察到DKD几率的显著趋势（p为趋势< 0.001）。在临床相关百分位数（第5、第50和第95位）有3个节的RCS回归证实了BRI和DKD之间的剂量-反应关系，呈正线性关系（非线性p = 0.628）。结论：BRI与DKD呈显著正相关，支持其作为早期识别高风险个体的临床风险指标的效用。有必要进行前瞻性队列研究，以评估BRI对事件DKD的预测能力。
期刊介绍：
Journal of Diabetes Research is a peer-reviewed, Open Access journal that publishes research articles, review articles, and clinical studies related to type 1 and type 2 diabetes. The journal welcomes submissions focusing on the epidemiology, etiology, pathogenesis, management, and prevention of diabetes, as well as associated complications, such as diabetic retinopathy, neuropathy and nephropathy.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
