Association Between Thyroid Function Parameters and Plasma Branched-Chain Amino and Keto Acids in Patients With Euthyroid Type 2 Diabetes Mellitus.

IF 3.4 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Journal of Diabetes Research Pub Date : 2025-07-02 eCollection Date: 2025-01-01 DOI:10.1155/jdr/2540444
Xinghua Cai, Yuanying Xu, Jie Gao, Huihui Zhang, Jun Lu, Tao Lei
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Abstract

Objectives: The objective of the study is to determine the association between thyroid function parameters and plasma levels of branched-chain amino acids (BCAAs) and their metabolites, branched-chain keto acids (BCKAs), in patients with euthyroid Type 2 diabetes mellitus (T2DM). Methods: We conducted a cross-sectional study among 357 participants with euthyroid T2DM. Plasma BCAAs and BCKAs were measured using enzyme-linked immunosorbent assay (ELISA), while four thyroid function parameters, including triiodothyronine (T3), thyroxine (T4), free triiodothyronine (FT3), and free thyroxine (FT4), were determined by an automatic biochemical analyzer. The variance inflation factor (VIF) was used to investigate variable collinearity. Pearson correlation and multivariate linear regression analysis were used to establish the relationship between BCAAs or BCKAs and thyroid function parameters. Results: The means of T3, T4, FT3, and FT4 were different among the three groups divided by BCAA tertiles (all p < 0.05), and the means of T3 and FT3 were different among the three groups divided by BCKA tertiles (all p < 0.01). Pearson correlation analysis indicated a positive relationship between all the thyroid function parameters and BCAA levels (p < 0.05), while a statistically significant inverse relationship was established between T3 and FT3 levels and BCKA levels (p < 0.01). Collinearity analysis demonstrated no collinearity among the variables (tolerance: 0.501~0.922; VIF: 1.084~1.995). Multivariate linear regression analysis showed that thyroid function parameters were significantly associated with BCAAs (coefficients: 0.042 to 4.614, p < 0.05) and BCKAs (coefficients: -0.200 to -0.156, p < 0.01) after adjusting for other potential confounding factors. Conclusions: Thyroid function parameters positively correlated with plasma BCAAs but negatively correlated with plasma BCKAs in patients with euthyroid T2DM. However, further prospective studies are needed to explore potential causal relationships and verify these findings.

甲状腺功能正常的2型糖尿病患者血浆支链氨基酸和酮酸与甲状腺功能参数的关系
目的:本研究的目的是确定甲状腺功能参数与血浆支链氨基酸(BCAAs)及其代谢产物支链酮酸(BCKAs)水平之间的关系。方法:我们对357例甲状腺功能正常的T2DM患者进行了横断面研究。采用酶联免疫吸附法(ELISA)检测血浆BCAAs和BCKAs,采用全自动生化分析仪检测甲状腺功能参数三碘甲状腺原氨酸(T3)、甲状腺素(T4)、游离三碘甲状腺原氨酸(FT3)和游离甲状腺素(FT4)。用方差膨胀因子(VIF)考察变量共线性。采用Pearson相关和多元线性回归分析建立BCAAs或BCKAs与甲状腺功能参数的关系。结果:三组患者T3、T4、FT3、FT4均值以BCAA分位数划分差异有统计学意义(均p < 0.05),三组患者T3、FT3均值以BCKA分位数划分差异有统计学意义(均p < 0.01)。Pearson相关分析显示,甲状腺功能各项指标与BCAA水平呈正相关(p < 0.05), T3、FT3水平与BCKA水平呈显著负相关(p < 0.01)。共线性分析显示各变量间无共线性(公差范围为0.501~0.922;VIF: 1.084 ~ 1.995)。多因素线性回归分析显示,在校正其他潜在混杂因素后,甲状腺功能参数与BCAAs(系数:0.042 ~ 4.614,p < 0.05)和BCKAs(系数:-0.200 ~ -0.156,p < 0.01)有显著相关性。结论:甲状腺功能参数与血浆BCAAs呈正相关,与血浆BCKAs呈负相关。然而,需要进一步的前瞻性研究来探索潜在的因果关系并验证这些发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Diabetes Research
Journal of Diabetes Research ENDOCRINOLOGY & METABOLISM-MEDICINE, RESEARCH & EXPERIMENTAL
CiteScore
8.40
自引率
2.30%
发文量
152
审稿时长
14 weeks
期刊介绍: Journal of Diabetes Research is a peer-reviewed, Open Access journal that publishes research articles, review articles, and clinical studies related to type 1 and type 2 diabetes. The journal welcomes submissions focusing on the epidemiology, etiology, pathogenesis, management, and prevention of diabetes, as well as associated complications, such as diabetic retinopathy, neuropathy and nephropathy.
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