Journal of Drug Targeting最新文献_第5页

Food allergen immunotherapy via electrospray coated microneedles - a potential transdermal therapy. 电喷雾包被微针的食物过敏原免疫治疗-一种潜在的透皮疗法。

IF 4.7 4区医学

Journal of Drug Targeting Pub Date : 2026-09-22 DOI: 10.1080/1061186X.2026.2734512

Ambreen Akhtar, Saman Zafar, Neenu Singh, Stuart Jones, Muhammad Sohail Arshad, Zeeshan Ahmad

{"title":"Food allergen immunotherapy via electrospray coated microneedles - a potential transdermal therapy.","authors":"Ambreen Akhtar, Saman Zafar, Neenu Singh, Stuart Jones, Muhammad Sohail Arshad, Zeeshan Ahmad","doi":"10.1080/1061186X.2026.2734512","DOIUrl":"10.1080/1061186X.2026.2734512","url":null,"abstract":"Microneedle (MN) technologies offer a minimally invasive platform for allergen delivery; however, controlled transdermal administration of complex allergenic proteins remains a challenge. This communication reports the fabrication and evaluation of peanut (PN), and pistachio (PS) loaded polylactic-co-glycolic acid (PLGA) coatings onto stainless-steel MNs via electrohydrodynamic atomisation (EHDA). Electrosprayed coatings exhibited uniform morphology and comparable hydrophilicity across formulations. In-vitro release study revealed an early burst (20% release within 24 h) followed by sustained delivery. The kinetic modelling indicated near-zero-order release governed by Fickian or quasi-Fickian diffusion. Ex-vivo insertion studies confirmed consistent membrane penetration with minimal invasiveness. Permeation study demonstrated efficient allergen transport (80-90%) across rat skin from coated MNs. In rats, a significant (p < 0.05) elevation in IgE (immunoglobulin E) titres following MN mediated delivery of PN (1.78-fold) and PS (1.39-fold) loaded PLGA matrices was recorded by day 50. These findings established EHDA-processed nut-PLGA coated MNs as a potentially promising platform for transdermal food allergen immunotherapy, enabling controlled release, effective skin permeation and preserved immunogenicity. The ability to coat allergen-formulations in minute and scalable quantities provides an opportunity to personalise specific food therapies using transdermal MNs.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1-10"},"PeriodicalIF":4.7,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148977036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Senescence-associated extracellular vesicles in skin aging and regeneration: from pathophysiology to therapeutic opportunities. 衰老相关的细胞外囊泡在皮肤老化和再生：从病理生理学到治疗机会。

IF 4.7 4区医学

Journal of Drug Targeting Pub Date : 2026-09-22 DOI: 10.1080/1061186X.2026.2735986

Barathan Muttiah, Gopinath Venkatraman

{"title":"Senescence-associated extracellular vesicles in skin aging and regeneration: from pathophysiology to therapeutic opportunities.","authors":"Barathan Muttiah, Gopinath Venkatraman","doi":"10.1080/1061186X.2026.2735986","DOIUrl":"10.1080/1061186X.2026.2735986","url":null,"abstract":"Cellular senescence is an important factor which significantly impairs the homeostasis and regeneration capability of skin through causing chronic inflammation, degradation of the extracellular matrix, depletion of stem cells, and angiogenesis impairment. In addition to the already known senescence associated secretory phenotype (SASP), senescent cells secrete senescence associated extracellular vesicles (SA-EVs) serving as powerful signalling molecules. SA-EVs are distinguished by the increased secretion rates, altered biogenesis and selective cargo loading which include proinflammatory microRNAs, cytokines, mitochondrial DNA, EphA2 protein and noncoding RNAs (tRNAs, lncRNAs, snoRNAs). SA-EVs promote senescence in a paracrine manner, impair the wound healing process and contribute to the development of chronic wounds, diabetic ulcers, burns, pathological scarring, skin ageing and other skin disorders. The treatment approaches which target the reduction of the SA-EV burden can be either senolytic or senomorphic while the application of regenerative mesenchymal stem cell-derived EVs and modified EV platforms as well as using the biomaterial assisted systems are promising therapeutic options.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1-20"},"PeriodicalIF":4.7,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149001948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute effects of ultrasound-targeted microbubble destruction on tumor interstitial fluid pressure and intratumoral distribution of doxorubicin and nab-paclitaxel in an orthotopic breast cancer model. 超声靶向微泡破坏对原位乳腺癌模型肿瘤间质液压力及阿霉素和nab -紫杉醇在肿瘤内分布的急性影响

IF 4.7 4区医学

Journal of Drug Targeting Pub Date : 2026-09-21 DOI: 10.1080/1061186X.2026.2733604

Minhua Lin, Yangcheng He, Xiansheng Zhu, Jianhua Liu

{"title":"Acute effects of ultrasound-targeted microbubble destruction on tumor interstitial fluid pressure and intratumoral distribution of doxorubicin and nab-paclitaxel in an orthotopic breast cancer model.","authors":"Minhua Lin, Yangcheng He, Xiansheng Zhu, Jianhua Liu","doi":"10.1080/1061186X.2026.2733604","DOIUrl":"10.1080/1061186X.2026.2733604","url":null,"abstract":"Insufficient drug delivery remains a major challenge in solid tumour therapy. Ultrasound-targeted microbubble destruction (UTMD) can modulate the tumour microenvironment and improve intratumoral drug delivery. This study evaluated the acute effects of UTMD on tumour interstitial fluid pressure (IFP) and the distribution of doxorubicin and nab-paclitaxel in an MCF7-derived orthotopic breast cancer model. IFP was measured approximately 2 min after treatment. Significant IFP reductions were observed in the doxorubicin-USMB, nab-paclitaxel-USMB, and USMB-alone groups, indicating that UTMD itself contributes to the acute pressure response. Fluorescence imaging showed increased doxorubicin-associated signal in both peripheral and central tumour regions after UTMD, whereas Cy5-labeled nab-paclitaxel increased mainly in the tumour periphery. H&E staining revealed vascular dilation, erythrocyte extravasation, and microthrombus formation after USMB treatment. These findings suggest that UTMD reduces tumour IFP and alters intratumoral drug distribution, particularly in peripheral regions. However, because the two drugs differ in multiple physicochemical and formulation properties and antitumour efficacy was not assessed, their distribution differences cannot be attributed solely to size or interpreted as evidence of improved therapeutic efficacy.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1-8"},"PeriodicalIF":4.7,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148969235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PLGA nanoparticles co-loaded with resveratrol and doxycycline for dual-action periodontal therapy: in vitro and in vivo evaluation. PLGA纳米颗粒与白藜芦醇和强力霉素共同负载用于双重作用牙周治疗：体外和体内评估。

IF 4.7 4区医学

Journal of Drug Targeting Pub Date : 2026-09-21 DOI: 10.1080/1061186X.2026.2709758

Seyed Ebrahim Alavi, Reza Boshrouyeh, Saeideh Sadeghi Neshat, Lavanya A Sharma, Ajay Sharma, Hasan Ebrahimi Shahmabadi

{"title":"PLGA nanoparticles co-loaded with resveratrol and doxycycline for dual-action periodontal therapy: in vitro and in vivo evaluation.","authors":"Seyed Ebrahim Alavi, Reza Boshrouyeh, Saeideh Sadeghi Neshat, Lavanya A Sharma, Ajay Sharma, Hasan Ebrahimi Shahmabadi","doi":"10.1080/1061186X.2026.2709758","DOIUrl":"10.1080/1061186X.2026.2709758","url":null,"abstract":"Periodontitis is a chronic inflammatory disease caused by a dysbiotic subgingival biofilm that triggers an imbalanced host immune response. This study developed and evaluated poly(lactic-co-glycolic acid) (PLGA) nanoparticles co-loaded with doxycycline (DOX) and resveratrol (RV) for dual-action periodontal therapy. Nanoparticles were prepared by double-emulsion solvent evaporation and characterised for size, charge, encapsulation efficiency, release kinetics, antimicrobial activity, cytocompatibility, and osteogenic effects in vitro and in vivo. The co-loaded nanoparticles (PLGA-DOX/RV) had a mean size of 256.6 ± 13.4 nm, zeta potential of -17.3 ± 2.2 mV, and encapsulation efficiencies of 94.6% (DOX) and 95.8% (RV). In vitro release showed a biphasic profile, with cumulative release reaching 67.6% and 75.9% at 72 h, respectively. PLGA-DOX/RV reduced minimum inhibitory and bactericidal concentrations fourfold against P. gingivalis and A. actinomycetemcomitans, and inhibited biofilm formation by >55%. Cytotoxicity assays indicated 65.3% fibroblast viability at 200 µg/mL, while alkaline phosphatase activity increased by 67.3%. In vivo, PLGA-DOX/RV reduced alveolar bone loss (0.65 mm vs. 0.89 mm in control) and lowered IL-1β, IL-6, and TNF-α by 67.4%, 80.1%, and 74.2%, respectively. These results demonstrate PLGA-DOX/RV as a potent localised therapy for periodontitis.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1-19"},"PeriodicalIF":4.7,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148955961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Statement of Retraction. 撤回声明。

IF 4.7 4区医学

Journal of Drug Targeting Pub Date : 2026-09-20 DOI: 10.1080/1061186X.2026.2735536

引用次数: 0

ECM-mimetic silk fibroin/GelMA hydrogel integrating manganese dioxide nanozymes and sustained nitric oxide release for sequential immunomodulation and healing of chronic infected wounds. 整合二氧化锰纳米酶和持续一氧化氮释放的ecm模拟丝素/凝胶用于慢性感染伤口的顺序免疫调节和愈合。

IF 4.7 4区医学

Journal of Drug Targeting Pub Date : 2026-09-18 DOI: 10.1080/1061186X.2026.2733611

Dalia A Gaber

{"title":"ECM-mimetic silk fibroin/GelMA hydrogel integrating manganese dioxide nanozymes and sustained nitric oxide release for sequential immunomodulation and healing of chronic infected wounds.","authors":"Dalia A Gaber","doi":"10.1080/1061186X.2026.2733611","DOIUrl":"10.1080/1061186X.2026.2733611","url":null,"abstract":"Background: Chronic infected diabetic wounds are difficult to heal because bacterial colonisation, oxidative stress, hypoxia, and prolonged inflammation disrupt normal repair. This study developed a multifunctional extracellular matrix (ECM)-mimetic hydrogel to control infection, regulate the wound microenvironment, and promote tissue regeneration.Methods: A photocrosslinked silk fibroin/gelatine methacryloyl (SF/GelMA) hydrogel incorporating hollow δ-MnO₂ nanozymes and the nitric oxide donor S-nitrosoglutathione (GSNO) was developed as the NO-GSNO@MnO₂/SF-GelMA platform. Physicochemical, mechanical, nitric oxide release, oxygen generation, and antibacterial properties were characterised. Cytocompatibility, intracellular ROS scavenging, macrophage polarisation, endothelial tube formation, and angiogenesis were evaluated. Therapeutic efficacy was assessed in an MRSA-infected diabetic full-thickness wound model.Results: The hydrogel formed a stable porous network with improved mechanical properties and biocompatibility. Under acidic conditions, it provided controlled nitric oxide release, while MnO₂ nanozymes converted hydrogen peroxide into oxygen, reducing oxidative stress and hypoxia. The platform showed potent antibacterial activity against Escherichia coli and methicillin-resistant Staphylococcus aureus (MRSA), promoted M2 macrophage polarisation, enhanced endothelial tube formation, and stimulated neovascularization. In vivo, it accelerated wound healing, achieving 96.8 ± 1.4% wound closure after 14 days, with improved collagen remodelling, reduced inflammation, and enhanced vascular maturation.Conclusion: The NO-GSNO@MnO₂/SF-GelMA hydrogel integrates antimicrobial, oxygen-generating, ROS-scavenging, and immunomodulatory functions into a single platform, providing a multifunctional strategy for chronic infected diabetic wound repair.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1-17"},"PeriodicalIF":4.7,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148963386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ufasomal nanocarriers for enhanced cardiac delivery of nifedipine: a novel strategy to mitigate doxorubicin-induced cardiotoxicity in breast cancer therapy. 用于增强硝苯地平心脏递送的异常纳米载体：一种减轻乳腺癌治疗中阿霉素引起的心脏毒性的新策略。

IF 4.7 4区医学

Journal of Drug Targeting Pub Date : 2026-09-13 DOI: 10.1080/1061186X.2026.2729358

Hanan O Farouk, Fatma I Abo El-Ela, Fahad H Baali, Amany Belal, Yousef N Alharbi, Saeed Saad A Alghamdi, Yasmine K Rabea, Amr Gamal Fouad, Doaa S Hamad

{"title":"Ufasomal nanocarriers for enhanced cardiac delivery of nifedipine: a novel strategy to mitigate doxorubicin-induced cardiotoxicity in breast cancer therapy.","authors":"Hanan O Farouk, Fatma I Abo El-Ela, Fahad H Baali, Amany Belal, Yousef N Alharbi, Saeed Saad A Alghamdi, Yasmine K Rabea, Amr Gamal Fouad, Doaa S Hamad","doi":"10.1080/1061186X.2026.2729358","DOIUrl":"10.1080/1061186X.2026.2729358","url":null,"abstract":"The cardiotoxicity of doxorubicin significantly restricts its effectiveness, even though it remains a crucial element of breast cancer chemotherapy. Nifedipine (NFP) offers multi-mechanistic therapeutic benefits, including vasodilation, anti-proliferative activities, suppression of cellular apoptosis, and potent anti-inflammatory and antioxidant properties. However, the translation of oral NFP into an effective cardioprotective adjuvant is hindered by its poor solubility, first-pass hepatic metabolism, and poor bioavailability. Hence, this study aimed to develop a nasal NFP-loaded ufasomes (NLU) spray formulation to enhance the permeation, bioavailability, sustained release, and cardiac accumulation of NFP when co-administered with doxorubicin. Various NLU formulations were developed and optimised employing Design-Expert® software. The in vivo cardioprotective efficacy of the nasal NLU was comprehensively evaluated in a doxorubicin-induced cardiotoxicity rat model. The optimal NLU substantially prolonged drug sustainability and amplified mucosal permeability by 69.07% and 6.47-fold, respectively, compared to the free NFP suspension. Furthermore, nasal NLU formulation achieved a remarkable 7.33-fold enhancement in bioavailability and a 5.40-fold increase in cardiac tissue accumulation when contrasted with conventional oral NFP administration. Furthermore, the nasal NLU spray exhibited superior cardioprotective and antioxidant performance over the oral NFP. In conclusion, these findings establish the nasal NLU formulation as a promising therapeutic platform to mitigate doxorubicin-induced cardiotoxicity.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1-14"},"PeriodicalIF":4.7,"publicationDate":"2026-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148897347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rosa damascena-derived nanovesicles restore GAS6-driven efferocytic balance in LPS-induced inflammatory model. 玫瑰衍生的纳米囊泡在lps诱导的炎症模型中恢复gas6驱动的Efferocytic平衡。

IF 4.7 4区医学

Journal of Drug Targeting Pub Date : 2026-09-10 DOI: 10.1080/1061186X.2026.2729353

Subhashini Brahadeeswaran, Ramasamy Tamizhselvi

{"title":"Rosa damascena-derived nanovesicles restore GAS6-driven efferocytic balance in LPS-induced inflammatory model.","authors":"Subhashini Brahadeeswaran, Ramasamy Tamizhselvi","doi":"10.1080/1061186X.2026.2729353","DOIUrl":"10.1080/1061186X.2026.2729353","url":null,"abstract":"Resolution of inflammation is an active, tightly regulated process, and its dysregulation contributes to acute and chronic inflammatory diseases. This study investigated the anti-inflammatory and pro-resolving effects of Rosa damascena-derived nanovesicles (RD-NVs), with particular emphasis on efferocytosis. RD-NVs were isolated by ultracentrifugation and characterised using dynamic light scattering, nanoparticle tracking analysis, zeta potential analysis, and electron microscopy. The nanoparticles exhibited spherical morphology, an average diameter of approximately 212 nm, and a zeta potential of approximately -40 mV, indicating good colloidal stability. RD-NVs were biocompatible with RAW264.7 macrophages, and the concentrations of RD-NVs (4.47 × 108 and 8.94 × 108 particles/mL) significantly reduced intracellular reactive oxygen species (68.48% and 41.18%) while restoring mitochondrial membrane potential (90.80% and 93.82%) in LPS-stimulated cells. They also downregulated TNF-α and HMGB1 expression while restoring GAS6 expression in a dose-dependent manner, supporting enhanced efferocytosis and inflammation resolution. Western blotting confirmed GAS6 restoration, and the reduction in HMGB1 mRNA expression level suggested diminished secondary necrosis. Biodistribution studies showed preferential accumulation in the liver and spleen. In vivo, RD-NVs significantly attenuated LPS-induced paw edoema, reduced leukocyte infiltration, and suppressed TNF-α expression. These findings demonstrate that RD-NVs promote inflammation resolution through restoration of GAS6-associated efferocytosis, mitochondrial protection, and suppression of inflammatory mediators, highlighting their potential as plant-derived resolution-oriented nanotherapeutics.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1-12"},"PeriodicalIF":4.7,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Silk sericin/fibroin composite drug delivery systems for lung cancer: mechanistic Rationale, potential functional complementarity, and future perspectives. 丝胶蛋白/丝素复合给药系统用于肺癌：机制原理、潜在的功能互补和未来展望。

IF 4.7 4区医学

Journal of Drug Targeting Pub Date : 2026-09-10 DOI: 10.1080/1061186X.2026.2729357

Hyeyoun Cho, Sanghyo Park, Seonmin Choi, Yoonho Hwang, Jaehong Key

{"title":"Silk sericin/fibroin composite drug delivery systems for lung cancer: mechanistic Rationale, potential functional complementarity, and future perspectives.","authors":"Hyeyoun Cho, Sanghyo Park, Seonmin Choi, Yoonho Hwang, Jaehong Key","doi":"10.1080/1061186X.2026.2729357","DOIUrl":"10.1080/1061186X.2026.2729357","url":null,"abstract":"Objectives: Silk fibroin (SF) and silk sericin (SS) are promising biomaterials for lung cancer drug delivery because of their biocompatibility, biodegradability, and versatile processing. SF-based systems can provide structural stability and controlled or prolonged release, although release behaviour depends on drug properties, loading strategy, secondary structure, and formulation architecture. Engineered SS-containing systems may contribute hydrophilicity, formulation-dependent environmental responsiveness, and biologically relevant interactions, but SS-rich formulations can show limited structural robustness.Methods: This review compares representative SF-based, SS-based, and SS/SF composite systems, focusing on pulmonary targeting, responsive drug release, tumour-microenvironment interactions, and translational considerations.Results: Selected SS/SF composites have demonstrated combinations of geometry-associated pulmonary accumulation, environment-associated release, prolonged local retention, and immune- or tumour-microenvironment-related activity. However, evidence for SF/SS complementarity remains limited and heterogeneous, with major differences in silk source, processing, composition, cargo, administration route, and disease model. Accordingly, this complementarity should be regarded as a provisional conceptual framework rather than a universally validated mechanism.Conclusions: Future progress requires standardised materials, composition-matched comparisons, formulation-specific safety assessment, reproducible manufacturing, and clinically relevant delivery strategies to determine whether SS/SF composites provide measurable advantages over simpler silk-based or non-silk systems.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1-19"},"PeriodicalIF":4.7,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chitosan nanoparticles for the treatment of ischemia-reperfusion injury: mechanisms, preclinical evidence, challenges, and future perspectives. 壳聚糖纳米颗粒治疗缺血再灌注损伤：机制、临床前证据、挑战和未来展望。

IF 4.7 4区医学

Journal of Drug Targeting Pub Date : 2026-09-03 DOI: 10.1080/1061186X.2026.2723295

Yongxin Dong, Weidong Qiang

{"title":"Chitosan nanoparticles for the treatment of ischemia-reperfusion injury: mechanisms, preclinical evidence, challenges, and future perspectives.","authors":"Yongxin Dong, Weidong Qiang","doi":"10.1080/1061186X.2026.2723295","DOIUrl":"10.1080/1061186X.2026.2723295","url":null,"abstract":"Ischaemia-reperfusion injury (IRI) is a complex pathological process involved in conditions such as organ transplantation, trauma, vascular surgery, myocardial infarction, and stroke. Although reperfusion is essential for restoring oxygen and nutrients to ischaemic tissues, it can paradoxically worsen tissue damage through oxidative stress, mitochondrial dysfunction, endothelial injury, inflammation, immune-cell infiltration, microvascular dysfunction, and regulated cell death. The multifactorial and rapidly evolving nature of IRI limits the effectiveness of traditional therapeutic approaches. Therefore, there is a strong need for strategies capable of simultaneously targeting multiple pathological pathways. Chitosan nanoparticles have emerged as promising nanocarriers for IRI therapy due to their biocompatibility, biodegradability, low toxicity, and ability to be chemically modified. They can encapsulate diverse therapeutic agents, including antioxidants, anti-inflammatory compounds, proteins, peptides, and nucleic acids, thereby improving drug stability, bioavailability, tissue retention, and enabling controlled or stimuli-responsive release. This review summarises current knowledge on IRI pathophysiology and highlights the therapeutic mechanisms of chitosan nanoparticles, particularly their effects on oxidative stress, inflammation, mitochondrial dysfunction, endothelial injury, and apoptosis. In addition, recent preclinical studies applying chitosan-based nanocarriers in cerebral, hepatic, renal, cardiac, and intestinal IRI are discussed.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1-13"},"PeriodicalIF":4.7,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0