Journal of Drug Targeting最新文献_第10页

Exosomes derived from cancer cells relieve inflammatory bowel disease in mice. 从癌细胞中提取的外泌体能缓解小鼠的炎症性肠病。

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2024-11-01 Epub Date: 2024-07-03 DOI: 10.1080/1061186X.2024.2369876

Shuyi Zhang, Guangyao Li, Kewen Qian, Yitan Zou, Xinya Zheng, Hongru Ai, Fangxing Lin, Changhai Lei, Shi Hu

{"title":"Exosomes derived from cancer cells relieve inflammatory bowel disease in mice.","authors":"Shuyi Zhang, Guangyao Li, Kewen Qian, Yitan Zou, Xinya Zheng, Hongru Ai, Fangxing Lin, Changhai Lei, Shi Hu","doi":"10.1080/1061186X.2024.2369876","DOIUrl":"10.1080/1061186X.2024.2369876","url":null,"abstract":"Exosome therapy has garnered significant attention due to its natural delivery capabilities, low toxicity, high biocompatibility, and potential for personalised treatment through engineering modifications. Recent studies have highlighted the ability of tumour cell-derived exosomes (TDEs) to interact with immune cells or modify the immune microenvironment to suppress host immune responses, as well as their unique homing ability to parental cells. The core question of this study is whether this immunomodulatory property of TDEs can be utilised for the immunotherapy of inflammatory diseases. In our experiments, we prepared exosomes derived from murine colon cancer cells CT26 (CT26 exo) using ultracentrifugation, characterised them, and conducted proteomic analysis. The therapeutic potential of CT26 exo was evaluated in our dextran sulphate sodium salt (DSS)-induced inflammatory bowel disease (IBD) mouse model. Compared to the control and 293 T exo treatment groups, mice treated with CT26 exo showed a reduction in the disease activity index (DAI) and colon shortening rate, with no noticeable weight loss. Haematoxylin and eosin (H&E) staining of colon paraffin sections revealed reduced inflammatory infiltration and increased epithelial goblet cells in the colons of CT26 exo-treated group. Furthermore, we conducted preliminary mechanistic explorations by examining the phenotyping and function of CD4+ T cells and dendritic cells (DCs) in the colonic lamina propria of mice. The results indicated that the ameliorative effect of CT26 exosomes might be due to their inhibition of pro-inflammatory cytokine secretion by colonic DCs and selective suppression of Th17 cell differentiation in the colon. Additionally, CT26 exo exhibited good biosafety. Our findings propose a novel exosome-based therapeutic approach for IBD and suggest the potential application of TDEs in the treatment of inflammatory diseases.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1073-1085"},"PeriodicalIF":4.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141492214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Smart nanocarriers for enzyme-activated prodrug therapy. 用于酶促药物治疗的智能纳米载体。

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2024-11-01 Epub Date: 2024-07-26 DOI: 10.1080/1061186X.2024.2383688

Louay Abo Qoura, Elena Morozova, С S Ramaa, Vadim S Pokrovsky

{"title":"Smart nanocarriers for enzyme-activated prodrug therapy.","authors":"Louay Abo Qoura, Elena Morozova, С S Ramaa, Vadim S Pokrovsky","doi":"10.1080/1061186X.2024.2383688","DOIUrl":"10.1080/1061186X.2024.2383688","url":null,"abstract":"Exogenous enzyme-activated prodrug therapy (EPT) is a potential cancer treatment strategy that delivers non-human enzymes into or on the surface of the cell and subsequently converts a non-toxic prodrug into an active cytotoxic substance at a specific location and time. The development of several pharmacological pairs based on EPT has been the focus of anticancer research for more than three decades. Numerous of these pharmacological pairs have progressed to clinical trials, and a few have achieved application in specific cancer therapies. The current review highlights the potential of enzyme-activated prodrug therapy as a promising anticancer treatment. Different microbial, plant, or viral enzymes and their corresponding prodrugs that advanced to clinical trials have been listed. Additionally, we discuss new trends in the field of enzyme-activated prodrug nanocarriers, including nanobubbles combined with ultrasound (NB/US), mesoscopic-sized polyion complex vesicles (PICsomes), nanoparticles, and extracellular vesicles (EVs), with special emphasis on smart stimuli-triggered drug release, hybrid nanocarriers, and the main application of nanotechnology in improving prodrugs.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1029-1051"},"PeriodicalIF":4.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141751842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interactions and communications in the prostate tumour microenvironment: evolving towards effective cancer therapy. 前列腺肿瘤微环境中的相互作用和交流：向有效的癌症治疗发展。

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2024-10-24 DOI: 10.1080/1061186X.2024.2418344

Qiang Dai, Yanling Peng, Peng He, Xiaojun Wu

{"title":"Interactions and communications in the prostate tumour microenvironment: evolving towards effective cancer therapy.","authors":"Qiang Dai, Yanling Peng, Peng He, Xiaojun Wu","doi":"10.1080/1061186X.2024.2418344","DOIUrl":"https://doi.org/10.1080/1061186X.2024.2418344","url":null,"abstract":"Prostate cancer is one of the most common malignancies in men. The tumour microenvironment (TME) has a critical role in the initiation, progression, and metastasis of prostate cancer. TME contains various cell types, including cancer-associated fibroblasts (CAFs), endothelial cells, immune cells such as macrophages, lymphocytes B and T, natural killer (NK) cells, and other proteins such as extracellular matrix (ECM) components. The interactions and communications between these cells within the TME are crucial for the growth and response of various solid tumours, such as prostate cancer to different anticancer modalities. In this review article, we exemplify the various mechanisms by which the TME influences prostate cancer progression. The roles of different cells, cytokines, chemokines, and growth factors in modulating the immune response and prostate tumour growth will be discussed. The impact of these cells and factors and other ECM components on tumour cell invasion and metastasis will also be discussed. We explain how these interactions in TME can affect the response of prostate cancer to therapy. We also highlight the importance of understanding these interactions to develop novel therapeutic approaches for prostate cancer.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1-21"},"PeriodicalIF":4.3,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Methotrexate-Loaded solid lipid nanoparticles enhance the viability of cutaneous flaps: potential for surgical wound healing. 装载甲氨蝶呤的固体脂质纳米粒子可增强皮瓣的存活能力：外科伤口愈合的潜力。

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2024-10-24 DOI: 10.1080/1061186X.2024.2409884

Cristina Pires Camargo, Maria Carolina Guido, Elaine Rufo Tavares, Priscila Oliveira Carvalho, Rolf Gemperli, Raul Cavalcante Maranhão

{"title":"Methotrexate-Loaded solid lipid nanoparticles enhance the viability of cutaneous flaps: potential for surgical wound healing.","authors":"Cristina Pires Camargo, Maria Carolina Guido, Elaine Rufo Tavares, Priscila Oliveira Carvalho, Rolf Gemperli, Raul Cavalcante Maranhão","doi":"10.1080/1061186X.2024.2409884","DOIUrl":"https://doi.org/10.1080/1061186X.2024.2409884","url":null,"abstract":"Skin flaps are employed to cover cutaneous denuded surfaces, but ensuing flap necrosis often occurs. Previously, rats with myocardial infarction treated with lipid-core nanoparticles (LDE) loaded with methotrexate (MTX) improved myocardial irrigation and reduced necrosis. Here, the aim was to investigate the efficacy of LDE-MTX to preserve the viability of cutaneous flaps and its implications for surgical wound healing. Twenty-eight male rats were divided into 4 groups: (1) LDE, injected intraperitoneally with LDE only; (2) MTX (1 mg/Kg commercial MTX): (3) LDE-MTX (1 mg/Kg MTX associated with LDE), and controls without treatment. LDE, MTX or LDE-MTX were repeated after 2 days. Then, flap surgery (9x3cm) was performed on the dorsal region. Injections were continued every other day until day 7 when animals were euthanized. LDE-MTX treatment improved the total viable area of the flaps with a fourfold increase in blood flow and reduced inflammatory cell number (p < 0.001), accompanied by decreased protein expression of pro-inflammatory factors. SOD-1 was higher in LDE-MTX-treated rats (p < 0.05). In conclusion, LDE-MTX treatment achieved total viability of cutaneous flaps, with increased irrigation and diminished local inflammation. LDE-MTX may offer efficient and cost-effective prevention of cutaneous flaps and treatment for wounds from surgical procedures to be tested in future clinical studies.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1-9"},"PeriodicalIF":4.3,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of Non-Viral Targeted RNA Delivery Vehicles - A Key Factor in Success of Therapeutic RNA. 开发非病毒靶向 RNA 运送载体--治疗 RNA 成功的关键因素。

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2024-10-11 DOI: 10.1080/1061186X.2024.2416241

Muhammad Waqas Choudry, Rabia Riaz, Muhammad Hassan Raza, Pashma Nawaz, Bilal Ahmad, Neelam Jahan, Shazia Rafique, Samia Afza, Iram Amin, Muhammad Shahid

{"title":"Development of Non-Viral Targeted RNA Delivery Vehicles - A Key Factor in Success of Therapeutic RNA.","authors":"Muhammad Waqas Choudry, Rabia Riaz, Muhammad Hassan Raza, Pashma Nawaz, Bilal Ahmad, Neelam Jahan, Shazia Rafique, Samia Afza, Iram Amin, Muhammad Shahid","doi":"10.1080/1061186X.2024.2416241","DOIUrl":"https://doi.org/10.1080/1061186X.2024.2416241","url":null,"abstract":"Decade-long efforts in medicinal biotechnology have enabled large-scale in-vitro production of optimized therapeutic RNA constructs for stable in-vivo delivery and modify the expression of disease-related genes. The success of lipid nanoparticle-formulated mRNA vaccines against Severe acute respiratory syndrome Coronavirus-2 (SARS-Cov2) has opened a new era of RNA therapeutics and non-viral drug delivery systems. The major limiting factor in the clinical translation of RNA-based drugs is the availability of suitable delivery vehicles that can protect RNA payloads from degradation, offer controlled release, and pose minimal inherent toxicity. Unwanted immune response, payload size constraints, genome integration, and non-specific tissue targeting limit the application of conventional viral drug-delivery vehicles. This review summarizes current research on nano-sized drug carriers, including lipid nanoparticles, polymer-based formulations, cationic nanoemulsion, and cell-penetrating peptides, for targeted therapeutic RNA delivery. Further, this paper highlights the biomimetic approaches (i.e., mimicking naturally occurring bio-compositions, molecular designs, and systems), including virus-like particles (VLPs), exosomes, and selective endogenous eNcapsidation (SEND) technology being explored as safer and more efficient alternatives.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1-24"},"PeriodicalIF":4.3,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unlocking hope: GSK-3 inhibitors and Wnt pathway activation in Alzheimer's therapy. 开启希望：GSK-3 抑制剂和 Wnt 通路激活在阿尔茨海默氏症治疗中的应用。

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2024-09-01 Epub Date: 2024-06-11 DOI: 10.1080/1061186X.2024.2365263

Magham Sai Varshini, Ramakkamma Aishwarya Reddy, Praveen Thaggikuppe Krishnamurthy

{"title":"Unlocking hope: GSK-3 inhibitors and Wnt pathway activation in Alzheimer's therapy.","authors":"Magham Sai Varshini, Ramakkamma Aishwarya Reddy, Praveen Thaggikuppe Krishnamurthy","doi":"10.1080/1061186X.2024.2365263","DOIUrl":"10.1080/1061186X.2024.2365263","url":null,"abstract":"Alzheimer's disease (AD) is a complex neurodegenerative disorder characterised by progressive cognitive decline and the accumulation of amyloid-β plaques and tau tangles. The Wnt signalling pathway known for its crucial role in neurodevelopment and adult neurogenesis has emerged as a potential target for therapeutic intervention in AD. Glycogen synthase kinase-3 beta (GSK-3β), a key regulator of the Wnt pathway, plays a pivotal role in AD pathogenesis by promoting tau hyperphosphorylation and neuroinflammation. Several preclinical studies have demonstrated that inhibiting GSK-3β leads to the activation of Wnt pathway thereby promoting neuroprotective effects, and mitigating cognitive deficits in AD animal models. The modulation of Wnt signalling appears to have multifaceted benefits including the reduction of amyloid-β production, tau hyperphosphorylation, enhancement of synaptic plasticity, and inhibition of neuroinflammation. These findings suggest that targeting GSK-3β to activate Wnt pathway may represent a novel approach for slowing or halting the progression of AD. This hypothesis reviews the current state of research exploring the activation of Wnt pathway through the inhibition of GSK-3β as a promising therapeutic strategy in AD.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"909-917"},"PeriodicalIF":4.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141261712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulation of IFP in solid tumours through acoustic pressure to enhance infiltration of nanoparticles of various sizes. 通过声压调节实体瘤中的 IFP，以增强不同尺寸纳米粒子的浸润。

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2024-09-01 Epub Date: 2024-06-24 DOI: 10.1080/1061186X.2024.2367579

Yangcheng He, Yuyi Feng, Danxai Qiu, MinHua Lin, Hai Jin, Zhiwen Hu, Xue Huang, Suihong Ma, Yan He, Meiqi Lai, Wenhui Jin, Jianhua Liu

{"title":"Regulation of IFP in solid tumours through acoustic pressure to enhance infiltration of nanoparticles of various sizes.","authors":"Yangcheng He, Yuyi Feng, Danxai Qiu, MinHua Lin, Hai Jin, Zhiwen Hu, Xue Huang, Suihong Ma, Yan He, Meiqi Lai, Wenhui Jin, Jianhua Liu","doi":"10.1080/1061186X.2024.2367579","DOIUrl":"10.1080/1061186X.2024.2367579","url":null,"abstract":"Numerous nanomedicines have been developed recently that can accumulate selectively in tumours due to the enhanced permeability and retention (EPR) effect. However, the high interstitial fluid pressure (IFP) in solid tumours limits the targeted delivery of nanomedicines. We were previously able to relieve intra-tumoural IFP by low-frequency non-focused ultrasound (LFNFU) through ultrasonic targeted microbubble destruction (UTMD), improving the targeted delivery of FITC-dextran. However, the accumulation of nanoparticles of different sizes and the optimal acoustic pressure were not evaluated. In this study, we synthesised Cy5.5-conjugated mesoporous silica nanoparticles (Cy5.5-MSNs) of different sizes using a one-pot method. The Cy5.5-MSNs exhibited excellent stability and biosafety regardless of size. MCF7 tumour-bearing mice were subjected to UTMD over a range of acoustic pressures (0.5, 0.8, 1.5 and 2.0 MPa), and injected intravenously with Cy5.5-MSNs. Blood perfusion, tumour IFP and intra-tumoural accumulation of Cy5.5-MSNs were analysed. Blood perfusion and IFP initially rose, and then declined, as acoustic pressure intensified. Furthermore, UTMD significantly enhanced the accumulation of differentially sized Cy5.5-MSNs in tumour tissues compared to that of the control group, and the increase was sevenfold higher at an acoustic pressure of 1.5 MPa. Taken together, UTMD enhanced the infiltration and accumulation of Cy5.5-MSNs of different sizes in solid tumours by reducing intra-tumour IFP.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"964-976"},"PeriodicalIF":4.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141331072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The pharmacological blockade of P2X4 receptor as a viable approach to manage visceral pain in a rat model of colitis. 药物阻断 P2X4 受体是控制大鼠结肠炎模型内脏疼痛的可行方法。

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2024-09-01 Epub Date: 2024-07-02 DOI: 10.1080/1061186X.2024.2367563

Clelia Di Salvo, Vanessa D'Antongiovanni, Laura Benvenuti, Matteo Fornai, Giulia Valdiserra, Gianfranco Natale, Larisa Ryskalin, Elena Lucarini, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Rocchina Colucci, György Haskó, Carolina Pellegrini, Luca Antonioli

{"title":"The pharmacological blockade of P2X4 receptor as a viable approach to manage visceral pain in a rat model of colitis.","authors":"Clelia Di Salvo, Vanessa D'Antongiovanni, Laura Benvenuti, Matteo Fornai, Giulia Valdiserra, Gianfranco Natale, Larisa Ryskalin, Elena Lucarini, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Rocchina Colucci, György Haskó, Carolina Pellegrini, Luca Antonioli","doi":"10.1080/1061186X.2024.2367563","DOIUrl":"10.1080/1061186X.2024.2367563","url":null,"abstract":"Nowadays, the pharmacological management of visceral hypersensitivity associated with colitis is ineffective. In this context, targeting purinergic P2X4 receptor (P2X4R), which can modulate visceral pain transmission, could represent a promising therapeutic strategy. Herein, we tested the pain-relieving effect of two novel and selective P2X4R antagonists (NC-2600 and NP-1815-PX) in a murine model of DNBS-induced colitis and investigated the mechanisms underlying their effect. Tested drugs and dexamethasone (DEX) were administered orally, two days after colitis induction. Treatment with tested drugs and DEX improved tissue inflammatory parameters (body weight, spleen weight, macroscopic damage, TNF and IL-1β levels) in DNBS-rats. In addition, NC-2600 and NP-1815-PX attenuated visceral pain better than DEX and prevented the reduction of occludin expression. In in vitro studies, treatment of CaCo2 cells with supernatant from THP-1 cells, previously treated with LPS plus ATP, reduced the expression of tight junctions protein. By contrast, CaCo2 cells treated with supernatant from THP-1 cells, previously incubated with tested drugs, counteracted the reduction of tight junctions due to the inhibition of P2X4R/NLRP3/IL-1β axis. In conclusion, these results suggest that the direct and selective inhibition of P2X4R represents a viable approach for the management of visceral pain associated with colitis via NLRP3/IL-1β axis inhibition.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"953-963"},"PeriodicalIF":4.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141306089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Folic acid modified precision nanocarriers: charting new frontiers in breast cancer management beyond conventional therapies. 叶酸修饰的精准纳米载体：描绘超越传统疗法的乳腺癌治疗新前沿。

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2024-09-01 Epub Date: 2024-05-22 DOI: 10.1080/1061186X.2024.2356735

Nida Nehal, Aashish Rohilla, Ali Sartaj, Sanjula Baboota, Javed Ali

{"title":"Folic acid modified precision nanocarriers: charting new frontiers in breast cancer management beyond conventional therapies.","authors":"Nida Nehal, Aashish Rohilla, Ali Sartaj, Sanjula Baboota, Javed Ali","doi":"10.1080/1061186X.2024.2356735","DOIUrl":"10.1080/1061186X.2024.2356735","url":null,"abstract":"Breast cancer presents a significant global health challenge, ranking highest incidence rate among all types of cancers. Functionalised nanocarriers offer a promising solution for precise drug delivery by actively targeting cancer cells through specific receptors, notably folate receptors. By overcoming the limitations of passive targeting in conventional therapies, this approach holds the potential for enhanced treatment efficacy through combination therapy. Encouraging outcomes from studies like in vitro and in vivo, underscore the promise of this innovative approach. This review explores the therapeutic potential of FA (Folic acid) functionalised nanocarriers tailored for breast cancer management, discussing various chemical modification techniques for functionalization. It examines FA-conjugated nanocarriers containing chemotherapeutics to enhance treatment efficacy and addresses the pharmacokinetic aspect of these functionalised nanocarriers. Additionally, the review integrates active targeting via folic acid with theranostics, photothermal therapy, and photodynamic therapy, offering a comprehensive management strategy. Emphasising rigorous experimental validation for practical utility, the review underscores the need to bridge laboratory research to clinical application. While these functionalised nanocarriers show promise, their credibility and applicability in real-world settings necessitate thorough validation for effective clinical use.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"855-873"},"PeriodicalIF":4.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140944235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting Nrf2 signaling pathway: new therapeutic strategy for cardiovascular diseases. 靶向 Nrf2 信号通路：心血管疾病的新治疗策略。

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2024-09-01 Epub Date: 2024-05-24 DOI: 10.1080/1061186X.2024.2356736

Qi Wu, Jiangting Yao, Mengyun Xiao, Xiawei Zhang, Mengxiao Zhang, Xinting Xi

引用次数: 0