Journal of Drug Targeting最新文献

Advances in nanomedicine for retinal drug delivery: overcoming barriers and enhancing therapeutic outcomes. 视网膜给药纳米医学研究进展：克服障碍，提高治疗效果。

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2025-06-01 Epub Date: 2024-12-27 DOI: 10.1080/1061186X.2024.2443144

Pratikeswar Panda, Shreyashree Mohanty, Sangita Ranee Gouda, Rajaram Mohapatra

{"title":"Advances in nanomedicine for retinal drug delivery: overcoming barriers and enhancing therapeutic outcomes.","authors":"Pratikeswar Panda, Shreyashree Mohanty, Sangita Ranee Gouda, Rajaram Mohapatra","doi":"10.1080/1061186X.2024.2443144","DOIUrl":"10.1080/1061186X.2024.2443144","url":null,"abstract":"Nanomedicine offers a promising avenue for improving retinal drug delivery, effectively addressing challenges associated with ocular diseases like age-related macular degeneration and diabetic retinopathy. Nanoparticles, with their submicron size and customisable surface properties, enable enhanced permeability and retention within retinal tissues, supporting sustained drug release and minimising systemic side effects. Nanostructured scaffolds further provide a supportive environment for retinal cell growth and tissue regeneration, crucial for treating degenerative conditions. Additionally, advanced nanodevices facilitate real-time monitoring and controlled drug release, marking significant progress in retinal therapy. This study reviews recent advancements in nanomedicine for retinal drug delivery, critically analysing design innovations, therapeutic benefits, and limitations of these systems. By advancing nanotechnology integration in ocular therapies, this field holds strong potential for overcoming current barriers, ultimately improving patient outcomes and quality of life.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"587-611"},"PeriodicalIF":4.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Green synthesis of magnesium oxide nanoparticles using the extract of Falcaria vulgaris to enhance the healing of burn wounds. 绿色合成氧化镁纳米颗粒利用寻常镰孢菌提取物促进烧伤创面愈合。

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2025-06-01 Epub Date: 2025-01-06 DOI: 10.1080/1061186X.2024.2445744

Mozafar Khazaei, Mohammadali Meskaraf-Asadabadi, Fatemeh Khazaei, Sepide Kadivarian, Elham Ghanbari

{"title":"Green synthesis of magnesium oxide nanoparticles using the extract of Falcaria vulgaris to enhance the healing of burn wounds.","authors":"Mozafar Khazaei, Mohammadali Meskaraf-Asadabadi, Fatemeh Khazaei, Sepide Kadivarian, Elham Ghanbari","doi":"10.1080/1061186X.2024.2445744","DOIUrl":"10.1080/1061186X.2024.2445744","url":null,"abstract":"Treating burn lesions has always been challenging because any product should be cheap, accessible, and have anti-bacterial commodities and tissue regeneration properties. The green synthesis of magnesium oxide nanoparticles (GS-MgONPs) can create an optimal prospect that is safe with low toxicity in biological tissue and better safety for application while including the antibacterial effect. This recent study aimed to evaluate the effectiveness of burn wound treatment using GS-MgONPs in rats. GS-MgONPs were synthesised for the first time using a Falcaria vulgaris extract (FVE) and characterised. Thirty male Wistar rats were divided into five groups: An untreated group, conventional product treated group, GS-MgONPs (1 wt%), GS-MgONPs (3 wt%) and 5. FVE (1 wt%). Treatments commenced immediately following burn induction and were administered daily for a duration of 21 d. GS-MgONPs showed a spherical morphology with a diameter of less than 100 nm. The NPs (1% and 3 wt%) and FVE demonstrated significant growth inhibition against Staphylococcus aureus while showing no cytotoxic effects on human fibroblast cells. The proposed subjects treated with 1 wt% and 3 wt% GS-MgONPs were able to significantly increase the rate of wound closure (p < 0.05). Histological observations revealed that collagen formation and epithelial regeneration were more pronounced in the groups receiving 1 wt% and 3 wt% MgONPs. These results indicate that GS-MgONPs effectively enhance the regeneration process.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"761-772"},"PeriodicalIF":4.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The biomedical applications of artificial intelligence: an overview of decades of research. 人工智能的生物医学应用：几十年研究综述。

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2025-06-01 Epub Date: 2025-01-09 DOI: 10.1080/1061186X.2024.2448711

Sweet Naskar, Suraj Sharma, Ketousetuo Kuotsu, Suman Halder, Goutam Pal, Subhankar Saha, Shubhadeep Mondal, Ujjwal Kumar Biswas, Mayukh Jana, Sunirmal Bhattacharjee

{"title":"The biomedical applications of artificial intelligence: an overview of decades of research.","authors":"Sweet Naskar, Suraj Sharma, Ketousetuo Kuotsu, Suman Halder, Goutam Pal, Subhankar Saha, Shubhadeep Mondal, Ujjwal Kumar Biswas, Mayukh Jana, Sunirmal Bhattacharjee","doi":"10.1080/1061186X.2024.2448711","DOIUrl":"10.1080/1061186X.2024.2448711","url":null,"abstract":"A significant area of computer science called artificial intelligence (AI) is successfully applied to the analysis of intricate biological data and the extraction of substantial associations from datasets for a variety of biomedical uses. AI has attracted significant interest in biomedical research due to its features: (i) better patient care through early diagnosis and detection; (ii) enhanced workflow; (iii) lowering medical errors; (v) lowering medical costs; (vi) reducing morbidity and mortality; (vii) enhancing performance; (viii) enhancing precision; and (ix) time efficiency. Quantitative metrics are crucial for evaluating AI implementations, providing insights, enabling informed decisions, and measuring the impact of AI-driven initiatives, thereby enhancing transparency, accountability, and overall impact. The implementation of AI in biomedical fields faces challenges such as ethical and privacy concerns, lack of awareness, technology unreliability, and professional liability. A brief discussion is given of the AI techniques, which include Virtual screening (VS), DL, ML, Hidden Markov models (HMMs), Neural networks (NNs), Generative models (GMs), Molecular dynamics (MD), and Structure-activity relationship (SAR) models. The study explores the application of AI in biomedical fields, highlighting its enhanced predictive accuracy, treatment efficacy, diagnostic efficiency, faster decision-making, personalised treatment strategies, and precise medical interventions.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"717-748"},"PeriodicalIF":4.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142914960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancements in colorectal cancer immunotherapy: from CAR-T cells to exosome-based therapies. 结直肠癌免疫治疗的进展：从CAR-T细胞到基于外泌体的治疗

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2025-06-01 Epub Date: 2025-01-08 DOI: 10.1080/1061186X.2024.2449482

Sepideh Arabi, Manouchehr Fadaee, Tohid Kazemi, Mohammadreza Rahmani

{"title":"Advancements in colorectal cancer immunotherapy: from CAR-T cells to exosome-based therapies.","authors":"Sepideh Arabi, Manouchehr Fadaee, Tohid Kazemi, Mohammadreza Rahmani","doi":"10.1080/1061186X.2024.2449482","DOIUrl":"10.1080/1061186X.2024.2449482","url":null,"abstract":"Colorectal cancer (CRC) continues to be a major worldwide health issue, with elevated death rates linked to late stages of the illness. Immunotherapy has made significant progress in developing effective techniques to improve the immune system's capacity to identify and eradicate cancerous cells. This study examines the most recent advancements in CAR-T cell treatment and exosome-based immunotherapy for CRC. CAR-T cell therapy, although effective in treating blood cancers, encounters obstacles when used against solid tumours such as CRC. These obstacles include the presence of an immunosuppressive tumour microenvironment and a scarcity of tumour-specific antigens. Nevertheless, novel strategies like dual-receptor CAR-T cells and combination therapy involving cytokines have demonstrated promise in surmounting these obstacles. Exosome-based immunotherapy is a promising approach for targeted delivery of therapeutic drugs to tumour cells, with high specificity and minimal off-target effects. However, there are still obstacles to overcome in the field, such as resistance to treatment, adverse effects associated with the immune system, and the necessity for more individualised methods. The current research is focused on enhancing these therapies, enhancing the results for patients, and ultimately incorporating these innovative immunotherapeutic approaches into the standard treatment protocols for CRC.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"749-760"},"PeriodicalIF":4.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced pharmacokinetic approach for anastrozole via macromolecule-based silk fibroin nanoparticles incorporated in situ injectables for oestrogen-positive breast cancer therapy. 基于大分子丝素纳米颗粒的阿那曲唑原位注射治疗雌激素阳性乳腺癌的强化药代动力学研究。

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2025-06-01 Epub Date: 2025-01-08 DOI: 10.1080/1061186X.2024.2449486

Arfa Nasrine, Sourav Mohanto, Soumya Narayana, Mohammed Gulzar Ahmed

{"title":"Enhanced pharmacokinetic approach for anastrozole via macromolecule-based silk fibroin nanoparticles incorporated in situ injectables for oestrogen-positive breast cancer therapy.","authors":"Arfa Nasrine, Sourav Mohanto, Soumya Narayana, Mohammed Gulzar Ahmed","doi":"10.1080/1061186X.2024.2449486","DOIUrl":"10.1080/1061186X.2024.2449486","url":null,"abstract":"Breast cancer (BC) is a substantial reason for cancer-related mortality among women across the globe. Anastrozole (ANS) is an effective orally administered hormonal therapy for oestrogen-positive (ER+) BC treatment. However, several side effects and pharmacokinetic limitations restricted the uses of ANS in BC therapy. Therefore, this investigation developed an in situ gelling injectable-loaded silk fibroin (SF)-ANS NPs, which offers sustained drug release and improved pharmacokinetic properties compared to conventional oral formulations at the targeted site. The optimised in situ gel (ISG) incorporated SF-ANS-NPs were developed, and the pharmacokinetic parameters were accessed in subcutaneous administration of NMU-induced Wistar albino rats. The results demonstrated that SF-ANS-NP-ISG exhibited a significantly higher Cmax, Tmax, and AUC compared to pure ANS suspension. In addition, tumour multiplicity (1.40 ± 0.66), tumour latency (75 ± 9.2 days), and incidence rate (90 ± 2.1%) were recorded, and post-treatment analysis reported a marked reduction in tumour volume and weight compared to positive control within 90 days of a single dose. The SF-ANS-NP-ISG treated group's histopathological assessment indicated a low-grade carcinoma, reduced epithelial hyperplasia, and haemorrhage in mammary tumour tissues compared to positive control. Thus, the SF-ANS-NPs-ISG investigated to overcome the pharmacokinetic limitations of ANS further exhibited targeted delivery and bioavailability compared to conventional dosage forms.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"793-803"},"PeriodicalIF":4.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondrial-targeted liposome-based drug delivery - therapeutic potential and challenges. 线粒体靶向脂质体给药-治疗潜力和挑战。

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2025-06-01 Epub Date: 2024-12-08 DOI: 10.1080/1061186X.2024.2437440

Lissette Sanchez-Aranguren, Mohamad Anas Al Tahan, Muhammad Uppal, Parag Juvale, Mandeep Kaur Marwah

{"title":"Mitochondrial-targeted liposome-based drug delivery - therapeutic potential and challenges.","authors":"Lissette Sanchez-Aranguren, Mohamad Anas Al Tahan, Muhammad Uppal, Parag Juvale, Mandeep Kaur Marwah","doi":"10.1080/1061186X.2024.2437440","DOIUrl":"10.1080/1061186X.2024.2437440","url":null,"abstract":"Liposomes, as nanocarriers for therapeutics, are a prominent focus in translational medicine. Given their biocompatibility, liposomes are suitable drug delivery systems rendering highly efficient therapeutic outcomes with minimal off-site toxicity. In different scenarios of human disease, it is essential not only to maintain therapeutic drug levels but also to target them to the appropriate intracellular compartment. Mitochondria regulate cellular signalling, calcium balance, and energy production, playing a crucial role in various human diseases. The notion of focusing on mitochondria for targeted drug delivery was proposed several decades ago, yet the practical application of this idea and its translation to clinical use is still in development. Mitochondrial-targeted liposomes offer an alternative to standard drug delivery systems, potentially reducing off-target interactions, side effects, and drug dosage or frequency. To advance this field, it is imperative to integrate various disciplines such as efficient chemical design, pharmacology, pharmaceutics, and cell biology. This review summarises scientific advances in the design, development and characterisation of novel liposome-based drug delivery systems targeting the mitochondria while revisiting their translational potential.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"575-586"},"PeriodicalIF":4.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Review on anti-tumour lipid nano drug delivery systems of traditional Chinese medicine. 中药抗肿瘤脂质纳米给药系统研究进展。

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2025-06-01 Epub Date: 2025-01-03 DOI: 10.1080/1061186X.2024.2448708

Ziwei Zhang, Rui Xiong, Qiyan Hu, Qiang Zhang, Shaozhen Wang, Yunyan Chen

{"title":"Review on anti-tumour lipid nano drug delivery systems of traditional Chinese medicine.","authors":"Ziwei Zhang, Rui Xiong, Qiyan Hu, Qiang Zhang, Shaozhen Wang, Yunyan Chen","doi":"10.1080/1061186X.2024.2448708","DOIUrl":"10.1080/1061186X.2024.2448708","url":null,"abstract":"In recent years, the use of traditional Chinese medicine (TCM) in the treatment of cancer has received widespread attention. Treatment of tumours using TCM can effectively reduce the side effects of anti-tumour drugs, meanwhile to improve the treatment efficacy of patients. However, most of the active ingredients in TCM, such as saponins, alkaloids, flavonoids, volatile oils, etc., have defects such as low bioavailability and poor solubility in clinical application, which seriously restrict the application of TCM. Meanwhile, the encapsulation of TCM into lipid nano-delivery systems for cancer therapy has received much attention. Lipid nano-delivery systems are obtained by using phospholipids as the base material and adding other auxiliary materials under a certain preparation process, including, for example, liposomes, solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), microemulsions, and self-microemulsion drug delivery systems (SMEDDS), can resolve the application problems of TCM by improving the efficacy of active ingredients of TCM and reducing the toxicity of anti-tumour drugs. This paper focuses on the categories, development status, and research progress of lipid nano delivery system of TCM, aiming to provide a certain theoretical basis for further in-depth research and rational application of these systems.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"704-716"},"PeriodicalIF":4.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142914847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A state-of-the-art review of the recent advances in drug delivery systems for different therapeutic agents in periodontitis. 牙周炎不同治疗药物输送系统的最新进展综述。

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2025-06-01 Epub Date: 2024-12-27 DOI: 10.1080/1061186X.2024.2445051

Mehrnaz Fayazi, Mitra Rostami, Masoud Amiri Moghaddam, Kamyar Nasiri, Azadeh Tadayonfard, Mohammadreza Behnam Roudsari, Hani Moslem Ahmad, Zahra Parhizgar, Amirhossein Majbouri Yazdi

{"title":"A state-of-the-art review of the recent advances in drug delivery systems for different therapeutic agents in periodontitis.","authors":"Mehrnaz Fayazi, Mitra Rostami, Masoud Amiri Moghaddam, Kamyar Nasiri, Azadeh Tadayonfard, Mohammadreza Behnam Roudsari, Hani Moslem Ahmad, Zahra Parhizgar, Amirhossein Majbouri Yazdi","doi":"10.1080/1061186X.2024.2445051","DOIUrl":"10.1080/1061186X.2024.2445051","url":null,"abstract":"Periodontitis (PD) is a chronic gum illness that may be hard to cure for a number of reasons, including the fact that no one knows what causes it, the side effects of anti-microbial treatment, and how various kinds of bacteria interact with one another. As a result, novel therapeutic approaches for PD treatment must be developed. Additionally, supplementary antibacterial regimens, including local and systemic medication administration of chemical agents, are necessary for deep pockets to assist with mechanical debridement of tooth surfaces. As our knowledge of periodontal disease and drug delivery systems (DDSs) grows, new targeted delivery systems like extracellular vesicles, lipid-based nanoparticles (NPs), metallic NPs, and polymer NPs have been developed. These systems aim to improve the targeting and precision of PD treatments while reducing the systemic side effects of antibiotics. Nanozymes, photodermal therapy, antibacterial metallic NPs, and traditional PD therapies have all been reviewed in this research. Medicinal herbs, antibiotics, photothermal therapy, nanozymes, antibacterial metallic NPs, and conventional therapies for PD have all been examined in this research. After that, we reviewed the key features of many innovative DDSs and how they worked for PD therapy. Finally, we have discussed the advantages and disadvantages of these DDSs.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"612-647"},"PeriodicalIF":4.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Delivery vehicles for light-mediated drug delivery: microspheres, microbots, and nanoparticles: a review. 光介导的药物递送载体：微球、微机器人和纳米颗粒：综述。

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2025-06-01 Epub Date: 2025-01-03 DOI: 10.1080/1061186X.2024.2446636

Engi Nadia Massoud, Mariana Katharine Hebert, AishwaryaRaksha Siddharthan, Tyler Ferreira, Abid Neron, Mary Goodrow, Tracie Ferreira

{"title":"Delivery vehicles for light-mediated drug delivery: microspheres, microbots, and nanoparticles: a review.","authors":"Engi Nadia Massoud, Mariana Katharine Hebert, AishwaryaRaksha Siddharthan, Tyler Ferreira, Abid Neron, Mary Goodrow, Tracie Ferreira","doi":"10.1080/1061186X.2024.2446636","DOIUrl":"10.1080/1061186X.2024.2446636","url":null,"abstract":"This review delves into the evolving landscape of mediated drug delivery, focusing on the versatility of a variety of drug delivery vehicles such as microspheres, microbots, and nanoparticles (NPs). The review also expounds on the critical components and mechanisms for light-mediated drug delivery, including photosensitizers and light sources such as visible light detectable by the human eye, ultraviolet (UV) light, shorter wavelengths than visible light, and near-infra-red (NIR) light, which has longer wavelength than visible light. This longer wavelength has been implemented in drug delivery for its ability to penetrate deeper tissues and highlighted for its role in precise and controlled drug release. Furthermore, this review discusses the significance of these drug delivery vehicles towards a spectrum of diverse applications spanning gene therapy, cancer treatment, diagnostics, and microsurgery, and the materials used in the fabrication of these vehicles encompassing polymers, ceramics, and lipids. Moreover, the review analyses the challenges and limitations of such drug delivery vehicles as areas of improvement to provide researchers with valuable insights for addressing current obstacles in the progression of drug delivery. Overall, this review underscores the potential of light-mediated drug delivery to revolutionise healthcare and personalised medicine, providing precise, targeted, and effective therapeutic interventions.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"691-703"},"PeriodicalIF":4.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insulin for oral bone tissue engineering: a review on innovations in targeted insulin-loaded nanocarrier scaffold. 胰岛素用于口腔骨组织工程：靶向胰岛素纳米载体支架的研究进展。

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2025-06-01 Epub Date: 2025-01-03 DOI: 10.1080/1061186X.2024.2445737

Jiyaur Rahaman, Dhrubojyoti Mukherjee

{"title":"Insulin for oral bone tissue engineering: a review on innovations in targeted insulin-loaded nanocarrier scaffold.","authors":"Jiyaur Rahaman, Dhrubojyoti Mukherjee","doi":"10.1080/1061186X.2024.2445737","DOIUrl":"10.1080/1061186X.2024.2445737","url":null,"abstract":"The occurrence of oral bone tissue degeneration and bone defects by osteoporosis, tooth extraction, obesity, trauma, and periodontitis are major challenges for clinicians. Traditional bone regeneration methods often come with limitations such as donor site morbidity, limitation of special shape, inflammation, and resorption of the implanted bone. The treatment oriented with biomimetic bone materials has achieved significant attention recently. In the oral bone tissue engineering arena, insulin has gained considerable attention among all the known biomaterials for osteogenesis and angiogenesis. It also exhibits osteogenic and angiogenic properties by interacting with insulin receptors on osteoblasts. Insulin influences bone remodelling both directly and indirectly. It acts directly through the PI3K/Akt and MAPK signalling pathways and indirectly by modulating the RANK/RANKL/OPG pathway, which helps reduce bone resorption. The current review reports the role of insulin in bone remodelling and bone tissue regeneration in the oral cavity in the form of scaffolds and nanomaterials. Different insulin delivery systems, utilising nanomaterials and scaffolds functionalised with polymeric biomaterials have been explored for oral bone tissue regeneration. The review put forward a theoretical basis for future research in insulin delivery in the form of scaffolds and composite materials for oral bone tissue regeneration.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"648-665"},"PeriodicalIF":4.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0