Journal of Drug Targeting最新文献

Mucoadhesive and pH-responsive berberine-Bletilla striata polysaccharide core-shell microspheres for colon-targeted synergistic therapy of ulcerative colitis. 黏附性和ph响应性小檗-白芨多糖核壳微球结肠靶向协同治疗溃疡性结肠炎。

IF 4.7 4区医学

Journal of Drug Targeting Pub Date : 2026-11-01 Epub Date: 2026-05-20 DOI: 10.1080/1061186X.2026.2672153

Huiru Li, Lingfeng Sun, Wenjie Lu, Juan Sun, Lingzhen Ding, Dan Su, Denggao Zheng, Tianming Wang, Mingchao Xu, Wenyou Fang, Hongxing Kan, Shengqi Chen, Song Gao, Rongfeng Hu

{"title":"Mucoadhesive and pH-responsive berberine-Bletilla striata polysaccharide core-shell microspheres for colon-targeted synergistic therapy of ulcerative colitis.","authors":"Huiru Li, Lingfeng Sun, Wenjie Lu, Juan Sun, Lingzhen Ding, Dan Su, Denggao Zheng, Tianming Wang, Mingchao Xu, Wenyou Fang, Hongxing Kan, Shengqi Chen, Song Gao, Rongfeng Hu","doi":"10.1080/1061186X.2026.2672153","DOIUrl":"10.1080/1061186X.2026.2672153","url":null,"abstract":"Although berberine has notable anti-inflammatory and antioxidant effects for ulcerative colitis (UC) treatment, its clinical application is limited by poor oral bioavailability. To improve berberine delivery, we developed colon-targeted mucoadhesive Eudragit® S100/Bletilla striata polysaccharide (EB)-coated microspheres (MPs) encapsulating berberine hydrochloride (BH)-hydrogenated soy phosphatidylcholine (HSPC) complex. BSP acts as both a bioadhesive carrier for prolonged mucosal retention and an immunoregulatory agent synergizing with berberine. Fabricated via electrospray and fluidised-bed coating, the formulation realized pH-responsive colon-specific release. In vitro studies, it showed favorable pH-dependent release, scavenged reactive oxygen species, and promoted M2 macrophage polarization. Small animal fluorescence imaging studies have confirmed its colon-targeting and mucoadhesive properties. In DSS-induced acute and FXY-DSS-induced chronic colitis models, EB@BH-HSPC significantly alleviated inflammation, restored intestinal barrier function, and reduced oxidative stress, with improved therapeutic effects attributed to berberine-BSP synergy and integrated delivery advantages. BSP serves as both film-forming adhesive component and synergistic therapeutic component, making this system a potent strategy for UC treatment.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1839-1854"},"PeriodicalIF":4.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147930185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Post-transcriptional knockdown of BRCC3 via siRNA-loaded niosomes modulates autophagy and endoplasmic reticulum stress in rotenone-induced Parkinson's Disease model. 在鱼藤酮诱导的帕金森病模型中，通过装载sirna的niosomes转录后敲低BRCC3可调节自噬和内质网应激。

IF 4.7 4区医学

Journal of Drug Targeting Pub Date : 2026-11-01 Epub Date: 2026-05-07 DOI: 10.1080/1061186X.2026.2669781

Çevik Gürel, Ezgi Tut, Gökçe Ceren Kuşçu, Aylin Buhur, Özgün Selim Germiyan, Leila Sabour-Takanlou, Maryam Sabour-Takanlou, Cem Güler, Nefise Ülkü Karabay Yavaşoğlu, Fatih Oltulu, Altuğ Yavaşoğlu

{"title":"Post-transcriptional knockdown of BRCC3 via siRNA-loaded niosomes modulates autophagy and endoplasmic reticulum stress in rotenone-induced Parkinson's Disease model.","authors":"Çevik Gürel, Ezgi Tut, Gökçe Ceren Kuşçu, Aylin Buhur, Özgün Selim Germiyan, Leila Sabour-Takanlou, Maryam Sabour-Takanlou, Cem Güler, Nefise Ülkü Karabay Yavaşoğlu, Fatih Oltulu, Altuğ Yavaşoğlu","doi":"10.1080/1061186X.2026.2669781","DOIUrl":"10.1080/1061186X.2026.2669781","url":null,"abstract":"Parkinson's Disease (PD) is a prevalent neurodegenerative disorder. Recent studies implicate BRCA1-/BRCA2-containing complex 3 (BRCC3) in PD-related mechanisms such as ubiquitin-proteasome system dysfunction. This study aimed to evaluate the therapeutic potential of BRCC3 silencing via systemically administered siRNA-loaded niosomes in a rotenone-induced rat model of PD. Niosomes were synthesised by thin-film hydration, and three BRCC3-targeted siRNA sequences were tested in primary midbrain dopaminergic neurons. The most effective sequence, identified by Real-Time Quantitative PCR (RT-qPCR) and immunofluorescence, was used for in vivo studies. The PD model was induced in adult male rats (n = 24/group) by subcutaneous rotenone administration (2 mg/kg/day) for 35 days. In the in vivo phase of the study, behavioural, biochemical, in vivo imaging (IVIS), histological, and RT-qPCR analyses were performed. IVIS analysis confirmed brain accumulation of niosome-siRNA complexes within 3-5 h. Complementary analyses demonstrated that siRNA treatment significantly enhanced locomotor performance, restored redox homeostasis and dopamine levels, attenuated neuronal loss, upregulated autophagy-related proteins (↑LC3-II, ↑Beclin), suppressed endoplasmic reticulum stress markers (↓GRP78/Bip, ↓CHOP), elevated tyrosine hydroxylase expression, and reduced α-synuclein accumulation. In conclusion, siRNA-mediated suppression of BRCC3 via siRNA-loaded niosomes provides neuroprotection by modulating autophagy, ER stress, and antioxidant pathways, supporting BRCC3 as a promising therapeutic target for PD.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1786-1805"},"PeriodicalIF":4.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In-situ gel systems for periodontitis: advances in localized drug delivery and regenerative therapy. 牙周炎原位凝胶系统：局部药物递送和再生治疗的进展。

IF 4.7 4区医学

Journal of Drug Targeting Pub Date : 2026-11-01 Epub Date: 2026-04-06 DOI: 10.1080/1061186X.2026.2653982

Afrasim Moin, Sateesha Shivally Boregowda, Ranjitha S, Gokul Chowdappa, Rajamma Abburu Jayaramu, Shivanand K

{"title":"In-situ gel systems for periodontitis: advances in localized drug delivery and regenerative therapy.","authors":"Afrasim Moin, Sateesha Shivally Boregowda, Ranjitha S, Gokul Chowdappa, Rajamma Abburu Jayaramu, Shivanand K","doi":"10.1080/1061186X.2026.2653982","DOIUrl":"10.1080/1061186X.2026.2653982","url":null,"abstract":"Periodontitis is a chronic inflammatory condition initiated by pathogenic microbial biofilms and exacerbated by host immune responses, leading to progressive connective tissue, alveolar bone destruction and eventual tooth loss. Conventional therapies such as scaling and root planning, systemic antibiotics and surgical interventions provide only short-term relief due to rapid drug clearance, limited penetration into deep periodontal pockets and poor efficacy against structured biofilms. These limitations underscore the need for localised, sustained drug delivery systems capable of maintaining therapeutic concentrations at the target site. In-situ gel systems have emerged as innovative localised delivery platforms for periodontal therapy. In-situ gels are administered as liquids, they undergo sol-to-gel transitions in response to physiological stimuli such as temperature, pH, or ionic strength within the periodontal pocket, ensuring prolonged retention and improved therapeutic performance. Advances in polymer design, crosslinking chemistry and fabrication methods including click reactions and supramolecular assembly have enhanced gel stability, responsiveness and controlled release behaviour. Integration of nanotechnology, advanced biomaterials, three-dimensional bioprinting and AI-driven formulation strategies has further refined drug loading and delivery precision. Collectively, these innovations position smart in-situ gels as next generation systems for effective and sustained management of chronic periodontitis.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1640-1651"},"PeriodicalIF":4.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147592578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advanced co-delivery nanocarriers to overcome drug resistance in breast cancer: carrier-mediated synergistic treatment by chemotherapy and gene therapy. 先进的共递送纳米载体克服乳腺癌耐药：通过化疗和基因治疗的载体介导的协同治疗。

IF 4.7 4区医学

Journal of Drug Targeting Pub Date : 2026-11-01 Epub Date: 2026-06-19 DOI: 10.1080/1061186X.2026.2659211

Jiale Yao, Jia Ju, Zedong Cai, Xiaofei Zhang, Bang-Le Zhang

{"title":"Advanced co-delivery nanocarriers to overcome drug resistance in breast cancer: carrier-mediated synergistic treatment by chemotherapy and gene therapy.","authors":"Jiale Yao, Jia Ju, Zedong Cai, Xiaofei Zhang, Bang-Le Zhang","doi":"10.1080/1061186X.2026.2659211","DOIUrl":"10.1080/1061186X.2026.2659211","url":null,"abstract":"Chemoresistance is a primary factor contributing to chemotherapy failure in breast cancer. Combining chemotherapeutic agents with nucleic acids that interfere with drug resistance-related genes can effectively overcome chemoresistance in breast cancer. However, the stark differences in key physicochemical properties such as hydrophobicity versus hydrophilicity and surface charge, along with their divergent pharmacokinetic profiles, significantly compromise the synergistic therapeutic potential. Co-delivery nanocarriers enable the encapsulation of both chemotherapeutic agents and nucleic acids within a single carrier, which facilitates simultaneously and spatiotemporally targeted and controlled delivery and represents a promising strategy for treating chemoresistant breast cancer. This review summarised the progress of polymer, lipid and inorganic materials used in the co-delivery of chemotherapeutic drugs and nucleic acids, with a focus on major advances achieved over the past decade. The critical challenges in the design and optimisation, clinical translation of these co-delivery systems and insights for future research were also discussed.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1672-1683"},"PeriodicalIF":4.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147699006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeted delivery of Naringenin-enriched mannosylated niosomal nanogel for effective therapy of skin cancer. 靶向递送富含柚皮素的甘露糖基化乳质体纳米凝胶有效治疗皮肤癌。

IF 4.7 4区医学

Journal of Drug Targeting Pub Date : 2026-11-01 Epub Date: 2026-04-27 DOI: 10.1080/1061186X.2026.2659915

Nikita Verma, Swarnlata Saraf, Soniya Sarthi, Harish Bhardwaj

{"title":"Targeted delivery of Naringenin-enriched mannosylated niosomal nanogel for effective therapy of skin cancer.","authors":"Nikita Verma, Swarnlata Saraf, Soniya Sarthi, Harish Bhardwaj","doi":"10.1080/1061186X.2026.2659915","DOIUrl":"10.1080/1061186X.2026.2659915","url":null,"abstract":"Skin cancer is caused by excessive UVR exposure, which poses a serious health risk. The use of phytoconstituents as medicaments for the management of various diseases has been trending in recent years due to their fewer adverse effects than synthetic medicines. Naringenin (NG) is a natural polyphenol and a potent antioxidant, with remarkable ROS-scavenging and UVR-protection potential. However, NG exhibits limitations in bioavailability, permeability, stability and half-life. We address this drawback with a novel approach to formulate NG-loaded niosomes as a ligand-specific nanocarrier system. A modified thin-film hydration technique and a Box-Behnken experimental design were used to formulate and optimise NG-loaded niosomes (NG-Nio), respectively. The optimised NG-Nio and Mn-NG-Nio formulations were further characterised for vesicular size, ZP, DE, DL and mannose content. Furthermore, the incorporation of Mn-NG-Nio into a topical gel formulation. The Mn-NG-Nio-gel was characterised for rheological properties, spreadability, in vitro drug release and skin permeation. An in vitro cytotoxicity assay demonstrated higher cellular uptake and significant dose-dependent activity across different cell lines. The in vivo study showed significant reductions in myeloperoxidase levels and in UVB-induced 4-HNE and COX-2 protein levels. The research highlights the potential of Mn-NG-Nio for targeting skin cancer cells, reducing UVB-induced inflammation and oxidative stress.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1731-1746"},"PeriodicalIF":4.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and evaluation of intranasal nanostructured lipid carriers encapsulating donepezil HCl and Caesalpinia bonduc seed extract for targeting Alzheimer's disease: in vitro and in vivo evaluation. 用于治疗阿尔茨海默病的多奈哌齐盐酸和海鞘籽提取物鼻内纳米结构脂质载体的开发和评价：体外和体内评价

IF 4.7 4区医学

Journal of Drug Targeting Pub Date : 2026-11-01 Epub Date: 2026-05-26 DOI: 10.1080/1061186X.2026.2671309

Avinash Tekade, Rushikesh Shinde, Janhavi Nimbalkar, Prasad Kadam, Manoj Aswar, H N Shivakumar

{"title":"Development and evaluation of intranasal nanostructured lipid carriers encapsulating donepezil HCl and Caesalpinia bonduc seed extract for targeting Alzheimer's disease: in vitro and in vivo evaluation.","authors":"Avinash Tekade, Rushikesh Shinde, Janhavi Nimbalkar, Prasad Kadam, Manoj Aswar, H N Shivakumar","doi":"10.1080/1061186X.2026.2671309","DOIUrl":"10.1080/1061186X.2026.2671309","url":null,"abstract":"Alzheimer's disease (AD) is a progressive neurodegenerative disorder marked by memory loss and cognitive decline. This study aimed to develop and optimise an intranasal nanostructured lipid carrier (NLC) system co-loaded with donepezil (DPZ) hydrochloride and Caesalpinia bonduc seed extract (CBSE) to enhance therapeutic outcomes. LC-MS/MS profiling identified a CBSE bioactive compound with 93.16% structural similarity to neostigmine, suggesting synergistic cholinergic activity. NLCs were prepared using high-pressure homogenisation and ultrasonication, optimised using Design of Experiments (DoEs). The optimised NLCs exhibited an average particle size (PS) of 144.3 ± 1.78 nm, polydispersity index of 0.245 ± 0.025 and a zeta potential of -42.13 ± 2.14 mV, indicating uniformity and stability. Transmission electron microscopy (TEM) confirmed spherical morphology and PS. The formulation showed high entrapment efficiency (67.27 ± 2.32%) with drug loading (16.81 ± 3.59%) and sustained drug release (72.43 ± 4.78%) over 5 h, following zero-order kinetics with super case II transport. Ex vivo nasal permeation studies showed significantly higher permeability (p < 0.05) than control, while histological analysis confirmed nasal mucosal safety. In vivo behavioural studies on AD-induced rats demonstrated significantly improved memory and cognition (p < 0.05) following nasal NLC administration. The DPZ-CBSE NLCs present a promising, safe and non-invasive strategy for effective AD management.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1821-1838"},"PeriodicalIF":4.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147868516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ROS-responsive polyethylenimine-phenylboronic acid-bovine serum albumin nanoparticles for targeted siMETTL3 delivery in hepatocellular carcinoma treatment. 靶向siMETTL3递送的ros响应聚乙烯亚胺-苯硼酸-牛血清白蛋白纳米颗粒在肝癌治疗中的应用。

IF 4.7 4区医学

Journal of Drug Targeting Pub Date : 2026-11-01 Epub Date: 2026-05-18 DOI: 10.1080/1061186X.2026.2673103

Jingjing Hu, Ke Chen, Yang Chen, Hua Yin

{"title":"ROS-responsive polyethylenimine-phenylboronic acid-bovine serum albumin nanoparticles for targeted siMETTL3 delivery in hepatocellular carcinoma treatment.","authors":"Jingjing Hu, Ke Chen, Yang Chen, Hua Yin","doi":"10.1080/1061186X.2026.2673103","DOIUrl":"10.1080/1061186X.2026.2673103","url":null,"abstract":"Hepatocellular carcinoma (HCC) is highly aggressive and chemoresistant, severely limiting the clinical efficacy of current therapies. Methyltransferase-like 3 (METTL3), a key regulator of N6-adenosine methylation (m6A), is overexpressed in HCC and promotes its malignant progression, serving as a promising therapeutic target. siMETTL3 can specifically silence METTL3 but suffers from poor in vivo stability, nuclease degradation, and low delivery efficiency, hindering its clinical translation. To address these issues, we developed a reactive oxygen species (ROS)-responsive nanocarrier termed PEI-PBA-BSA for efficient siMETTL3 delivery, and systematically evaluated its physicochemical properties, tumour-targeting ability, and anti-HCC efficacy. Our results demonstrated that the nanocarrier encapsulated and protected siMETTL3. Through enhanced cellular uptake and ROS-triggered controlled release in the tumour microenvironment (TME), this nanocarrier efficiently silenced METTL3. In vitro, the nanoparticles significantly inhibited hepatoma cell proliferation, migration, invasion, and stemness. In vivo, the nanoparticles effectively suppressed tumour growth (with a tumour inhibition rate of up to 68%) and demonstrated good biosafety. In summary, PEI-PBA-BSA@siMETTL3 (PPB@siM3) represents a promising nanoplatform that mediates targeted and controlled siRNA release via TME-specific ROS responsiveness, overcoming core bottlenecks in traditional METTL3 gene therapy.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1855-1866"},"PeriodicalIF":4.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147930270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic potential of mesenchymal stem cells-derived exosomes loaded with elemental or nano selenium on diabetic nephropathy. 装载元素或纳米硒的间充质干细胞来源的外泌体对糖尿病肾病的治疗潜力。

IF 4.7 4区医学

Journal of Drug Targeting Pub Date : 2026-11-01 Epub Date: 2026-04-29 DOI: 10.1080/1061186X.2026.2660824

Fatema Suliman Alatawi, Lashin S Ali, Khalid Elfaki Ibrahim, Esmael M Alyami, Dalal Sulaiman Alshaya, Tamer M Shawky, Ehab I El-Hallous, Nermine Beshara, Maha Ali Alghamdi, Soha Y Alkhaldi, Eman Fayad, Dlovan Y Khalil, Kholoud H Radwan, Mohamed G Shalan, Hanan M Rashwan, Ibrahim Youssef, Shady G El-Sawah

{"title":"Therapeutic potential of mesenchymal stem cells-derived exosomes loaded with elemental or nano selenium on diabetic nephropathy.","authors":"Fatema Suliman Alatawi, Lashin S Ali, Khalid Elfaki Ibrahim, Esmael M Alyami, Dalal Sulaiman Alshaya, Tamer M Shawky, Ehab I El-Hallous, Nermine Beshara, Maha Ali Alghamdi, Soha Y Alkhaldi, Eman Fayad, Dlovan Y Khalil, Kholoud H Radwan, Mohamed G Shalan, Hanan M Rashwan, Ibrahim Youssef, Shady G El-Sawah","doi":"10.1080/1061186X.2026.2660824","DOIUrl":"10.1080/1061186X.2026.2660824","url":null,"abstract":"Endocrinologists and nephrologists continually seek new therapeutic approaches for diabetic nephropathy (DN). Lately, mesenchymal stem cell (MSC)-derived exosomes (MSC-EXs) have been applied as natural carriers for targeted drug delivery. Thus, we aim to estimate the therapeutic potential of MSCs-EXs loaded with elemental selenium (Se) or its nanoform (NSe) as a promising cell-free therapy for DN. Eighty rats were split into 8 groups; control, EXs, EXs + Se, EXs + NSe, diabetic (D), D + EXs, D + EXs + Se, and D + EXs + NSe. After 4 weeks, our results indicated that unloaded or loaded EXs with Se or NSe had renal ameliorating effects, as evidenced by significantly decreased serum levels of urea, uric acid, and creatinine compared to untreated diabetics. Such observations might be a reflection of the observed antioxidant activity of both EXs alone or in the combined form with either Se or NSe, evidenced by markedly decreased renal MDA, NO, H2O2 levels coupled with increased GSH, SOD, CAT, and GPX, besides their anti-inflammatory and antiapoptotic effects, indicated by the decreased renal levels of IL-6, TGF-β, TNF-α, BAX, caspase-3, and P53, with Bcl-2 upregulation. Consequently, the kidney architecture in all diabetic-treated groups was greatly improved. Likely, the EX-loaded NSe treatment protocol highlighted the DN improvement superiority over the other two treatments.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1747-1758"},"PeriodicalIF":4.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147699056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exosome-inspired liposomal nanocarriers for precision methotrexate delivery in rheumatoid arthritis. 类风湿性关节炎中精确甲氨蝶呤递送的外泌体启发脂质体纳米载体

IF 4.7 4区医学

Journal of Drug Targeting Pub Date : 2026-11-01 Epub Date: 2026-05-21 DOI: 10.1080/1061186X.2026.2669792

Gaurav Tiwari, V Rao, Praveen Katiyar, Tora Shah, Manish R Bhise, Sekar Variavel, Pankaj Sharma

{"title":"Exosome-inspired liposomal nanocarriers for precision methotrexate delivery in rheumatoid arthritis.","authors":"Gaurav Tiwari, V Rao, Praveen Katiyar, Tora Shah, Manish R Bhise, Sekar Variavel, Pankaj Sharma","doi":"10.1080/1061186X.2026.2669792","DOIUrl":"10.1080/1061186X.2026.2669792","url":null,"abstract":"Rheumatoid arthritis (RA) is a progressive autoimmune disorder marked by synovial inflammation and cartilage erosion. Conventional methotrexate (MTX) therapy suffers from poor joint targeting and systemic toxicity. This study developed exosome-mimicking liposomes (EMLs) for precision MTX delivery. The optimised formulation (F8), as determined by a 32 factorial design, had vesicle size of 101.4 ± 2.3 nm, encapsulation efficiency (EE) of 82.6 ± 2.4% and a zeta potential of -30.7 ± 1.2 mV. For 24 h, EMLs gave a consistent release pattern (73.4%), matching the kinetics observed using the Korsmeyer-Peppas model (R2 = 0.991). MTX taken up by cells was increased approximately 6-7 times higher than free MTX in RAW 264.7 cells. An in vivo study found that EMLs reached a Cmax value of 9.6 ± 0.48 µg/mL, had an AUC0-∞ of 54.3 ± 2.8 µg h/mL and showed 76.8% reduction in paw oedema in collagen-induced arthritis animals. Histopathology analysis found that joints were better protected and there was decreased inflammation and cartilage damage. The results show that EMLs are a reliable and biocompatible way to carry out safe, effective and targeted treatment of RA.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1806-1820"},"PeriodicalIF":4.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147930188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanomedicines for neurodegenerative ageing: nasal delivery innovations for Alzheimer's and Parkinson's disease. 神经退行性衰老的纳米药物：阿尔茨海默病和帕金森病的鼻腔给药创新。

IF 4.7 4区医学

Journal of Drug Targeting Pub Date : 2026-11-01 Epub Date: 2026-04-27 DOI: 10.1080/1061186X.2026.2659210

Rajshekher Upadhyay, Ayush Jain, Trivedi Karthik, Madhuri Desavathu

{"title":"Nanomedicines for neurodegenerative ageing: nasal delivery innovations for Alzheimer's and Parkinson's disease.","authors":"Rajshekher Upadhyay, Ayush Jain, Trivedi Karthik, Madhuri Desavathu","doi":"10.1080/1061186X.2026.2659210","DOIUrl":"10.1080/1061186X.2026.2659210","url":null,"abstract":"Alzheimer's disease and Parkinson's disease are progressive, age-related neurodegenerative disorders with increasing global prevalence, yet their treatment remains challenging despite the availability of multiple therapeutic agents. Conventional formulations are often limited by poor solubility, restricted blood-brain barrier penetration, extensive first-pass metabolism, short elimination half-life, low brain bioavailability, and systemic adverse effects. The nose-to-brain route has emerged as a promising strategy for delivering therapeutics directly to the brain. This approach offers non-invasive administration, rapid onset of action, direct brain targeting via olfactory and trigeminal pathways, bypassing of first-pass metabolism, improved bioavailability, and enhanced patient compliance. To exploit these advantages, a variety of biodegradable nanocarrier systems have been investigated, including lipid-based, Polymer-based, hybrid nanoparticles, nasal gel-based systems, nanoemulsions, nanosuspensions, and nasal sprays. This review provides a comprehensive synthesis of preclinical studies evaluating nose-to-brain nanocarrier-based delivery strategies for Alzheimer's and Parkinson's disease, with particular emphasis on their pharmacokinetic and pharmacodynamic performance. This indicates that nose-to-brain nanocarriers can effectively address key limitations. However, successful clinical translation will require addressing formulation-related challenges such as mucociliary clearance, nasal irritation, burst drug release, alongside well-designed clinical studies. Future research should focus on exploring emerging delivery platforms to advance nose-to-brain strategies for the management of neurodegenerative diseases.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1652-1671"},"PeriodicalIF":4.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147699035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0