Journal of Drug Targeting最新文献_第2页

Application of small interfering RNAs and drug combination for pancreatic cancer therapy. 小干扰rna及联合用药在胰腺癌治疗中的应用。

IF 4.7 4区医学

Journal of Drug Targeting Pub Date : 2026-11-01 Epub Date: 2026-06-01 DOI: 10.1080/1061186X.2026.2663993

Chaoyang Zeng, Shu-Zhen Chen

引用次数: 0

Paclitaxel-loaded bone acellular extracellular matrix Injectable hydrogel for osteosarcoma treatment. 用于骨肉瘤治疗的紫杉醇负载骨脱细胞细胞外基质注射水凝胶。

IF 4.7 4区医学

Journal of Drug Targeting Pub Date : 2026-11-01 Epub Date: 2026-05-22 DOI: 10.1080/1061186X.2026.2666805

He Chen, Kaili Ye, Chaonan Zhang

{"title":"Paclitaxel-loaded bone acellular extracellular matrix Injectable hydrogel for osteosarcoma treatment.","authors":"He Chen, Kaili Ye, Chaonan Zhang","doi":"10.1080/1061186X.2026.2666805","DOIUrl":"10.1080/1061186X.2026.2666805","url":null,"abstract":"A novel local chemotherapy delivery system was developed to improve the therapeutic efficacy of paclitaxel (PTX) for osteosarcoma while reducing systemic toxicity, low bioavailability, and tumour recurrence. PTX-loaded polylactic-co-glycolic acid nanoparticles (PLGA/PTX) were fabricated by an emulsification solvent evaporation method. Meanwhile, low-immunogenicity bone extracellular matrix (ECM) was prepared from porcine/bovine femurs through gradient decellularization combined with physical, chemical, and enzymatic treatments, followed by pepsin digestion to create a temperature-responsive injectable hydrogel. PLGA/PTX nanoparticles were incorporated into the bone ECM pre-gel to form a composite hydrogel system (H@PLGA/PTX). The processed bone ECM achieved over 97% decellularization while preserving collagen structure and biocompatibility. The composite hydrogel exhibited a porous three-dimensional network and released 62.5 ± 4.5% of PTX within 48 h under mildly acidic conditions (pH 6.5). In vitro assays showed superior anti-tumour effects against MG-63 osteosarcoma cells compared with free PTX. In vivo studies demonstrated significant tumour inhibition, stable body weight, and prolonged survival, associated with enhanced Caspase-3-mediated apoptosis. Overall, H@PLGA/PTX provides sustained local drug release with strong anti-tumour activity and low systemic toxicity, offering a promising strategy for adjuvant osteosarcoma chemotherapy.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1772-1785"},"PeriodicalIF":4.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erythrocyte membrane-camouflaged doxorubicin nanoparticles for enhancing therapeutic efficacy in primary liver cancer. 红细胞膜伪装的阿霉素纳米颗粒增强原发性肝癌的治疗效果。

IF 4.7 4区医学

Journal of Drug Targeting Pub Date : 2026-11-01 Epub Date: 2026-03-26 DOI: 10.1080/1061186X.2026.2647068

Ting-Ting Hu, Ying Ding, Yi-Ren Yao, Xin Zhang, Xi-Wen Zhang, Yang Gu

{"title":"Erythrocyte membrane-camouflaged doxorubicin nanoparticles for enhancing therapeutic efficacy in primary liver cancer.","authors":"Ting-Ting Hu, Ying Ding, Yi-Ren Yao, Xin Zhang, Xi-Wen Zhang, Yang Gu","doi":"10.1080/1061186X.2026.2647068","DOIUrl":"10.1080/1061186X.2026.2647068","url":null,"abstract":"Doxorubicin (DOX), an anthracycline antibiotic, stands as one of the most potent and clinically ubiquitous chemotherapeutic agents for cancer treatment. Despite advances in clinical supportive care, strategies to prevent DOX-induced toxicity remain inadequate - with cardiotoxicity being a particularly devastating complication that can progress to heart failure. To address this unmet need, we engineered a novel core-shell biomimetic nanoparticle (NP) camouflaged with erythrocyte membranes, tailored for the targeted delivery of DOX to treat liver cancer while mitigating DOX-induced cardiotoxicity. This erythrocyte membrane-camouflaged biomimetic NP system exhibits an average diameter of 262.4 nm - an optimal size for prolonged systemic circulation - and possesses exceptional biocompatibility, coupled with enhanced responsiveness to the acidic tumour microenvironment. These synergistic features collectively augment the anti-tumour efficacy of DOX against hepatocellular carcinoma (HCC). Our findings highlight that the erythrocyte membrane-camouflaged NP serves as a promising biomimetic nanocarrier: it enables efficient delivery of chemotherapeutics to tumour sites while attenuating their off-target side effects (e.g. DOX-induced cardiotoxicity). This work thus provides a valuable strategy for improving the therapeutic index of anthracycline-based cancer treatments.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1701-1712"},"PeriodicalIF":4.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147468082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond drug delivery: nanoparticles as active modulators of immunometabolism for treating inflammatory diseases. 超越药物递送：纳米颗粒作为治疗炎症性疾病的免疫代谢活性调节剂。

IF 4.7 4区医学

Journal of Drug Targeting Pub Date : 2026-11-01 Epub Date: 2026-03-25 DOI: 10.1080/1061186X.2026.2647069

Hailing Wang, Ahequeli Gemingnuer, Yinan Wang, Yan Liu, Xin Meng

{"title":"Beyond drug delivery: nanoparticles as active modulators of immunometabolism for treating inflammatory diseases.","authors":"Hailing Wang, Ahequeli Gemingnuer, Yinan Wang, Yan Liu, Xin Meng","doi":"10.1080/1061186X.2026.2647069","DOIUrl":"10.1080/1061186X.2026.2647069","url":null,"abstract":"Immunometabolism is central to chronic inflammatory diseases, with metabolic reprogramming including dysregulated glycolysis, mitochondrial dysfunction and excessive reactive oxygen species (ROS) production driving pathology in conditions like inflammatory bowel disease (IBD), rheumatoid arthritis and psoriasis. Although metabolic regulators hold therapeutic promise, their efficacy is limited by poor site-specific delivery and bioavailability. Nanotechnology-based platforms (e.g. liposomes, polymeric nanoparticles (NPs), nanoemulsions and metal NPs) address these barriers by enhancing bioavailability and forming a protein corona that modulates NP uptake by macrophages and T cells, directly influencing metabolic fate. Advanced organelle-targeting strategies such as mitochondria-directed liposomes and lysosome-responsive polymers enable precise metabolic rescue by restoring mitochondrial respiration or modulating nutrient-sensing pathways. By targeting key metabolic nodes including HIF-1α, mTOR and AMPK, nanocarriers actively shift immune cells from pro-inflammatory glycolysis towards anti-inflammatory oxidative phosphorylation, minimising toxicity and restoring immune homeostasis. Thus, nanocarriers function not as passive delivery vehicles but as sophisticated immunometabolism modulators. Despite progress, a comprehensive review bridging nanomaterial design and metabolic intervention remains lacking. This review addresses that gap by highlighting nanoscale phenomena such as stimulus-responsive release, membrane perturbation and organelle-specific targeting.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1623-1639"},"PeriodicalIF":4.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147468164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential role of PVP/poloxamer 407 nanofibers loaded with resveratrol nanocrystals in skin cancer therapy. 负载白藜芦醇纳米晶体的PVP/ poloxam407纳米纤维在皮肤癌治疗中的潜在作用

IF 4.7 4区医学

Journal of Drug Targeting Pub Date : 2026-11-01 Epub Date: 2026-04-13 DOI: 10.1080/1061186X.2026.2657595

Mahmoud A Elgewelly, Soha M Elmasry, Maged Wasfy Helmy, Haidy Abbas

{"title":"Potential role of PVP/poloxamer 407 nanofibers loaded with resveratrol nanocrystals in skin cancer therapy.","authors":"Mahmoud A Elgewelly, Soha M Elmasry, Maged Wasfy Helmy, Haidy Abbas","doi":"10.1080/1061186X.2026.2657595","DOIUrl":"10.1080/1061186X.2026.2657595","url":null,"abstract":"This work focused on producing resveratrol nanocrystals using a high-pressure, high-speed basic homogeniser to improve resveratrol's aqueous solubility, and subsequently electrospinning them into novel polyvinylpyrrolidone/poloxamer 407 nanofiber scaffolds for application in the Ehrlich-induced murine skin cancer model. The final concentrations of resveratrol, polyvinylpyrrolidone, and poloxamer 407 in the electrospinning solution were 0.5% w/v, 12.5% w/v, and 2.5% w/v, respectively. Following 48 h of drug release, Nanofibers NF-NC2 and NF-NC4, which included the nanocrystals NC2 and NC4 consisting of 2.5% w/w poloxamer 407 and 2.5% w/w HPMC, respectively, demonstrated the highest drug release, at 66.65 ± 1.4% and 42.31 ± 0.37%, respectively. Only 33 ± 0.7% of the free drug-loaded nanofibers NF-D were released. Microscopic analyses of NF-NC 2 and NF-NC 4 revealed regular, homogeneous fibres, whereas NF-D displayed distortions and beads. The in vitro cytotoxicity assay compared NF-NC2 with NF-D, demonstrating NF-NC2's efficacy against squamous malignant cell viability. In the Ehrlich-induced animal model of skin cancer, mice treated with NF-NC2 showed the greatest alleviation of symptoms, as evidenced by reduced tumour growth and preserved healthy skin. Assessments of Ki-67 and tumour biomarkers demonstrated that NF-NC2 maintained levels comparable to those observed in healthy animals. It is concluded that selected resveratrol-loaded nanocrystals in nanofibers, NF-NC2, improved the resveratrol topical anti-skin cancer effect.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1713-1730"},"PeriodicalIF":4.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147654323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of venlafaxine hydrochloride nasal thermosensitive in-situ gel with P407/P188: enhanced bioavailability and antidepressant effects in depressive rats. 含P407/P188的盐酸文拉法辛鼻腔热敏原位凝胶的研制：提高抑郁大鼠的生物利用度和抗抑郁作用

IF 4.7 4区医学

Journal of Drug Targeting Pub Date : 2026-11-01 Epub Date: 2026-04-27 DOI: 10.1080/1061186X.2026.2662398

Yili Wu, Yujia Zhang, Dong Li, Xiangchun Sheng, Xiaofeng Hu, Meihong Ding, Qunxing Wang, Beihua Xu, Ting Zhang, Yiling He, Senlin Shi

{"title":"Development of venlafaxine hydrochloride nasal thermosensitive in-situ gel with P407/P188: enhanced bioavailability and antidepressant effects in depressive rats.","authors":"Yili Wu, Yujia Zhang, Dong Li, Xiangchun Sheng, Xiaofeng Hu, Meihong Ding, Qunxing Wang, Beihua Xu, Ting Zhang, Yiling He, Senlin Shi","doi":"10.1080/1061186X.2026.2662398","DOIUrl":"10.1080/1061186X.2026.2662398","url":null,"abstract":"Objective: To develop and optimise a VEN nasal thermosensitive in-situ gel for reducing the first-pass effect and enhancing bioavailability.Methods: High performance liquid chromatography, central composite design-response surface methodology, the membrane-free erosion and the Franz vertical diffusion cell method were used to clarify the optimised formulation. Pharmacokinetic and pharmacodynamic studies evaluated sustained release and efficacy.Results: The optimal formulation (32.87-33.17 °C gelation temp) comprised 12.5% w/v VEN, 20.44% w/v poloxamer 407, 0.74% w/v P188, 5% w/v 2-Hydroxypropyl-β-cyclodextrin, 0.5% w/v hydroxypropyl methyl cellulose, 0.12% w/v potassium sorbate, 10% v/v glycerol, and 90% v/v water; it had a good stability and sustained-release effect of VEN and increased bioavailability and reduced O-desmethylvenlafaxine production. It achieved 90% cumulative release at 15h in vitro, and its intranasal Cmax was higher than oral VEN (p < 0.05) without detectable O-desmethylvenlafaxine. Treatment with VEN thermosensitive in-situ gel in a depressive rat model improved the sucrose preference rate in the sucrose preference test and the total distance of movement in the open field test, also significantly increased the level of 5-hydroxytryptamine and norepinephrine in the hippocampus (p < 0.01).Conclusion: This innovative P407/P188-based gel enhances VEN bioavailability and antidepressant efficacy via sustained release and brain targeting, providing critical data for nasal formulation development.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1759-1771"},"PeriodicalIF":4.7,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147728972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biased agonists for the treatment of type 2 diabetes and obesity: a novel pharmacological paradigm edging closer to clinical reality? 偏倚激动剂治疗2型糖尿病和肥胖症：一种接近临床现实的新药理学范式？

IF 4.7 4区医学

Journal of Drug Targeting Pub Date : 2026-11-01 Epub Date: 2026-05-08 DOI: 10.1080/1061186X.2026.2656880

Ibrahim E Hashem, Baha H Abuajameia, Saghir Akhtar

引用次数: 0

Liver-targeted DGAT2 siRNA ameliorates steatosis and fibrosis in a high-fat diet-induced MASH mouse model. 肝脏靶向DGAT2 siRNA改善高脂肪饮食诱导的MASH小鼠模型中的脂肪变性和纤维化

IF 4.7 4区医学

Journal of Drug Targeting Pub Date : 2026-10-20 DOI: 10.1080/1061186X.2026.2721709

Enhua Zhang, Wei Zheng, Yizhe Li, Zihui Cheng, Ying Cai, Yong Cheng, Xiaojuan Zhang, Qiongqiong Hou, Yujie Liu, Bingxue Meng, Mengying Hou, Can Wang, Tianwen Hu, Guanghui Tian, Jingshan Shen

{"title":"Liver-targeted DGAT2 siRNA ameliorates steatosis and fibrosis in a high-fat diet-induced MASH mouse model.","authors":"Enhua Zhang, Wei Zheng, Yizhe Li, Zihui Cheng, Ying Cai, Yong Cheng, Xiaojuan Zhang, Qiongqiong Hou, Yujie Liu, Bingxue Meng, Mengying Hou, Can Wang, Tianwen Hu, Guanghui Tian, Jingshan Shen","doi":"10.1080/1061186X.2026.2721709","DOIUrl":"10.1080/1061186X.2026.2721709","url":null,"abstract":"Diacylglycerol O-acyltransferase 2 (DGAT2), a key enzyme in hepatic triglyceride (TG) synthesis, is considered a promising therapeutic target for metabolic dysfunction-associated steatohepatitis (MASH). Small interfering RNAs (siRNAs) targeting conserved regions of human and mouse DGAT2 mRNA were designed, synthesised and screened in vitro leading to the identification of a GalNAc-conjugated siRNA, VX093L, which mediates potent DGAT2 mRNA knockdown in both human and mouse hepatocytes and exhibits sustained hepatic DGAT2 silencing in healthy mice. In a high-fat diet (HFD)-induced MASH mouse model, the effects of VX093L (1 or 3 mg/kg, biweekly) were evaluated in comparison with the approved drug resmetirom (10 mg/kg, daily). Eight weeks of treatment with VX093L potently silenced hepatic DGAT2 (>80%, p < 0.0001), thereby inhibiting hepatic TG synthesis and significantly ameliorating hepatic steatosis. Notably, VX093L treatment also effectively attenuated fibrosis, with 1 mg/kg VX093L exhibiting greater anti-fibrotic efficacy than resmetirom, without an increase in inflammation. In conclusion, VX093L represents a promising siRNA-based therapeutic for the treatment of MASH.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1-13"},"PeriodicalIF":4.7,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biofluid-Programmed Biological Identity of Nanocarriers: Consequences for Drug Targeting and Reproducible Delivery. 纳米载体的生物流体编程生物学特性：药物靶向和可重复递送的后果。

IF 4.7 4区医学

Journal of Drug Targeting Pub Date : 2026-10-19 DOI: 10.1080/1061186X.2026.2751938

Adnan Amin, Touseef Nawaz, Mohamed El Fadili, Rasny M R M

{"title":"Biofluid-Programmed Biological Identity of Nanocarriers: Consequences for Drug Targeting and Reproducible Delivery.","authors":"Adnan Amin, Touseef Nawaz, Mohamed El Fadili, Rasny M R M","doi":"10.1080/1061186X.2026.2751938","DOIUrl":"https://doi.org/10.1080/1061186X.2026.2751938","url":null,"abstract":"Nanocarriers are commonly designed and evaluated based on their physicochemical properties, including size, morphology, surface charge, composition, ligand density, drug loading, and release behavior. After administration, however, nanocarrier surfaces are rapidly remodeled by proteins, lipids, metabolites, enzymes, mucins, salts, and immune components present in systemic, mucosal, luminal, and disease-associated biofluids, thereby generating an acquired biological identity. Rather than focusing predominantly on plasma protein coronas or individual exposure environments, this review integrates biofluid-specific biological identity across administration routes and pathological states with the dynamic evolution of hard and soft coronas and its consequences for colloidal stability, immune recognition, and therapeutic performance. A further distinguishing emphasis is the translation of these nano-bio interactions into biological-identity-by-design strategies, standardized biofluid testing, and formulation and quality-control considerations. Strategies for biological-identity-by-design, including controlled corona formation, albumin and apolipoprotein pre-coating, ligand-protein co-design, antifouling interfaces, biomimetic camouflage, and disease-fluid programming, are evaluated. Treating biological identity as a formulation and quality attribute may improve the predictability, reproducibility, safety, and clinical translation of advanced drug-delivery systems.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1-42"},"PeriodicalIF":4.7,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual Transdermal Delivery Of Etodolac And Atorvastatin Calcium Via Spanlastic Nanovesicles-Loaded HPMC Hydrogel: Formulation, Characterization, Anti-Inflammatory Activity, And Preliminary In Vitro Cytotoxicity Against MCF-7 Cells. 依托度酸和阿托伐他汀钙通过塑料纳米囊载HPMC水凝胶的双重经皮递送：配方、表征、抗炎活性和对MCF-7细胞的初步体外细胞毒性

IF 4.7 4区医学

Journal of Drug Targeting Pub Date : 2026-10-19 DOI: 10.1080/1061186X.2026.2749053

Aml I Mekkawy, Mostafa M Mahmoud, Mahmoud Mostafa, Deiaa E Elsayed Abouzed, Fatma M Mady

{"title":"Dual Transdermal Delivery Of Etodolac And Atorvastatin Calcium Via Spanlastic Nanovesicles-Loaded HPMC Hydrogel: Formulation, Characterization, Anti-Inflammatory Activity, And Preliminary In Vitro Cytotoxicity Against MCF-7 Cells.","authors":"Aml I Mekkawy, Mostafa M Mahmoud, Mahmoud Mostafa, Deiaa E Elsayed Abouzed, Fatma M Mady","doi":"10.1080/1061186X.2026.2749053","DOIUrl":"https://doi.org/10.1080/1061186X.2026.2749053","url":null,"abstract":"Combination therapy employing nanotechnology provides augmented efficacy over monotherapy. Spanlastics (SPs) are flexible nanovesicles that facilitate permeation across biological barriers. This study developed etodolac (ETD)-loaded SPs and atorvastatin calcium (ATR)-loaded SPs and evaluated the combined effects of ETD-SPs/ATR-SPs versus monotherapy using MCF-7 cells and a CFA-induced arthritis rat model. SPs were prepared and the effects of edge activator type and Span 60:EA ratio on in vitro characterization were evaluated. SPs were spherical, negatively charged, with particle sizes suitable for transdermal delivery. SPs dispersions showed enhanced skin permeation of ETD and ATR compared with free-drug controls. In vitro cytotoxicity studies against MCF-7 cells demonstrated concentration-dependent cytotoxic activity of ETD- and ATR-loaded SPs under the tested conditions. The combination therapy of ETD-SPs and ATR-SPs showed a lower estimated IC50 compared with the corresponding single-agent SPs formulations, evidenced by combination index lower than 1, indicating synergistic interaction at selected effect levels. In vivo anti-inflammatory assessment demonstrated that ETD-SPs and ATR-SPs combination-loaded hydrogel reduced paw thickness and modulated inflammatory biomarkers more effectively than monotherapy, with improved histological appearance. This research establishes SPs-based combination therapy as a promising delivery approach for improving cytotoxicity against MCF-7 cells and anti-inflammatory activity in CFA-induced arthritis.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1-27"},"PeriodicalIF":4.7,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0