Journal of Drug Targeting最新文献_第2页

Thermosensitive transniosomal in situ gel of hesperetin for intranasal administration: novel approach for Parkinson's therapy. 用于鼻内给药的热敏经皮体原位橙皮素凝胶：帕金森治疗的新方法。

IF 3.9 4区医学

Journal of Drug Targeting Pub Date : 2026-06-01 Epub Date: 2025-10-27 DOI: 10.1080/1061186X.2025.2576112

Nazreen Tabassum, Niha Sultana, Asad Ali, Nasr A Emad, Syed Amir Azam Zaidi, Samreen Jahan, Bushra Jabi, Abdul Ahad, Mohd Mujeeb, Mohd Aqil

{"title":"Thermosensitive transniosomal in situ gel of hesperetin for intranasal administration: novel approach for Parkinson's therapy.","authors":"Nazreen Tabassum, Niha Sultana, Asad Ali, Nasr A Emad, Syed Amir Azam Zaidi, Samreen Jahan, Bushra Jabi, Abdul Ahad, Mohd Mujeeb, Mohd Aqil","doi":"10.1080/1061186X.2025.2576112","DOIUrl":"10.1080/1061186X.2025.2576112","url":null,"abstract":"The present study aims to formulate and evaluate a thermosensitive transniosomal in situ gel of hesperetin (HST-TN) for intranasal delivery to improve its therapeutic efficacy in Parkinson's disease management. HST-TN was prepared via thin film hydration and optimised using Box-Behnken design. The optimised formulation (Opt-HST-TN) was incorporated into a Poloxamer 407-based in situ gel for sustained drug release. Opt-HST-TN exhibited vesicles size (100.50 ± 4.60 nm), PDI (0.247 ± 0.01), zeta potential (-32.50 ± 5.4 mV), and entrapment efficiency (91.71 ± 2.28%). The in vitro drug release study demonstrated 77.58 ± 0.15% drug release from Opt-HST-TN in 24 h. Ex vivo permeation finding showed 82.24% penetration and a flux of 5.16 µg/cm2/h, approximately 2-fold higher than HST suspension. Confocal laser scanning microscopy confirmed that Opt-HST-TN containing Rhodamine B showed superior mucosal penetration (30 µm) than Rhodamine B hydroethanolic solution (20 µm). Further, nasal toxicity studies have confirmed the Opt-HST-TTN's non-irritant nature. The prepared formulation significantly improved motor coordination, grip strength, and locomotor activity in haloperidol-induced Parkinson's disease Wistar rats after intranasal administration. These findings suggest that HST-loaded thermosensitive transniosomal in situ gel is an encouraging intranasal drug delivery system for PD, offering enhanced bioavailability, nasal permeability, and therapeutic efficacy.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"787-804"},"PeriodicalIF":3.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145301268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alginate-based wound dressings loaded with natural essential oils: physicochemical characterisation and antibacterial performance. 含有天然精油的海藻酸盐伤口敷料：理化特性和抗菌性能。

IF 3.9 4区医学

Journal of Drug Targeting Pub Date : 2026-06-01 Epub Date: 2025-11-19 DOI: 10.1080/1061186X.2025.2585041

Elif Hatice Gürkan, Özge İskender

{"title":"Alginate-based wound dressings loaded with natural essential oils: physicochemical characterisation and antibacterial performance.","authors":"Elif Hatice Gürkan, Özge İskender","doi":"10.1080/1061186X.2025.2585041","DOIUrl":"10.1080/1061186X.2025.2585041","url":null,"abstract":"Bacterial infections are a major challenge in wound healing, increasing complications and delaying recovery. This study developed alginate-based composite films incorporating three essential oils (EOs) - Hypericum perforatum (healing), Laurus nobilis (antibacterial) and Lavandula angustifolia (analgesic) - individually and in combinations, into a 3% sodium alginate matrix via solvent casting. Films were characterised for thickness, water solubility, swelling capacity and water vapour transmission rate (WVTR), as well as structural features (Fourier-transform infra-red spectroscopy (FTIR), scanning electron microscopy (SEM)) and antibacterial activity against Escherichia coli and Staphylococcus aureus. Essential oil incorporation enhanced moisture retention, maintained an optimal WVTR (1799-1906 g·m-2·day-1), and improved antibacterial activity, particularly against S. aureus (inhibition zones up to 16.3 mm). SEM analysis revealed increased surface roughness and porosity, while FTIR confirmed interactions between alginate and phenolic EO components. These results suggest that EO-loaded alginate films are promising, biocompatible wound dressings with infection-control and moist-healing capabilities, warranting further in vivo studies.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"912-925"},"PeriodicalIF":3.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145451948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biased agonists for the treatment of type 2 diabetes and obesity: a novel pharmacological paradigm edging closer to clinical reality? 偏倚激动剂治疗2型糖尿病和肥胖症：一种接近临床现实的新药理学范式？

IF 3.9 4区医学

Journal of Drug Targeting Pub Date : 2026-05-08 DOI: 10.1080/1061186X.2026.2656880

Ibrahim E Hashem, Baha H Abuajameia, Saghir Akhtar

引用次数: 0

Post-transcriptional knockdown of BRCC3 via siRNA-loaded niosomes modulates autophagy and endoplasmic reticulum stress in rotenone-induced Parkinson's Disease model. 在鱼藤酮诱导的帕金森病模型中，通过装载sirna的niosomes转录后敲低BRCC3可调节自噬和内质网应激。

IF 3.9 4区医学

Journal of Drug Targeting Pub Date : 2026-05-07 DOI: 10.1080/1061186X.2026.2669781

Çevik Gürel, Ezgi Tut, Gökçe Ceren Kuşçu, Aylin Buhur, Özgün Selim Germiyan, Leila Sabour-Takanlou, Maryam Sabour-Takanlou, Cem Güler, Nefise Ülkü Karabay Yavaşoğlu, Fatih Oltulu, Altuğ Yavaşoğlu

{"title":"Post-transcriptional knockdown of BRCC3 via siRNA-loaded niosomes modulates autophagy and endoplasmic reticulum stress in rotenone-induced Parkinson's Disease model.","authors":"Çevik Gürel, Ezgi Tut, Gökçe Ceren Kuşçu, Aylin Buhur, Özgün Selim Germiyan, Leila Sabour-Takanlou, Maryam Sabour-Takanlou, Cem Güler, Nefise Ülkü Karabay Yavaşoğlu, Fatih Oltulu, Altuğ Yavaşoğlu","doi":"10.1080/1061186X.2026.2669781","DOIUrl":"https://doi.org/10.1080/1061186X.2026.2669781","url":null,"abstract":"Parkinson's Disease (PD) is a prevalent neurodegenerative disorder. Recent studies implicate BRCA1-/BRCA2-containing complex 3 (BRCC3) in PD-related mechanisms such as ubiquitin-proteasome system dysfunction. This study aimed to evaluate the therapeutic potential of BRCC3 silencing via systemically administered siRNA-loaded niosomes in a rotenone-induced rat model of PD. Niosomes were synthesised by thin-film hydration, and three BRCC3-targeted siRNA sequences were tested in primary midbrain dopaminergic neurons. The most effective sequence, identified by Real-Time Quantitative PCR (RT-qPCR) and immunofluorescence, was used for in vivo studies. The PD model was induced in adult male rats (n = 24/group) by subcutaneous rotenone administration (2 mg/kg/day) for 35 days. In the in vivo phase of the study, behavioural, biochemical, in vivo imaging (IVIS), histological, and RT-qPCR analyses were performed. IVIS analysis confirmed brain accumulation of niosome-siRNA complexes within 3-5 h. Complementary analyses demonstrated that siRNA treatment significantly enhanced locomotor performance, restored redox homeostasis and dopamine levels, attenuated neuronal loss, upregulated autophagy-related proteins (↑LC3-II, ↑Beclin), suppressed endoplasmic reticulum stress markers (↓GRP78/Bip, ↓CHOP), elevated tyrosine hydroxylase expression, and reduced α-synuclein accumulation. In conclusion, siRNA-mediated suppression of BRCC3 via siRNA-loaded niosomes provides neuroprotection by modulating autophagy, ER stress, and antioxidant pathways, supporting BRCC3 as a promising therapeutic target for PD.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1-20"},"PeriodicalIF":3.9,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic potential of mesenchymal stem cells-derived exosomes loaded with elemental or nano selenium on diabetic nephropathy. 装载元素或纳米硒的间充质干细胞来源的外泌体对糖尿病肾病的治疗潜力。

IF 3.9 4区医学

Journal of Drug Targeting Pub Date : 2026-04-29 DOI: 10.1080/1061186X.2026.2660824

Fatema Suliman Alatawi, Lashin S Ali, Khalid Elfaki Ibrahim, Esmael M Alyami, Dalal Sulaiman Alshaya, Tamer M Shawky, Ehab I El-Hallous, Nermine Beshara, Maha Ali Alghamdi, Soha Y Alkhaldi, Eman Fayad, Dlovan Y Khalil, Kholoud H Radwan, Mohamed G Shalan, Hanan M Rashwan, Ibrahim Youssef, Shady G El-Sawah

{"title":"Therapeutic potential of mesenchymal stem cells-derived exosomes loaded with elemental or nano selenium on diabetic nephropathy.","authors":"Fatema Suliman Alatawi, Lashin S Ali, Khalid Elfaki Ibrahim, Esmael M Alyami, Dalal Sulaiman Alshaya, Tamer M Shawky, Ehab I El-Hallous, Nermine Beshara, Maha Ali Alghamdi, Soha Y Alkhaldi, Eman Fayad, Dlovan Y Khalil, Kholoud H Radwan, Mohamed G Shalan, Hanan M Rashwan, Ibrahim Youssef, Shady G El-Sawah","doi":"10.1080/1061186X.2026.2660824","DOIUrl":"10.1080/1061186X.2026.2660824","url":null,"abstract":"Endocrinologists and nephrologists continually seek new therapeutic approaches for diabetic nephropathy (DN). Lately, mesenchymal stem cell (MSC)-derived exosomes (MSC-EXs) have been applied as natural carriers for targeted drug delivery. Thus, we aim to estimate the therapeutic potential of MSCs-EXs loaded with elemental selenium (Se) or its nanoform (NSe) as a promising cell-free therapy for DN. Eighty rats were split into 8 groups; control, EXs, EXs + Se, EXs + NSe, diabetic (D), D + EXs, D + EXs + Se, and D + EXs + NSe. After 4 weeks, our results indicated that unloaded or loaded EXs with Se or NSe had renal ameliorating effects, as evidenced by significantly decreased serum levels of urea, uric acid, and creatinine compared to untreated diabetics. Such observations might be a reflection of the observed antioxidant activity of both EXs alone or in the combined form with either Se or NSe, evidenced by markedly decreased renal MDA, NO, H2O2 levels coupled with increased GSH, SOD, CAT, and GPX, besides their anti-inflammatory and antiapoptotic effects, indicated by the decreased renal levels of IL-6, TGF-β, TNF-α, BAX, caspase-3, and P53, with Bcl-2 upregulation. Consequently, the kidney architecture in all diabetic-treated groups was greatly improved. Likely, the EX-loaded NSe treatment protocol highlighted the DN improvement superiority over the other two treatments.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1-12"},"PeriodicalIF":3.9,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147699056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paclitaxel-loaded Bone Acellular Extracellular Matrix Injectable Hydrogel for Osteosarcoma Treatment. 用于骨肉瘤治疗的紫杉醇负载骨脱细胞细胞外基质注射水凝胶。

IF 3.9 4区医学

Journal of Drug Targeting Pub Date : 2026-04-28 DOI: 10.1080/1061186X.2026.2666805

He Chen, Kaili Ye, Chaonan Zhang

{"title":"Paclitaxel-loaded Bone Acellular Extracellular Matrix Injectable Hydrogel for Osteosarcoma Treatment.","authors":"He Chen, Kaili Ye, Chaonan Zhang","doi":"10.1080/1061186X.2026.2666805","DOIUrl":"https://doi.org/10.1080/1061186X.2026.2666805","url":null,"abstract":"A novel local chemotherapy delivery system was developed to improve the therapeutic efficacy of paclitaxel (PTX) for osteosarcoma while reducing systemic toxicity, low bioavailability, and tumor recurrence. PTX-loaded polylactic-co-glycolic acid nanoparticles (PLGA/PTX) were fabricated by an emulsification solvent evaporation method. Meanwhile, low-immunogenicity bone extracellular matrix (ECM) was prepared from porcine/bovine femurs through gradient decellularization combined with physical, chemical, and enzymatic treatments, followed by pepsin digestion to create a temperature-responsive injectable hydrogel. PLGA/PTX nanoparticles were incorporated into the bone ECM pre-gel to form a composite hydrogel system (H@PLGA/PTX). The processed bone ECM achieved over 97% decellularization while preserving collagen structure and biocompatibility. The composite hydrogel exhibited a porous three-dimensional network and released 62.5 ± 4.5% of PTX within 48 hours under mildly acidic conditions (pH 6.5). In vitro assays showed superior anti-tumor effects against MG-63 osteosarcoma cells compared with free PTX. In vivo studies demonstrated significant tumor inhibition, stable body weight, and prolonged survival, associated with enhanced Caspase-3-mediated apoptosis. Overall, H@PLGA/PTX provides sustained local drug release with strong anti-tumor activity and low systemic toxicity, offering a promising strategy for adjuvant osteosarcoma chemotherapy.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1-23"},"PeriodicalIF":3.9,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeted delivery of Naringenin-enriched mannosylated niosomal nanogel for effective therapy of skin cancer. 靶向递送富含柚皮素的甘露糖基化乳质体纳米凝胶有效治疗皮肤癌。

IF 3.9 4区医学

Journal of Drug Targeting Pub Date : 2026-04-27 DOI: 10.1080/1061186X.2026.2659915

Nikita Verma, Swarnlata Saraf, Soniya Sarthi, Harish Bhardwaj

{"title":"Targeted delivery of Naringenin-enriched mannosylated niosomal nanogel for effective therapy of skin cancer.","authors":"Nikita Verma, Swarnlata Saraf, Soniya Sarthi, Harish Bhardwaj","doi":"10.1080/1061186X.2026.2659915","DOIUrl":"10.1080/1061186X.2026.2659915","url":null,"abstract":"Skin cancer is caused by excessive UVR exposure, which poses a serious health risk. The use of phytoconstituents as medicaments for the management of various diseases has been trending in recent years due to their fewer adverse effects than synthetic medicines. Naringenin (NG) is a natural polyphenol and a potent antioxidant, with remarkable ROS-scavenging and UVR-protection potential. However, NG exhibits limitations in bioavailability, permeability, stability and half-life. We address this drawback with a novel approach to formulate NG-loaded niosomes as a ligand-specific nanocarrier system. A modified thin-film hydration technique and a Box-Behnken experimental design were used to formulate and optimise NG-loaded niosomes (NG-Nio), respectively. The optimised NG-Nio and Mn-NG-Nio formulations were further characterised for vesicular size, ZP, DE, DL and mannose content. Furthermore, the incorporation of Mn-NG-Nio into a topical gel formulation. The Mn-NG-Nio-gel was characterised for rheological properties, spreadability, in vitro drug release and skin permeation. An in vitro cytotoxicity assay demonstrated higher cellular uptake and significant dose-dependent activity across different cell lines. The in vivo study showed significant reductions in myeloperoxidase levels and in UVB-induced 4-HNE and COX-2 protein levels. The research highlights the potential of Mn-NG-Nio for targeting skin cancer cells, reducing UVB-induced inflammation and oxidative stress.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1-16"},"PeriodicalIF":3.9,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanomedicines for neurodegenerative ageing: nasal delivery innovations for Alzheimer's and Parkinson's disease. 神经退行性衰老的纳米药物：阿尔茨海默病和帕金森病的鼻腔给药创新。

IF 3.9 4区医学

Journal of Drug Targeting Pub Date : 2026-04-27 DOI: 10.1080/1061186X.2026.2659210

Rajshekher Upadhyay, Ayush Jain, Trivedi Karthik, Madhuri Desavathu

{"title":"Nanomedicines for neurodegenerative ageing: nasal delivery innovations for Alzheimer's and Parkinson's disease.","authors":"Rajshekher Upadhyay, Ayush Jain, Trivedi Karthik, Madhuri Desavathu","doi":"10.1080/1061186X.2026.2659210","DOIUrl":"10.1080/1061186X.2026.2659210","url":null,"abstract":"Alzheimer's disease and Parkinson's disease are progressive, age-related neurodegenerative disorders with increasing global prevalence, yet their treatment remains challenging despite the availability of multiple therapeutic agents. Conventional formulations are often limited by poor solubility, restricted blood-brain barrier penetration, extensive first-pass metabolism, short elimination half-life, low brain bioavailability, and systemic adverse effects. The nose-to-brain route has emerged as a promising strategy for delivering therapeutics directly to the brain. This approach offers non-invasive administration, rapid onset of action, direct brain targeting via olfactory and trigeminal pathways, bypassing of first-pass metabolism, improved bioavailability, and enhanced patient compliance. To exploit these advantages, a variety of biodegradable nanocarrier systems have been investigated, including lipid-based, Polymer-based, hybrid nanoparticles, nasal gel-based systems, nanoemulsions, nanosuspensions, and nasal sprays. This review provides a comprehensive synthesis of preclinical studies evaluating nose-to-brain nanocarrier-based delivery strategies for Alzheimer's and Parkinson's disease, with particular emphasis on their pharmacokinetic and pharmacodynamic performance. This indicates that nose-to-brain nanocarriers can effectively address key limitations. However, successful clinical translation will require addressing formulation-related challenges such as mucociliary clearance, nasal irritation, burst drug release, alongside well-designed clinical studies. Future research should focus on exploring emerging delivery platforms to advance nose-to-brain strategies for the management of neurodegenerative diseases.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1-20"},"PeriodicalIF":3.9,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147699035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of venlafaxine hydrochloride nasal thermosensitive in-situ gel with P407/P188: enhanced bioavailability and antidepressant effects in depressive rats. 含P407/P188的盐酸文拉法辛鼻腔热敏原位凝胶的研制：提高抑郁大鼠的生物利用度和抗抑郁作用

IF 3.9 4区医学

Journal of Drug Targeting Pub Date : 2026-04-27 DOI: 10.1080/1061186X.2026.2662398

Yili Wu, Yujia Zhang, Dong Li, Xiangchun Sheng, Xiaofeng Hu, Meihong Ding, Qunxing Wang, Beihua Xu, Ting Zhang, Yiling He, Senlin Shi

{"title":"Development of venlafaxine hydrochloride nasal thermosensitive in-situ gel with P407/P188: enhanced bioavailability and antidepressant effects in depressive rats.","authors":"Yili Wu, Yujia Zhang, Dong Li, Xiangchun Sheng, Xiaofeng Hu, Meihong Ding, Qunxing Wang, Beihua Xu, Ting Zhang, Yiling He, Senlin Shi","doi":"10.1080/1061186X.2026.2662398","DOIUrl":"10.1080/1061186X.2026.2662398","url":null,"abstract":"Objective: To develop and optimise a VEN nasal thermosensitive in-situ gel for reducing the first-pass effect and enhancing bioavailability.Methods: High performance liquid chromatography, central composite design-response surface methodology, the membrane-free erosion and the Franz vertical diffusion cell method were used to clarify the optimised formulation. Pharmacokinetic and pharmacodynamic studies evaluated sustained release and efficacy.Results: The optimal formulation (32.87-33.17 °C gelation temp) comprised 12.5% w/v VEN, 20.44% w/v poloxamer 407, 0.74% w/v P188, 5% w/v 2-Hydroxypropyl-β-cyclodextrin, 0.5% w/v hydroxypropyl methyl cellulose, 0.12% w/v potassium sorbate, 10% v/v glycerol, and 90% v/v water; it had a good stability and sustained-release effect of VEN and increased bioavailability and reduced O-desmethylvenlafaxine production. It achieved 90% cumulative release at 15h in vitro, and its intranasal Cmax was higher than oral VEN (p < 0.05) without detectable O-desmethylvenlafaxine. Treatment with VEN thermosensitive in-situ gel in a depressive rat model improved the sucrose preference rate in the sucrose preference test and the total distance of movement in the open field test, also significantly increased the level of 5-hydroxytryptamine and norepinephrine in the hippocampus (p < 0.01).Conclusion: This innovative P407/P188-based gel enhances VEN bioavailability and antidepressant efficacy via sustained release and brain targeting, providing critical data for nasal formulation development.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1-13"},"PeriodicalIF":3.9,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147728972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advanced co-delivery nanocarriers to overcome drug resistance in breast cancer: carrier-mediated synergistic treatment by chemotherapy and gene therapy. 先进的共递送纳米载体克服乳腺癌耐药：通过化疗和基因治疗的载体介导的协同治疗。

IF 3.9 4区医学

Journal of Drug Targeting Pub Date : 2026-04-16 DOI: 10.1080/1061186X.2026.2659211

Jiale Yao, Jia Ju, Zedong Cai, Xiaofei Zhang, Bang-Le Zhang

{"title":"Advanced co-delivery nanocarriers to overcome drug resistance in breast cancer: carrier-mediated synergistic treatment by chemotherapy and gene therapy.","authors":"Jiale Yao, Jia Ju, Zedong Cai, Xiaofei Zhang, Bang-Le Zhang","doi":"10.1080/1061186X.2026.2659211","DOIUrl":"https://doi.org/10.1080/1061186X.2026.2659211","url":null,"abstract":"Chemoresistance is a primary factor contributing to chemotherapy failure in breast cancer. Combining chemotherapeutic agents with nucleic acids that interfere with drug resistance-related genes can effectively overcome chemoresistance in breast cancer. However, the stark differences in key physicochemical properties such as hydrophobicity versus hydrophilicity and surface charge, along with their divergent pharmacokinetic profiles, significantly compromise the synergistic therapeutic potential. Co-delivery nanocarriers enable the encapsulation of both chemotherapeutic agents and nucleic acids within a single carrier, which facilitates simultaneously and spatiotemporally targeted and controlled delivery and represents a promising strategy for treating chemoresistant breast cancer. This review summarized the progress of polymer, lipid, and inorganic materials used in the co-delivery of chemotherapeutic drugs and nucleic acids, with a focus on major advances achieved over the past decade. The critical challenges in the design and optimization, clinical translation of these co-delivery systems, and insights for future research were also discussed.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1-23"},"PeriodicalIF":3.9,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147699006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0