Journal of Drug Targeting最新文献_第3页

Potential role of PVP/poloxamer 407 nanofibers loaded with resveratrol nanocrystals in skin cancer therapy. 负载白藜芦醇纳米晶体的PVP/ poloxam407纳米纤维在皮肤癌治疗中的潜在作用

IF 3.9 4区医学

Journal of Drug Targeting Pub Date : 2026-04-13 DOI: 10.1080/1061186X.2026.2657595

Mahmoud A Elgewelly, Soha M Elmasry, Maged Wasfy Helmy, Haidy Abbas

{"title":"Potential role of PVP/poloxamer 407 nanofibers loaded with resveratrol nanocrystals in skin cancer therapy.","authors":"Mahmoud A Elgewelly, Soha M Elmasry, Maged Wasfy Helmy, Haidy Abbas","doi":"10.1080/1061186X.2026.2657595","DOIUrl":"10.1080/1061186X.2026.2657595","url":null,"abstract":"This work focused on producing resveratrol nanocrystals using a high-pressure, high-speed basic homogeniser to improve resveratrol's aqueous solubility, and subsequently electrospinning them into novel polyvinylpyrrolidone/poloxamer 407 nanofiber scaffolds for application in the Ehrlich-induced murine skin cancer model. The final concentrations of resveratrol, polyvinylpyrrolidone, and poloxamer 407 in the electrospinning solution were 0.5% w/v, 12.5% w/v, and 2.5% w/v, respectively. Following 48 h of drug release, Nanofibers NF-NC2 and NF-NC4, which included the nanocrystals NC2 and NC4 consisting of 2.5% w/w poloxamer 407 and 2.5% w/w HPMC, respectively, demonstrated the highest drug release, at 66.65 ± 1.4% and 42.31 ± 0.37%, respectively. Only 33 ± 0.7% of the free drug-loaded nanofibers NF-D were released. Microscopic analyses of NF-NC 2 and NF-NC 4 revealed regular, homogeneous fibres, whereas NF-D displayed distortions and beads. The in vitro cytotoxicity assay compared NF-NC2 with NF-D, demonstrating NF-NC2's efficacy against squamous malignant cell viability. In the Ehrlich-induced animal model of skin cancer, mice treated with NF-NC2 showed the greatest alleviation of symptoms, as evidenced by reduced tumour growth and preserved healthy skin. Assessments of Ki-67 and tumour biomarkers demonstrated that NF-NC2 maintained levels comparable to those observed in healthy animals. It is concluded that selected resveratrol-loaded nanocrystals in nanofibers, NF-NC2, improved the resveratrol topical anti-skin cancer effect.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1-18"},"PeriodicalIF":3.9,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147654323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring chitosan/clay microparticles enriched with fenugreek extract as a potential treatment strategy for infectious diarrhea: preclinical investigation. 探索富含胡芦巴提取物的壳聚糖/粘土微颗粒作为感染性腹泻的潜在治疗策略：临床前研究。

IF 3.9 4区医学

Journal of Drug Targeting Pub Date : 2026-04-09 DOI: 10.1080/1061186X.2025.2596083

Yan Cheng

引用次数: 0

Curcumin suppresses pancreatic cancer progression and glycolysis by modulating the circ_0001535/miR-126-5p/HIPK2 axis. 姜黄素通过调节circ_0001535/miR-126-5p/HIPK2轴抑制胰腺癌进展和糖酵解。

IF 3.9 4区医学

Journal of Drug Targeting Pub Date : 2026-04-07 DOI: 10.1080/1061186X.2026.2646184

Luoluo Wang, Xiang Wu, Yi Ruan, Xueming Zhang, Gong Cheng, Xinhua Zhou

{"title":"Curcumin suppresses pancreatic cancer progression and glycolysis by modulating the circ_0001535/miR-126-5p/HIPK2 axis.","authors":"Luoluo Wang, Xiang Wu, Yi Ruan, Xueming Zhang, Gong Cheng, Xinhua Zhou","doi":"10.1080/1061186X.2026.2646184","DOIUrl":"https://doi.org/10.1080/1061186X.2026.2646184","url":null,"abstract":"Although curcumin exerts anticancer effects in pancreatic cancer (PC) through various molecular pathways, its regulatory mechanisms mediated by non-coding RNA networks remain incompletely understood. This study sought to elucidate its functional role in PC progression, with particular focus on circRNA-driven regulatory networks. Cellular functions including viability, clonogenicity, migration, and invasion were examined through CCK-8, colony formation, and Transwell assays. Commercial kits and Seahorse XP 96 were used to measure glycolytic activity, while RT-qPCR and Western blot were applied to detect RNA and protein expression levels. Bioinformatic tools were utilised to predict possible circRNA-miRNA interactions, which were then experimentally verified using dual-luciferase reporter assays and RIP. In vivo tumour suppression was evaluated in xenografted mouse models treated with curcumin and/or circ_0001535 overexpression. Downregulation of circ_0001535 and HIPK2 was observed in PC, whereas miR-126-5p showed elevated expression. Curcumin treatment significantly upregulated circ_0001535 expression and suppressed malignant cellular behaviours. Mechanistically, circ_0001535 modulates HIPK2 expression by sponging miR-126-5p. Notably, overexpression of circ_0001535 enhanced the antitumor effects of curcumin in vivo. These findings suggest that curcumin inhibits PC progression by upregulating circ_0001535, which modulates the miR-126-5p/HIPK2 signalling axis. This study provides novel mechanistic insights into the therapeutic potential of curcumin in PC treatment.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1-14"},"PeriodicalIF":3.9,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147633612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In-situ gel systems for periodontitis: advances in localized drug delivery and regenerative therapy. 牙周炎原位凝胶系统：局部药物递送和再生治疗的进展。

IF 3.9 4区医学

Journal of Drug Targeting Pub Date : 2026-04-06 DOI: 10.1080/1061186X.2026.2653982

Afrasim Moin, Sateesha Shivally Boregowda, Ranjitha S, Gokul Chowdappa, Rajamma Abburu Jayaramu, Shivanand K

{"title":"In-situ gel systems for periodontitis: advances in localized drug delivery and regenerative therapy.","authors":"Afrasim Moin, Sateesha Shivally Boregowda, Ranjitha S, Gokul Chowdappa, Rajamma Abburu Jayaramu, Shivanand K","doi":"10.1080/1061186X.2026.2653982","DOIUrl":"10.1080/1061186X.2026.2653982","url":null,"abstract":"Periodontitis is a chronic inflammatory condition initiated by pathogenic microbial biofilms and exacerbated by host immune responses, leading to progressive connective tissue, alveolar bone destruction and eventual tooth loss. Conventional therapies such as scaling and root planning, systemic antibiotics and surgical interventions provide only short-term relief due to rapid drug clearance, limited penetration into deep periodontal pockets and poor efficacy against structured biofilms. These limitations underscore the need for localised, sustained drug delivery systems capable of maintaining therapeutic concentrations at the target site. In-situ gel systems have emerged as innovative localised delivery platforms for periodontal therapy. In-situ gels are administered as liquids, they undergo sol-to-gel transitions in response to physiological stimuli such as temperature, pH, or ionic strength within the periodontal pocket, ensuring prolonged retention and improved therapeutic performance. Advances in polymer design, crosslinking chemistry and fabrication methods including click reactions and supramolecular assembly have enhanced gel stability, responsiveness and controlled release behaviour. Integration of nanotechnology, advanced biomaterials, three-dimensional bioprinting and AI-driven formulation strategies has further refined drug loading and delivery precision. Collectively, these innovations position smart in-situ gels as next generation systems for effective and sustained management of chronic periodontitis.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1-12"},"PeriodicalIF":3.9,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147592578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human Serum Albumin-coated macromolecular niosomes for enhanced immunotherapeutic efficacy in rheumatoid arthritis: optimization, characterization and in-vivo assessment. 人血清白蛋白包被大分子Niosomes增强类风湿关节炎的免疫治疗效果：优化、表征和体内评估。

IF 3.9 4区医学

Journal of Drug Targeting Pub Date : 2026-04-06 DOI: 10.1080/1061186X.2026.2646186

Laxmi Rani, Ashwini Kumar Mishra, Neha S L, Shweta Paroha, Hitesh Kumar Dewangan, Perwez Alam, Pravat Kumar Sahoo

{"title":"Human Serum Albumin-coated macromolecular niosomes for enhanced immunotherapeutic efficacy in rheumatoid arthritis: optimization, characterization and in-vivo assessment.","authors":"Laxmi Rani, Ashwini Kumar Mishra, Neha S L, Shweta Paroha, Hitesh Kumar Dewangan, Perwez Alam, Pravat Kumar Sahoo","doi":"10.1080/1061186X.2026.2646186","DOIUrl":"10.1080/1061186X.2026.2646186","url":null,"abstract":"The purpose of this study was to design and optimise Baricitinib-loaded biomimetic (BCTB) niosomes for treatment of complete Freund's adjuvant (CFA)-induced rheumatoid arthritis (RA) in a rat model that mimics human joint inflammation. To enhance therapeutic efficacy and reduce infection risks, Human-Serum-Albumin (HSA)-decorated BCTB-loaded niosomes were formulated and evaluated against marketed BCTB tablets. Niosomes were developed using sonication followed by reverse-phase evaporation method and optimised via Central-Composite-Design. They were characterised for vesicle-size, zeta-potential, entrapment efficiency, morphology, in-vitro release, and molecular interactions (FTIR, DSC, XRD). In-vivo evaluation was conducted on Wistar rats, assessing interleukin-6 levels, body weight changes, arthritic index, radiographic findings, hematological parameters, and histopathology of rear paw joints. Optimised niosomes exhibited spherical morphology with a vesicle-size of 161.7 ± 0.1 nm, PDI 0.145 ± 0.013, zeta-potential -52 ± 7.68 mV, and high entrapment efficiency (93.40 ± 1.8%). FTIR, DSC, and XRD confirmed no significant drug-excipient interactions. HSA-decoration enhanced therapeutic effects of BCTB by prolonging drug release, mitigating adverse effects, and improving disease outcomes. BCTB niosomes significantly alleviated clinical and histopathological signs of RA, showing comparable efficacy to marketed BCTB tablets in 2 mg/kg treated group. The following results prove that, BCTB-loaded niosomes as a targeted drug delivery platform for RA treatment, offering improved bioavailability, sustained release, and reduced systemic toxicity.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1-16"},"PeriodicalIF":3.9,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147574201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of an effective drug carrier for targeted therapy in lung adenocarcinoma using ROS-responsive micelles. 利用ros反应胶束靶向治疗肺腺癌的有效药物载体的开发。

IF 3.9 4区医学

Journal of Drug Targeting Pub Date : 2026-04-01 Epub Date: 2025-10-15 DOI: 10.1080/1061186X.2025.2571547

Yuan Liu, Lu Zhang, Liang Kong, Ying Bi, Yu Zhang, Lingling Han, Wuri Ouen, Tianye Yu, Zhuang Ma

{"title":"Development of an effective drug carrier for targeted therapy in lung adenocarcinoma using ROS-responsive micelles.","authors":"Yuan Liu, Lu Zhang, Liang Kong, Ying Bi, Yu Zhang, Lingling Han, Wuri Ouen, Tianye Yu, Zhuang Ma","doi":"10.1080/1061186X.2025.2571547","DOIUrl":"10.1080/1061186X.2025.2571547","url":null,"abstract":"Lung cancer is the malignant tumour with the highest growing morbidity and mortality rates worldwide. Lung adenocarcinoma is the most prevalent type of non-small cell lung cancer (NSCLC). It is highly malignant and may lead to distant metastasis at an early stage. The standard treatment for lung adenocarcinoma involves a combination of surgery and chemotherapy, which is frequently associated with severe side effects. In response to this challenge, a safe and effective drug carrier has been designed to facilitate drug delivery. The surface of this polymer micelle is modified with reactive oxygen species (ROS)-responsive targeting ligands and cell-penetrating ligands. Pemetrexed (PMX) and baicalein (BAI) are encapsulated within the micelle. The micelles exploit the high expression of ROS in the tumour microenvironment and cell-penetrating peptides to deliver drugs safely and efficiently into tumour cells, thereby inhibiting the invasion and metastasis of these cells and ultimately suppressing tumour growth. This carrier holds significant potential for guiding clinical treatment strategies for lung adenocarcinoma.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"610-627"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improving the therapeutic efficacy and bioavailability of carvedilol for control of diabetes-associated heart failure: in vitro and in vivo characterisation. 提高卡维地洛控制糖尿病相关性心力衰竭的疗效和生物利用度：体外和体内表征

IF 3.9 4区医学

Journal of Drug Targeting Pub Date : 2026-04-01 Epub Date: 2025-10-20 DOI: 10.1080/1061186X.2025.2573051

Tamer Mohamed Mahmoud, Mohammed Ayad Alboreadi, Amr Gamal Fouad, Nada H Mohammed, Amany Belal, Fahad H Baali, Nisreen Khalid Aref Albezrah, Mohammed S Alharthi, Sherif Faysal Abdelfattah Khalil, Fatma I Abo El-Ela

{"title":"Improving the therapeutic efficacy and bioavailability of carvedilol for control of diabetes-associated heart failure: in vitro and in vivo characterisation.","authors":"Tamer Mohamed Mahmoud, Mohammed Ayad Alboreadi, Amr Gamal Fouad, Nada H Mohammed, Amany Belal, Fahad H Baali, Nisreen Khalid Aref Albezrah, Mohammed S Alharthi, Sherif Faysal Abdelfattah Khalil, Fatma I Abo El-Ela","doi":"10.1080/1061186X.2025.2573051","DOIUrl":"10.1080/1061186X.2025.2573051","url":null,"abstract":"Carvedilol (CRD) is an oral beta-adrenergic antagonist approved for treating heart failure (HF). However, due to its short half-life and poor solubility, CRD has limited bioavailability and effectiveness. This study aimed to develop a nasal spray of CRD-loaded novasomes (CLNs) to enhance CRD's sustainability, targeting, bioavailability and efficacy as a therapy for diabetes mellitus-associated HF (DMHF). Several CLN formulations were created using Box-Behnken's design and characterised in vitro to identify the optimised formulation, which was later evaluated in vivo using an experimental DMHF rat model. The selected optimised CLN formulation consists of 30.079 mg of oleic acid, 56.897 mg of Span 60, and 60 mg of cholesterol. The optimised CLN demonstrated significant improvements over free CRD, enhancing CRD's sustainability and permeability by 71.39% and 6.08-fold, respectively. When compared to oral free CRD, the nasal CLN increased the bioavailability and target efficiency of CRD by 5.74-fold and 4.24-fold, respectively. In relation to DMHF positive control, the nasal CLN significantly lowered glucose, LDH and CK-MB levels by 93.68%, 94.29% and 96.50%, respectively, showcasing its efficacy. Histopathological and toxicity studies further validated the activity and safety of the optimised CLN. These findings indicate that the nasal CLN spray shows potential as a therapy for DMHF.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"628-642"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanotransethosomal co-drug delivery system of diclofenac sodium and rosmarinic acid against rheumatoid arthritis: design, formulation, characterisation and pre-clinical studies. 双氯芬酸钠和迷迭香酸抗类风湿性关节炎的纳米经酶体共给药系统：设计、配方、表征和临床前研究。

IF 3.9 4区医学

Journal of Drug Targeting Pub Date : 2026-04-01 Epub Date: 2025-10-27 DOI: 10.1080/1061186X.2025.2573052

Akanksha, Neeraj Kumar, Asad Ali, Mohd Aqil, Abul Kalam Najmi, Mohd Mujeeb

{"title":"Nanotransethosomal co-drug delivery system of diclofenac sodium and rosmarinic acid against rheumatoid arthritis: design, formulation, characterisation and pre-clinical studies.","authors":"Akanksha, Neeraj Kumar, Asad Ali, Mohd Aqil, Abul Kalam Najmi, Mohd Mujeeb","doi":"10.1080/1061186X.2025.2573052","DOIUrl":"10.1080/1061186X.2025.2573052","url":null,"abstract":"Rosmarinic acid, an ester between caffeic acid and 3,4-dihydroxyphenyllactic acid, is distributed in broad distribution throughout plants within the Boraginaceae family and Nepetoideae subfamily of Lamiaceae. It has been identified with its multifaceted biological and pharmacological activities and thus has been the subject of significant interest for therapeutic application. Diclofenac sodium is a widely used NSAID for pain relief and inflammation control. Here, a transethosomal delivery form of rosmarinic acid & diclofenac sodium (RD-TE) was prepared and formulated into a gel for local application. Optimisation was performed utilising the Box-Behnken design, determining the effect of three independent variables Phospholipid 90 G, sodium cholate, and ethanol on vesicle size, polydispersity index (PDI), and entrapment efficiency. The optimised formulation (RD-TE-Opt) had a vesicle size of 110.9 nm, PDI of 0.37, zeta potential of -20.76 mV, % entrapment efficiency of romarinic acid and diclofenac sodium was found to be 82.44 and 81.23% respectively. In vivo evaluation using an arthritic rat model demonstrated a significant reduction in paw volume, from 3.65 ± 0.03 to 3.42 ± 0.04, along with an RBC count of 8.23 ± 0.03 in the group treated with RD-TE-OptG. Radiographic analysis confirmed the therapeutic efficacy of the formulation. RD-TE gel shows potential as a topical arthritis treatment.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"643-658"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting glioblastoma with hybrid H₃R antagonists with piperidinylpropoxy and trimethoxychalcone motifs results in broad oncosuppressive effects. 以哌啶基丙氧基和三甲氧基查尔酮为基序的杂合H3R拮抗剂靶向胶质母细胞瘤可产生广泛的抑癌作用。

IF 3.9 4区医学

Journal of Drug Targeting Pub Date : 2026-04-01 Epub Date: 2025-10-15 DOI: 10.1080/1061186X.2025.2573063

Waldemar Wagner, Anna Stasiak, Dorota Łażewska, Katarzyna Sobierajska, Katarzyna Kieć-Kononowicz, Wojciech M Ciszewski

{"title":"Targeting glioblastoma with hybrid H3R antagonists with piperidinylpropoxy and trimethoxychalcone motifs results in broad oncosuppressive effects.","authors":"Waldemar Wagner, Anna Stasiak, Dorota Łażewska, Katarzyna Sobierajska, Katarzyna Kieć-Kononowicz, Wojciech M Ciszewski","doi":"10.1080/1061186X.2025.2573063","DOIUrl":"10.1080/1061186X.2025.2573063","url":null,"abstract":"Among the many emerging strategies in precision medicine, surface receptor-directed drugs offer a promising pathway for the targeted and effective delivery of a cure. Histamine receptor (H3R) antagonists have been demonstrated to target and effectively suppress cancer cells that overexpress H3R. The present study aimed to evaluate the anticancer potential of (E)-3-(3,4,5-trimethoxyphenyl)-1-(4-(3-(piperidin-1-yl)propoxy)phenyl)prop-2-en-1-one (AR71), a hybrid H3R antagonist/inverse agonist featuring a piperidinylpropoxy motif conjugated to trimethoxychalcone, which mimics colchicine and disrupts microtubule assembly. Following incubation with AR71, we observed significant inhibition of growth and cell cycle arrest at G2/M in glioblastoma and neuroblastoma cells, which correlated with their H3R expression levels. AR71 treatment decreased the invasion potential of cancer cells by 60-80% along with a decrease in MMP-2 release. In-depth immunocytochemical investigations revealed dose-dependent impairment of microtubule organisation after treatment with AR71. Consequently, tubulin polymerisation and cytokinesis failure led to a greater incidence of aneuploid cells and tripolar mitotic events. We also observed an increase in mitochondrial reactive oxygen species in cancer cells following exposure to AR71. As a result, the mitochondrial membrane potential decreased significantly. In summary, targeting dual molecules with AR71 may create favourable conditions for the selective and synergistic action of combined anticancer compounds against glioblastoma and neuroblastoma.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"702-720"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of glucosamine hydrochloride and eperisone with exercise therapy on inflammatory factors and knee joint function in patients with knee osteoarthritis. 盐酸氨基葡萄糖、依培力松联合运动疗法对膝关节骨性关节炎患者炎症因子及膝关节功能的影响。

IF 3.9 4区医学

Journal of Drug Targeting Pub Date : 2026-04-01 Epub Date: 2025-10-15 DOI: 10.1080/1061186X.2025.2573055

Jun Ruan, Xuanying Li

{"title":"Effectiveness of glucosamine hydrochloride and eperisone with exercise therapy on inflammatory factors and knee joint function in patients with knee osteoarthritis.","authors":"Jun Ruan, Xuanying Li","doi":"10.1080/1061186X.2025.2573055","DOIUrl":"10.1080/1061186X.2025.2573055","url":null,"abstract":"Objective: This study aimed to unveil the effect of glucosamine hydrochloride (GAH) and eperisone combined with exercise therapy on inflammatory markers and knee joint function in patients with knee osteoarthritis (KOA).Methods: Sixty KOA patients were randomly assigned into two groups. Group A (n = 30) received GAH plus exercise therapy, while Group B (n = 30) received GAH combined with eperisone and exercise therapy. Serum inflammatory factors, knee symptom scores (pain, stiffness, daily function), and functional measures [knee flexion range of motion (ROM), Lysholm score, five-time sit-to-stand test, and 15-meter walking time] were assessed before and after treatment. Clinical efficacy was also evaluated.Results: Post-treatment, both groups showed decreased serum MMP-3, TNF-α, and IL-6 levels, with significantly greater reductions in Group B (p < 0.001). Group B had lower symptom scores (p < 0.05), greater ROM and Lysholm improvements (p < 0.001), and better functional performance (p < 0.001). The effective rate was higher in Group B (100.00%) than in Group A (86.67%) (p = 0.038).Conclusion: GAH combined with eperisone and exercise therapy is more effective than GAH alone in patients with KOA. It significantly reduces inflammatory markers and symptoms, and enhances knee joint function.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"696-701"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0