Journal of Drug Targeting最新文献_第3页

Investigation of silicon oxide nanoparticle-enhanced self-healing hydrogel for cartilage repair and regeneration in rabbit earlobe models.

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2025-03-07 DOI: 10.1080/1061186X.2025.2473675

Seyedeh-Sara Hashemi, Reza Alizadeh, Alireza Rafati, Aliakbar Mohammadi, Mojtaba Mortazavi, Mohammad Hashem Hashempur

{"title":"Investigation of silicon oxide nanoparticle-enhanced self-healing hydrogel for cartilage repair and regeneration in rabbit earlobe models.","authors":"Seyedeh-Sara Hashemi, Reza Alizadeh, Alireza Rafati, Aliakbar Mohammadi, Mojtaba Mortazavi, Mohammad Hashem Hashempur","doi":"10.1080/1061186X.2025.2473675","DOIUrl":"10.1080/1061186X.2025.2473675","url":null,"abstract":"This study developed an alginate, gelatine and chondroitin sulphate hydrogel incorporating silicon oxide nanoparticles to assess hydrogel morphology, cell proliferation and viability. The effectiveness of these hydrogels for cartilage repair was evaluated in vivo using male albino rabbits, divided into three groups: a control group without hydrogels, an observer group with hydrogels lacking nanoparticles and a treatment group with nanoparticle-enhanced hydrogels for post-injury repair. At 15, 30 and 60 days post-surgery, the rabbits were humanely euthanized and excised tissue samples were fixed in 10% formalin for histopathological analysis, then processed and embedded in paraffin for microscopic evaluation. Statistical analysis was performed using SPSS software with ANOVA and Tukey's post hoc test. Results indicated that the hydrogels supported cell viability and encouraged differentiation into chondrocyte-like phenotypes. Scanning electron microscopy confirmed the hydrogels' porosity and showed significant differences in cell survival rates compared to the control group, underscoring the potential of hydrogels in cartilage tissue engineering and regenerative repair strategies.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1-13"},"PeriodicalIF":4.3,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of insulin aspart combined with insulin detemir and metformin on islet function in newly diagnosed type 2 diabetes mellitus.

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2025-03-06 DOI: 10.1080/1061186X.2025.2477074

Hui Wang, Shang Li, Tianqi Zhao, Xixi Pan, Liangxue Wang

{"title":"Effect of insulin aspart combined with insulin detemir and metformin on islet function in newly diagnosed type 2 diabetes mellitus.","authors":"Hui Wang, Shang Li, Tianqi Zhao, Xixi Pan, Liangxue Wang","doi":"10.1080/1061186X.2025.2477074","DOIUrl":"https://doi.org/10.1080/1061186X.2025.2477074","url":null,"abstract":"This trial evaluated the effects of insulin aspart (IAsp) and insulin detemir and metformin on islet function in newly diagnosed type 2 diabetes mellitus (T2DM). A total of 96 T2DM patients were randomized into the control group (insulin detemir + metformin treatment) and the study group (insulin detemir + metformin + IAsp treatment), with 48 cases each. The study compared clinical outcomes, as well as changes in fasting plasma glucose (FPG), 2-hour postprandial blood glucose (PBG), glycated hemoglobin (HbA1c), fasting insulin (FINS), homeostasis model assessment of insulin resistance (HOMA-IR), HOMA-β, quality of life, and sleep quality scores before and after treatment. Compared to the control group, the study group showed a higher total effective treatment rate, lower levels of FPG, 2-hour PBG, HbA1c, FINS, HOMA-IR, and sleep quality scores, while demonstrating higher HOMA-β and quality of life scores (all P < 0.05). Insulin detemir + metformin + IAsp was effective in treating T2DM, significantly enhancing insulin function and blood glucose levels, quality of life, and sleep quality. This combination therapy, though not commonly utilized in newly diagnosed T2DM patients, offers a novel therapeutic approach in clinical practice.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1-10"},"PeriodicalIF":4.3,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-nanoemulsifying drug delivery system (SNEDDS) as nano-carrier framework for permeability modulating approaches of BCS class III drug.

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2025-03-04 DOI: 10.1080/1061186X.2025.2469751

Amulya Jindal, Pankaj Kumar Sharma, Anoop Kumar

{"title":"Self-nanoemulsifying drug delivery system (SNEDDS) as nano-carrier framework for permeability modulating approaches of BCS class III drug.","authors":"Amulya Jindal, Pankaj Kumar Sharma, Anoop Kumar","doi":"10.1080/1061186X.2025.2469751","DOIUrl":"10.1080/1061186X.2025.2469751","url":null,"abstract":"The purpose of this review is to focus on the Self-Nanoemulsifying Drug Delivery System (SNEDDS) as an effective nanocarrier framework for permeability modulating approaches (PMA) of BCS class-III drugs and its challenges. Present review updates the recent trends in the SNEDDS research where it was employed as a cargo carrier for PMA and challenges. Patient compliance, ease of administration and non-invasiveness mode are non-trivial aspects in the oral administration of drugs. However, low aqueous solubility and impaired permeability are two prominent challenges resulting poor absorption of a drug. SNEDDS emerged as a dual nano-carrier system to enable nanodispersion of PMA via e.g. ion-pairing, phospholipid-complex, surfactant-drug interaction, loading of non-ionizable, free drug bases etc. These PMAs are embedded within the lipid phase of SNEDDS to produce nanosizing, enhancing nano-dispersibility via micellization/solubilization mechanism owing to its ternary components. Review highlights different PMAs employed in bioavailability enhancement of BCS class-III. It covers excipients employed in SNEDDS-loaded PMA, strategies for the hydrophobic transformation of water-soluble drugs for BCS class-III drugs. SNEDDS as a nano-cargo system for PMAs significantly modifies the bioavailability of BCS class-III drugs. SNEDDS is an isotropic-mixture of oil, surfactant:co-surfactant offers multipoint access to PMA loading and produces nano-dispersion in aqueous-medium.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1-21"},"PeriodicalIF":4.3,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Niosomes as a targeted drug delivery system in the treatment of breast cancer: preparation, classification and mechanisms of cellular uptake.

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2025-03-03 DOI: 10.1080/1061186X.2025.2468750

Muneeb Ur Rahman, Hafiz Rashid Hussain, Habiba Akram, Muhammad Sarfraz, Muhammad Nouman, Jawad Akbar Khan, Memona Ishtiaq

{"title":"Niosomes as a targeted drug delivery system in the treatment of breast cancer: preparation, classification and mechanisms of cellular uptake.","authors":"Muneeb Ur Rahman, Hafiz Rashid Hussain, Habiba Akram, Muhammad Sarfraz, Muhammad Nouman, Jawad Akbar Khan, Memona Ishtiaq","doi":"10.1080/1061186X.2025.2468750","DOIUrl":"10.1080/1061186X.2025.2468750","url":null,"abstract":"Breast cancer (BC) remains one of the significant health issues across the globe, being diagnosed in millions of women worldwide annually. Conventional therapeutic options have substantial adverse effects due to their non-specificity and limited drug bioavailability. Niosomes, being novel drug delivery systems formed from non-ionic surfactants, with or without cholesterol and charge-inducing agents, are used as therapeutic options in treating BC. Their formulation by various methods enhances the therapeutic efficacy and bioavailability and minimises side effects. Niosomal formulation of tamoxifen exhibits target drug delivery with enhanced stability, whereas docetaxel and methotrexate show sustained and controlled drug release, respectively. 5-Fluorouracil, doxorubicin, paclitaxel, cyclophosphamide and epirubicin show improved cytotoxic effects against BC when combined with other agents. Furthermore, repurposed niosomal formulations of anti-cancer drugs show improved penetration, reduced tumour volume and significantly enhanced anti-tumour effect. This review article focuses on the composition of niosomes and their application in BC treatment and then examines how niosomes could contribute to BC research.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1-17"},"PeriodicalIF":4.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From adhesion to invasion: the multifaceted roles of Mycobacterium tuberculosis lipoproteins.

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2025-03-03 DOI: 10.1080/1061186X.2025.2472208

Min Li, Qiao Zhang, Yun Wang, Jianping Xie, Tian Liang, Zhou Liu, Xiaohong Xiang, Qiang Zhou, Zhen Gong

引用次数: 0

Role of liposomes in chemoimmunotherapy of breast cancer.

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2025-03-03 DOI: 10.1080/1061186X.2025.2467139

Fatemeh Attarian, Ghazaleh Hatamian, Shamim Nosrati, Mahsa Akbari Oryani, Hossein Javid, Alireza Hashemzadeh, Mojtaba Tarin

{"title":"Role of liposomes in chemoimmunotherapy of breast cancer.","authors":"Fatemeh Attarian, Ghazaleh Hatamian, Shamim Nosrati, Mahsa Akbari Oryani, Hossein Javid, Alireza Hashemzadeh, Mojtaba Tarin","doi":"10.1080/1061186X.2025.2467139","DOIUrl":"10.1080/1061186X.2025.2467139","url":null,"abstract":"In the dynamic arena of cancer therapeutics, chemoimmunotherapy has shown tremendous promise, especially for aggressive forms of breast cancer like triple-negative breast cancer (TNBC). This review delves into the significant role of liposomes in enhancing the effectiveness of chemoimmunotherapy by leveraging breast cancer-specific mechanisms such as the induction of immunogenic cell death (ICD), reprogramming the tumour microenvironment (TME), and enabling sequential drug release. We examine innovative dual-targeting liposomes that capitalise on tumour heterogeneity, as well as pH-sensitive formulations that offer improved control over drug delivery. Unlike prior analyses, this review directly links advancements in preclinical research-such as PAMAM dendrimer-based nanoplatforms and RGD-decorated liposomes-to clinical trial results, highlighting their potential to revolutionise TNBC treatment strategies. Additionally, we address ongoing challenges related to scalability, toxicity, and regulatory compliance, and propose future directions for personalised, immune-focused nanomedicine. This work not only synthesises the latest research but also offers a framework for translating liposomal chemoimmunotherapy from laboratory research to clinical practice.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1-29"},"PeriodicalIF":4.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review of recombinant HER3 affibodies with an effective diagnostic view of cancer cells. 综述重组 HER3 亲和体对癌细胞的有效诊断。

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2025-03-01 Epub Date: 2024-11-21 DOI: 10.1080/1061186X.2024.2420202

Sahar Babaei Khorzoughi, Mehrnoosh Tavakoli, Mojtaba Mortazavi, Zahra Jafarnejad, Abdorrasoul Malekpour, Tara Kopaiee Malek, Farzane Kargar

{"title":"A review of recombinant HER3 affibodies with an effective diagnostic view of cancer cells.","authors":"Sahar Babaei Khorzoughi, Mehrnoosh Tavakoli, Mojtaba Mortazavi, Zahra Jafarnejad, Abdorrasoul Malekpour, Tara Kopaiee Malek, Farzane Kargar","doi":"10.1080/1061186X.2024.2420202","DOIUrl":"10.1080/1061186X.2024.2420202","url":null,"abstract":"Breast cancer is one of the leading causes of cancer-related deaths among women globally. Factors like increased expression of HER family members contribute to its development, with elevated HER3 levels-especially in conjunction with tyrosine kinase receptors like HER2-playing a critical role in activating cancer pathways essential for cell survival and proliferation. Detecting high HER3 levels is vital for effective treatment. Affibody proteins, a class that includes antibodies, are used to identify elevated HER3 expression due to their high binding affinity. These innovative non-immune probes show promise in therapy, diagnostics, and biotechnology because of their exceptional specificity and affinity for target proteins. The design of recombinant affibodies enhances HER3 detection accuracy and supports the development of targeted therapies. Advanced engineering techniques optimize these affibodies for stability and binding efficacy, making them suitable for clinical applications. Additionally, their versatility allows integration with imaging technologies for real-time monitoring of HER3 expression and therapeutic responses. This comprehensive approach could lead to more personalized treatment options for patients with HER3-positive breast cancers, improving patient management and outcomes. This study presents recombinant affibodies designed to bind HER3 for cancer cell identification and introduces novel methods for producing various affibody molecules.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"316-327"},"PeriodicalIF":4.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of anti-diabetic effects of glimepiride/metformin cocrystal. 评估格列美脲/二甲双胍共晶体的抗糖尿病作用。

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2025-03-01 Epub Date: 2024-11-22 DOI: 10.1080/1061186X.2024.2424901

Xiaoli Li, Duanfang Zhou, Mingpu Liu, Hongfang Zeng, Xiaoping Yu, Yi Song, Qichen He, Xu Liu, Huan Zhang, Zhengze Shen, Zeng Zhu, Mingyan Gu, Xiangnan Hu, Weiying Zhou

{"title":"Evaluation of anti-diabetic effects of glimepiride/metformin cocrystal.","authors":"Xiaoli Li, Duanfang Zhou, Mingpu Liu, Hongfang Zeng, Xiaoping Yu, Yi Song, Qichen He, Xu Liu, Huan Zhang, Zhengze Shen, Zeng Zhu, Mingyan Gu, Xiangnan Hu, Weiying Zhou","doi":"10.1080/1061186X.2024.2424901","DOIUrl":"10.1080/1061186X.2024.2424901","url":null,"abstract":"Emerging data suggest that cocrystal of two compounds may have a different pharmacological effect from two compounds alone or their physical combination. Glimepiride (Gli) and metformin (Met) are two types of anti-diabetic drugs. Previously, we generated the glimepiride/metformin cocrystal (GM). In this study, we evaluated the anti-diabetic effects of GM and explored the underlying mechanisms. Our result showed that GM reduced the blood glucose and HbA1c levels in db/db mice, and low doses of GM can achieve the hypoglycaemic effect as Gli or Met alone, and high dose of GM was better than Gli and Met alone in improving the pathological changes of liver. In vivo studies showed that GM activated AMPK and STAT3 signalling, downregulated TXNIP expression and upregulated MaFA expression. Moreover, GM promoted the secretion of insulin in pancreas of db/db mice and in high glucose-treated INS-1 and MIN-6 cells. Together, GM possesses slightly better anti-diabetic effects than Met or Gli alone in db/db mice, and the mechanism of GM protecting β-cell dysfunction induced by glucotoxicity may be associated with activation of the AMPK/TXNIP/MaFA pathway.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"397-409"},"PeriodicalIF":4.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interactions and communications in the prostate tumour microenvironment: evolving towards effective cancer therapy. 前列腺肿瘤微环境中的相互作用和交流：向有效的癌症治疗发展。

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2025-03-01 Epub Date: 2024-10-24 DOI: 10.1080/1061186X.2024.2418344

Qiang Dai, Yanling Peng, Peng He, Xiaojun Wu

{"title":"Interactions and communications in the prostate tumour microenvironment: evolving towards effective cancer therapy.","authors":"Qiang Dai, Yanling Peng, Peng He, Xiaojun Wu","doi":"10.1080/1061186X.2024.2418344","DOIUrl":"10.1080/1061186X.2024.2418344","url":null,"abstract":"Prostate cancer is one of the most common malignancies in men. The tumour microenvironment (TME) has a critical role in the initiation, progression, and metastasis of prostate cancer. TME contains various cell types, including cancer-associated fibroblasts (CAFs), endothelial cells, immune cells such as macrophages, lymphocytes B and T, natural killer (NK) cells, and other proteins such as extracellular matrix (ECM) components. The interactions and communications between these cells within the TME are crucial for the growth and response of various solid tumours, such as prostate cancer to different anticancer modalities. In this review article, we exemplify the various mechanisms by which the TME influences prostate cancer progression. The roles of different cells, cytokines, chemokines, and growth factors in modulating the immune response and prostate tumour growth will be discussed. The impact of these cells and factors and other ECM components on tumour cell invasion and metastasis will also be discussed. We explain how these interactions in TME can affect the response of prostate cancer to therapy. We also highlight the importance of understanding these interactions to develop novel therapeutic approaches for prostate cancer.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"295-315"},"PeriodicalIF":4.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SIRT1: a potential therapeutic target for coronary heart disease combined with anxiety or depression. SIRT1：冠心病合并焦虑或抑郁的潜在治疗靶点

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2025-03-01 Epub Date: 2024-12-23 DOI: 10.1080/1061186X.2024.2422882

Hubin Yu, Xinping Li, Bo Ning, Lanshuan Feng, Yaolong Ren, Shilin Li, Yalong Kang, Jing Ma, Mingjun Zhao

{"title":"SIRT1: a potential therapeutic target for coronary heart disease combined with anxiety or depression.","authors":"Hubin Yu, Xinping Li, Bo Ning, Lanshuan Feng, Yaolong Ren, Shilin Li, Yalong Kang, Jing Ma, Mingjun Zhao","doi":"10.1080/1061186X.2024.2422882","DOIUrl":"10.1080/1061186X.2024.2422882","url":null,"abstract":"Coronary heart disease (CHD) combined with anxiety or depression is increasingly receiving attention in the clinical field of cardiology, and exploring the comorbidity pathological mechanisms of cardiovascular disease combined with psychological disorders is a hot research topic for scholars in this field. Current research suggests that Silent Information Regulatory Factor 1 (SIRT1) may serve as a potential biomarker for the comorbidity mechanism and treatment of CHD with anxiety or depression. SIRT1 is considered a promising therapeutic target for CHD combined with anxiety or depression, with the ability to regulate inflammatory cytokine levels, alleviate oxidative stress damage, activate multiple signalling pathways, reduce platelet hyperresponsiveness, and exert neuroprotective and cardioprotective effects. In this comprehensive review, we deeply studied the structure, function, and mechanism of SIRT1, and discussed its protective effects in the cardiovascular and nervous system. The latest progress in the mechanism of SIRT1's role in CHD combined with anxiety or depression was emphasised, including its specific mechanisms in regulating inflammatory response, alleviating oxidative stress, and mediating various signalling pathways. In addition, this article also summarises the therapeutic potential of SIRT1 as a potential biomarker in patients with CHD combined with anxiety or depression.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"328-340"},"PeriodicalIF":4.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0