Journal of Drug Targeting最新文献_第4页

Quercetin-loaded magnetic nanoparticles: a promising tool for antitumor treatment in human breast cancer cells. 载槲皮素的磁性纳米粒子：有望用于人类乳腺癌细胞抗肿瘤治疗的工具

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2025-03-13 DOI: 10.1080/1061186X.2025.2477764

Silvina Tiburzi, Virginia Lezcano, Gabriel Principe, María Gabriela Montiel Schneider, Alicia B Miravalles, Verónica Lassalle, Ariana Bruzzone, Verónica González-Pardo

{"title":"Quercetin-loaded magnetic nanoparticles: a promising tool for antitumor treatment in human breast cancer cells.","authors":"Silvina Tiburzi, Virginia Lezcano, Gabriel Principe, María Gabriela Montiel Schneider, Alicia B Miravalles, Verónica Lassalle, Ariana Bruzzone, Verónica González-Pardo","doi":"10.1080/1061186X.2025.2477764","DOIUrl":"10.1080/1061186X.2025.2477764","url":null,"abstract":"Quercetin (QUE) is a phytoestrogen with known antitumor properties; however, its hydrophobic nature and low bioavailability limit its efficacy as an anticancer drug. To address this, we explored loading QUE onto a non-toxic nanocarrier. This study focused on the biological activity of magnetic iron oxide nanoparticles coated with polyethylene glycol (MAG@PEG) loaded with QUE (MAG@PEG@QUE) in MCF-7 cells. The MAG@PEG nanosystem was synthesised using a hydrothermal method, and QUE was incorporated by adding an alcoholic solution of QUE to an aqueous dispersion of MAG@PEG. QUE incorporation was confirmed qualitatively by FTIR spectroscopy and quantitatively through UV-visible spectroscopy. Cytotoxicity studies showed that MAG@PEG@QUE, at a concentration equivalent to the half-maximal inhibitory concentration (IC50) of free QUE, significantly reduced cell proliferation and viability while increasing apoptosis. MCF-7 cells treated with MAG@PEG@QUE also displayed actin cytoskeleton alterations typical of apoptotic cells. Transmission electron microscopy revealed clusters of magnetic nanoparticles within cellular vesicles. Targeted delivery of these nanoparticles was achieved using a static magnetic field, leading to high intracellular accumulation and selective cell death in targeted areas, without affecting adjacent cells. In conclusion, MAG@PEG@QUE shows comparable antitumor effects to free QUE and has the potential to enhance QUE's bioavailability and targeted delivery for breast cancer treatment.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1-16"},"PeriodicalIF":4.3,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patient-derived organoid models of malignant phyllodes tumours for drug sensitivity testing and identification of targeted therapeutic strategies.

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2025-03-13 DOI: 10.1080/1061186X.2025.2473010

Jie Chen, Liangquan Liu, Yunxu Yang, Jing Luo, Shengchun Liu

{"title":"Patient-derived organoid models of malignant phyllodes tumours for drug sensitivity testing and identification of targeted therapeutic strategies.","authors":"Jie Chen, Liangquan Liu, Yunxu Yang, Jing Luo, Shengchun Liu","doi":"10.1080/1061186X.2025.2473010","DOIUrl":"10.1080/1061186X.2025.2473010","url":null,"abstract":"Background: Malignant phyllodes tumours (MPT) of the breast are rare fibroepithelial neoplasms. It exhibits rapid growth, large size, and a high local recurrence rate.Methods: In this study, we established novel patient-derived organoid (PDO) models from two primary MPT samples and conducted comprehensive genetic profiling and drug screening.Results: The PDO models faithfully recapped the histopathological and molecular features of the primary tumours, including stromal overgrowth, leaf-like projections, and the expression of key diagnostic markers. Drug testing revealed significant heterogeneity in response profiles to chemotherapeutic reagents between the two MPT-derived organoids, implying the importance of personalised drug testing. Next-generation sequencing analysis identified recurrent mutations in TP53, RB1, EGFR, ATM, and RECQL4, which correlated with the drug sensitivity profiles observed in the organoid models. Targeted therapeutic drugs, such as Abemaciclib (targeting the RB1 pathway) with an IC50 value of 1.744 µM, and Alflutinib Mesylate (targeting the EGFR pathway) with an IC50 value of 0.9150 µM, exhibited significant cytotoxic effects in the MPT2 organoid models.Conclusions: This study highlights the novel application of PDOs for studying the molecular landscape of MPTs and identifying effective therapeutic targets, offering a promising platform for guiding personalised treatment strategies for this rare and challenging cancer.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1-11"},"PeriodicalIF":4.3,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

2,2,6,6-tetramethylpiperidin-1-oxyl: a new potential targeted ligand based on lipid peroxidation for targeted drug delivery.

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2025-03-11 DOI: 10.1080/1061186X.2025.2474639

Xiaofei Zhang, Guohao Yin, Minbo Lan, Hongli Zhao

{"title":"2,2,6,6-tetramethylpiperidin-1-oxyl: a new potential targeted ligand based on lipid peroxidation for targeted drug delivery.","authors":"Xiaofei Zhang, Guohao Yin, Minbo Lan, Hongli Zhao","doi":"10.1080/1061186X.2025.2474639","DOIUrl":"10.1080/1061186X.2025.2474639","url":null,"abstract":"The side effects of chemotherapy drugs have prompted the development of targeted therapies. Distinctive abundance of lipid peroxidation (LPO) in tumour cells represents a potential target for drug delivery. However, LPO-based targeted ligands remain under-exploited. In this work, the targeting of 2,2,6,6-tetramethylpiperidin-1-oxyl (TEMPO), was investigated within a mesoporous silica nanoparticle (MSN) loaded with doxorubicin (DOX) and connected with 4-NH2-TEMPO obtaining DOX/MSN-TEMPO. A cellular uptake assay showed a faster uptake of DOX/MSN-TEMPO than blank group on Hela, L929 and 4T1 cells, revealing TEMPO's active targeting ability for tumour cells. After observing this phenomenon, the fabrication of a basic copolymer module carrying cyanine5.5 (Cy5.5) and TEMPO was reported. In vivo experiments were conducted on mouse MCF-7 tumour models, displaying selective aggregation of nano micelles at the tumour site and thereby verifying the broad applicability of TEMPO. Since the large amounts of LPO lead to the presence of numerous free radicals, whereas TEMPO, as a free radical capture agent, further selectively targets tumour cells. These findings verify the targeting ability of TEMPO for most tumour cells and collectively underscore the potential of TEMPO and analogous capture agents as innovative targeted ligands for drug delivery.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1-12"},"PeriodicalIF":4.3,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of PTP1B in cardiometabolic disorders and endothelial dysfunction.

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2025-03-10 DOI: 10.1080/1061186X.2025.2473024

Mona A Sawali, Muhammad Ammar Zahid, Shahenda Salah Abdelsalam, Raed M Al-Zoubi, Mohanad Shkoor, Abdelali Agouni

{"title":"The role of PTP1B in cardiometabolic disorders and endothelial dysfunction.","authors":"Mona A Sawali, Muhammad Ammar Zahid, Shahenda Salah Abdelsalam, Raed M Al-Zoubi, Mohanad Shkoor, Abdelali Agouni","doi":"10.1080/1061186X.2025.2473024","DOIUrl":"10.1080/1061186X.2025.2473024","url":null,"abstract":"Cardiovascular diseases (CVD) are a global health concern that accounts for a large share of annual mortality. Endothelial dysfunction is the main underlying factor that eventually leads to cardiovascular events. Recent studies have underscored the critical function of Protein Tyrosine Phosphatase 1B (PTP1B) in the onset of endothelial dysfunction, chiefly through its involvement in metabolic diseases such as diabetes, obesity, and leptin resistance. PTP1B attenuates insulin and leptin signalling by dephosphorylating their respective receptors at key tyrosine residues, resulting in resistance-both of which are significant mechanisms underpinning the development of endothelial dysfunction. PTP1B also contributes to the disruption of the endoplasmic reticulum, causing endoplasmic reticulum stress, another molecular driver of endothelial dysfunction. Efforts to inhibit PTP1B activity hold the promise of advancing the prevention and management of CVD and metabolic disorders, as these conditions share common risk factors and underlying cellular mechanisms. Numerous small molecules have been reported as PTP1B inhibitors; however, their progression to advanced clinical trials has been hindered by major challenges such as low selectivity and undesirable side effects. This review provides an in-depth analysis of PTP1B's involvement in metabolic diseases and its interaction with CVD and examines the strategies and challenges related to inhibiting this enzyme.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1-16"},"PeriodicalIF":4.3,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resveratrol in ulcerative colitis: therapeutic mechanisms, animal model evidence and novel approaches.

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2025-03-10 DOI: 10.1080/1061186X.2025.2469750

Yukta Garg, Nandini Sharma, Shivang Saxena, Nihar Ranjan Sahoo, Sushil Kumar, Sankushdeep Singh, Amandeep Singh

{"title":"Resveratrol in ulcerative colitis: therapeutic mechanisms, animal model evidence and novel approaches.","authors":"Yukta Garg, Nandini Sharma, Shivang Saxena, Nihar Ranjan Sahoo, Sushil Kumar, Sankushdeep Singh, Amandeep Singh","doi":"10.1080/1061186X.2025.2469750","DOIUrl":"https://doi.org/10.1080/1061186X.2025.2469750","url":null,"abstract":"Ulcerative colitis is a type of chronic inflammatory bowel disease characterised by abdominal pain, bloody diarrhoea, rectal bleeding and ulcerations in colon. This illness has significant health risks as it easily relapses, thus, providing a considerable threat to human health. A number of inflammatory mediators, oxidative stress and role of gut microbes have been studied thoroughly to understand the exact pathophysiology behind the disease occurrence. Several conventional therapies are available for the treatment of ulcerative colitis but each one of them have one or the other side effect. Therefore, to overcome this limitation, we are moving ahead towards herbal drug therapies. The current review presents the emerging role of Resveratrol, a natural occurring polyphenol derived from plant species. It is associated with potential antioxidative and anti-inflammatory properties. Protective effects of Resveratrol in different ulcerative colitis induced animal models are discussed in this review. Various strategies to improve bioavailability of drug include encapsulation of drug in several nanocarriers. Although many animal models have proved the effectiveness of Resveratrol in the treatment of ulcerative colitis, further research on human subjects is still required to understand the exact mechanism and safety to establish its uses clinically.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1-24"},"PeriodicalIF":4.3,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a bio-inspired phagocytic stable nanoghost with anti-inflammatory properties for management of inflammation in ulcerative colitis. 开发具有抗炎特性的生物启发吞噬稳定纳米幽灵，用于控制溃疡性结肠炎的炎症。

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2025-03-10 DOI: 10.1080/1061186X.2025.2474644

Ahmed Mohsin Huran Al-Jawadri, Zahra Karami, Ismaeil Haririan, Mohammad Akrami, Mahdi Gholami

{"title":"Development of a bio-inspired phagocytic stable nanoghost with anti-inflammatory properties for management of inflammation in ulcerative colitis.","authors":"Ahmed Mohsin Huran Al-Jawadri, Zahra Karami, Ismaeil Haririan, Mohammad Akrami, Mahdi Gholami","doi":"10.1080/1061186X.2025.2474644","DOIUrl":"10.1080/1061186X.2025.2474644","url":null,"abstract":"Background: New bio-mimetic approaches are needed to develop effective delivery systems for inflammation regulation in chronic diseases like ulcerative colitis, avoiding fast clearance by immune system. The cell membrane-coated nanoparticle with a therapeutic payload has been considered as a promising delivery system to address the requirement.Methods: Here, Glibenclamide (GLY)-loaded PLGA nanoparticles (NPs) were constructed by a single emulsion procedure and camouflaged by a layer of monocyte membrane using the extrusion technique to fabricate bio-mimetic nanoghosts (NGs), followed by physiochemical and biological characterisations.Results: Upon coating the NPs by the membrane, the hydrodynamic size and zeta potential of NGs was changed. The formation of the shell compartment with diameter of about 15.5 nm around NP core was confirmed by TEM. The expression levels of NLRP3, IL-1β, IL-18, caspase-1, TNF-α and IL-6 were decreased upon the NGs treatment. The lower cellular internalisation of the NGs exhibited potential for improved circulation stability against macrophage phagocytosis. Treatment of acetic acid-induced UC with NGs exhibited healing of the mucosal lining in the colon tissue.Conclusion: The monocyte membrane-coated NPs with a sulfonylurea derivatives payload can be considered as an excellent biologically inspired candidate for management of inflammatory diseases like UC via inflammation regulation.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1-12"},"PeriodicalIF":4.3,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of silicon oxide nanoparticle-enhanced self-healing hydrogel for cartilage repair and regeneration in rabbit earlobe models.

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2025-03-07 DOI: 10.1080/1061186X.2025.2473675

Seyedeh-Sara Hashemi, Reza Alizadeh, Alireza Rafati, Aliakbar Mohammadi, Mojtaba Mortazavi, Mohammad Hashem Hashempur

{"title":"Investigation of silicon oxide nanoparticle-enhanced self-healing hydrogel for cartilage repair and regeneration in rabbit earlobe models.","authors":"Seyedeh-Sara Hashemi, Reza Alizadeh, Alireza Rafati, Aliakbar Mohammadi, Mojtaba Mortazavi, Mohammad Hashem Hashempur","doi":"10.1080/1061186X.2025.2473675","DOIUrl":"10.1080/1061186X.2025.2473675","url":null,"abstract":"This study developed an alginate, gelatine and chondroitin sulphate hydrogel incorporating silicon oxide nanoparticles to assess hydrogel morphology, cell proliferation and viability. The effectiveness of these hydrogels for cartilage repair was evaluated in vivo using male albino rabbits, divided into three groups: a control group without hydrogels, an observer group with hydrogels lacking nanoparticles and a treatment group with nanoparticle-enhanced hydrogels for post-injury repair. At 15, 30 and 60 days post-surgery, the rabbits were humanely euthanized and excised tissue samples were fixed in 10% formalin for histopathological analysis, then processed and embedded in paraffin for microscopic evaluation. Statistical analysis was performed using SPSS software with ANOVA and Tukey's post hoc test. Results indicated that the hydrogels supported cell viability and encouraged differentiation into chondrocyte-like phenotypes. Scanning electron microscopy confirmed the hydrogels' porosity and showed significant differences in cell survival rates compared to the control group, underscoring the potential of hydrogels in cartilage tissue engineering and regenerative repair strategies.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1-13"},"PeriodicalIF":4.3,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-nanoemulsifying drug delivery system (SNEDDS) as nano-carrier framework for permeability modulating approaches of BCS class III drug.

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2025-03-04 DOI: 10.1080/1061186X.2025.2469751

Amulya Jindal, Pankaj Kumar Sharma, Anoop Kumar

{"title":"Self-nanoemulsifying drug delivery system (SNEDDS) as nano-carrier framework for permeability modulating approaches of BCS class III drug.","authors":"Amulya Jindal, Pankaj Kumar Sharma, Anoop Kumar","doi":"10.1080/1061186X.2025.2469751","DOIUrl":"10.1080/1061186X.2025.2469751","url":null,"abstract":"The purpose of this review is to focus on the Self-Nanoemulsifying Drug Delivery System (SNEDDS) as an effective nanocarrier framework for permeability modulating approaches (PMA) of BCS class-III drugs and its challenges. Present review updates the recent trends in the SNEDDS research where it was employed as a cargo carrier for PMA and challenges. Patient compliance, ease of administration and non-invasiveness mode are non-trivial aspects in the oral administration of drugs. However, low aqueous solubility and impaired permeability are two prominent challenges resulting poor absorption of a drug. SNEDDS emerged as a dual nano-carrier system to enable nanodispersion of PMA via e.g. ion-pairing, phospholipid-complex, surfactant-drug interaction, loading of non-ionizable, free drug bases etc. These PMAs are embedded within the lipid phase of SNEDDS to produce nanosizing, enhancing nano-dispersibility via micellization/solubilization mechanism owing to its ternary components. Review highlights different PMAs employed in bioavailability enhancement of BCS class-III. It covers excipients employed in SNEDDS-loaded PMA, strategies for the hydrophobic transformation of water-soluble drugs for BCS class-III drugs. SNEDDS as a nano-cargo system for PMAs significantly modifies the bioavailability of BCS class-III drugs. SNEDDS is an isotropic-mixture of oil, surfactant:co-surfactant offers multipoint access to PMA loading and produces nano-dispersion in aqueous-medium.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1-21"},"PeriodicalIF":4.3,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Niosomes as a targeted drug delivery system in the treatment of breast cancer: preparation, classification and mechanisms of cellular uptake.

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2025-03-03 DOI: 10.1080/1061186X.2025.2468750

Muneeb Ur Rahman, Hafiz Rashid Hussain, Habiba Akram, Muhammad Sarfraz, Muhammad Nouman, Jawad Akbar Khan, Memona Ishtiaq

{"title":"Niosomes as a targeted drug delivery system in the treatment of breast cancer: preparation, classification and mechanisms of cellular uptake.","authors":"Muneeb Ur Rahman, Hafiz Rashid Hussain, Habiba Akram, Muhammad Sarfraz, Muhammad Nouman, Jawad Akbar Khan, Memona Ishtiaq","doi":"10.1080/1061186X.2025.2468750","DOIUrl":"10.1080/1061186X.2025.2468750","url":null,"abstract":"Breast cancer (BC) remains one of the significant health issues across the globe, being diagnosed in millions of women worldwide annually. Conventional therapeutic options have substantial adverse effects due to their non-specificity and limited drug bioavailability. Niosomes, being novel drug delivery systems formed from non-ionic surfactants, with or without cholesterol and charge-inducing agents, are used as therapeutic options in treating BC. Their formulation by various methods enhances the therapeutic efficacy and bioavailability and minimises side effects. Niosomal formulation of tamoxifen exhibits target drug delivery with enhanced stability, whereas docetaxel and methotrexate show sustained and controlled drug release, respectively. 5-Fluorouracil, doxorubicin, paclitaxel, cyclophosphamide and epirubicin show improved cytotoxic effects against BC when combined with other agents. Furthermore, repurposed niosomal formulations of anti-cancer drugs show improved penetration, reduced tumour volume and significantly enhanced anti-tumour effect. This review article focuses on the composition of niosomes and their application in BC treatment and then examines how niosomes could contribute to BC research.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1-17"},"PeriodicalIF":4.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From adhesion to invasion: the multifaceted roles of Mycobacterium tuberculosis lipoproteins.

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2025-03-03 DOI: 10.1080/1061186X.2025.2472208

Min Li, Qiao Zhang, Yun Wang, Jianping Xie, Tian Liang, Zhou Liu, Xiaohong Xiang, Qiang Zhou, Zhen Gong

引用次数: 0