盐酸氨基葡萄糖、依培力松联合运动疗法对膝关节骨性关节炎患者炎症因子及膝关节功能的影响。

IF 3.9 4区医学 Q1 PHARMACOLOGY & PHARMACY

Journal of Drug Targeting Pub Date : 2025-10-09 DOI:10.1080/1061186X.2025.2573055

Jun Ruan, Xuanying Li

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引用次数: 0

摘要

目的：探讨盐酸氨基葡萄糖（GAH）、依培力松联合运动治疗对膝关节骨性关节炎（KOA）患者炎症指标及膝关节功能的影响。方法：60例KOA患者随机分为两组。A组（n = 30）采用GAH +运动疗法，B组（n = 30）采用GAH +培立松+运动疗法。在治疗前后评估血清炎症因子、膝关节症状评分（疼痛、僵硬、日常功能）和功能指标[膝关节屈曲活动度（ROM）、Lysholm评分、5次坐立测试和15米步行时间]。并对临床疗效进行评价。结果：治疗后，两组患者血清MMP-3、TNF-α、IL-6水平均下降，其中B组降低幅度更大（P P P P P P = 0.038）。结论：GAH联合培立松和运动治疗KOA的疗效优于GAH单用。它能显著减少炎症标志物和症状，增强膝关节功能。

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Effectiveness of glucosamine hydrochloride and eperisone with exercise therapy on inflammatory factors and knee joint function in patients with knee osteoarthritis.

Objective: This study aimed to unveil the effect of glucosamine hydrochloride (GAH) and eperisone combined with exercise therapy on inflammatory markers and knee joint function in patients with knee osteoarthritis (KOA).

Methods: Sixty KOA patients were randomly assigned into two groups. Group A (n = 30) received GAH plus exercise therapy, while Group B (n = 30) received GAH combined with eperisone and exercise therapy. Serum inflammatory factors, knee symptom scores (pain, stiffness, daily function), and functional measures [knee flexion range of motion (ROM), Lysholm score, five-time sit-to-stand test, and 15-meter walking time] were assessed before and after treatment. Clinical efficacy was also evaluated.

Results: Post-treatment, both groups showed decreased serum MMP-3, TNF-α, and IL-6 levels, with significantly greater reductions in Group B (P < 0.001). Group B had lower symptom scores (P < 0.05), greater ROM and Lysholm improvements (P < 0.001), and better functional performance (P < 0.001). The effective rate was higher in Group B (100.00%) than in Group A (86.67%) (P = 0.038).

Conclusion: GAH combined with eperisone and exercise therapy is more effective than GAH alone in patients with KOA. It significantly reduces inflammatory markers and symptoms, and enhances knee joint function.

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来源期刊

Journal of Drug Targeting 医学-药学

CiteScore

9.10

自引率

0.00%

发文量

165

审稿时长

2 months

期刊介绍： Journal of Drug Targeting publishes papers and reviews on all aspects of drug delivery and targeting for molecular and macromolecular drugs including the design and characterization of carrier systems (whether colloidal, protein or polymeric) for both vitro and/or in vivo applications of these drugs. Papers are not restricted to drugs delivered by way of a carrier, but also include studies on molecular and macromolecular drugs that are designed to target specific cellular or extra-cellular molecules. As such the journal publishes results on the activity, delivery and targeting of therapeutic peptides/proteins and nucleic acids including genes/plasmid DNA, gene silencing nucleic acids (e.g. small interfering (si)RNA, antisense oligonucleotides, ribozymes, DNAzymes), as well as aptamers, mononucleotides and monoclonal antibodies and their conjugates. The diagnostic application of targeting technologies as well as targeted delivery of diagnostic and imaging agents also fall within the scope of the journal. In addition, papers are sought on self-regulating systems, systems responsive to their environment and to external stimuli and those that can produce programmed, pulsed and otherwise complex delivery patterns.