Brain targeted polymeric micelles as drug carriers for ischaemic stroke treatment.

IF 4.3 4区医学 Q1 PHARMACOLOGY & PHARMACY

Journal of Drug Targeting Pub Date : 2025-02-01 Epub Date: 2024-10-18 DOI:10.1080/1061186X.2024.2417190

Zirui Zhao, Huijia Song, Mengge Qi, Yurong Liu, Yanchao Zhang, Shuo Li, Huimin Zhang, Yongjun Sun, Yanping Sun, Zibin Gao

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Abstract

Ischaemic stroke is a central nervous system disease with high morbidity, recurrence and mortality rates. Thrombolytic and neuroprotective therapies are the main therapeutic strategies for ischaemic stroke, however, the poor delivery efficiency of thrombolytic and neuroprotective drugs to the brain limits their clinical application. So far, the development of nanomedicine has brought opportunities for the above challenges, which can not only realise the effective accumulation of drugs in the target site, but also improve the pharmacokinetic behaviour of the drugs. Among the most rapidly developing nanoparticles, micelles gradually emerging as an effective strategy for ischaemic stroke treatment due to their own unique advantages. This review provided an overview of targeted and response-release micelles based on the physicochemical properties of the ischaemic stroke microenvironment, summarised the targeting strategies for delivering micellar formulations to the thrombus, blood-brain barrier, and brain parenchyma, and finally described the potentials and challenges of polymeric micelles in the treatment of ischaemic stroke.

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脑靶向聚合物胶束作为治疗缺血性中风的药物载体。

缺血性中风是一种发病率、复发率和死亡率都很高的中枢神经系统疾病。溶栓和神经保护疗法是缺血性脑卒中的主要治疗策略，但溶栓和神经保护药物在脑部的传输效率较低，限制了其临床应用。迄今为止，纳米医学的发展为上述挑战带来了机遇，它不仅能实现药物在靶点的有效蓄积，还能改善药物的药代动力学行为。在发展最迅速的纳米粒子中，胶束因其独特的优势逐渐成为缺血性脑卒中治疗的有效策略。本综述概述了基于缺血性中风微环境理化特性的靶向和反应释放胶束，总结了向血栓、血脑屏障和脑实质输送胶束制剂的靶向策略，最后阐述了聚合物胶束在缺血性中风治疗中的潜力和挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Drug Targeting 医学-药学

CiteScore

9.10

自引率

0.00%

发文量

165

审稿时长

2 months

期刊介绍： Journal of Drug Targeting publishes papers and reviews on all aspects of drug delivery and targeting for molecular and macromolecular drugs including the design and characterization of carrier systems (whether colloidal, protein or polymeric) for both vitro and/or in vivo applications of these drugs. Papers are not restricted to drugs delivered by way of a carrier, but also include studies on molecular and macromolecular drugs that are designed to target specific cellular or extra-cellular molecules. As such the journal publishes results on the activity, delivery and targeting of therapeutic peptides/proteins and nucleic acids including genes/plasmid DNA, gene silencing nucleic acids (e.g. small interfering (si)RNA, antisense oligonucleotides, ribozymes, DNAzymes), as well as aptamers, mononucleotides and monoclonal antibodies and their conjugates. The diagnostic application of targeting technologies as well as targeted delivery of diagnostic and imaging agents also fall within the scope of the journal. In addition, papers are sought on self-regulating systems, systems responsive to their environment and to external stimuli and those that can produce programmed, pulsed and otherwise complex delivery patterns.