{"title":"Analysis of Superb Microvascular Imaging Blood Flow Scoring, Disease Duration, and Laboratory Indicators Involved in Gout.","authors":"Jianming Lu, Qian Zhang, Guangfei Yang, Zhile Gu, Yating Wu","doi":"10.1002/jcu.23940","DOIUrl":"https://doi.org/10.1002/jcu.23940","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the correlation among semi-quantitative scoring of blood flow by superb microvascular imaging (SMI), hypersensitive C-reactive protein (hs-CRP), erythrocyte sedimentation rate (ESR), and serum uric acid (SUA) levels in different gout duration.</p><p><strong>Methods: </strong>103 patients (total 157 affected joints) with clinically confirmed acute gout attack from January 2021 to May 2022 were performed with laboratory tests (hs-CRP, ESR, SUA), routine joint ultrasound scanning, along with semi-quantitative scoring of SMI, and correlations between which were analyzed.</p><p><strong>Results: </strong>Statistically significant differences were found in semi-quantitative scoring of SMI in the affected joints between different disease duration. The differences between SMI scoring in gouty tophi, synovial hyperplasia, and the levels of different hs-CRP and ESR subgroups of the affected joints were statistically significant (p < 0.05). R values between SMI scoring in synovial hyperplasia as well as gouty tophi and hs-CRP levels were 0.711 and 0.579, respectively, and those of ESR were 0.430 and 0.418, respectively, while those of SUA levels were -0.227 and 0.120, respectively.</p><p><strong>Conclusion: </strong>With a prolonged progression of gout, hs-CRP and ESR levels amplify, along with a concurrent intensification in the SMI scorings of blood flow signals in the affected joints (grades 2 and 3). In the acute gout attack, SMI blood flow scoring showed a moderate correlation to hs-CRP, a low correlation to ESR, and no correlation to SUA, among which the best correlation was found between SMI scoring and hs-CRP levels in the synovial hyperplasia.</p>","PeriodicalId":15386,"journal":{"name":"Journal of Clinical Ultrasound","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Primitive Ewing Sarcoma of Epididymis: A Case Report and Literature Review.","authors":"Lan Liu, Min Xu, Xianmei Liu, Shi Zhou","doi":"10.1002/jcu.23936","DOIUrl":"https://doi.org/10.1002/jcu.23936","url":null,"abstract":"<p><p>We present the case of a 22-year-old man with a firm and tender mass in the left scrotum region. Color Doppler ultrasound and radiographic examination (CT and MRI) suggested that the mass arose from the left epididymis without tumor metastasis. The histopathological and immunohistochemical findings revealed a chrysanthemum-like arrangement of round tumor cells, along with strong positive expression of CD99, vimentin, CD117, CD56, and Ki-67 (70%), supporting the diagnosis of primary epididymal Ewing sarcoma. The patient underwent surgical excision and received 3 cycles of postoperative chemotherapy with vincristine, doxorubicin, and cyclophosphamide. The patient is recovering satisfactorily, and his follow-up treatments and condition are being monitored.</p>","PeriodicalId":15386,"journal":{"name":"Journal of Clinical Ultrasound","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wenjie Hu, Lu Liu, Ting Zhao, Jie Lin, Yong Wang, Fan Li, Hong Ding
{"title":"Analysis of Ultrasound Features for Breast Cancers With Different Risk Categories and Evaluation of a New Predicting Method.","authors":"Wenjie Hu, Lu Liu, Ting Zhao, Jie Lin, Yong Wang, Fan Li, Hong Ding","doi":"10.1002/jcu.23919","DOIUrl":"https://doi.org/10.1002/jcu.23919","url":null,"abstract":"<p><strong>Objectives: </strong>To explore pathology and ultrasound features of breast cancers with different risk categories. To establish and validate a nomogram primarily based on grayscale ultrasound features for non-invasive preoperative prediction of high-risk breast cancers and for rapid individual risk assessment and clinical decision making.</p><p><strong>Methods: </strong>A total of 685 breast malignant lesions were enrolled in this study. All lesions were classified according to the St. Gallen risk categories criteria. The pathology and ultrasound features were compared among different risk groups. A multifactorial Logistic model and a nomogram primarily based on grayscale ultrasound were established. Then prediction ability was evaluated.</p><p><strong>Results: </strong>In training cohort, the ultrasound features with significant differences were selected again through Lasso regression. Then, age, maximum diameter in ultrasound, posterior echo attenuation, spiculate margin and suspicious axillary lymph nodes were selected to establish the prediction model and nomogram. The areas under the curve in training cohort and internal test cohort were 0.833 and 0.827. Diagnostic sensitivity, specificity, accuracy, positive likelihood ratio and negative likelihood ratio were 75.6%, 76.6%, 76.4%, 41.4% and 93.5%, respectively.</p><p><strong>Conclusions: </strong>Breast cancers with different risk categories exhibit distinct pathology and ultrasound features. The prediction model and nomogram have good and stable diagnostic efficiency.</p>","PeriodicalId":15386,"journal":{"name":"Journal of Clinical Ultrasound","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparison of Shear Wave Elastography Measurements in Chronic Kidney Disease Patients and Healthy Volunteers.","authors":"Sezer Kula, Nuray Haliloglu","doi":"10.1002/jcu.23949","DOIUrl":"https://doi.org/10.1002/jcu.23949","url":null,"abstract":"<p><p>To evaluate renal parenchymal stiffness using 2D shear wave elastography (SWE) in patients with chronic kidney disease (CKD) and to investigate the correlation between SWE results and demographic as well as laboratory findings. We evaluated 41 CKD patients and 40 controls who underwent abdominal ultrasound (US) between December 2020 and November 2022. SWE measurements were performed by a single radiologist, assessing renal stiffness in the lower pole, middle section, and upper pole of each kidney. The mean stiffness values were calculated from at least six measurements per kidney. Laboratory data, including glomerular filtration rate (GFR), serum urea, and creatinine levels, were obtained. Mann-Whitney U and Spearman correlation tests were used for statistical analysis. CKD patients (mean age: 66 years) showed significantly higher cortical stiffness compared with controls (15.6 kPa vs. 5.5 kPa, p < 0.001). A positive correlation was found between stiffness and serum urea/creatinine levels, while an inverse correlation was observed with GFR (p < 0.001). A negative correlation was observed between kidney size and SWE (r = -0.215, p = 0.054), while parenchymal thickness showed a stronger and statistically significant inverse relationship with SWE (r = -0.301, p = 0.006). No significant correlation was found with age or gender (p > 0.05). SWE is a reliable, noninvasive method for assessing renal fibrosis in CKD. With standardization, it could become a valuable tool in routine CKD evaluation.</p>","PeriodicalId":15386,"journal":{"name":"Journal of Clinical Ultrasound","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sarah Razaq, Vincenzo Ricci, Costantino Ricci, Levent Özçakar
{"title":"Ultrasound-Guided Hydro-Dissection of the Superficial Fascia for Cervical Myofascial Pain: A Case Series.","authors":"Sarah Razaq, Vincenzo Ricci, Costantino Ricci, Levent Özçakar","doi":"10.1002/jcu.23947","DOIUrl":"https://doi.org/10.1002/jcu.23947","url":null,"abstract":"<p><p>The fascial system has recently gained attention for its potential role in various painful disorders. With the advancement of our understanding regarding the rich innervation of the fascia, it has emerged as a potential pain generator and a target for treatment in many cases. The superficial fascia presents a rich plexiform intrinsic neural network and runs within the subcutaneous fat tissue. It is pierced by several cutaneous nerves originating from the spine and reaching the dermo-epidermal complex along the posterior surface of the trunk. Unlike the deep fascia that envelopes the paraspinal muscles and for which several interventional techniques have been described, poor scientific data about ultrasound-guided procedures targeting the paravertebral superficial fascia are available. In this sense, this brief report describes three relevant cases whereby hydro-dissection of the cervical superficial fascia has been performed under ultrasound guidance to manage myofascial pain non-responsive to first-line conservative treatments. Likewise, we discuss the potential role of this often-forgotten anatomical structure in chronic cervical myofascial pain, cervicogenic dizziness, and paresthesias with non-dermatomal distribution of the cervical and periscapular region.</p>","PeriodicalId":15386,"journal":{"name":"Journal of Clinical Ultrasound","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ultrasonographic Evaluation of the Fetal Thymic-Thoracic Ratio in Pregnant Women With Asthma.","authors":"Zahid Agaoglu, Atakan Tanacan, Bergen Laleli Koc, Burcu Bozkurt Ozdal, Betul Akgun Aktas, Aysegul Atalay, Ozgur Kara, Dilek Sahin","doi":"10.1002/jcu.23939","DOIUrl":"https://doi.org/10.1002/jcu.23939","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the thymic-thoracic ratio (TTR) in pregnant women with asthma to determine whether fetal thymus size is affected in this condition.</p><p><strong>Methods: </strong>A total of 139 patients, 69 patients diagnosed with asthma and 70 controls were prospectively included in the study at a single tertiary center. Eighteen of the patients diagnosed with asthma experienced at least one asthma attack, while 51 patients did not have any asthma attacks during pregnancy. TTR was calculated from the anterior-posterior dimensions of the thymus and intrathoracic mediastinal measurements.</p><p><strong>Results: </strong>TTR was found to be statistically significantly lower in patients with asthma compared to the controls (p < 0.001). The rate of neonatal intensive care unit admission was higher and the TTR value was lower among the cases presenting with an asthma attack during pregnancy compared to patients without asthma attack and controls (p = 0.043 and p = 0.001, respectively). A statistical difference was found between patients with and without asthma attacks regarding the use of medication for asthma (p < 0.05).</p><p><strong>Conclusion: </strong>The fetal thymus has been found to be affected in patients with asthma. The TTR is lower in patients who have asthma attacks during pregnancy and in patients taking medication for treatment, which may be related to chronic inflammatory process as well as to the use of exogenous steroids.</p>","PeriodicalId":15386,"journal":{"name":"Journal of Clinical Ultrasound","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shuang Zheng, Lian-di Liu, Dawei Wang, Li Lin, Ran Chen, Bin Xiao
{"title":"Uveal Melanoma in a Child: A Case Report.","authors":"Shuang Zheng, Lian-di Liu, Dawei Wang, Li Lin, Ran Chen, Bin Xiao","doi":"10.1002/jcu.23938","DOIUrl":"https://doi.org/10.1002/jcu.23938","url":null,"abstract":"<p><p>Uveal melanoma is a rare and highly malignant tumor. Its occurrence in children is rare and challenging to differentiate from retinoblastoma. The present work reports on the unusual case of a 4-year-old male patient who presented a mass in the right eye unresponsive to 18 days of ophthalmic artery chemotherapy. Enucleation revealed a solid black mass with high melanin content. The pathological diagnosis indicated uveal melanoma in the right eyeball, infiltrating the cornea and sclera. Whole-exome sequencing found no pathogenic gene variants. Further exploration of pathogenesis and molecular genetics is needed.</p>","PeriodicalId":15386,"journal":{"name":"Journal of Clinical Ultrasound","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prevalence and Doppler Indices of Late-Onset Fetal Growth Restriction at a Single University Hospital in Southern Thailand.","authors":"Wattanan Watthanasathitnukun, Chitkasaem Suwanrath, Natthicha Chainarong, Chusana Petpichetchian, Chutinun Leelarujijareon","doi":"10.1002/jcu.23948","DOIUrl":"https://doi.org/10.1002/jcu.23948","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the prevalence of late-onset fetal growth restriction (FGR), and comprehensively assess maternal and fetal Doppler indices by comparing the Doppler measurements of the uterine artery (UtA), umbilical artery (UA), umbilical vein (UV), middle cerebral artery (MCA), and ductus venosus (DV) between normal and FGR groups.</p><p><strong>Methods: </strong>This prospective study enrolled 306 singleton pregnant women at ≥ 32 weeks' gestation between June 1, 2023 and April 30, 2024. Fetal biometry and Doppler indices were measured via transabdominal ultrasonography by a single operator. The Mann-Whitney U test was used for statistical comparison.</p><p><strong>Results: </strong>Late-onset FGR prevalence was 4.9% (15/306). The FGR group had a significantly higher UtA pulsatility index (PI) and lower cerebroplacental ratio (CPR), cerebral-placental-uterine ratio (CPUR), and UV blood flow normalized for fetal abdominal circumference (UVBF/AC) compared to the normal group.</p><p><strong>Conclusion: </strong>Late-onset FGR prevalence was approximately 5%. The higher UtA-PI and lower CPR, CPUR, and UVBF/AC in the FGR group indicated mild placental insufficiency.</p>","PeriodicalId":15386,"journal":{"name":"Journal of Clinical Ultrasound","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ee Tein Tay, James W Tsung, Yue Jay Lin, Jennifer E Sanders
{"title":"Differentiate Between Angioedema From Cellulitis in Pediatric Patients With Periorbital Swelling on Point-of-Care Ultrasound.","authors":"Ee Tein Tay, James W Tsung, Yue Jay Lin, Jennifer E Sanders","doi":"10.1002/jcu.23941","DOIUrl":"https://doi.org/10.1002/jcu.23941","url":null,"abstract":"<p><strong>Purpose: </strong>This study evaluated the use of point-of-care (POCUS) to differentiate between angioedema and cellulitis in pediatric patients who presented to the emergency department (ED) with periorbital swelling from suspected insect bites.</p><p><strong>Methods: </strong>Subanalysis of patients under 21 years old with periorbital swelling from suspected insect bites was performed in patients presenting to the ED. Participating physicians received hands-on soft tissue ultrasound training prior to study enrollment. Pre- and post-POCUS diagnoses and findings, disposition, ED discharge diagnosis, additional imaging studies, and treatment medications were recorded. Patients received telephone follow-up 1 week after the visit.</p><p><strong>Results: </strong>Twenty-three subjects were enrolled. Twenty (86.9%) cases had a pre-POCUS diagnosis of allergic skin reaction, one (4.3%) had cellulitis, and two (8.7%) were undetermined. After POCUS, providers changed diagnoses and treatment management on five (21.7%) patients. Ultrasound features of linear bands were identified in 22 ultrasound images suggesting angioedema. No patients received further imaging or were admitted for hospitalization.</p><p><strong>Conclusions: </strong>POCUS may serve as an adjunct tool in differentiating between cellulitis and angioedema in patients with periorbital swelling from local allergic skin reactions from insect bites and decreasing unnecessary imaging studies and hospital admissions.</p>","PeriodicalId":15386,"journal":{"name":"Journal of Clinical Ultrasound","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Imaging Findings of a Pediatric Patient With Focal Intrahepatic Bile Duct Hamartoma: A Case Report.","authors":"Yi Zhang, Jing Chen, Yan Du","doi":"10.1002/jcu.23937","DOIUrl":"https://doi.org/10.1002/jcu.23937","url":null,"abstract":"<p><p>A 15-year-old female adolescent was previously in good health. Ultrasound examination revealed an 84 × 45 mm heterogeneous echo mass in the left inner lobe of the liver, exhibiting clear boundaries and a regular shape. Additionally, multiple small cysts were observed within the heterogeneous echo mass, and occasionally, a strong spot-like echo with a comet tail sign was noted. Imaging results indicated that the left inner lobe of the liver exhibited a lamellar structure with an anomalous signal shadow, suggesting a high probability of bile duct hamartoma.</p>","PeriodicalId":15386,"journal":{"name":"Journal of Clinical Ultrasound","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}