Meta-Analysis of Carotid Contrast-Enhanced Ultrasonography to Assess the Activity of Takayasu Arteritis.

IF 1.4 4区医学 Q3 ACOUSTICS

Journal of Clinical Ultrasound Pub Date : 2025-09-30 DOI:10.1002/jcu.70097

Liwen Zhu, Shipei Xu, Jiqing Xuan

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引用次数: 0

Abstract

Objectives: This meta-analysis evaluated the diagnostic value of carotid contrast ultrasonography (CEUS) for disease activity in Takayasu arteritis (TAK).

Methods: Systematic reviews were conducted in PubMed, Embase, Cochrane Library, and Web of Science using the following search terms: Takayasu Arteritis, aortic arch syndrome, pulseless disease, contrast-enhanced ultrasound, contrast-enhanced ultrasonography, and CEUS. Studies published from the beginning up until October 2024 were collected. Two researchers performed screening, full-text review, and data extraction. The QUADAS-2 tool was used to assess the risk of bias. A random-effects model was used for the meta-analysis.

Results: Nine articles involving 498 patients and 704 carotid artery examinations were included in the study. The combined sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and area under the curve of CEUS for detecting TAK disease activity were 0.80 (0.76-0.83), 0.71 (0.67-0.74), 3.87 (2.41-6.21), 0.31 (0.22-0.42), 21.87 (11.32-42.23), and 0.8941, respectively.

Conclusion: The assessment of TAK activity using CEUS has certain sensitivity and specificity; as a result, it can be used to judge the condition of patients with TAK and the treatment effect to provide a more comprehensive and reliable objective basis for clinical treatment.

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颈动脉超声造影评估高松动脉炎活动性的meta分析。

目的：本荟萃分析评估颈动脉超声造影（CEUS）对高松动脉炎（Takayasu arteritis， TAK）疾病活动性的诊断价值。方法：系统检索PubMed、Embase、Cochrane Library和Web of Science，检索词为：Takayasu Arteritis、主动脉弓综合征、无脉疾病、超声造影、超声造影和超声造影。收集了从一开始到2024年10月发表的研究。两名研究人员进行筛选、全文审查和数据提取。使用QUADAS-2工具评估偏倚风险。meta分析采用随机效应模型。结果：纳入9篇文章，498例患者，704例颈动脉检查。CEUS检测TAK病变活动性的综合敏感性、特异性、阳性似然比、阴性似然比、诊断优势比、曲线下面积分别为0.80（0.76 ~ 0.83）、0.71（0.67 ~ 0.74）、3.87（2.41 ~ 6.21）、0.31（0.22 ~ 0.42）、21.87（11.32 ~ 42.23）、0.8941。结论：超声造影评价TAK活性具有一定的敏感性和特异性；可用于判断TAK患者的病情及治疗效果，为临床治疗提供更全面、可靠的客观依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Ultrasound 医学-核医学

CiteScore

1.90

自引率

0.00%

发文量

248

审稿时长

6 months

期刊介绍： The Journal of Clinical Ultrasound (JCU) is an international journal dedicated to the worldwide dissemination of scientific information on diagnostic and therapeutic applications of medical sonography. The scope of the journal includes--but is not limited to--the following areas: sonography of the gastrointestinal tract, genitourinary tract, vascular system, nervous system, head and neck, chest, breast, musculoskeletal system, and other superficial structures; Doppler applications; obstetric and pediatric applications; and interventional sonography. Studies comparing sonography with other imaging modalities are encouraged, as are studies evaluating the economic impact of sonography. Also within the journal''s scope are innovations and improvements in instrumentation and examination techniques and the use of contrast agents. JCU publishes original research articles, case reports, pictorial essays, technical notes, and letters to the editor. The journal is also dedicated to being an educational resource for its readers, through the publication of review articles and various scientific contributions from members of the editorial board and other world-renowned experts in sonography.