Journal of Cerebral Blood Flow and Metabolism最新文献_第6页

Arterial specification precedes microvascular restitution in the peri-infarct cortex that is driven by small microvessels. 梗死周围皮层的微血管恢复是由小微血管驱动的，动脉规格化先于微血管恢复。

IF 4.9 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2025-01-01 Epub Date: 2024-08-07 DOI: 10.1177/0271678X241270407

Nina Hagemann, Yachao Qi, Ayan Mohamud Yusuf, AnRan Li, Xiaoni Zhang, Philippa Spangenberg, Anthony Squire, Thorsten R Doeppner, Fengyan Jin, Shuo Zhao, Jianxu Chen, Axel Mosig, Matthias Gunzer, Dirk M Hermann

{"title":"Arterial specification precedes microvascular restitution in the peri-infarct cortex that is driven by small microvessels.","authors":"Nina Hagemann, Yachao Qi, Ayan Mohamud Yusuf, AnRan Li, Xiaoni Zhang, Philippa Spangenberg, Anthony Squire, Thorsten R Doeppner, Fengyan Jin, Shuo Zhao, Jianxu Chen, Axel Mosig, Matthias Gunzer, Dirk M Hermann","doi":"10.1177/0271678X241270407","DOIUrl":"10.1177/0271678X241270407","url":null,"abstract":"Evaluation of microvascular networks was impeded until recently by the need of histological tissue sectioning, which precluded 3D analyses. Using light-sheet microscopy, we investigated microvascular network characteristics in the peri-infarct cortex of mice 3-56 days after transient middle cerebral artery occlusion. In animal subgroups, the sphingosine-1-phosphate analog FTY720 (Fingolimod) was administered starting 24 hours post-ischemia. Light-sheet microscopy revealed a striking pattern of microvascular changes in the peri-infarct cortex, that is, a loss of microvessels, which was most prominent after 7 days and followed by the reappearance of microvessels over 56 days which revealed an increased branching point density and shortened branches. Using a novel AI-based image analysis algorithm we found that the length density of microvessels expressing the arterial specification marker α-smooth muscle actin markedly increased in the peri-infarct cortex already at 7 days post-ischemia. The length and branch density of small microvessels, but not of intermediate or large microvessels increased above pre-ischemic levels within 14-56 days. FTY720 increased the length and branch density of small microvessels. This study demonstrates long-term alterations of microvascular architecture post-ischemia indicative of increased collateralization most notably of small microvessels. Light-sheet microscopy will greatly advance the assessment of microvascular responses to restorative stroke therapies.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"171-186"},"PeriodicalIF":4.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11571960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141901927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasminogen activator inhibitor-1 mediates cerebral ischemia-induced astrocytic reactivity. 血浆酶原激活剂抑制剂-1介导脑缺血诱发的星形胶质细胞反应。

IF 4.9 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2025-01-01 Epub Date: 2024-08-07 DOI: 10.1177/0271678X241270445

Pavel Yanev, Cynthia Martin-Jimenez, Diego Julian Vesga-Jimenez, Laura Zvinys, Nicholas Weinrich, Mary Ann Cree, Todd M Preuss, Xiaodong Zhang, Manuel Yepes

{"title":"Plasminogen activator inhibitor-1 mediates cerebral ischemia-induced astrocytic reactivity.","authors":"Pavel Yanev, Cynthia Martin-Jimenez, Diego Julian Vesga-Jimenez, Laura Zvinys, Nicholas Weinrich, Mary Ann Cree, Todd M Preuss, Xiaodong Zhang, Manuel Yepes","doi":"10.1177/0271678X241270445","DOIUrl":"10.1177/0271678X241270445","url":null,"abstract":"Although ischemia increases the abundance of plasminogen activator inhibitor-1 (PAI-1), its source and role in the ischemic brain remain unclear. We detected PAI-1-immunoreactive cells with morphological features of reactive astrocytes in the peri-ischemic cortex of mice after an experimentally-induced ischemic lesion, and of a chimpanzee that suffered a naturally-occurring stroke. We found that although the abundance of PAI-1 increases 24 hours after the onset of the ischemic injury in a non-reperfusion murine model of ischemic stroke, at that time-point there is no difference in astrocytic reactivity and the volume of the ischemic lesion between wild-type (Wt) animals and in mice either genetically deficient (PAI-1-/-) or overexpressing PAI-1 (PAI-1Tg). In contrast, 72 hours later astrocytic reactivity and the volume of the ischemic lesion were decreased in PAI-1-/- mice and increased in PAI-1Tg animals. Our immunoblottings and fractal analysis studies show that the abundance of astrocytic PAI-1 rises during the recovery phase from a hypoxic injury, which in turn increases the abundance of glial fibrillary acidic protein (GFAP) and triggers morphological features of reactive astrocytes. These studies indicate that cerebral ischemia-induced release of astrocytic PAI-1 triggers astrocytic reactivity associated with enlargement of the necrotic core.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"102-114"},"PeriodicalIF":4.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11572231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141901946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anesthetics in pathological cerebrovascular conditions. 病理脑血管情况下的麻醉剂。

IF 4.9 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2025-01-01 Epub Date: 2024-10-25 DOI: 10.1177/0271678X241295857

Yuhui Hou, Wei Ye, Ziyuan Tang, Fengxian Li

{"title":"Anesthetics in pathological cerebrovascular conditions.","authors":"Yuhui Hou, Wei Ye, Ziyuan Tang, Fengxian Li","doi":"10.1177/0271678X241295857","DOIUrl":"10.1177/0271678X241295857","url":null,"abstract":"The increasing prevalence of pathological cerebrovascular conditions, including stroke, hypertensive encephalopathy, and chronic disorders, underscores the importance of anesthetic considerations for affected patients. Preserving cerebral oxygenation and blood flow during anesthesia is paramount to prevent neurological deterioration. Furthermore, protecting vulnerable neurons from damage is crucial for optimal outcomes. Recent research suggests that anesthetic agents may provide a potentially therapeutic approach for managing pathological cerebrovascular conditions. Anesthetics target neural mechanisms underlying cerebrovascular dysfunction, thereby modulating neuroinflammation, protecting neurons against ischemic injury, and improving cerebral hemodynamics. However, optimal strategies regarding mechanisms, dosage, and indications remain uncertain. This review aims to clarify the physiological effects, mechanisms of action, and reported neuroprotective benefits of anesthetics in patients with various pathological cerebrovascular conditions. Investigating anesthetic effects in cerebrovascular disease holds promise for developing novel therapeutic strategies.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"32-47"},"PeriodicalIF":4.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuronal plasma biomarkers in acute ischemic stroke. 急性缺血性中风的神经元血浆生物标志物。

IF 4.9 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2025-01-01 Epub Date: 2024-10-25 DOI: 10.1177/0271678X241293537

Julia K Gundersen, Fernando Gonzalez-Ortiz, Thomas Karikari, Bjørn-Eivind Kirsebom, Katrin Mertes, Henrik Zetterberg, Hlin Kvartsberg, Ole Morten Rønning, Berglind Gísladóttir, Kaj Blennow, Tormod Fladby

{"title":"Neuronal plasma biomarkers in acute ischemic stroke.","authors":"Julia K Gundersen, Fernando Gonzalez-Ortiz, Thomas Karikari, Bjørn-Eivind Kirsebom, Katrin Mertes, Henrik Zetterberg, Hlin Kvartsberg, Ole Morten Rønning, Berglind Gísladóttir, Kaj Blennow, Tormod Fladby","doi":"10.1177/0271678X241293537","DOIUrl":"10.1177/0271678X241293537","url":null,"abstract":"Early imaging-based detection of acute ischemic stroke (AIS) has improved in the era of reperfusion therapy. Despite of this, prognosis of outcome after AIS remains a challenge. Therefore, parameters that support clinical decision making are sought. Blood-based biomarkers have the potential to provide valuable information in addition to the established prognostic factors. Neuronal biomarkers of acute or degenerative neuronal injury have shown to be reliably detected in plasma. These biomarkers are well-established in neurodegenerative pathology, such as Alzheimer's disease. In this study, we explored the association between stroke diameter and plasma biomarkers for neuronal injury and tau pathophysiology (brain-derived tau [BD-tau], phosphorylated-tau-217 [p-tau21] and neurofilament light [NfL]) in patients (n = 193) admitted to the acute ward, Akershus University Hospital. All patients received a final diagnosis of AIS, transient ischemic attack or stroke mimics. Blood samples were obtained the day after admission. We find that levels of BD-tau (p = .004) and NfL (p = .011) were higher after AIS than in patients with stroke mimics. The cortical stroke diameter correlated with BD-tau (tau-b = 0.64, p < .001) and p-tau217 (tau-b = 0.36, p = .003). Linear regression confirmed BD-tau to be the strongest variable associated with stroke diameter, pointing to the potential clinical value of plasma BD-tau in outcome prediction after AIS.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"77-84"},"PeriodicalIF":4.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clearance rate of contrast extravasation after endovascular therapy is associated with functional outcome and mediated by cerebral edema. 血管内治疗后造影剂外渗的清除率与功能预后有关，并由脑水肿介导。

IF 4.9 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2025-01-01 Epub Date: 2024-08-20 DOI: 10.1177/0271678X241275763

Jiaqi Luo, Xiaolin Zhao, Mengxuan Xiao, Lihua Wei, Zhiliang Zhu, Bingbing Li, Zhong Ji, Yongming Wu, Zhenzhou Lin, Suyue Pan, Kaibin Huang

{"title":"Clearance rate of contrast extravasation after endovascular therapy is associated with functional outcome and mediated by cerebral edema.","authors":"Jiaqi Luo, Xiaolin Zhao, Mengxuan Xiao, Lihua Wei, Zhiliang Zhu, Bingbing Li, Zhong Ji, Yongming Wu, Zhenzhou Lin, Suyue Pan, Kaibin Huang","doi":"10.1177/0271678X241275763","DOIUrl":"10.1177/0271678X241275763","url":null,"abstract":"The brain's function of clearance and transport is closely related to the prognosis of acute ischemic stroke (AIS). In this study, we proposed a novel method, clearance rate of contrast extravasation (CROCE), to measure brain clearance and transport function in AIS patients undergoing endovascular therapy (EVT), and examined its association with cerebral edema and functional outcome. We conducted a pooled analysis of AIS patients of anterior circulation large vessel occlusion who underwent EVT in two academic hospitals. Patients who experienced contrast extravasation but not intracerebral hemorrhage following EVT were included. CROCE was defined as the mass of contrast agent cleared per hour on non-contrast CT (NCCT). Among the 215 patients finally included, we found that high CROCE was significantly associated with 90-day favorable functional outcome, and the association retained after adjustment for potential confounders. Different correlation analysis demonstrated a significant correlation between CROCE, cerebral edema, and functional outcome. Further mediation analysis revealed that cerebral edema mediated the effect of CROCE on functional outcome. These results revealed that CROCE may be a promising indicator of brain clearance function for patients who received EVT and had contrast extravasation.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"66-76"},"PeriodicalIF":4.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11572124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142004367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Statistical non-independence of brain metabolite concentrations whether normalized to creatine or water. 无论是以肌酸还是以水为标准，大脑代谢物浓度在统计上都不具有独立性。

IF 4.9 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2025-01-01 Epub Date: 2024-10-18 DOI: 10.1177/0271678X241290018

Richard J Maddock

引用次数: 0

Critical role of Slc22a8 in maintaining blood-brain barrier integrity after experimental cerebral ischemia-reperfusion. Slc22a8 在实验性脑缺血再灌注后维持血脑屏障完整性的关键作用

IF 4.9 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2025-01-01 Epub Date: 2024-07-28 DOI: 10.1177/0271678X241264401

Yangyang Liu, Xiang Li, Chang Cao, Haojie Ding, Xuan Shi, Juyi Zhang, Haiying Li

{"title":"Critical role of Slc22a8 in maintaining blood-brain barrier integrity after experimental cerebral ischemia-reperfusion.","authors":"Yangyang Liu, Xiang Li, Chang Cao, Haojie Ding, Xuan Shi, Juyi Zhang, Haiying Li","doi":"10.1177/0271678X241264401","DOIUrl":"10.1177/0271678X241264401","url":null,"abstract":"Blood-brain barrier (BBB) damage significantly affects the prognosis of ischemic stroke patients. This project employed multi-omics analysis to identify key factors regulating BBB disruption during cerebral ischemia-reperfusion. An integrated analysis of three transcriptome sequencing datasets from mouse middle cerebral artery occlusion/reperfusion (MCAO/R) models identified eight downregulated genes in endothelial cells. Additionally, transcriptome analysis of BBB (cortex) and non-BBB (lung) endothelium of E13.5 mice revealed 2,102 upregulated genes potentially associated with BBB integrity. The eight downregulated genes were intersected with the 2,102 BBB-related genes and mapped using single-cell RNA sequencing data, revealing that solute carrier family 22 member 8 (Slc22a8) is specifically expressed in endothelial cells and pericytes and significantly decreases after MCAO/R. This finding was validated in the mouse MCAO/R model at both protein and mRNA levels in this study. External overexpression of Slc22a8 using a lentivirus carrying Tie2 improved Slc22a8 and tight junction protein levels and reduced BBB leakage after MCAO/R, accompanied by Wnt/β-catenin signaling activation. In conclusion, this study suggested that MCAO/R-induced downregulation of Slc22a8 expression may be a crucial mechanism underlying BBB disruption. Interventions that promote Slc22a8 expression or enhance its function hold promise for improving the prognosis of patients with cerebral ischemia.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"85-101"},"PeriodicalIF":4.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11572098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141788197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The temporal dynamic of bradykinin type 2 receptor effects reveals its neuroprotective role in the chronic phase of cerebral and retinal ischemic injury. 缓激肽 2 型受体作用的时间动态揭示了它在脑和视网膜缺血性损伤慢性期的神经保护作用。

IF 4.9 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2025-01-01 Epub Date: 2024-08-07 DOI: 10.1177/0271678X241270241

Helena Justić, Anja Barić, Martina Ratko, Iva Šimunić, Marin Radmilović, Marta Pongrac, Siniša Škokić, Marina Dobrivojević Radmilović

{"title":"The temporal dynamic of bradykinin type 2 receptor effects reveals its neuroprotective role in the chronic phase of cerebral and retinal ischemic injury.","authors":"Helena Justić, Anja Barić, Martina Ratko, Iva Šimunić, Marin Radmilović, Marta Pongrac, Siniša Škokić, Marina Dobrivojević Radmilović","doi":"10.1177/0271678X241270241","DOIUrl":"10.1177/0271678X241270241","url":null,"abstract":"The activation of the bradykinin type 2 receptor is intricately involved in acute post-ischemic inflammatory responses. However, its precise role in different stages of ischemic injury, especially in the chronic phase, remains unclear. Following simultaneous cerebral and retinal ischemia, bradykinin type 2 receptor knockout mice and their controls were longitudinally monitored for 35 days via magnetic resonance imaging, fundus photography, fluorescein angiography, behavioral assessments, vascular permeability measurements, and immunohistochemistry, as well as glycemic status assessments. Without impacting the lesion size, bradykinin type 2 receptor deficiency reduced acute cerebral vascular permeability preventing the loss of pericytes and tight junctions. In the chronic phase of ischemia, however, it resulted in increased astrogliosis and cortical neuronal loss, as well as higher functional deficits. The retinal findings demonstrated a similar pattern. Bradykinin type 2 receptor deficiency delayed, but exacerbated the development of retinal necrosis, increased subacute vascular permeability, and promoted retinal ganglion cell loss in the chronic phase of ischemia. This investigation sheds light on the temporal dynamic of bradykinin type 2 receptor effects in ischemia, pointing to a therapeutic potential in the subacute and chronic phases of ischemic injury.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"153-170"},"PeriodicalIF":4.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11572167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141901947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alterations of cerebrovascular reactivity following pediatric mild traumatic brain injury are independent of neurodevelopmental changes. 小儿轻度脑外伤后脑血管反应性的改变与神经发育变化无关。

IF 4.9 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2025-01-01 Epub Date: 2024-08-07 DOI: 10.1177/0271678X241270531

Harm Jan van der Horn, Andrew B Dodd, Tracey V Wick, Cidney Robertson-Benta, Jessica R McQuaid, Erik B Erhardt, Samuel D Miller, Divyasree Sasi Kumar, Upasana Nathaniel, Josef M Ling, Sephira G Ryman, Andrei A Vakhtin, Robert E Sapien, John P Phillips, Richard A Campbell, Andrew R Mayer

{"title":"Alterations of cerebrovascular reactivity following pediatric mild traumatic brain injury are independent of neurodevelopmental changes.","authors":"Harm Jan van der Horn, Andrew B Dodd, Tracey V Wick, Cidney Robertson-Benta, Jessica R McQuaid, Erik B Erhardt, Samuel D Miller, Divyasree Sasi Kumar, Upasana Nathaniel, Josef M Ling, Sephira G Ryman, Andrei A Vakhtin, Robert E Sapien, John P Phillips, Richard A Campbell, Andrew R Mayer","doi":"10.1177/0271678X241270531","DOIUrl":"10.1177/0271678X241270531","url":null,"abstract":"Cerebrovascular dysfunction following mild traumatic brain injury (mTBI) is understudied relative to other microstructural injuries, especially during neurodevelopment. The blood-oxygen level dependent response was used to investigate cerebrovascular reactivity (CVR) in response to hypercapnia following pediatric mTBI (pmTBI; ages 8-18 years), as well as pseudocontinuous arterial spin labeling to measure cerebral blood flow (CBF). Data were collected ∼1-week (N = 107) and 4 months (N = 73) post-injury. Sex- and age-matched healthy controls (HC) underwent identical examinations at comparable time points (N = 110 and N = 91). Subtle clinical and cognitive deficits existed at ∼1 week that resolved for some, but not all domains at 4 months post-injury. At both visits, pmTBI showed an increased maximal fit between end-tidal CO2 regressor and the cerebrovascular response across multiple regions (primarily fronto-temporal), as well as increased latency to maximal fit in independent regions (primarily posterior). Hypoperfusion was also noted within the bilateral cerebellum. A biphasic relationship existed between CVR amplitude and age (i.e., positive until 14.5 years, negative thereafter) in both gray and white matter, but these neurodevelopment effects did not moderate injury effects. CVR metrics were not associated with post-concussive symptoms or cognitive deficits. In conclusion, cerebrovascular dysfunction may persist for up to four months following pmTBI.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"125-139"},"PeriodicalIF":4.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11572250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141901926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Absence of BOLD adaptation in chronic fatigue syndrome revealed by task functional MRI. 任务功能磁共振成像揭示慢性疲劳综合征缺乏BOLD适应。

IF 4.9 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2025-01-01 Epub Date: 2024-08-07 DOI: 10.1177/0271678X241270528

Laura Schönberg, Abdalla Z Mohamed, Qiang Yu, Richard A Kwiatek, Peter Del Fante, Vince D Calhoun, Zack Y Shan

{"title":"Absence of BOLD adaptation in chronic fatigue syndrome revealed by task functional MRI.","authors":"Laura Schönberg, Abdalla Z Mohamed, Qiang Yu, Richard A Kwiatek, Peter Del Fante, Vince D Calhoun, Zack Y Shan","doi":"10.1177/0271678X241270528","DOIUrl":"10.1177/0271678X241270528","url":null,"abstract":"Neurological symptoms are central to Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), yet its underlying neurophysiological mechanisms remain elusive. We examined a neglected aspect of task-based functional MRI, focusing on how blood oxygenation level-dependent (BOLD) signals alter during cognitive tasks in ME/CFS. This prospective observational study utilised MRI scans on ME/CFS participants and healthy controls (HCs) with sedentary lifestyles (ACTRN12622001095752). Participants completed two blocks of a Symbol Digit Modalities Test, with 30 trials per block split into two sets. The fMRI signal changes between blocks and sets were compared within and between groups. Thirty-four ME/CFS participants (38 years ± 10; 27 women) and 34 HCs (38 ± 10; 27 women), were evaluated. In the second task block, ME/CFS participants exhibited increased activation in the right postcentral gyrus, contrasting with decreased activation in multiple regions in HCs. These results were further confirmed by significantly higher bilateral dynamic changes (2nd vs 1st set) in the motor, sensory and cognitive cortex in ME/CFS compared to HCs and significant correlations between those changes in the left primary motor cortex with fatigue severities. BOLD adaptation, potentially improving energy economy, was absent in ME/CFS, which may provide an underlying neurophysiological process in ME/CFS.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"115-124"},"PeriodicalIF":4.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141901925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0