Journal of Cerebral Blood Flow and Metabolism最新文献_第6页

Respiratory influence on cerebral blood flow and blood volume - A 4D flow MRI study. 呼吸对脑血流量和血容量的影响——4D血流MRI研究。

IF 4.7 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2025-08-01 Epub Date: 2025-01-30 DOI: 10.1177/0271678X251316395

Pontus Söderström, Anders Eklund, Nina Karalija, Britt M Andersson, Katrine Riklund, Lars Bäckman, Jan Malm, Anders Wåhlin

{"title":"Respiratory influence on cerebral blood flow and blood volume - A 4D flow MRI study.","authors":"Pontus Söderström, Anders Eklund, Nina Karalija, Britt M Andersson, Katrine Riklund, Lars Bäckman, Jan Malm, Anders Wåhlin","doi":"10.1177/0271678X251316395","DOIUrl":"10.1177/0271678X251316395","url":null,"abstract":"Variations in cerebral blood flow and blood volume interact with intracranial pressure and cerebrospinal fluid dynamics, all of which play a crucial role in brain homeostasis. A key physiological modulator is respiration, but its impact on cerebral blood flow and volume has not been thoroughly investigated. Here we used 4D flow MRI in a population-based sample of 65 participants (mean age = 75 ± 1) to quantify these effects. Two gating approaches were considered, one using respiratory-phase and the other using respiratory-time (i.e. raw time in the cycle). For both gating methods, the arterial inflow was significantly larger during exhalation compared to inhalation, whereas the venous outflow was significantly larger during inhalation compared to exhalation. The cerebral blood volume variation per respiratory cycle was 0.83 [0.62, 1.13] ml for respiratory-phase gating and 0.78 [0.59, 1.02] ml for respiratory-time gating. For comparison, the volume variation of the cardiac cycle was 1.01 [0.80, 1.30] ml. Taken together, our results clearly demonstrate respiratory influences on cerebral blood flow. The corresponding vascular volume variations appear to be of the same order of magnitude as those of the cardiac cycle, highlighting respiration as an important modulator of cerebral blood flow and blood volume.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"1531-1542"},"PeriodicalIF":4.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two possible hemodynamic mechanisms underlying the growth of cerebral aneurysms depending on their size: The NHO CFD ABO study. 脑动脉瘤生长的两种可能的血流动力学机制取决于它们的大小：NHO CFD ABO研究。

IF 4.5 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2025-08-01 Epub Date: 2025-03-13 DOI: 10.1177/0271678X251325972

Shunichi Fukuda, Yuji Shimogonya, Aoi Watanabe, Naohiro Yonemoto, Miyuki Fukuda, Akihiro Yasoda

{"title":"Two possible hemodynamic mechanisms underlying the growth of cerebral aneurysms depending on their size: The NHO CFD ABO study.","authors":"Shunichi Fukuda, Yuji Shimogonya, Aoi Watanabe, Naohiro Yonemoto, Miyuki Fukuda, Akihiro Yasoda","doi":"10.1177/0271678X251325972","DOIUrl":"10.1177/0271678X251325972","url":null,"abstract":"Cerebral aneurysm rupture has a poor prognosis, and growing aneurysms are prone to rupture. We therefore conducted a prospective observational study to clarify hemodynamics inducing aneurysm growth, which are poorly understood. Computational fluid dynamics analysis was performed using the patient-specific arterial geometry and flow velocities. Hemodynamic metrics were compared by multivariate analysis between aneurysms enlarged ≥1 mm and stable aneurysms. We enrolled 481 patients. For aneurysms <4 mm, the time-averaged wall shear stress (WSS) was significantly higher in growing aneurysms for the whole aneurysm, neck, body and parent artery, and transverse WSS was significantly higher on the neck and parent artery. In aneurysms ≥4 mm, the normalized transverse WSS was significantly higher in growing aneurysms for the whole aneurysm and dome. Aneurysms <4 mm were likely to show whole-aneurysm growth, while aneurysms ≥4 mm were enlarged at the dome. There may exist two hemodynamic mechanisms for aneurysm growth depending on size. Aneurysms <4 mm may grow near the neck with high magnitudes and multi-directional WSS disturbances, while aneurysms ≥4 mm may grow on the dome with enhanced multi-directional WSS disturbance. These results may be useful in considering indications for surgical treatment. They may help resolve two conflicting hemodynamic rupture theories.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"1581-1592"},"PeriodicalIF":4.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From mechanism to classification: Understanding a novel model of cerebral small vessel disease. 从机制到分类：了解一种新的脑血管疾病模型。

IF 4.7 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2025-08-01 Epub Date: 2025-04-11 DOI: 10.1177/0271678X251326373

Masato Kanazawa, Masahiro Hatakeyama

引用次数: 0

Treatment for moyamoya disease with hyperhomocysteinemia. 烟雾病伴高同型半胱氨酸血症的治疗。

IF 4.7 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2025-08-01 Epub Date: 2025-03-13 DOI: 10.1177/0271678X251325676

Gan Gao, Si-Meng Liu, Fang-Bin Hao, Min-Jie Wang, Qian-Nan Wang, Ri-Miao Yang, Qing-Bao Guo, Xiao-Peng Wang, Jing-Jie Li, Cong Han, Lian Duan, Jian-Ning Zhang

{"title":"Treatment for moyamoya disease with hyperhomocysteinemia.","authors":"Gan Gao, Si-Meng Liu, Fang-Bin Hao, Min-Jie Wang, Qian-Nan Wang, Ri-Miao Yang, Qing-Bao Guo, Xiao-Peng Wang, Jing-Jie Li, Cong Han, Lian Duan, Jian-Ning Zhang","doi":"10.1177/0271678X251325676","DOIUrl":"10.1177/0271678X251325676","url":null,"abstract":"This study aimed to investigate the impact of controlling serum homocysteine on improving surgical outcomes in patients with moyamoya disease (MMD) and hyperhomocysteinemia. In this prospective observational cohort study, 477 patients with MMD post-encephaloduroarteriosynangiosis are divided into the HHcy-MMD post-control group (n = 193), HHcy-MMD uncontrolled group (n = 91), and MMD group (n = 193), with the HHcy-MMD post-control group further subdivided into good (homocysteine 0-10 μmol/L, n = 121) and general (homocysteine 10-15 μmol/L, n = 72) control groups. The differences in imaging and long-term clinical prognosis among the three groups were compared. No significant differences were noted in the Matsushima grade after encephaloduroarteriosynangiosis between the MMD group and HHcy-MMD post-control group (P > 0.05); however, there was a significant difference between the HHcy-MMD post-control group and HHcy-MMD uncontrolled group (P < 0.001). A significant difference was noted between the good and general control groups in the Matsushima grade (P = 0.025) and long-term follow-up clinical outcomes (P = 0.035). The area under the curve of homocysteine levels for predicting adverse clinical outcomes was 85.48% (95% confidence interval: 80.31-90.65%). Effective control of serum Hcy level after EDAS surgery in Moyamoya disease patients with HHcy may lead to better prognosis.Clinical Trial Registration: This study was registered at ClinicalTrials.gov (NCT03613701).","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"1469-1478"},"PeriodicalIF":4.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex-specific effects of intensity and dose of physical activity on BOLD-fMRI cerebrovascular reactivity and cerebral pulsatility. 体力活动强度和剂量对BOLD-fMRI脑血管反应性和脑搏动的性别特异性影响。

IF 4.7 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2025-08-01 Epub Date: 2025-03-13 DOI: 10.1177/0271678X251325399

Zacharie Potvin-Jutras, Brittany Intzandt, Hanieh Mohammadi, Peiying Liu, Jean J Chen, Claudine J Gauthier

{"title":"Sex-specific effects of intensity and dose of physical activity on BOLD-fMRI cerebrovascular reactivity and cerebral pulsatility.","authors":"Zacharie Potvin-Jutras, Brittany Intzandt, Hanieh Mohammadi, Peiying Liu, Jean J Chen, Claudine J Gauthier","doi":"10.1177/0271678X251325399","DOIUrl":"10.1177/0271678X251325399","url":null,"abstract":"Cerebrovascular reactivity (CVR) and cerebral pulsatility (CP) are important indicators of cerebrovascular health, which are associated with physical activity (PA). While sex differences influence the impact of PA on cerebrovascular health, sex-specific effects of PA intensity and dose on CP and CVR remains unknown. This study aimed to evaluate the sex-specific effects of self-reported PA dose and intensity on CVR and CP. The Human Connectome Project - Aging dataset was used, including 626 participants (350 females, 276 males) aged 36-85. The effect of menopausal status was also assessed. Resting state fMRI data was used to estimate both CVR and CP. Weekly self-reported PA was quantified as metabolic equivalent of task. Females presented a unique non-linear relationship between relative CVR and total PA in the cerebral cortex. Females and menopausal subgroups revealed negative linear relationships with total and walking PA in occipital and cingulate regions. Males exhibited negative linear relationships between total and vigorous PA and CVR in parietal and cingulate regions. Postmenopausal females showed greater reductions across more regions in CP than other groups. Overall, males and females appear to benefit from different amounts and intensities of PA, with menopause status influencing the effect of PA on cerebrovascular health.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"1543-1557"},"PeriodicalIF":4.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnetic resonance imaging indices for early Alzheimer's disease detection: Brain clearance markers. 早期阿尔茨海默病的磁共振成像检测指标：脑清除标志物。

IF 4.7 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2025-08-01 Epub Date: 2025-03-13 DOI: 10.1177/0271678X251321305

Moto Nakaya, Koji Kamagata, Kaito Takabayashi, Christina Andica, Wataru Uchida, Akifumi Hagiwara, Toshiaki Akashi, Akihiko Wada, Toshiaki Taoka, Shinji Naganawa, Osamu Abe, Shigeki Aoki

{"title":"Magnetic resonance imaging indices for early Alzheimer's disease detection: Brain clearance markers.","authors":"Moto Nakaya, Koji Kamagata, Kaito Takabayashi, Christina Andica, Wataru Uchida, Akifumi Hagiwara, Toshiaki Akashi, Akihiko Wada, Toshiaki Taoka, Shinji Naganawa, Osamu Abe, Shigeki Aoki","doi":"10.1177/0271678X251321305","DOIUrl":"10.1177/0271678X251321305","url":null,"abstract":"The Alzheimer's disease (AD) continuum is characterized by amyloid and tau protein deposition, which is partly attributable to the dysfunction of the brain clearance system. However, the specific phase in the AD continuum wherein aberrant clearance is present remains unclear. This study aimed to assess noninvasive magnetic resonance imaging (MRI) indices related to brain clearance functions, such as choroid plexus volume (CPV), lateral ventricular volume (LVV), and the index of diffusivity along the perivascular space (ALPS index), across the Alzheimer's disease (AD) spectrum. The CPV, LVV, and ALPS index in amyloid beta (Aβ)-negative healthy controls (HCs) and Aβ-positive HCs as well as in patients with Aβ-negative subjective cognitive decline (SCD), with Aβ-positive SCD, with mild cognitive impairment, and with AD were evaluated. The CPV and LVV were higher, whereas the ALPS index was lower in the patients with more severe disease. The ALPS index was significantly lower in Aβ-positive HCs than in Aβ-negative HCs. In SCD patients and those in the AD continuum, the MRI-based clearance markers were correlated with P-tau and T-tau protein levels and cognitive scores. In summary, brain clearance markers on MRI are associated with tau deposition, neurodegeneration and cognitive dysfunction.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"1558-1568"},"PeriodicalIF":4.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurological complications associated with chimeric antigen receptor T cell therapy. 与嵌合抗原受体T细胞治疗相关的神经系统并发症。

IF 4.7 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2025-08-01 Epub Date: 2025-05-02 DOI: 10.1177/0271678X251332492

Sijia Yan, Mi Zhou, Xiaojian Zhu, Yi Xiao

引用次数: 0

Selective deletion of interleukin-1 alpha in microglia does not modify acute outcome but may regulate neurorepair processes after experimental ischemic stroke. 小胶质细胞中白细胞介素-1 α的选择性缺失不会改变急性结果，但可能调节实验性缺血性卒中后的神经修复过程。

IF 4.7 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2025-08-01 Epub Date: 2025-03-20 DOI: 10.1177/0271678X251323371

Eloïse Lemarchand, Alba Grayston, Raymond Wong, Miyako Rogers, Blake Ouvrier, Benjamin Llewellyn, Freddie Webb, Nikolett Lénárt, Ádám Dénes, David Brough, Stuart M Allan, Gregory J Bix, Emmanuel Pinteaux

{"title":"Selective deletion of interleukin-1 alpha in microglia does not modify acute outcome but may regulate neurorepair processes after experimental ischemic stroke.","authors":"Eloïse Lemarchand, Alba Grayston, Raymond Wong, Miyako Rogers, Blake Ouvrier, Benjamin Llewellyn, Freddie Webb, Nikolett Lénárt, Ádám Dénes, David Brough, Stuart M Allan, Gregory J Bix, Emmanuel Pinteaux","doi":"10.1177/0271678X251323371","DOIUrl":"10.1177/0271678X251323371","url":null,"abstract":"Inflammation is a key contributor to stroke pathogenesis and exacerbates brain damage leading to poor outcome. Interleukin-1 (IL-1) is an important regulator of post-stroke inflammation, and blocking its actions is beneficial in pre-clinical stroke models and safe in the clinical setting. However, the distinct roles of the two major IL-1 receptor type 1 agonists, IL-1α and IL-1β, and the specific role of IL-1α in ischemic stroke remain largely unknown. Here we show that IL-1α and IL-1β have different spatio-temporal expression profiles in the brain after experimental stroke, with early microglial IL-1α expression (4 h) and delayed IL-1β expression in infiltrated neutrophils and a small microglial subset (24-72 h). We examined for the first time the specific role of microglial-derived IL-1α in experimental permanent and transient ischemic stroke through microglial-specific tamoxifen-inducible Cre-loxP-mediated recombination. Microglial IL-1α deletion did not influence acute outcome after ischemic stroke. However, microglial IL-1α knock out (KO) mice showed reduced peri-infarct vessel density and reactive astrogliosis at 14 days post-stroke, alongside long-term impaired functional recovery. Our study identifies for the first time a critical role for microglial IL-1α on post-stroke neurorepair and recovery, highlighting the importance of targeting specific IL-1 mechanisms in brain injury to develop effective therapies.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"1479-1492"},"PeriodicalIF":4.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electroacupuncture improves cerebral blood flow in pMCAO rats during acute phase via promoting leptomeningeal collaterals. 电针通过促进脑膜侧支，改善急性期pMCAO大鼠脑血流量。

IF 4.7 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2025-08-01 Epub Date: 2025-02-26 DOI: 10.1177/0271678X241270240

Lu Wang, Xin-Tong Su, Na-Na Yang, Qing-Yong Wang, Jing-Wen Yang, Cun-Zhi Liu

{"title":"Electroacupuncture improves cerebral blood flow in pMCAO rats during acute phase via promoting leptomeningeal collaterals.","authors":"Lu Wang, Xin-Tong Su, Na-Na Yang, Qing-Yong Wang, Jing-Wen Yang, Cun-Zhi Liu","doi":"10.1177/0271678X241270240","DOIUrl":"10.1177/0271678X241270240","url":null,"abstract":"Perfusion through leptomeningeal collateral vessels is a likely pivotal factor in the outcome of ischemic stroke patients. Acupuncture has been reported to restore cerebral blood flow (CBF) after acute ischemic stroke, but the underlying mechanisms are poorly understood. This study aimed to examine whether electroacupuncture (EA) could improve CBF following an acute ischemic injury by regulating leptomeningeal collaterals. The clinical outcomes suggest that EA resulted in an increase in the average CBF within the whole brain and gray matter of healthy subjects compared to pre-intervention. The experiments conducted on animals revealed that EA was able to improve neurological function, reduce infarct volume, and salvage tissue damage in the peri-infarct areas of permanent middle cerebral artery occlusion rats. Additionally, EA was found to increase cerebral perfusion and the diameter of developed leptomeningeal anastomoses, accompanied by activation of cholinergic neurons of the nucleus basalis of Meynert (NBM). However, these effects of EA were reversed by chemogenetic inhibition of cholinergic neurons in the NBM or by intraperitoneal injection of acetylcholine receptors antagonist atropine. These findings suggest that EA improved CBF after acute ischemic stroke, partially via activating cholinergic projections from the NBM to the cortex, thereby promoting leptomeningeal collateral circulation. ClinicalTrials.gov identifier: NCT03444896.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"1507-1518"},"PeriodicalIF":4.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143501535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vivo quantification of [¹¹C]BIO-1819578 in non-human primates, a novel radioligand for O-GlcNAcase. [11C]BIO-1819578在非人类灵长类动物体内的定量分析，一种新的O-GlcNAcase放射配体。

IF 4.7 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2025-08-01 Epub Date: 2025-04-12 DOI: 10.1177/0271678X251332487

Martin Bolin, Sangram Nag, Ryosuke Arakawa, Andrea Varrone, Lars Farde, Laurent Martarello, Maciej A Kaliszczak, Christer Halldin, Anton Forsberg Morén

{"title":"In vivo quantification of [11C]BIO-1819578 in non-human primates, a novel radioligand for O-GlcNAcase.","authors":"Martin Bolin, Sangram Nag, Ryosuke Arakawa, Andrea Varrone, Lars Farde, Laurent Martarello, Maciej A Kaliszczak, Christer Halldin, Anton Forsberg Morén","doi":"10.1177/0271678X251332487","DOIUrl":"10.1177/0271678X251332487","url":null,"abstract":"Neurofibrillary tangles (NFTs), composed of aggregated tau protein, in the brain is a neuropathological hallmark and feature of Alzheimer's disease (AD) and other tauopathies. One promising approach to prevent tau aggregates is to inhibit O-GlcNAcase (OGA), an enzyme that regulates tau O-GlcNAcylation. [11C]BIO-1819578 has emerged as a promising candidate to determine target occupancy of such OGA inhibitor drugs. The aim of this study was to further evaluate the pharmacokinetic properties of [11C]BIO-1819578 in non-human primates (NHPs) and to estimate its effective dose. Kinetic compartment analyses of [11C]BIO-1819578 binding to OGA in the brain were performed on positron emission tomography (PET) measurements conducted in three cynomolgus NHPs. Whole-body PET measurements were carried out in two NHPs to estimate the effective radiation dose. Both the 1-tissue-compartment (1TCM) and 2-tissue-compartment model (2TCM) could describe the regional time activity curves of [11C]BIO-1819578. The 2TCM was the statistically preferred model. The effective radiation dose was estimated to be 0.0033 mSv/MBq. The results showed that [11C]BIO-1819578 has suitable characteristics for reliable quantification of OGA using full kinetic modelling. The effective dose was on par with other 11C radioligands and is unlikely to pose an issue for human use.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"1606-1616"},"PeriodicalIF":4.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11994644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0