Neurological complications associated with chimeric antigen receptor T cell therapy.

IF 4.5 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2025-05-02 DOI:10.1177/0271678X251332492

Sijia Yan, Mi Zhou, Xiaojian Zhu, Yi Xiao

引用次数: 0

Abstract

Chimeric antigen receptor T (CAR-T) cells have made brilliant achievements in the treatment of many kinds of malignant tumors, and six kinds of CAR-T products have been approved by the Food and Drug Administration (FDA), bringing new hope for the treatment of diseases. However, the complications associated with CAR-T cell therapy should not be ignored. Neurological complications often jeopardize patients' lives, including immune effector cell-associated neurotoxicity syndrome, cerebrovascular accidents, movement and neurocognitive treatment-emergent adverse events. The current knowledge of the mechanism and treatment of these complications is still insufficient, which is a direction that needs to be solved in the future.

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与嵌合抗原受体T细胞治疗相关的神经系统并发症。

嵌合抗原受体T （CAR-T）细胞在治疗多种恶性肿瘤方面取得了辉煌的成就，目前已有6种CAR-T产品获得美国食品药品监督管理局（FDA）的批准，为疾病的治疗带来了新的希望。然而，CAR-T细胞治疗的并发症也不容忽视。神经系统并发症常常危及患者的生命，包括免疫效应细胞相关的神经毒性综合征、脑血管意外、运动和神经认知治疗引起的不良事件。目前对这些并发症的发生机制和治疗方法的认识还不够充分，这是今后需要解决的一个方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cerebral Blood Flow and Metabolism 医学-内分泌学与代谢

CiteScore

12.00

自引率

4.80%

发文量

300

审稿时长

3 months

期刊介绍： JCBFM is the official journal of the International Society for Cerebral Blood Flow & Metabolism, which is committed to publishing high quality, independently peer-reviewed research and review material. JCBFM stands at the interface between basic and clinical neurovascular research, and features timely and relevant research highlighting experimental, theoretical, and clinical aspects of brain circulation, metabolism and imaging. The journal is relevant to any physician or scientist with an interest in brain function, cerebrovascular disease, cerebral vascular regulation and brain metabolism, including neurologists, neurochemists, physiologists, pharmacologists, anesthesiologists, neuroradiologists, neurosurgeons, neuropathologists and neuroscientists.