Journal of Cerebral Blood Flow and Metabolism最新文献

TSPO deficiency exacerbates acute brain damage after intracerebral hemorrhage in male mice. TSPO缺乏可加重雄性小鼠脑出血后的急性脑损伤。

IF 4.5 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2025-09-01 Epub Date: 2025-05-15 DOI: 10.1177/0271678X251340509

Frederick Bonsack, Rajaneekar Dasari, Ashwin Thomas, Hongyan Xu, Sangeetha Sukumari-Ramesh

{"title":"TSPO deficiency exacerbates acute brain damage after intracerebral hemorrhage in male mice.","authors":"Frederick Bonsack, Rajaneekar Dasari, Ashwin Thomas, Hongyan Xu, Sangeetha Sukumari-Ramesh","doi":"10.1177/0271678X251340509","DOIUrl":"10.1177/0271678X251340509","url":null,"abstract":"Intracerebral hemorrhage (ICH) is a stroke subtype with no effective treatment despite high morbidity and mortality rates. The delineation of the mechanisms of brain damage after ICH is critical to identifying novel molecular targets for therapeutic intervention. Apart from the augmented expression of 18 kDa translocator protein (TSPO) in microglia/macrophages post-ICH and its potential to track neuroinflammation, the precise function of TSPO after brain damage remains largely enigmatic. In the present study, we employed transgenic animal models, such as global and myeloid-specific conditional knockouts, to elucidate the functional role of TSPO in ICH-induced acute brain damage. Neurological deficits, neurodegeneration, and neuroinflammation were assessed at 3-days post-ICH in male and female mice. Male TSPO global knockout and conditional knockout exhibited enhanced neurobehavioral deficits with a concomitant increase in neurodegeneration and neuroinflammation compared to their respective controls. Interestingly, their female counterparts did not exhibit augmented brain damage compared to the respective controls. Mechanistically, studies employing RNA-Seq and subsequent functional validation demonstrate that TSPO could regulate brain cholesterol efflux, which could partly be responsible for enhanced brain damage in TSPO KO male mice after ICH, warranting further investigation.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"1816-1830"},"PeriodicalIF":4.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimal filtering strategies for task-specific functional PET imaging. 特定任务功能PET成像的最佳过滤策略。

IF 4.5 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2025-09-01 Epub Date: 2025-04-02 DOI: 10.1177/0271678X251325668

Murray Bruce Reed, Magdalena Ponce de León, Sebastian Klug, Christian Milz, Leo Robert Silberbauer, Pia Falb, Godber Mathis Godbersen, Sharna Jamadar, Zhaolin Chen, Lukas Nics, Marcus Hacker, Rupert Lanzenberger, Andreas Hahn

{"title":"Optimal filtering strategies for task-specific functional PET imaging.","authors":"Murray Bruce Reed, Magdalena Ponce de León, Sebastian Klug, Christian Milz, Leo Robert Silberbauer, Pia Falb, Godber Mathis Godbersen, Sharna Jamadar, Zhaolin Chen, Lukas Nics, Marcus Hacker, Rupert Lanzenberger, Andreas Hahn","doi":"10.1177/0271678X251325668","DOIUrl":"10.1177/0271678X251325668","url":null,"abstract":"Functional Positron Emission Tomography (fPET) is an effective tool for studying dynamic processes in glucose metabolism and neurotransmitter action, providing insights into brain function and disease progression. However, optimizing signal processing to extract stimulation-specific information remains challenging. This study systematically evaluates state-of-the-art filtering techniques for fPET imaging. Forty healthy participants performed a cognitive task (Tetris®) during [18F]FDG PET/MR scans. Seven filtering techniques and multiple hyperparameters were tested: including 3D and 4D Gaussian smoothing, highly constrained backprojection (HYPR), iterative HYPR (IHYPR4D), MRI-Markov Random Field (MRI-MRF) filters, and dynamic/extended dynamic Non-Local Means (dNLM/edNLM). Filters were assessed based on test-retest reliability, task signal identifiability (temporal signal-to-noise ratio, tSNR), spatial task-based activation, and sample size calculations were assessed. Compared to 3D Gaussian smoothing, edNLM, dNLM, MRI-MRF L = 10, and IHYPR4D filters improved tSNR, while edNLM and HYPR enhanced test-retest reliability. Spatial task-based activation was enhanced by NLM filters and MRI-MRF approaches. The edNLM filter reduced the required sample size by 15.4%. Simulations supported these findings. This study highlights the strengths and limitations of fPET filtering techniques, emphasizing how hyperparamter adjustments affect outcome parameters. The edNLM filter shows promise with improved performance across all metrics, but filter selection should consider specific study objectives and resource constraints.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"1760-1773"},"PeriodicalIF":4.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12409040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contributions of synaptic glutamate versus neuronal spiking activity to cerebral vascular responses in awake mice. 突触谷氨酸和神经元尖峰活动对清醒小鼠脑血管反应的贡献。

IF 4.5 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2025-09-01 Epub Date: 2025-05-15 DOI: 10.1177/0271678X251338407

Jenna M Peretin, Christopher G Cover, Alberto L Vazquez

{"title":"Contributions of synaptic glutamate versus neuronal spiking activity to cerebral vascular responses in awake mice.","authors":"Jenna M Peretin, Christopher G Cover, Alberto L Vazquez","doi":"10.1177/0271678X251338407","DOIUrl":"10.1177/0271678X251338407","url":null,"abstract":"Neurovascular coupling is the temporal relationship between neuronal activity and regional blood flow changes presumably to meet the high metabolic demands of the brain. Prior fMRI studies have reported excitatory synaptic transmission as more metabolically demanding than neuronal spiking, thus correlating better with cerebral hemodynamics. To investigate this finding with newer optical imaging techniques, we used fluorescent markers for extracellular synaptic glutamate and intracellular neuronal calcium to directly measure relationships between synaptic and spiking activities on local vascular changes in awake mice under evoked and spontaneous conditions. To determine which signal better predicts hemodynamic responses, we used a linear convolution model. Using wide field optical imaging (WFOI), we observed peak fluorescence values of 0.38% and 5.60% in synaptic glutamate and neuronal calcium, respectively, to whisker stimulation, and values of 3.13% and 35.77%, respectively, using two-photon microscopy (2PM). Following whisker stimulation, mean R2 values were 0.64 and 0.79 for synaptic glutamate and neuronal calcium, respectively, with WFOI and 0.67 and 0.56, respectively, with 2PM. From WFOI resting-state, mean R2 values were 0.73 and 0.68 for synaptic glutamate and neuronal calcium, respectively. Altogether, both signals perform similarly in predicting hemodynamic responses, with no significant differences in their prediction efficacy.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"1670-1683"},"PeriodicalIF":4.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preclinical PET imaging of the developing fetus during pregnancy: Current state and future potential. 妊娠期胎儿发育的临床前PET显像：现状和未来潜力。

IF 4.5 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2025-09-01 Epub Date: 2025-05-14 DOI: 10.1177/0271678X251340510

Torben D Pearson, Sarah Bricault, Yu-Shiuan Lin, Katelyn E Barusso, Samhitha Bodangi, Hsiao-Ying Wey

{"title":"Preclinical PET imaging of the developing fetus during pregnancy: Current state and future potential.","authors":"Torben D Pearson, Sarah Bricault, Yu-Shiuan Lin, Katelyn E Barusso, Samhitha Bodangi, Hsiao-Ying Wey","doi":"10.1177/0271678X251340510","DOIUrl":"10.1177/0271678X251340510","url":null,"abstract":"During pregnancy, the fetus is subject to complex interactions of biological and environmental factors that can influence developmental trajectories even into adulthood. Although several factors, such as maternal malnutrition and substance abuse, have been associated with offspring development, the mechanisms through which short- and long-term effects manifest in the fetus are not well understood. To this end, positron emission tomography (PET) imaging using preclinical models has been a promising and underutilized technique for investigating fetal exposure and physiology in utero with minimal invasiveness. Herein, we review the application of PET imaging to fetal medicine and survey the limitations and opportunities for future longitudinal studies of development. Over the past two decades, several studies have utilized preclinical PET in quantitative studies of maternal-fetal exchange dynamics of pharmaceuticals, environmental toxins, or drugs of abuse. Another application has shown [18F]FDG PET to be a potential biomarker for fetal glucose transport, hypoxia, and brain function in utero. In contrast, only a few studies have employed reversibly binding radioligands to quantify protein markers of dopaminergic signaling and synaptic density in the fetal brain. As PET technology continues to improve, our review highlights a future role for PET in longitudinal studies of fetal health and development.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"1623-1634"},"PeriodicalIF":4.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12078245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deletion of microsomal epoxide hydrolase gene leads to increased density in cerebral vasculature and enhances cerebral blood flow in mice. 小鼠微粒体环氧化物水解酶基因缺失导致脑血管密度增加，脑血流增强。

IF 4.5 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2025-09-01 Epub Date: 2025-04-12 DOI: 10.1177/0271678X251333234

Anne Marowsky, Matthias T Wyss, Diana Kindler, Noor-Ul-Ain Khalid, Markus Rudin, Bruno Weber, Michael Arand

{"title":"Deletion of microsomal epoxide hydrolase gene leads to increased density in cerebral vasculature and enhances cerebral blood flow in mice.","authors":"Anne Marowsky, Matthias T Wyss, Diana Kindler, Noor-Ul-Ain Khalid, Markus Rudin, Bruno Weber, Michael Arand","doi":"10.1177/0271678X251333234","DOIUrl":"10.1177/0271678X251333234","url":null,"abstract":"Microsomal epoxide hydrolase (mEH), first identified as detoxifying enzyme, can hydrolyze epoxyeicosatrienoic acids (EETs) to less active diols (DHETs). EETs are potent vasodilatory and pro-angiogenic lipids, also implicated in neurovascular coupling. In mouse brain, mEH is strongly expressed in vascular and perivascular cells in contrast to the related soluble epoxide hydrolase (sEH), predominantly found in astrocytes. While sEH inhibition in stroke has demonstrated neuroprotective effects and increases cerebral blood flow (CBF), data regarding the role of mEH in brain are scarce. Here, we explored the function of mEH in cerebral vasculature by comparing mEH-KO, sEH-KO and WT mice. Basal cerebral volume (CBV0) was significantly higher in various mEH-KO brain areas compared to WT and sEH-KO. In line, quantification of cerebral vasculature in cortex and thalamus revealed a higher capillary density in mEH-KO, but not in sEH-KO brain. Whisker-stimulated CBF changes were by factor two higher in both mEH-KO and sEH-KO. In acutely isolated cerebral endothelial cells the loss of mEH, but not of sEH, augmented total EET levels and decreased the DHET:EET ratio. Collectively, these data suggest an important function of mEH in the regulation of cerebral vasculature and activity-modulated CBF, presumably by controlling local levels of endothelial-derived EETs.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"1702-1716"},"PeriodicalIF":4.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11994649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantitation of regional distribution of antibodies in rat brain following systemic and intra-CNS administration. 全身和中枢神经系统内给药后大鼠脑内抗体区域分布的定量研究。

IF 4.5 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2025-09-01 Epub Date: 2025-05-13 DOI: 10.1177/0271678X251333536

Shengjia Wu, Hsien Wei Huang, Aditi Panchal, Ekram Ahmed Chowdhury, Dhaval K Shah

{"title":"Quantitation of regional distribution of antibodies in rat brain following systemic and intra-CNS administration.","authors":"Shengjia Wu, Hsien Wei Huang, Aditi Panchal, Ekram Ahmed Chowdhury, Dhaval K Shah","doi":"10.1177/0271678X251333536","DOIUrl":"10.1177/0271678X251333536","url":null,"abstract":"Antibody therapy has demonstrated great potential for treating central nervous system (CNS) disorders. Since therapeutic efficacy relies on sufficient exposure in specific brain regions, quantitative understanding of antibody distribution within the brain is crucial. Additionally, insights into antibody brain distribution help elucidate how pathological antibodies accumulate during encephalitis. Accordingly, this study investigated the regional distribution of a non-target-binding antibody (trastuzumab) and a brain-target-binding antibody (anti-NMDAR1) following systemic and intra-CNS administration in rats. After systemic administration, both antibodies showed similar distribution across brain regions, with the olfactory bulb exhibiting significantly higher concentrations. Other regions had comparable exposure, with the striatum or hippocampus showing the lowest exposure. Intra-CSF administration resulted in similar distribution patterns but achieved significantly higher concentrations than systemic administration. In contrast, intra-striatal administration led to diverse distribution, with the highest concentrations near the injection site. Calculations based on striatum and interstitial fluid (ISF) concentrations indicated antibody accumulation in the perivascular space after intra-CNS administration. Target binding influenced distribution primarily after intra-CSF administration, where anti-NMDAR1 showed lower ISF concentrations early and reduced CSF concentrations later. These findings provide valuable quantitative insights for optimizing brain-targeted antibody therapies and understanding pathological antibody distribution in CNS disorders.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"1785-1798"},"PeriodicalIF":4.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neural and vascular contributions to sensory impairments in a human alpha-synuclein transgenic mouse model of Parkinson's disease. 在人类α -突触核蛋白转基因帕金森病小鼠模型中，神经和血管对感觉障碍的贡献。

IF 4.5 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2025-09-01 Epub Date: 2025-05-07 DOI: 10.1177/0271678X251338952

Ruxanda Lungu, Francisca F Fernandes, Sara Pires Monteiro, Tiago F Outeiro, Noam Shemesh

{"title":"Neural and vascular contributions to sensory impairments in a human alpha-synuclein transgenic mouse model of Parkinson's disease.","authors":"Ruxanda Lungu, Francisca F Fernandes, Sara Pires Monteiro, Tiago F Outeiro, Noam Shemesh","doi":"10.1177/0271678X251338952","DOIUrl":"10.1177/0271678X251338952","url":null,"abstract":"Parkinson's disease (PD) is a complex progressive neurodegenerative disorder involving hallmarks such as <math><mi>α</mi></math>-Synuclein (<math><mi>α</mi></math>Syn) aggregation and dopaminergic dysfunction that affect brain-wide neural activity. Although movement disorders are prominent in PD, sensory impairments also occur relatively early on, mainly in olfactory and, to a lesser extent visual systems. While these deficits have been described mainly at the behavioral and molecular levels, the underlying network-level activity remains poorly understood. Here, we harnessed a human <math><mi>α</mi></math>Syn transgenic mouse model of PD with in vivo functional MRI (fMRI) to map evoked activity in the visual and olfactory pathways, along with pseudo-Continuous Arterial Spin Labeling (pCASL) and c-FOS measurements to disentangle vascular from neuronal effects. Upon stimulation with either odors or flickering lights, we found significant decreases in fMRI responses along both olfactory and visual pathways, in multiple cortical and subcortical sensory areas. Average Cerebral Blood Flow rates were decreased by ∼10% in the <math><mi>α</mi></math>Syn group, while c-FOS levels were reduced by over 50%, suggesting a strong neural driver for the dysfunction, along with more modest vascular contributions. Our study provides insight into brain-level activity in an <math><mi>α</mi></math>Syn-based model, and suggests a novel target for biomarking via quantification of simple sensory evoked responses.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"1654-1669"},"PeriodicalIF":4.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perfusion-derived metrics to calculate cerebral infarct growth rate, "ultrafast progressor" phenotype, and neuroprotection. 用于计算脑梗死生长速率、“超快进展”表型和神经保护的灌注衍生指标。

IF 4.5 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2025-09-01 Epub Date: 2025-04-11 DOI: 10.1177/0271678X251330867

Umberto Pensato, Johanna M Ospel

引用次数: 0

Oxygen extraction fraction changes in ischemic tissue from 24-72 hours to 12 months after successful reperfusion. 缺血组织在再灌注成功后24-72小时至12个月的氧萃取分数变化。

IF 4.5 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2025-09-01 Epub Date: 2025-04-12 DOI: 10.1177/0271678X251333940

Victoria Mercy Kataike, Patricia M Desmond, Christopher Steward, Bruce Cv Campbell, Peter J Mitchell, Felix Ng, Vijay Venkatraman

{"title":"Oxygen extraction fraction changes in ischemic tissue from 24-72 hours to 12 months after successful reperfusion.","authors":"Victoria Mercy Kataike, Patricia M Desmond, Christopher Steward, Bruce Cv Campbell, Peter J Mitchell, Felix Ng, Vijay Venkatraman","doi":"10.1177/0271678X251333940","DOIUrl":"10.1177/0271678X251333940","url":null,"abstract":"Oxygen Extraction Fraction (OEF) is a critical measure of a tissue's metabolic state post-ischemic stroke. This study investigated OEF changes in stroke-affected tissue compared to healthy tissue, post-reperfusion. OEF maps generated from gradient echo MRI images of 87 ischemic stroke patients at three time points after successful Endovascular Thrombectomy (EVT) were analysed in a prospective longitudinal multicentre study. Regions of interest (ROIs) delineating the infarct areas and corresponding mirror regions were drawn. The MR-derived OEF index values were obtained from the ROIs and compared using Wilcoxon signed rank tests. The cross-sectional comparison of OEF index values revealed lower values in the infarct areas than the corresponding contralateral areas at all three time points after successful EVT, presented as median (interquartile range) [24-72 hours: 20.84 (17.56-26.82)% vs 27.56 (23.22-31.87)%; 3 months: 27.37 (23.28-30.35)% vs 32.55 (28.00-35.81)%; 12 months: 24.38 (22.35-29.77)% vs 29.39 (25.86-34.04)%, p < 0.001 for all three time points]. Longitudinally, relative OEF index values increased gradually over time [24-72 hours: 0.81 (0.67-0.87); 3 months: 0.86 (0.79-0.95); 12 months: 0.88 (0.75-0.95)]. The findings revealed that following successful EVT, OEF in infarct tissue improves over time, indicating potential tissue recovery.Trial registration name and URL: Post-Reperfusion Pathophysiology in Acute Ischemic Stroke https://trialsearch.who.int/Trial2.aspx?TrialID=ACTRN12624000629538.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"1748-1759"},"PeriodicalIF":4.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11993554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Towards whole brain mapping of the hemodynamic response function. 血流动力学反应功能的全脑制图。

IF 4.5 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2025-09-01 Epub Date: 2025-04-12 DOI: 10.1177/0271678X251325413

Fabio Mangini, Marta Moraschi, Daniele Mascali, Maria Guidi, Michela Fratini, Silvia Mangia, Mauro DiNuzzo, Fabrizio Frezza, Federico Giove

{"title":"Towards whole brain mapping of the hemodynamic response function.","authors":"Fabio Mangini, Marta Moraschi, Daniele Mascali, Maria Guidi, Michela Fratini, Silvia Mangia, Mauro DiNuzzo, Fabrizio Frezza, Federico Giove","doi":"10.1177/0271678X251325413","DOIUrl":"10.1177/0271678X251325413","url":null,"abstract":"Functional magnetic resonance imaging time-series are conventionally processed by linear modelling the evoked response as the convolution of the experimental conditions with a stereotyped hemodynamic response function (HRF). However, the neural signal in response to a stimulus can vary according to task, brain region, and subject-specific conditions. Moreover, HRF shape has been suggested to carry physiological information. The BOLD signal across a range of sensorial and cognitive tasks was fitted using a sine series expansion, and modelled signals were deconvolved, thus giving rise to a task-specific deconvolved HRF (dHRF), which was characterized in terms of amplitude, latency, time-to-peak and full-width at half maximum for each task. We found that the BOLD response shape changes not only across activated regions and tasks, but also across subjects despite the age homogeneity of the cohort. Largest variabilities were observed in mean amplitude and latency across tasks and regions, while time-to-peak and full width at half maximum were relatively more consistent. Additionally, the dHRF was found to deviate from canonicity in several brain regions. Our results suggest that the choice of a standard, uniform HRF may be not optimal for all fMRI analyses and may lead to model misspecifications and statistical bias.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"1731-1747"},"PeriodicalIF":4.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11994648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0