对“任务激活导致人脑区域13c -乳酸信号增加”的评论。

IF 4.5 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Fahmeed Hyder
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引用次数: 0

摘要

新陈代谢是功能性脑成像的基础。虽然功能磁共振成像(fMRI)对神经科学大有裨益,但13C-MRS测量的是神经能量学和神经传递之间的耦合。然而,人类大脑的超极化13C-MRI研究显示,在fmri定义的激活区域内,13c -乳酸增加(即胞质有氧糖酵解),而13c -碳酸氢盐没有变化(即线粒体氧化)。我们讨论了超极化与非超极化13C实验的优势,以及乳酸增加对代谢的影响:乳酸是少突胶质细胞、星形胶质细胞还是神经元的燃料?乳酸盐是神经调节剂还是血管调节剂?乳酸是星形细胞糖原溶解的副产物吗?撇开警告不谈,人们对超极化13C-fMRI有着极大的热情。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Commentary to "Task activation results in regional 13C-lactate signal increase in the human brain".

Metabolism is fundamental to functional brain imaging. While functional MRI (fMRI) has greatly benefited neuroscience, 13C-MRS measures coupling between neuroenergetics and neurotransmission. However, a hyperpolarized 13C-MRI study in human brain shows increased 13C-lactate (i.e., cytosolic aerobic glycolysis) with no 13C-bicarbonate change (i.e., mitochondrial oxidation) within fMRI-defined activated areas. We discuss (dis)advantages of hyperpolarized vs. non-hyperpolarized 13C experiments and metabolic implications regarding the lactate increase: Is lactate a fuel for oligodendrocytes, astrocytes, or neurons? Is lactate a neuromodulator or a vasomodulator? Is lactate a byproduct of astrocytic glycogenolysis? Caveats aside, there is great enthusiasm for hyperpolarized 13C-fMRI.

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来源期刊
Journal of Cerebral Blood Flow and Metabolism
Journal of Cerebral Blood Flow and Metabolism 医学-内分泌学与代谢
CiteScore
12.00
自引率
4.80%
发文量
300
审稿时长
3 months
期刊介绍: JCBFM is the official journal of the International Society for Cerebral Blood Flow & Metabolism, which is committed to publishing high quality, independently peer-reviewed research and review material. JCBFM stands at the interface between basic and clinical neurovascular research, and features timely and relevant research highlighting experimental, theoretical, and clinical aspects of brain circulation, metabolism and imaging. The journal is relevant to any physician or scientist with an interest in brain function, cerebrovascular disease, cerebral vascular regulation and brain metabolism, including neurologists, neurochemists, physiologists, pharmacologists, anesthesiologists, neuroradiologists, neurosurgeons, neuropathologists and neuroscientists.
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