{"title":"对“任务激活导致人脑区域13c -乳酸信号增加”的评论。","authors":"Fahmeed Hyder","doi":"10.1177/0271678X251327935","DOIUrl":null,"url":null,"abstract":"<p><p>Metabolism is fundamental to functional brain imaging. While functional MRI (fMRI) has greatly benefited neuroscience, <sup>13</sup>C-MRS measures coupling between neuroenergetics and neurotransmission. However, a hyperpolarized <sup>13</sup>C-MRI study in human brain shows increased <sup>13</sup>C-lactate (i.e., cytosolic aerobic glycolysis) with no <sup>13</sup>C-bicarbonate change (i.e., mitochondrial oxidation) within fMRI-defined activated areas. We discuss (dis)advantages of hyperpolarized vs. non-hyperpolarized <sup>13</sup>C experiments and metabolic implications regarding the lactate increase: Is lactate a fuel for oligodendrocytes, astrocytes, or neurons? Is lactate a neuromodulator or a vasomodulator? Is lactate a byproduct of astrocytic glycogenolysis? Caveats aside, there is great enthusiasm for hyperpolarized <sup>13</sup>C-fMRI.</p>","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"1413-1416"},"PeriodicalIF":4.5000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11993549/pdf/","citationCount":"0","resultStr":"{\"title\":\"Commentary to \\\"Task activation results in regional <sup>13</sup>C-lactate signal increase in the human brain\\\".\",\"authors\":\"Fahmeed Hyder\",\"doi\":\"10.1177/0271678X251327935\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Metabolism is fundamental to functional brain imaging. While functional MRI (fMRI) has greatly benefited neuroscience, <sup>13</sup>C-MRS measures coupling between neuroenergetics and neurotransmission. However, a hyperpolarized <sup>13</sup>C-MRI study in human brain shows increased <sup>13</sup>C-lactate (i.e., cytosolic aerobic glycolysis) with no <sup>13</sup>C-bicarbonate change (i.e., mitochondrial oxidation) within fMRI-defined activated areas. We discuss (dis)advantages of hyperpolarized vs. non-hyperpolarized <sup>13</sup>C experiments and metabolic implications regarding the lactate increase: Is lactate a fuel for oligodendrocytes, astrocytes, or neurons? Is lactate a neuromodulator or a vasomodulator? Is lactate a byproduct of astrocytic glycogenolysis? Caveats aside, there is great enthusiasm for hyperpolarized <sup>13</sup>C-fMRI.</p>\",\"PeriodicalId\":15325,\"journal\":{\"name\":\"Journal of Cerebral Blood Flow and Metabolism\",\"volume\":\" \",\"pages\":\"1413-1416\"},\"PeriodicalIF\":4.5000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11993549/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Cerebral Blood Flow and Metabolism\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/0271678X251327935\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/4/11 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cerebral Blood Flow and Metabolism","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/0271678X251327935","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/11 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Commentary to "Task activation results in regional 13C-lactate signal increase in the human brain".
Metabolism is fundamental to functional brain imaging. While functional MRI (fMRI) has greatly benefited neuroscience, 13C-MRS measures coupling between neuroenergetics and neurotransmission. However, a hyperpolarized 13C-MRI study in human brain shows increased 13C-lactate (i.e., cytosolic aerobic glycolysis) with no 13C-bicarbonate change (i.e., mitochondrial oxidation) within fMRI-defined activated areas. We discuss (dis)advantages of hyperpolarized vs. non-hyperpolarized 13C experiments and metabolic implications regarding the lactate increase: Is lactate a fuel for oligodendrocytes, astrocytes, or neurons? Is lactate a neuromodulator or a vasomodulator? Is lactate a byproduct of astrocytic glycogenolysis? Caveats aside, there is great enthusiasm for hyperpolarized 13C-fMRI.
期刊介绍:
JCBFM is the official journal of the International Society for Cerebral Blood Flow & Metabolism, which is committed to publishing high quality, independently peer-reviewed research and review material. JCBFM stands at the interface between basic and clinical neurovascular research, and features timely and relevant research highlighting experimental, theoretical, and clinical aspects of brain circulation, metabolism and imaging. The journal is relevant to any physician or scientist with an interest in brain function, cerebrovascular disease, cerebral vascular regulation and brain metabolism, including neurologists, neurochemists, physiologists, pharmacologists, anesthesiologists, neuroradiologists, neurosurgeons, neuropathologists and neuroscientists.