Journal of Cerebral Blood Flow and Metabolism最新文献_第10页

Dysmaturation of sleep state and electroencephalographic activity after hypoxia-ischaemia in preterm fetal sheep. 早产胎羊缺氧缺血后的睡眠状态和脑电活动失调。

IF 4.9 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2024-08-01 Epub Date: 2024-02-28 DOI: 10.1177/0271678X241236014

Christopher A Lear, Benjamin A Lear, Joanne O Davidson, Victoria J King, Yoshiki Maeda, Alice McDouall, Simerdeep K Dhillon, Alistair J Gunn, Laura Bennet

{"title":"Dysmaturation of sleep state and electroencephalographic activity after hypoxia-ischaemia in preterm fetal sheep.","authors":"Christopher A Lear, Benjamin A Lear, Joanne O Davidson, Victoria J King, Yoshiki Maeda, Alice McDouall, Simerdeep K Dhillon, Alistair J Gunn, Laura Bennet","doi":"10.1177/0271678X241236014","DOIUrl":"10.1177/0271678X241236014","url":null,"abstract":"Antenatal hypoxia-ischaemia (HI) in preterm fetal sheep can trigger delayed evolution of severe, cystic white matter injury (WMI), in a similar timecourse to WMI in preterm infants. We therefore examined how severe hypoxia-ischaemia affects recovery of electroencephalographic (EEG) activity. Chronically instrumented preterm fetal sheep (0.7 gestation) received 25 min of complete umbilical cord occlusion (UCO, n = 9) or sham occlusion (controls, n = 9), and recovered for 21 days. HI was associated with a shift to lower frequency EEG activity for the first 5 days with persisting loss of EEG power in the delta and theta bands, and initial loss of power in the alpha and beta bands in the first 14 days of recovery. In the final 3 days of recovery, there was a marked rhythmic shift towards higher frequency EEG activity after UCO. The UCO group spent less time in high-voltage sleep, and in the early evening (7:02 pm ± 47 min) abruptly stopped cycling between sleep states, with a shift to a high frequency state for 2 h 48 min ± 40 min, with tonic electromyographic activity. These findings demonstrate persisting EEG and sleep state dysmaturation after severe hypoxia-ischaemia. Loss of fetal or neonatal sleep state cycling in the early evening may be a useful biomarker for evolving cystic WMI.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"1376-1392"},"PeriodicalIF":4.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11342719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139982966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term isoflurane anesthesia induces cognitive deficits via AQP4 depolarization mediated blunted glymphatic inflammatory proteins clearance. 长期异氟醚麻醉通过AQP4去极化介导的甘油炎症蛋白清除障碍诱发认知障碍。

IF 4.9 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2024-08-01 Epub Date: 2024-03-05 DOI: 10.1177/0271678X241237073

Rui Dong, Yuqiang Han, Pin Lv, Linhao Jiang, Zimo Wang, Liangyu Peng, Shuai Liu, Zhengliang Ma, Tianjiao Xia, Bing Zhang, Xiaoping Gu

{"title":"Long-term isoflurane anesthesia induces cognitive deficits via AQP4 depolarization mediated blunted glymphatic inflammatory proteins clearance.","authors":"Rui Dong, Yuqiang Han, Pin Lv, Linhao Jiang, Zimo Wang, Liangyu Peng, Shuai Liu, Zhengliang Ma, Tianjiao Xia, Bing Zhang, Xiaoping Gu","doi":"10.1177/0271678X241237073","DOIUrl":"10.1177/0271678X241237073","url":null,"abstract":"Perioperative neurocognitive disorders (PND) refer to cognitive deterioration that occurs after surgery or anesthesia. Prolonged isoflurane exposure has potential neurotoxicity and induces PND, but the mechanism is unclear. The glymphatic system clears harmful metabolic waste from the brain. This study sought to unveil the functions of glymphatic system in PND and explore the underlying molecular mechanisms. The PND mice model was established by long term isoflurane anesthesia. The glymphatic function was assessed by multiple in vitro and in vivo methods. An adeno-associated virus was used to overexpress AQP4 and TGN-020 was used to inhibit its function. This research revealed that the glymphatic system was impaired in PND mice and the blunted glymphatic transport was closely associated with the accumulation of inflammatory proteins in the hippocampus. Increasing AQP4 polarization could enhance glymphatic transport and suppresses neuroinflammation, thereby improve cognitive function in the PND model mice. However, a marked impaired glymphatic inflammatory proteins clearance and the more severe cognitive dysfunction were observed when decreasing AQP4 polarization. Therefore, long-term isoflurane anesthesia causes blunted glymphatic system by inducing AQP4 depolarization, enhanced the AQP4 polarization can alleviate the glymphatic system malfunction and reduce the neuroinflammatory response, which may be a potential treatment strategy for PND.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"1450-1466"},"PeriodicalIF":4.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11342724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140039462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perfusion imaging by arterial spin labeling in migraine: A literature review. 偏头痛的动脉自旋标记灌注成像：文献综述。

IF 4.9 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2024-08-01 Epub Date: 2024-03-14 DOI: 10.1177/0271678X241237733

Severin Schramm, Corinna Börner, Miriam Reichert, Gabriel Hoffmann, Stephan Kaczmarz, Michael Griessmair, Kirsten Jung, Maria T Berndt, Claus Zimmer, Thomas Baum, Florian Heinen, Michaela V Bonfert, Nico Sollmann

{"title":"Perfusion imaging by arterial spin labeling in migraine: A literature review.","authors":"Severin Schramm, Corinna Börner, Miriam Reichert, Gabriel Hoffmann, Stephan Kaczmarz, Michael Griessmair, Kirsten Jung, Maria T Berndt, Claus Zimmer, Thomas Baum, Florian Heinen, Michaela V Bonfert, Nico Sollmann","doi":"10.1177/0271678X241237733","DOIUrl":"10.1177/0271678X241237733","url":null,"abstract":"Arterial spin labeling (ASL) is a non-invasive magnetic resonance imaging (MRI) method for the assessment of cerebral blood flow (CBF). This review summarizes recent ASL-based investigations in adult and pediatric patients with migraine with aura, migraine without aura, and chronic migraine. A systematic search according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines was conducted within PubMed and reference sections of articles identified from April 2014 to November 2022. Out of 236 initial articles, 20 remained after filtering, encompassing data from 1155 subjects in total. Cross-sectional studies in adults showed inconsistent results, while longitudinal studies demonstrated that cerebral perfusion changes over the migraine cycle can be tracked using ASL. The most consistent findings were observed in ictal states among pediatric migraine patients, where studies showed hypoperfusion matching aura symptoms during early imaging followed by hyperperfusion. Overall, ASL is a useful but currently underutilized modality for evaluating cerebral perfusion in patients with migraine. The generalizability of results is currently limited by heterogeneities regarding study design and documentation of clinical variables (e.g., relation of attacks to scanning timepoint, migraine subtypes). Future MRI studies should consider augmenting imaging protocols with ASL to further elucidate perfusion dynamics in migraine.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"1253-1270"},"PeriodicalIF":4.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11342727/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140119616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacological preclinical comparison of tenecteplase and alteplase for the treatment of acute stroke. 替奈普酶和阿替普酶治疗急性中风的药理临床前比较。

IF 4.9 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2024-08-01 Epub Date: 2024-03-04 DOI: 10.1177/0271678X241237427

Clara Correa-Paz, María Pérez-Mato, Mathys Bellemain-Sagnard, Marco González-Domínguez, Pauline Marie, Lara Pérez-Gayol, Esteban López-Arias, Lucia Del Pozo-Filíu, Sonia López-Amoedo, Ana Bugallo-Casal, María Luz Alonso-Alonso, María Candamo-Lourido, María Santamaría-Cadavid, Susana Arias-Rivas, Manuel Rodríguez-Yañez, Ramón Iglesias-Rey, José Castillo, Denis Vivien, Marina Rubio, Francisco Campos

{"title":"Pharmacological preclinical comparison of tenecteplase and alteplase for the treatment of acute stroke.","authors":"Clara Correa-Paz, María Pérez-Mato, Mathys Bellemain-Sagnard, Marco González-Domínguez, Pauline Marie, Lara Pérez-Gayol, Esteban López-Arias, Lucia Del Pozo-Filíu, Sonia López-Amoedo, Ana Bugallo-Casal, María Luz Alonso-Alonso, María Candamo-Lourido, María Santamaría-Cadavid, Susana Arias-Rivas, Manuel Rodríguez-Yañez, Ramón Iglesias-Rey, José Castillo, Denis Vivien, Marina Rubio, Francisco Campos","doi":"10.1177/0271678X241237427","DOIUrl":"10.1177/0271678X241237427","url":null,"abstract":"Alteplase (rtPA) remains the standard thrombolytic drug for acute ischemic stroke. However, new rtPA-derived molecules, such as tenecteplase (TNK), with prolonged half-lives following a single bolus administration, have been developed. Although TNK is currently under clinical evaluation, the limited preclinical data highlight the need for additional studies to elucidate its benefits. The toxicities of rtPA and TNK were evaluated in endothelial cells, astrocytes, and neuronal cells. In addition, their in vivo efficacy was independently assessed at two research centers using an ischemic thromboembolic mouse model. Both therapies were tested via early (20 and 30 min) and late administration (4 and 4.5 h) after stroke. rtPA, but not TNK, caused cell death only in neuronal cultures. Mice were less sensitive to thrombolytic therapies than humans, requiring doses 10-fold higher than the established clinical dose. A single bolus dose of 2.5 mg/kg TNK led to an infarct reduction similar to perfusion with 10 mg/kg of rtPA. Early administration of TNK decreased the hemorrhagic transformations compared to that by the early administration of rtPA; however, this result was not obtained following late administration. These two independent preclinical studies support the use of TNK as a promising reperfusion alternative to rtPA.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"1306-1318"},"PeriodicalIF":4.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11342720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140021877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of cerebral oxygen extraction fraction using ASE and TRUST methods in patients with sickle cell disease and healthy controls. 使用 ASE 和 TRUST 方法比较镰状细胞病患者和健康对照组的脑氧萃取分数。

IF 4.9 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2024-08-01 Epub Date: 2024-03-04 DOI: 10.1177/0271678X241237072

Slim Fellah, Chunwei Ying, Yan Wang, Kristin P Guilliams, Melanie E Fields, Yasheng Chen, Josiah Lewis, Amy Mirro, Rachel Cohen, Nkemdilim Igwe, Cihat Eldeniz, Dengrong Jiang, Hanzhang Lu, William J Powers, Jin-Moo Lee, Andria L Ford, Hongyu An

{"title":"Comparison of cerebral oxygen extraction fraction using ASE and TRUST methods in patients with sickle cell disease and healthy controls.","authors":"Slim Fellah, Chunwei Ying, Yan Wang, Kristin P Guilliams, Melanie E Fields, Yasheng Chen, Josiah Lewis, Amy Mirro, Rachel Cohen, Nkemdilim Igwe, Cihat Eldeniz, Dengrong Jiang, Hanzhang Lu, William J Powers, Jin-Moo Lee, Andria L Ford, Hongyu An","doi":"10.1177/0271678X241237072","DOIUrl":"10.1177/0271678X241237072","url":null,"abstract":"Abnormal oxygen extraction fraction (OEF), a putative biomarker of cerebral metabolic stress, may indicate compromised oxygen delivery and ischemic vulnerability in patients with sickle cell disease (SCD). Elevated OEF was observed at the tissue level across the brain using an asymmetric spin echo (ASE) MR method, while variable global OEFs were found from the superior sagittal sinus (SSS) using a T2-relaxation-under-spin-tagging (TRUST) MRI method with different calibration models. In this study, we aimed to compare the average ASE-OEF in the SSS drainage territory and TRUST-OEF in the SSS from the same SCD patients and healthy controls. 74 participants (SCD: N = 49; controls: N = 25) underwent brain MRI. TRUST-OEF was quantified using the Lu-bovine, Bush-HbA and Li-Bush-HbS models. ASE-OEF and TRUST-OEF were significantly associated in healthy controls after controlling for hematocrit using the Lu-bovine or the Bush-HbA model. However, no association was found between ASE-OEF and TRUST-OEF in patients with SCD using either the Bush-HbA or the Li-Bush-HbS model. Plausible explanations include a discordance between spatially volume-averaged oxygenation brain tissue and flow-weighted volume-averaged oxygenation in SSS or sub-optimal calibration in SCD. Further work is needed to refine and validate non-invasive MR OEF measurements in SCD.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"1404-1416"},"PeriodicalIF":4.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11342725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140021876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vascular contributions to cognitive decline: Beyond amyloid and tau in the Harvard Aging Brain Study. 血管对认知能力下降的影响：哈佛大学老龄化大脑研究中的淀粉样蛋白和陶氏蛋白之外的因素。

IF 4.9 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2024-08-01 Epub Date: 2024-03-07 DOI: 10.1177/0271678X241237624

Zahra Shirzadi, Rory Boyle, Wai-Ying W Yau, Gillian Coughlan, Jessie Fanglu Fu, Michael J Properzi, Rachel F Buckley, Hyun-Sik Yang, Catherine E Scanlon, Stephanie Hsieh, Rebecca E Amariglio, Kathryn Papp, Dorene Rentz, Julie C Price, Keith A Johnson, Reisa A Sperling, Jasmeer P Chhatwal, Aaron P Schultz

{"title":"Vascular contributions to cognitive decline: Beyond amyloid and tau in the Harvard Aging Brain Study.","authors":"Zahra Shirzadi, Rory Boyle, Wai-Ying W Yau, Gillian Coughlan, Jessie Fanglu Fu, Michael J Properzi, Rachel F Buckley, Hyun-Sik Yang, Catherine E Scanlon, Stephanie Hsieh, Rebecca E Amariglio, Kathryn Papp, Dorene Rentz, Julie C Price, Keith A Johnson, Reisa A Sperling, Jasmeer P Chhatwal, Aaron P Schultz","doi":"10.1177/0271678X241237624","DOIUrl":"10.1177/0271678X241237624","url":null,"abstract":"In addition to amyloid and tau pathology, elevated systemic vascular risk, white matter injury, and reduced cerebral blood flow contribute to late-life cognitive decline. Given the strong collinearity among these parameters, we proposed a framework to extract the independent latent features underlying cognitive decline using the Harvard Aging Brain Study (N = 166 cognitively unimpaired older adults at baseline). We used the following measures from the baseline visit: cortical amyloid, inferior temporal cortex tau, relative cerebral blood flow, white matter hyperintensities, peak width of skeletonized mean diffusivity, and Framingham Heart Study cardiovascular disease risk. We used exploratory factor analysis to extract orthogonal factors from these variables and their interactions. These factors were used in a regression model to explain longitudinal Preclinical Alzheimer Cognitive Composite-5 (PACC) decline (follow-up = 8.5 ±2.7 years). We next examined whether gray matter volume atrophy acts as a mediator of factors and PACC decline. Latent factors of systemic vascular risk, white matter injury, and relative cerebral blood flow independently explain cognitive decline beyond amyloid and tau. Gray matter volume atrophy mediates these associations with the strongest effect on white matter injury. These results suggest that systemic vascular risk contributes to cognitive decline beyond current markers of cerebrovascular injury, amyloid, and tau.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"1319-1328"},"PeriodicalIF":4.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11342726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140059482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reduced oxygen extraction fraction in deep cerebral veins associated with cognitive impairment in multiple sclerosis. 多发性硬化症患者脑深部静脉氧气萃取率降低与认知障碍有关。

IF 4.9 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2024-08-01 Epub Date: 2024-05-31 DOI: 10.1177/0271678X241259551

Hasan Sawan, Chenyang Li, Sagar Buch, Evanthia Bernitsas, E Mark Haacke, Yulin Ge, Yongsheng Chen

{"title":"Reduced oxygen extraction fraction in deep cerebral veins associated with cognitive impairment in multiple sclerosis.","authors":"Hasan Sawan, Chenyang Li, Sagar Buch, Evanthia Bernitsas, E Mark Haacke, Yulin Ge, Yongsheng Chen","doi":"10.1177/0271678X241259551","DOIUrl":"10.1177/0271678X241259551","url":null,"abstract":"Studying the relationship between cerebral oxygen utilization and cognitive impairment is essential to understanding neuronal functional changes in the disease progression of multiple sclerosis (MS). This study explores the potential of using venous susceptibility in internal cerebral veins (ICVs) as an imaging biomarker for cognitive impairment in relapsing-remitting MS (RRMS) patients. Quantitative susceptibility mapping derived from fully flow-compensated MRI phase data was employed to directly measure venous blood oxygen saturation levels (SvO2) in the ICVs. Results revealed a significant reduction in the susceptibility of ICVs (212.4 ± 30.8 ppb vs 239.4 ± 25.9 ppb) and a significant increase of SvO2 (74.5 ± 1.89% vs 72.4 ± 2.23%) in patients with RRMS compared with age- and sex-matched healthy controls. Both the susceptibility of ICVs (r = 0.508, p = 0.031) and the SvO2 (r = -0.498, p = 0.036) exhibited a moderate correlation with cognitive decline in these patients assessed by the Paced Auditory Serial Addition Test, while no significant correlation was observed with clinical disability measured by the Expanded Disability Status Scale. The findings suggest that venous susceptibility in ICVs has the potential to serve as a specific indicator of oxygen metabolism and cognitive function in RRMS. .","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"1298-1305"},"PeriodicalIF":4.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11342723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141183722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cerebral arterial stiffness is linked to white matter hyperintensities and perivascular spaces in older adults - A 4D flow MRI study. 脑动脉僵化与老年人白质高密度和血管周围间隙有关--4D 流磁共振成像研究。

IF 4.9 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2024-08-01 Epub Date: 2024-02-05 DOI: 10.1177/0271678X241230741

Cecilia Björnfot, Anders Eklund, Jenny Larsson, William Hansson, Johan Birnefeld, Anders Garpebring, Sara Qvarlander, Lars-Owe D Koskinen, Jan Malm, Anders Wåhlin

{"title":"Cerebral arterial stiffness is linked to white matter hyperintensities and perivascular spaces in older adults - A 4D flow MRI study.","authors":"Cecilia Björnfot, Anders Eklund, Jenny Larsson, William Hansson, Johan Birnefeld, Anders Garpebring, Sara Qvarlander, Lars-Owe D Koskinen, Jan Malm, Anders Wåhlin","doi":"10.1177/0271678X241230741","DOIUrl":"10.1177/0271678X241230741","url":null,"abstract":"White matter hyperintensities (WMH), perivascular spaces (PVS) and lacunes are common MRI features of small vessel disease (SVD). However, no shared underlying pathological mechanism has been identified. We investigated whether SVD burden, in terms of WMH, PVS and lacune status, was related to changes in the cerebral arterial wall by applying global cerebral pulse wave velocity (gcPWV) measurements, a newly described marker of cerebral vascular stiffness. In a population-based cohort of 190 individuals, 66-85 years old, SVD features were estimated from T1-weighted and FLAIR images while gcPWV was estimated from 4D flow MRI data. Additionally, the gcPWV's stability to variations in field-of-view was analyzed. The gcPWV was 10.82 (3.94) m/s and displayed a significant correlation to WMH and white matter PVS volume (r = 0.29, p < 0.001; r = 0.21, p = 0.004 respectively from nonparametric tests) that persisted after adjusting for age, blood pressure variables, body mass index, ApoB/A1 ratio, smoking as well as cerebral pulsatility index, a previously suggested early marker of SVD. The gcPWV displayed satisfactory stability to field-of-view variations. Our results suggest that SVD is accompanied by changes in the cerebral arterial wall that can be captured by considering the velocity of the pulse wave transmission through the cerebral arterial network.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"1343-1351"},"PeriodicalIF":4.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11342729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139691962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lower GLUT1 and unchanged MCT1 in Alzheimer's disease cerebrovasculature. 阿尔茨海默氏症脑血管中的 GLUT1 降低，MCT1 不变。

IF 4.9 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2024-08-01 Epub Date: 2024-03-05 DOI: 10.1177/0271678X241237484

Manon Leclerc, Cyntia Tremblay, Philippe Bourassa, Julie A Schneider, David A Bennett, Frédéric Calon

{"title":"Lower GLUT1 and unchanged MCT1 in Alzheimer's disease cerebrovasculature.","authors":"Manon Leclerc, Cyntia Tremblay, Philippe Bourassa, Julie A Schneider, David A Bennett, Frédéric Calon","doi":"10.1177/0271678X241237484","DOIUrl":"10.1177/0271678X241237484","url":null,"abstract":"The brain is a highly demanding organ, utilizing mainly glucose but also ketone bodies as sources of energy. Glucose transporter-1 (GLUT1) and monocarboxylates transporter-1 (MCT1) respectively transport glucose and ketone bodies across the blood-brain barrier. While reduced glucose uptake by the brain is one of the earliest signs of Alzheimer's disease (AD), no change in the uptake of ketone bodies has been evidenced yet. To probe for changes in GLUT1 and MCT1, we performed Western immunoblotting in microvessel extracts from the parietal cortex of 60 participants of the Religious Orders Study. Participants clinically diagnosed with AD had lower cerebrovascular levels of GLUT1, whereas MCT1 remained unchanged. GLUT1 reduction was associated with lower cognitive scores. No such association was found for MCT1. GLUT1 was inversely correlated with neuritic plaques and cerebrovascular β-secretase-derived fragment levels. No other significant associations were found between both transporters, markers of Aβ and tau pathologies, sex, age at death or apolipoprotein-ε4 genotype. These results suggest that, while a deficit of GLUT1 may underlie the reduced transport of glucose to the brain in AD, no such impairment occurs for MCT1. This study thus supports the exploration of ketone bodies as an alternative energy source for the aging brain.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"1417-1432"},"PeriodicalIF":4.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11342728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140028187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The brain's "dark energy" puzzle: How strongly is glucose metabolism linked to resting-state brain activity? 大脑的 "暗能量 "之谜：葡萄糖代谢与静息状态大脑活动的联系有多强？

IF 4.9 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2024-08-01 Epub Date: 2024-03-05 DOI: 10.1177/0271678X241237974

Tommaso Volpi, Erica Silvestri, Marco Aiello, John J Lee, Andrei G Vlassenko, Manu S Goyal, Maurizio Corbetta, Alessandra Bertoldo

{"title":"The brain's \"dark energy\" puzzle: How strongly is glucose metabolism linked to resting-state brain activity?","authors":"Tommaso Volpi, Erica Silvestri, Marco Aiello, John J Lee, Andrei G Vlassenko, Manu S Goyal, Maurizio Corbetta, Alessandra Bertoldo","doi":"10.1177/0271678X241237974","DOIUrl":"10.1177/0271678X241237974","url":null,"abstract":"Brain glucose metabolism, which can be investigated at the macroscale level with [18F]FDG PET, displays significant regional variability for reasons that remain unclear. Some of the functional drivers behind this heterogeneity may be captured by resting-state functional magnetic resonance imaging (rs-fMRI). However, the full extent to which an fMRI-based description of the brain's spontaneous activity can describe local metabolism is unknown. Here, using two multimodal datasets of healthy participants, we built a multivariable multilevel model of functional-metabolic associations, assessing multiple functional features, describing the 1) rs-fMRI signal, 2) hemodynamic response, 3) static and 4) time-varying functional connectivity, as predictors of the human brain's metabolic architecture. The full model was trained on one dataset and tested on the other to assess its reproducibility. We found that functional-metabolic spatial coupling is nonlinear and heterogeneous across the brain, and that local measures of rs-fMRI activity and synchrony are more tightly coupled to local metabolism. In the testing dataset, the degree of functional-metabolic spatial coupling was also related to peripheral metabolism. Overall, although a significant proportion of regional metabolic variability can be described by measures of spontaneous activity, additional efforts are needed to explain the remaining variance in the brain's 'dark energy'.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"1433-1449"},"PeriodicalIF":4.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11342718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140039463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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