{"title":"脑卒中恢复和预后的基因组学研究。","authors":"Arne G Lindgren","doi":"10.1177/0271678X251332528","DOIUrl":null,"url":null,"abstract":"<p><p>The understanding of genomics has improved tremendously during the last decades. The concept of recovery and outcome after stroke has also progressed during this time. However, the connection between genomics and stroke recovery has only begun to emerge in a more structural and comprehensive way. Different types of outcomes and recovery occur after stroke. This depends on domain of neurological deficit, severity, resilience, receptivity for rehabilitation measures, and concomitant morbidity. Methods for assessing stroke patients' prognosis depend on these factors. Different genetic approaches are possible and there is an increasing need for linking genetic findings to other omics as well as to clinically meaningful results. This review addresses recent advances and views in clinical genomics of stroke recovery and outcome in humans with focus on current and previous studies, concepts, and future perspectives.</p>","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"271678X251332528"},"PeriodicalIF":4.5000,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11993556/pdf/","citationCount":"0","resultStr":"{\"title\":\"Genomics of stroke recovery and outcome.\",\"authors\":\"Arne G Lindgren\",\"doi\":\"10.1177/0271678X251332528\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The understanding of genomics has improved tremendously during the last decades. The concept of recovery and outcome after stroke has also progressed during this time. However, the connection between genomics and stroke recovery has only begun to emerge in a more structural and comprehensive way. Different types of outcomes and recovery occur after stroke. This depends on domain of neurological deficit, severity, resilience, receptivity for rehabilitation measures, and concomitant morbidity. Methods for assessing stroke patients' prognosis depend on these factors. Different genetic approaches are possible and there is an increasing need for linking genetic findings to other omics as well as to clinically meaningful results. This review addresses recent advances and views in clinical genomics of stroke recovery and outcome in humans with focus on current and previous studies, concepts, and future perspectives.</p>\",\"PeriodicalId\":15325,\"journal\":{\"name\":\"Journal of Cerebral Blood Flow and Metabolism\",\"volume\":\" \",\"pages\":\"271678X251332528\"},\"PeriodicalIF\":4.5000,\"publicationDate\":\"2025-04-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11993556/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Cerebral Blood Flow and Metabolism\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/0271678X251332528\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cerebral Blood Flow and Metabolism","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/0271678X251332528","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
The understanding of genomics has improved tremendously during the last decades. The concept of recovery and outcome after stroke has also progressed during this time. However, the connection between genomics and stroke recovery has only begun to emerge in a more structural and comprehensive way. Different types of outcomes and recovery occur after stroke. This depends on domain of neurological deficit, severity, resilience, receptivity for rehabilitation measures, and concomitant morbidity. Methods for assessing stroke patients' prognosis depend on these factors. Different genetic approaches are possible and there is an increasing need for linking genetic findings to other omics as well as to clinically meaningful results. This review addresses recent advances and views in clinical genomics of stroke recovery and outcome in humans with focus on current and previous studies, concepts, and future perspectives.
期刊介绍：
JCBFM is the official journal of the International Society for Cerebral Blood Flow & Metabolism, which is committed to publishing high quality, independently peer-reviewed research and review material. JCBFM stands at the interface between basic and clinical neurovascular research, and features timely and relevant research highlighting experimental, theoretical, and clinical aspects of brain circulation, metabolism and imaging. The journal is relevant to any physician or scientist with an interest in brain function, cerebrovascular disease, cerebral vascular regulation and brain metabolism, including neurologists, neurochemists, physiologists, pharmacologists, anesthesiologists, neuroradiologists, neurosurgeons, neuropathologists and neuroscientists.
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