Unlocking the potential of photobiomodulation therapy for brain neurovascular coupling: The biological effects and medical applications.

IF 4.9 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2025-01-07 DOI:10.1177/0271678X241311695

Bingzi Yan, Jie Zhou, Fengshuo Yan, Mingyang Gao, Jiaji Tang, Lin Huang, Yan Luo

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引用次数: 0

Abstract

Photobiomodulation (PBM) therapy stands as an innovative neurostimulation modality that has demonstrated both efficacy and safety in improving brain function. This therapy exerts multifaceted influences on neurons, blood vessels, and their intricate interplay known as neurovascular coupling (NVC). Growing evidence indicates that NVC may present a promising target for PBM intervention. However, the detailed mechanisms underlying its therapeutic benefits remain to be fully understood. This review aims to elucidate the potential metabolic pathways and signaling cascades involved in the modulatory effects of PBM, while also exploring the extensive repertoire of PBM applications in neurologic and psychiatric conditions. The prospects of PBM within the realm of NVC investigation are intensively considered, providing deeper insights into the powerful capabilities of PBM therapy and its potential to revolutionize neurostimulation treatments.

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释放光生物调节治疗脑神经血管耦合的潜力：生物学效应和医学应用。

光生物调节（PBM）治疗是一种创新的神经刺激方式，在改善脑功能方面已经证明了其有效性和安全性。这种疗法对神经元、血管及其复杂的相互作用产生多方面的影响，称为神经血管耦合（NVC）。越来越多的证据表明，NVC可能是PBM干预的一个有希望的目标。然而，其治疗效果背后的详细机制仍有待充分了解。本综述旨在阐明PBM调节作用的潜在代谢途径和信号级联反应，同时探索PBM在神经和精神疾病中的广泛应用。在NVC研究领域内，PBM的前景得到了深入的考虑，为PBM治疗的强大功能及其彻底改变神经刺激治疗的潜力提供了更深入的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cerebral Blood Flow and Metabolism 医学-内分泌学与代谢

CiteScore

12.00

自引率

4.80%

发文量

300

审稿时长

3 months

期刊介绍： JCBFM is the official journal of the International Society for Cerebral Blood Flow & Metabolism, which is committed to publishing high quality, independently peer-reviewed research and review material. JCBFM stands at the interface between basic and clinical neurovascular research, and features timely and relevant research highlighting experimental, theoretical, and clinical aspects of brain circulation, metabolism and imaging. The journal is relevant to any physician or scientist with an interest in brain function, cerebrovascular disease, cerebral vascular regulation and brain metabolism, including neurologists, neurochemists, physiologists, pharmacologists, anesthesiologists, neuroradiologists, neurosurgeons, neuropathologists and neuroscientists.