Retinal microvascular phenotypes can track small vessel disease burden and CPAP treatment effectiveness in obstructive sleep apnoea.

IF 4.9 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Ylenia Giarratano, Elizabeth A Hill, Charlene Hamid, Stewart Wiseman, Calum Gray, Francesca M Chappell, Roberto Duarte Coello, Maria C Valdés-Hernández, Lucia Ballerini, Michael S Stringer, Michael J Thrippleton, Daniela Jaime Garcia, Xiaodi Liu, William Hewins, Yajun Cheng, Sandra E Black, Andrew Lim, Rosa Sommer, Joel Ramirez, Bradley J MacIntosh, Rosalind Brown, Fergus Doubal, Tom MacGillivray, Joanna M Wardlaw, Renata Riha, Miguel O Bernabeu
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引用次数: 0

Abstract

Optical coherence tomography angiography (OCT-A) retinal imaging enables in vivo visualization of the retinal microvasculature that is developmentally related to the brain and can offer insight on cerebrovascular health. We investigated retinal phenotypes and neuroimaging markers of small vessel disease (SVD) in individuals with obstructive sleep apnoea (OSA). We enrolled 44 participants (mean age 50.1 ± SD 9.1 years) and performed OCT-A imaging before and after continuous positive airway pressure (CPAP) therapy. Pre-treatment analyses using a generalized estimating equations model adjusted for relevant covariates, revealed perivascular spaces (PVS) volume in basal ganglia associated with greater foveal vessel density (fVD) (p-value < 0.001), and smaller foveal avascular zone area (p-value = 0.01), whereas PVS count in centrum semiovale associated with lower retinal vessel radius (p-value = 0.02) and higher vessel tortuosity (p-value = 0.01). A reduction in retinal vessel radius was also observed with increased OSA severity (p-value = 0.05). Post-treatment analyses showed greater CPAP usage was associated with a decrease in fVD (p-value = 0.02), and increased retinal vessel radius (p-value = 0.01). The findings demonstrate for the first time the potential use of OCT-A to monitor CPAP treatment and its possible impact on both retinal and brain vascular health.

视网膜微血管表型可追踪阻塞性睡眠呼吸暂停患者的小血管疾病负担和 CPAP 治疗效果。
光学相干断层血管成像(OCT-A)视网膜成像技术能够在体内观察到与大脑发育相关的视网膜微血管,并能深入了解脑血管的健康状况。我们研究了阻塞性睡眠呼吸暂停(OSA)患者的视网膜表型和小血管疾病(SVD)的神经影像标记。我们招募了 44 名参与者(平均年龄 50.1 ± SD 9.1 岁),并在持续气道正压(CPAP)治疗前后进行了 OCT-A 成像。使用广义估计方程模型进行治疗前分析,并对相关协变量进行调整,结果显示基底节的血管周围空间(PVS)体积与更大的眼窝血管密度(fVD)相关(p值为0.05)。
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来源期刊
Journal of Cerebral Blood Flow and Metabolism
Journal of Cerebral Blood Flow and Metabolism 医学-内分泌学与代谢
CiteScore
12.00
自引率
4.80%
发文量
300
审稿时长
3 months
期刊介绍: JCBFM is the official journal of the International Society for Cerebral Blood Flow & Metabolism, which is committed to publishing high quality, independently peer-reviewed research and review material. JCBFM stands at the interface between basic and clinical neurovascular research, and features timely and relevant research highlighting experimental, theoretical, and clinical aspects of brain circulation, metabolism and imaging. The journal is relevant to any physician or scientist with an interest in brain function, cerebrovascular disease, cerebral vascular regulation and brain metabolism, including neurologists, neurochemists, physiologists, pharmacologists, anesthesiologists, neuroradiologists, neurosurgeons, neuropathologists and neuroscientists.
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