Journal of Cerebral Blood Flow and Metabolism最新文献_第7页

Early and enduring: Targeting the endothelium for blood-brain barrier protection. 早期和持久：以内皮为目标，保护血脑屏障。

IF 4.9 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2024-09-01 Epub Date: 2024-06-21 DOI: 10.1177/0271678X241264086

Silin Wu, Xuefang Sophie Ren, Yejie Shi

引用次数: 0

Metabolic coupling between glutamate and N-acetylaspartate in the human brain. 人脑中谷氨酸和 N-乙酰天冬氨酸之间的代谢耦合。

IF 4.9 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2024-09-01 Epub Date: 2024-03-14 DOI: 10.1177/0271678X241239783

Sungtak Hong, Jyoti Singh Tomar, Jun Shen

引用次数: 0

Quantification of brain-wide vascular resistivity via ultrafast Doppler in human neonates helps early detection of white matter injury. 通过超快多普勒对人类新生儿全脑血管电阻率进行量化，有助于早期检测白质损伤。

IF 4.9 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2024-09-01 Epub Date: 2024-02-10 DOI: 10.1177/0271678X241232197

Flora Faure, Jérôme Baranger, Marianne Alison, Béatrice Boutillier, Alice Frérot, Chung Lim, Grégory Planchette, Mickael Prigent, Mickaël Tanter, Olivier Baud, Valérie Biran, Charlie Demené

{"title":"Quantification of brain-wide vascular resistivity via ultrafast Doppler in human neonates helps early detection of white matter injury.","authors":"Flora Faure, Jérôme Baranger, Marianne Alison, Béatrice Boutillier, Alice Frérot, Chung Lim, Grégory Planchette, Mickael Prigent, Mickaël Tanter, Olivier Baud, Valérie Biran, Charlie Demené","doi":"10.1177/0271678X241232197","DOIUrl":"10.1177/0271678X241232197","url":null,"abstract":"Preterm birth is associated with cerebrovascular development disruption and can induce white matter injuries (WMI). Transfontanellar ultrasound Doppler is the most widely used clinical imaging technique to monitor neonatal cerebral vascularisation and haemodynamics based on vascular indexes such as the resistivity index (RI); however, it has poor predictive value for brain damage. Indeed, these RI measurements are currently limited to large vessels, leading to a very limited probing of the brain's vascularisation, which may hinder prognosis. Here we show that ultrafast Doppler imaging (UfD) enables simultaneous quantification, in the whole field of view, of the local RI and vessel diameter, even in small vessels. Combining both pieces of information, we defined two new comprehensive resistivity parameters of the vascular trees. First, we showed that our technique is more sensitive in the early characterisation of the RI modifications between term and preterm neonates and for the first time we could show that the RI depends both on the vessel diameter and vascular territory. We then showed that our parameters can be used for early prediction of WMI. Our results demonstrate the potential of UfD to provide new biomarkers and pave the way for continuous monitoring of neonatal brain resistivity.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"1577-1590"},"PeriodicalIF":4.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139716099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CO₂ cerebrovascular reactivity measured with CBF-MRI in older individuals: Association with cognition, physical function, amyloid and tau proteins. 用 CBF-MRI 测量老年人的 CO2 脑血管反应性：与认知能力、身体功能、淀粉样蛋白和 tau 蛋白的关系。

IF 4.9 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2024-09-01 Epub Date: 2024-03-15 DOI: 10.1177/0271678X241240582

Sandeepa Sur, Zixuan Lin, Yang Li, Sevil Yasar, Paul B Rosenberg, Abhay Moghekar, Xirui Hou, Dengrong Jiang, Rita R Kalyani, Kaisha Hazel, George Pottanat, Cuimei Xu, Jay J Pillai, Peiying Liu, Marilyn Albert, Hanzhang Lu

{"title":"CO2 cerebrovascular reactivity measured with CBF-MRI in older individuals: Association with cognition, physical function, amyloid and tau proteins.","authors":"Sandeepa Sur, Zixuan Lin, Yang Li, Sevil Yasar, Paul B Rosenberg, Abhay Moghekar, Xirui Hou, Dengrong Jiang, Rita R Kalyani, Kaisha Hazel, George Pottanat, Cuimei Xu, Jay J Pillai, Peiying Liu, Marilyn Albert, Hanzhang Lu","doi":"10.1177/0271678X241240582","DOIUrl":"10.1177/0271678X241240582","url":null,"abstract":"Vascular pathology is the second leading cause of cognitive impairment and represents a major contributing factor in mixed dementia. However, biomarkers for vascular cognitive impairment and dementia (VCID) are under-developed. Here we aimed to investigate the potential role of CO2 Cerebrovascular Reactivity (CVR) measured with phase-contrast quantitative flow MRI in cognitive impairment and dementia. Forty-five (69 ± 7 years) impaired (37 mild-cognitive-impairment and 8 mild-dementia by syndromic diagnosis) and 22 cognitively-healthy-control (HC) participants were recruited and scanned on a 3 T MRI. Biomarkers of AD pathology were measured in cerebrospinal fluid. We found that CBF-CVR was lower (p = 0.027) in the impaired (mean±SE, 3.70 ± 0.15%/mmHg) relative to HC (4.28 ± 0.21%/mmHg). After adjusting for AD pathological markers (Aβ42/40, total tau, and Aβ42/p-tau181), higher CBF-CVR was associated with better cognitive performance, including Montreal Cognitive Assessment, MoCA (p = 0.001), composite cognitive score (p = 0.047), and language (p = 0.004). Higher CBF-CVR was also associated with better physical function, including gait-speed (p = 0.006) and time for five chair-stands (p = 0.049). CBF-CVR was additionally related to the Clinical-Dementia-Rating, CDR, including global CDR (p = 0.026) and CDR Sum-of-Boxes (p = 0.015). CBF-CVR was inversely associated with hemoglobin A1C level (p = 0.017). In summary, CBF-CVR measured with phase-contrast MRI shows associations with cognitive performance, physical function, and disease-severity, independent of AD pathological markers.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"1618-1628"},"PeriodicalIF":4.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11532674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140136815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A dispensable role of mural cell-derived laminin-α5 in intracerebral hemorrhage. 壁细胞衍生的层粘连蛋白-α5在脑出血中发挥着不可或缺的作用。

IF 4.9 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2024-09-01 Epub Date: 2024-07-25 DOI: 10.1177/0271678X241264083

Jingsong Ruan, Minkyung Kang, Abhijit Nirwane, Yao Yao

引用次数: 0

A plasma lipid signature in acute human traumatic brain injury: Link with neuronal injury and inflammation markers. 急性人类创伤性脑损伤的血浆脂质特征：与神经元损伤和炎症标志物的联系。

IF 4.9 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2024-08-26 DOI: 10.1177/0271678X241276951

Isabell Nessel, Luke Whiley, Simon C Dyall, Adina T Michael-Titus

{"title":"A plasma lipid signature in acute human traumatic brain injury: Link with neuronal injury and inflammation markers.","authors":"Isabell Nessel, Luke Whiley, Simon C Dyall, Adina T Michael-Titus","doi":"10.1177/0271678X241276951","DOIUrl":"10.1177/0271678X241276951","url":null,"abstract":"Traumatic brain injury (TBI) leads to major membrane lipid breakdown. We investigated plasma lipids over 3 days post-TBI, to identify a signature of acute human TBI and assess its correlation with neuronal injury and inflammation. Plasma from patients with TBI (Abbreviated Injury Scale (AIS)3 - serious injury, n = 5; AIS4 - severe injury, n = 8), and controls (n = 13) was analysed for lipidomic profile, neurofilament light (NFL) and cytokines, and the omega-3 index was measured in red blood cells. A lipid signature separated TBI from controls, at 24 and 72 h. Major species driving the separation were: lysophosphatidylcholine (LPC), phosphatidylcholine (PC) and hexosylceramide (HexCer). Docosahexaenoic acid (DHA, 22:6) and LPC (0:0/22:6) decreased post-injury. NFL levels were increased at 24 and 72 h post-injury in AIS4 TBI vs. controls. Interleukin (IL-)6, IL-2 and IL-13 were elevated at 24 h in AIS4 patients vs. controls. NFL and IL-6 were negatively correlated with several lipids. The omega-3 index at admission was low in all patients (controls: 4.3 ± 1.1% and TBI: 4.0 ± 1.1%) and did not change significantly over 3 days post-injury. We have identified specific lipid changes, correlated with markers of injury and inflammation in acute TBI. These observations could inform future lipid-based therapeutic approaches.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"271678X241276951"},"PeriodicalIF":4.9,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11572080/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142072918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cerebral blood flow alterations and host genetic association in individuals with long COVID: A transcriptomic-neuroimaging study. 长COVID患者的脑血流改变与宿主基因相关性：转录组学-神经影像学研究。

IF 4.9 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2024-08-23 DOI: 10.1177/0271678X241277621

Yao Wang, Ziwei Yang, Xiumei Zheng, Xiao Liang, Lin Wu, Chengsi Wu, Jiankun Dai, Yuan Cao, Meng Li, Fuqing Zhou

{"title":"Cerebral blood flow alterations and host genetic association in individuals with long COVID: A transcriptomic-neuroimaging study.","authors":"Yao Wang, Ziwei Yang, Xiumei Zheng, Xiao Liang, Lin Wu, Chengsi Wu, Jiankun Dai, Yuan Cao, Meng Li, Fuqing Zhou","doi":"10.1177/0271678X241277621","DOIUrl":"10.1177/0271678X241277621","url":null,"abstract":"Neuroimaging studies have indicated that altered cerebral blood flow (CBF) was associated with the long-term symptoms of postacute sequelae of SARS-CoV-2 infection (PASC), also known as \"long COVID\". COVID-19 and long COVID were found to be strongly associated with host gene expression. Nevertheless, the relationships between altered CBF, clinical symptoms, and gene expression in the central nervous system (CNS) remain unclear in individuals with long COVID. This study aimed to explore the genetic mechanisms of CBF abnormalities in individuals with long COVID by transcriptomic-neuroimaging spatial association. Lower CBF in the left frontal-temporal gyrus was associated with higher fatigue and worse cognition in individuals with long COVID. This CBF pattern was spatially associated with the expression of 2,178 genes, which were enriched in the molecular functions and biological pathways of COVID-19. Our study suggested that lower CBF is associated with persistent clinical symptoms in long COVID individuals, possibly as a consequence of the complex interactions among multiple COVID-19-related genes, which contributes to our understanding of the impact of adverse CNS outcomes and the trajectory of development to long COVID.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"271678X241277621"},"PeriodicalIF":4.9,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11572096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142035981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Imaging the 5-HT_2C receptor with PET: Evaluation of 5-HT_2C and 5-HT_2A affinity of pimavanserin in the primate brain. 用 PET 对 5-HT2C 受体进行成像：评估灵长类动物大脑中匹马伐林的 5-HT2C 和 5-HT2A 亲和力。

IF 4.9 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2024-08-21 DOI: 10.1177/0271678X241276312

Khanum Ridler, Gaia Rizzo, Ethan S Burstein, Anton Forsberg Morén, Vladimir Stepanov, Christer Halldin, Eugenii A Rabiner

{"title":"Imaging the 5-HT2C receptor with PET: Evaluation of 5-HT2C and 5-HT2A affinity of pimavanserin in the primate brain.","authors":"Khanum Ridler, Gaia Rizzo, Ethan S Burstein, Anton Forsberg Morén, Vladimir Stepanov, Christer Halldin, Eugenii A Rabiner","doi":"10.1177/0271678X241276312","DOIUrl":"https://doi.org/10.1177/0271678X241276312","url":null,"abstract":"Two complimentary techniques were used to estimate occupancy of pimavanserin (a selective 5-HT2A/2C inverse agonist) to 5-HT2A and 5-HT2C receptors in non-human primate brains. One employed the 5-HT2A/2C selective radioligand [11C]CIMBI-36 combined with quantification of binding potentials in brain regions known to be enriched in 5-HT2A (cortex) or 5-HT2C (choroid plexus) receptors to estimate occupancy. Pimavanserin was 6-10 fold more potent displacing [11C]CIMBI-36 from cortex (ED50 = 0.007 mg/kg; EC50 = 0.6 ng/ml) than from choroid plexus (ED50 =0.046 mg/kg; EC50 = 6.0 ng/ml). The assignment of [11C]CIMBI-36 binding to 5-HT2A and 5-HT2C receptors by anatomical brain structure was confirmed using the 5-HT2A selective inverse agonist MDL 100,907 and the 5-HT2C selective antagonist SB 242584 to displace [11C]CIMBI-36. The second technique employed a novel, 5-HT2C selective tracer called [11C]AC1332. [11C]AC1332 bound robustly to choroid plexus, moderately to hippocampus, and minimally to cortex. Pimavanserin displaced [11C]AC1332 with similar potency (ED50 = 0.062 mg/kg; EC50 = 2.5 ng/ml) as its potency displacing [11C]CIMBI-36 binding from choroid plexus. These results demonstrate the feasibility of simultaneously estimating drug occupancy of 5-HT2A and 5-HT2C receptors in vivo, and the utility of a novel 5-HT2C receptor selective tracer ligand.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"271678X241276312"},"PeriodicalIF":4.9,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142017663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxygen extraction fraction change in M1-M6 brain regions of patients with unilateral or bilateral middle cerebral artery occlusion. 单侧或双侧大脑中动脉闭塞患者脑区 M1-M6 的析氧分数变化。

IF 4.9 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2024-08-20 DOI: 10.1177/0271678X241276386

Yu Xiao, Zhenghua Liu, Xinghua Wan

{"title":"Oxygen extraction fraction change in M1-M6 brain regions of patients with unilateral or bilateral middle cerebral artery occlusion.","authors":"Yu Xiao, Zhenghua Liu, Xinghua Wan","doi":"10.1177/0271678X241276386","DOIUrl":"10.1177/0271678X241276386","url":null,"abstract":"Cerebral blood flow (CBF) and oxygen extraction fraction (OEF) can be measured using arterial spin labeling (ASL) and quantitative susceptibility mapping (QSM) sequences, respectively. ASL and QSM sequences were performed on 13 healthy participants and 46 patients with unilateral or bilateral Middle cerebral artery (MCA) occlusion. M1-M3 and M4-M6 correspond to anterior, lateral, and posterior MCA territories within the insular ribbon and centrum semiovale, respectively. In patients with unilateral MCA occlusion, significant decreases in CBF were observed in the lesions in M1, M3, M5 and M6 regions, as well as in the contralateral M3 and M5 regions. The OEF of the lesion in the M1-M4 and M6 regions, and the contralateral M1-M3 regions were significantly higher. Additionally, the cerebral metabolic rate of oxygen (CMRO2) in the lesions of the M3 and M6 regions, and the contralateral M3 region, were significantly lower compared to the corresponding regions of healthy participants. For patients with bilateral MCA occlusion, the CMRO2 in the left M5 region and the right M3 and M6 regions were significantly lower than that in the corresponding regions of healthy participants. In conclusion, abnormal hemodynamics occur in the contralateral hemisphere of patients with unilateral MCA occlusion.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"271678X241276386"},"PeriodicalIF":4.9,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11572168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142004368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rethinking animal attrition in preclinical research: Expressing causal mechanisms of selection bias using directed acyclic graphs. 反思临床前研究中的动物自然减员：利用有向无环图表达选择偏差的因果机制。

IF 4.9 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2024-08-20 DOI: 10.1177/0271678X241275760

Anja Collazo, Hans-Georg Kuhn, Tobias Kurth, Marco Piccininni, Jessica L Rohmann

{"title":"Rethinking animal attrition in preclinical research: Expressing causal mechanisms of selection bias using directed acyclic graphs.","authors":"Anja Collazo, Hans-Georg Kuhn, Tobias Kurth, Marco Piccininni, Jessica L Rohmann","doi":"10.1177/0271678X241275760","DOIUrl":"10.1177/0271678X241275760","url":null,"abstract":"Animal attrition in preclinical experiments can introduce bias in the estimation of causal treatment effects, as the treatment-outcome association in surviving animals may not represent the causal effect of interest. This can compromise the internal validity of the study despite randomization at the outset. Directed Acyclic Graphs (DAGs) are useful tools to transparently visualize assumptions about the causal structure underlying observed data. By illustrating relationships between relevant variables, DAGs enable the detection of even less intuitive biases, and can thereby inform strategies for their mitigation. In this study, we present an illustrative causal model for preclinical stroke research, in which animal attrition induces a specific type of selection bias (i.e., collider stratification bias) due to the interplay of animal welfare, initial disease severity and negative side effects of treatment. Even when the treatment had no causal effect, our simulations revealed substantial bias across different scenarios. We show how researchers can detect and potentially mitigate this bias in the analysis phase, even when only data from surviving animals are available, if knowledge of the underlying causal process that gave rise to the data is available. Collider stratification bias should be a concern in preclinical animal studies with severe side effects and high post-randomization attrition.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"271678X241275760"},"PeriodicalIF":4.9,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11572016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142004369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0