小胶质细胞平衡大脑中的髓鞘增生和脱髓鞘。

IF 4.9 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2024-12-12 DOI:10.1177/0271678X241273623

Weijie Chen, Yueman Zhang, Peiying Li

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引用次数: 0

摘要

髓磷脂对神经元健康和中枢神经系统（CNS）功能至关重要。McNamara等人最近的研究强调了小胶质细胞在发育过程中紧实髓鞘的重要作用，它们的缺失会导致异常的少突胶质细胞簇和随后的认知障碍。本研究发现tgf - β1- tgf - β r1轴在小胶质细胞-少突胶质细胞通讯中的关键参与可以影响少突胶质细胞脂质代谢，从而调节髓磷脂完整性。需要进一步的探索来充分阐明小胶质细胞对髓鞘形成的双重影响，以及与其他胶质细胞的相互作用，以期发现髓鞘相关神经退行性疾病和中枢神经系统疾病的新靶点。

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Microglia balances hypermyelination and demyelination in the brain.

Myelin is crucial for neuron health and central nervous system (CNS) function. Recent research by McNamara et al. highlighted microglia's essential role in compacting the myelin sheath during development and their absence leads to aberrant oligodendrocyte clusters and subsequent cognitive impairment. The study revealed that the critical involvement of the TGFβ1-TGFβR1 axis in microglia-oligodendrocyte communication could influence the oligodendrocyte lipid metabolism and thereby regulate myelin integrity. Further exploration is needed to fully elucidate the dual impact of microglia on myelination, and interactions with other glial cells, holding promise for discovering new targets in myelin-related neurodegenerative and CNS disorders.

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来源期刊

Journal of Cerebral Blood Flow and Metabolism 医学-内分泌学与代谢

CiteScore

12.00

自引率

4.80%

发文量

300

审稿时长

3 months

期刊介绍： JCBFM is the official journal of the International Society for Cerebral Blood Flow & Metabolism, which is committed to publishing high quality, independently peer-reviewed research and review material. JCBFM stands at the interface between basic and clinical neurovascular research, and features timely and relevant research highlighting experimental, theoretical, and clinical aspects of brain circulation, metabolism and imaging. The journal is relevant to any physician or scientist with an interest in brain function, cerebrovascular disease, cerebral vascular regulation and brain metabolism, including neurologists, neurochemists, physiologists, pharmacologists, anesthesiologists, neuroradiologists, neurosurgeons, neuropathologists and neuroscientists.