Aging affects the mouse brain in a region-specific manner.

IF 4.9 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2024-10-18 DOI:10.1177/0271678X241289780

Ling Cai, Yueman Zhang, Yuxi Zhou, Xin Wang

引用次数: 0

Abstract

Aging-related cognitive decline is emerging as a health concern during the aging process of the global population. Hahn and colleagues found that glial aging was particularly accelerated in white matter compared to cortical regions. Specialized neuronal populations showed region-specific changes in gene expression. Acute dietary restriction triggers a reprogramming of genes associated with the circadian clock in glial cells, whereas injections of young mouse plasma selectively reverse age-related expression patterns. The discovery of region-specific aging could enhance our understanding of the aging process and offer new possibilities for innovative treatment strategies and interventions for cognitive impairments related to aging.

查看原文本刊更多论文

衰老以特定区域的方式影响小鼠大脑。

与衰老相关的认知能力下降正在成为全球人口老龄化过程中的一个健康问题。Hahn 及其同事发现，与皮质区域相比，白质区域的神经胶质老化尤其加速。特化的神经元群在基因表达方面出现了区域特异性变化。急性饮食限制会引发神经胶质细胞中与昼夜节律相关基因的重编程，而注射年轻小鼠血浆则会选择性地逆转与年龄相关的表达模式。区域特异性衰老的发现可以加深我们对衰老过程的理解，并为创新治疗策略和干预与衰老相关的认知障碍提供新的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Cerebral Blood Flow and Metabolism 医学-内分泌学与代谢

CiteScore

12.00

自引率

4.80%

发文量

300

审稿时长

3 months

期刊介绍： JCBFM is the official journal of the International Society for Cerebral Blood Flow & Metabolism, which is committed to publishing high quality, independently peer-reviewed research and review material. JCBFM stands at the interface between basic and clinical neurovascular research, and features timely and relevant research highlighting experimental, theoretical, and clinical aspects of brain circulation, metabolism and imaging. The journal is relevant to any physician or scientist with an interest in brain function, cerebrovascular disease, cerebral vascular regulation and brain metabolism, including neurologists, neurochemists, physiologists, pharmacologists, anesthesiologists, neuroradiologists, neurosurgeons, neuropathologists and neuroscientists.