Journal of Bone and Joint Infection最新文献

Effect of oral antibiotics after two-stage revision for periprosthetic joint infection on subsequent antibiotic resistance within a national cohort of United States veterans.

IF 1.8

Journal of Bone and Joint Infection Pub Date : 2025-02-04 eCollection Date: 2025-01-01 DOI: 10.5194/jbji-10-7-2025

Judd Payne, Jesse D Sutton, Brenna E Blackburn, Snehal Bansod, Hannah Imlay, Emily S Spivak, Jakrapun Pupaibool, Jeremy M Gililland, Laura K Certain

{"title":"Effect of oral antibiotics after two-stage revision for periprosthetic joint infection on subsequent antibiotic resistance within a national cohort of United States veterans.","authors":"Judd Payne, Jesse D Sutton, Brenna E Blackburn, Snehal Bansod, Hannah Imlay, Emily S Spivak, Jakrapun Pupaibool, Jeremy M Gililland, Laura K Certain","doi":"10.5194/jbji-10-7-2025","DOIUrl":"10.5194/jbji-10-7-2025","url":null,"abstract":"Background: Prior studies have indicated that administration of prolonged courses of oral antibiotics after Stage 2 reimplantation surgery for periprosthetic joint infection (PJI) results in a lower rate of recurrent PJI. However, there is concern that this antibiotic usage results in an increased risk of antibiotic resistance in any subsequent PJI that does occur. Methods: We retrospectively reviewed patients who underwent Stage 2 reimplantation surgery for PJI within the national Veterans Affairs hospital system of the United States. We compared those who received at least 2 weeks of oral antibiotics after Stage 2 reimplantation to those who did not. The primary outcome was the proportion of organisms resistant to four classes of antibiotics (tetracyclines, fluoroquinolones, oral beta-lactams, and sulfonamides) in recurrent PJI. Secondary outcomes included recurrent PJI and death. Results: Of the 605 patients who underwent Stage 2 reimplantation for PJI, 154 patients received at least 14 d of antibiotics after surgery and 451 patients did not. Bacteria causing recurrent PJI in patients who received prolonged antibiotics were more likely to be resistant to tetracyclines and trimethoprim-sulfamethoxazole but not oral beta-lactams or fluoroquinolones. There was no difference in risk of recurrent PJI or death between the two groups. Conclusions: Prolonged oral antibiotic treatment after Stage 2 reimplantation increases the risk of antibiotic resistance to some antibiotics in subsequent PJI. We recommend further research to identify the best choice of antibiotic and duration after Stage 2 reimplantation, to maximize benefits while minimizing risks.","PeriodicalId":15271,"journal":{"name":"Journal of Bone and Joint Infection","volume":"10 1","pages":"7-14"},"PeriodicalIF":1.8,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing cross-disciplinarity in bone and joint infection science using the COMBINE approach: an example from Denmark.

IF 1.8

Journal of Bone and Joint Infection Pub Date : 2025-01-09 eCollection Date: 2025-01-01 DOI: 10.5194/jbji-10-1-2025

Louise Kruse Jensen, Thomas Bjarnsholt, Hans Gottlieb, Mats Bue

引用次数: 0

A case report of fracture-related infection with Metamycoplasma hominis in an immunocompetent patient.

IF 1.8

Journal of Bone and Joint Infection Pub Date : 2024-12-05 eCollection Date: 2024-01-01 DOI: 10.5194/jbji-9-271-2024

Karishma Gokani, Prabu Balasubramanian, Edward Matthews, Dunisha Samarasinghe

引用次数: 0

Exploring the potential of naturally occurring antimicrobials for managing orthopedic-device-related infections. 探索天然抗菌剂在控制骨科器械相关感染方面的潜力。

IF 1.8

Journal of Bone and Joint Infection Pub Date : 2024-10-31 eCollection Date: 2024-01-01 DOI: 10.5194/jbji-9-249-2024

Baixing Chen, T Fintan Moriarty, Hans Steenackers, Georges F Vles, Jolien Onsea, Thijs Vackier, Isabel Spriet, Rob Lavigne, R Geoff Richards, Willem-Jan Metsemakers

{"title":"Exploring the potential of naturally occurring antimicrobials for managing orthopedic-device-related infections.","authors":"Baixing Chen, T Fintan Moriarty, Hans Steenackers, Georges F Vles, Jolien Onsea, Thijs Vackier, Isabel Spriet, Rob Lavigne, R Geoff Richards, Willem-Jan Metsemakers","doi":"10.5194/jbji-9-249-2024","DOIUrl":"10.5194/jbji-9-249-2024","url":null,"abstract":"Orthopedic-device-related infections (ODRIs) are challenging clinical complications that are often exacerbated by antibiotic resistance and biofilm formation. This review explores the efficacy of naturally occurring antimicrobials - including agents sourced from bacteria, fungi, viruses, animals, plants and minerals - against pathogens common in ODRIs. The limitations of traditional antibiotic agents are presented, and innovative naturally occurring antimicrobials, such as bacteriophage therapy and antimicrobial peptides, are evaluated with respect to their interaction with conventional antibiotics and antibiofilm efficacy. The integration of these natural agents into clinical practice could revolutionize ODRI treatment strategies, offering effective alternatives to conventional antibiotics and mitigating resistance development. However, the translation of these compounds from research into the clinic may require the substantial investment of intellectual and financial resources.","PeriodicalId":15271,"journal":{"name":"Journal of Bone and Joint Infection","volume":"9 5","pages":"249-260"},"PeriodicalIF":1.8,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11555427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A combined debridement, antibiotics, and implant retention (DAIR) procedure with flap coverage for acute soft tissue defects following total knee arthroplasty: a retrospective study. 针对全膝关节置换术后急性软组织缺损的皮瓣覆盖联合清创、抗生素和植入物保留（DAIR）术：一项回顾性研究。

IF 1.8

Journal of Bone and Joint Infection Pub Date : 2024-10-29 eCollection Date: 2024-01-01 DOI: 10.5194/jbji-9-241-2024

Laia Boadas-Gironès, Marta Sabater-Martos, Marc Ferrer-Banus, Àlex Soriano-Viladomiu, Juan Carlos Martínez-Pastor

{"title":"A combined debridement, antibiotics, and implant retention (DAIR) procedure with flap coverage for acute soft tissue defects following total knee arthroplasty: a retrospective study.","authors":"Laia Boadas-Gironès, Marta Sabater-Martos, Marc Ferrer-Banus, Àlex Soriano-Viladomiu, Juan Carlos Martínez-Pastor","doi":"10.5194/jbji-9-241-2024","DOIUrl":"10.5194/jbji-9-241-2024","url":null,"abstract":"Acute soft tissue defects, such as persistent drainage, wound dehiscence, or necrosis, following total knee arthroplasty (TKA) can lead to the devastating complication of deep infection. Typically, when a medium-sized defect is present, a gastrocnemius flap is widely employed for soft tissue reconstruction due to its low morbidity and favourable functional outcomes. When facing this situation, we should consider associating the coverage treatment with a debridement, antibiotics, and implant retention (DAIR) surgery procedure, in order to treat a possible acute infection, even when the diagnosis of infection is not clear. We performed a retrospective study to compare TKA outcomes in patients with DAIR and flap procedures in the same surgical act against those who had received an isolated flap procedure for soft tissue reconstruction after an acute surgical wound defect. Patients had been identified from a prospectively collated TKA database. Between 2005 and 2021, 18 patients met our inclusion criteria, with a mean follow-up of approximately 8 years. A medial gastrocnemius flap procedure was performed for 15 patients (83 %). We compared the rates of infection clearance between the two groups. No differences in comorbidities or risk factors were observed between both groups. In the combination treatment group, 66.6 % of patients healed after treatment compared to 33.3 % in the isolated flap group. Although no significant statistical differences were found, the association of DAIR with the muscle flap procedure is highly recommended in the treatment of acute soft tissue defects after TKA. Further studies with larger sample sizes are necessary to extrapolate these findings to the general population.","PeriodicalId":15271,"journal":{"name":"Journal of Bone and Joint Infection","volume":"9 5","pages":"241-248"},"PeriodicalIF":1.8,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11554718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predicting periprosthetic joint infection: external validation of preoperative prediction models. 假体周围关节感染的预测：术前预测模型的外部验证。

IF 1.8

Journal of Bone and Joint Infection Pub Date : 2024-10-25 eCollection Date: 2024-01-01 DOI: 10.5194/jbji-9-231-2024

Seung-Jae Yoon, Paul C Jutte, Alex Soriano, Ricardo Sousa, Wierd P Zijlstra, Marjan Wouthuyzen-Bakker

{"title":"Predicting periprosthetic joint infection: external validation of preoperative prediction models.","authors":"Seung-Jae Yoon, Paul C Jutte, Alex Soriano, Ricardo Sousa, Wierd P Zijlstra, Marjan Wouthuyzen-Bakker","doi":"10.5194/jbji-9-231-2024","DOIUrl":"10.5194/jbji-9-231-2024","url":null,"abstract":"Introduction: Prediction models for periprosthetic joint infections (PJIs) are gaining interest due to their potential to improve clinical decision-making. However, their external validity across various settings remains uncertain. This study aimed to externally validate promising preoperative PJI prediction models in a recent multinational European cohort. Methods: Three preoperative PJI prediction models - by Tan et al. (2018), Del Toro et al. (2019), and Bülow et al. (2022) - that have previously demonstrated high levels of accuracy were selected for validation. A retrospective observational analysis of patients undergoing total hip arthroplasty (THA) and total knee arthroplasty (TKA) at centers in the Netherlands, Portugal, and Spain between January 2020 and December 2021 was conducted. Patient characteristics were compared between our cohort and those used to develop the models. Performance was assessed through discrimination and calibration. Results: The study included 2684 patients, 60 of whom developed a PJI (2.2 %). Our cohort differed from the models' original cohorts with respect to demographic variables, procedural variables, and comorbidity prevalence. The overall accuracies of the models, measured with the <math><mi>c</mi></math> statistic, were 0.72, 0.69, and 0.72 for the Tan, Del Toro, and Bülow models, respectively. Calibration was reasonable, but the PJI risk estimates were most accurate for predicted infection risks below 3 %-4 %. The Tan model overestimated PJI risk above 4 %, whereas the Del Toro model underestimated PJI risk above 3 %. Conclusions: The Tan, Del Toro, and Bülow PJI prediction models were externally validated in this multinational cohort, demonstrating potential for clinical application in identifying high-risk patients and enhancing preoperative counseling and prevention strategies.","PeriodicalId":15271,"journal":{"name":"Journal of Bone and Joint Infection","volume":"9 5","pages":"231-239"},"PeriodicalIF":1.8,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11554715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glenohumeral joint septic arthritis and osteomyelitis caused by Moraxella catarrhalis after arthroscopic rotator cuff repair: case report and literature review. 关节镜下肩袖修复术后莫拉菌引起的盂肱关节化脓性关节炎和骨髓炎：病例报告和文献综述。

IF 1.8

Journal of Bone and Joint Infection Pub Date : 2024-10-18 eCollection Date: 2024-01-01 DOI: 10.5194/jbji-9-225-2024

Yong-Beom Kim, Jinjae Kim, Min Gon Song, Tae Hyong Kim, Tae-Yoon Choi, Gi-Won Seo

引用次数: 0

Yield of routine mycobacterial culture of osteoarticular specimens in a tertiary orthopaedic hospital in England, 2017-2022. 2017-2022 年英国一家三级骨科医院骨关节标本的常规霉菌培养产量。

IF 1.8

Journal of Bone and Joint Infection Pub Date : 2024-10-17 eCollection Date: 2024-01-01 DOI: 10.5194/jbji-9-217-2024

Tom A Yates, Olivier Vahesan, Simon Warren, Antonia Scobie

{"title":"Yield of routine mycobacterial culture of osteoarticular specimens in a tertiary orthopaedic hospital in England, 2017-2022.","authors":"Tom A Yates, Olivier Vahesan, Simon Warren, Antonia Scobie","doi":"10.5194/jbji-9-217-2024","DOIUrl":"10.5194/jbji-9-217-2024","url":null,"abstract":"Introduction: At our tertiary orthopaedic centre, mycobacterial cultures are routinely performed on bone and joint samples sent for bacterial culture. Methods: From laboratory records, we ascertained the number of mycobacterial cultures performed, the number positive for Mycobacterium tuberculosis complex (MTBC) and/or non-tuberculous mycobacteria (NTM), and the characteristics of individuals from whom mycobacteria were isolated. We collected the same data from 100 individuals with negative mycobacterial cultures. Results: Excluding sample types that were not bone or joint samples, 6162 mycobacterial cultures were performed between 4 July 2017 and 30 September 2022. A total of 22 patients had MTBC and 6 patients had NTM newly isolated from bone or joint samples placed in mycobacterial culture, while a further 1 patient had both Mycobacterium tuberculosis and Mycobacterium avium isolated. To identify one new mycobacterial infection of bone or joint (MTBC or NTM) that would not have been detected with routine bacterial cultures alone, 229 (95 % CI of 158-347) mycobacterial cultures were needed. Mycobacterial cultures were much less likely to be positive in samples taken from prosthetic joints. They were more likely to be positive in spinal samples and in samples taken from patients with suspected sarcoma. In patients from whom MTBC had been isolated, granulomatous inflammation was reported in 86 % (18 of 21) of contemporaneous histological specimens. Conclusions: Targeted, rather than routine, mycobacterial culture of bone and joint specimens should be considered in settings with a low burden of tuberculosis.","PeriodicalId":15271,"journal":{"name":"Journal of Bone and Joint Infection","volume":"9 5","pages":"217-223"},"PeriodicalIF":1.8,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11554712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of rezafungin in a case of Candida spondylodiskitis. 雷扎芬净对一例念珠菌性脊柱盘根炎的疗效。

IF 1.8

Journal of Bone and Joint Infection Pub Date : 2024-10-07 eCollection Date: 2024-01-01 DOI: 10.5194/jbji-9-213-2024

Marin Lahouati, Claire Tinévez, Frédéric Gabriel, Fabien Xuereb, Maxime Lefranc, Frédéric-Antoine Dauchy

引用次数: 0

Musculoskeletal infections associated with Nocardia species: a case series. 与诺卡菌相关的肌肉骨骼感染：病例系列。

IF 1.8

Journal of Bone and Joint Infection Pub Date : 2024-09-24 eCollection Date: 2024-01-01 DOI: 10.5194/jbji-9-207-2024

Ryan B Khodadadi, Jack W McHugh, Supavit Chesdachai, Nancy L Wengenack, Wendelyn Bosch, Maria Teresa Seville, Douglas R Osmon, Elena Beam, Zachary A Yetmar

{"title":"Musculoskeletal infections associated with Nocardia species: a case series.","authors":"Ryan B Khodadadi, Jack W McHugh, Supavit Chesdachai, Nancy L Wengenack, Wendelyn Bosch, Maria Teresa Seville, Douglas R Osmon, Elena Beam, Zachary A Yetmar","doi":"10.5194/jbji-9-207-2024","DOIUrl":"10.5194/jbji-9-207-2024","url":null,"abstract":"Background: Nocardia is an uncommon pathogen that has been reported to infect musculoskeletal structures. However, studies are largely limited to case reports, and little is known regarding management and outcomes of these infections. Methods: We performed a multicenter retrospective cohort study of adults with culture-confirmed musculoskeletal Nocardia infections at three Mayo Clinic centers in Arizona, Florida, and Minnesota from November 2011 through April 2022. Results: Nine cases of Nocardia musculoskeletal infection were identified. Seven (78 %) occurred in men, and the median age was 57.3 years (range 32.6-79.0). Specific infections included native joint septic arthritis with or without associated osteomyelitis ( <math><mrow><mi>N</mi> <mo>=</mo> <mn>3</mn></mrow> </math> ), hardware-associated infection ( <math><mrow><mi>N</mi> <mo>=</mo> <mn>1</mn></mrow> </math> ), sternal osteomyelitis ( <math><mrow><mi>N</mi> <mo>=</mo> <mn>1</mn></mrow> </math> ), pyomyositis ( <math><mrow><mi>N</mi> <mo>=</mo> <mn>2</mn></mrow> </math> ), bursitis ( <math><mrow><mi>N</mi> <mo>=</mo> <mn>1</mn></mrow> </math> ), and tenosynovitis ( <math><mrow><mi>N</mi> <mo>=</mo> <mn>1</mn></mrow> </math> ). Three cases (33 %) were associated with disseminated disease, all three occurring in solid organ transplant recipients. Surgical intervention was performed in all but the bursitis case. Length of treatment varied from 21 d for tenosynovitis to 467 d for osteomyelitis. The 1-year mortality was 22 %, and all fatal cases involved disseminated disease. Conclusion: Patients with localized nocardiosis affecting musculoskeletal structures generally have good outcomes, as opposed to those with disseminated infection. Management often required operative intervention, with one patient experiencing recurrence within 1 year.","PeriodicalId":15271,"journal":{"name":"Journal of Bone and Joint Infection","volume":"9 5","pages":"207-212"},"PeriodicalIF":1.8,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11554716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0