Journal of Bone and Joint Infection最新文献

{"title":"Comparison of surgical treatments for hip and knee periprosthetic joint infections using the desirability of outcome ranking in a prospective multicentre study.","authors":"Brenton P Johns, Mark R Loewenthal, David C Dewar, Laurens A Manning, Joshua S Davis","doi":"10.5194/jbji-10-73-2025","DOIUrl":"https://doi.org/10.5194/jbji-10-73-2025","url":null,"abstract":"<p><p><b>Introduction</b>: In periprosthetic joint infection (PJI), there is a paucity of prospective data comparing debridement, antibiotics and implant retention (DAIR) with two-stage revision while also accounting for time since the initial arthroplasty. Additionally, comparisons often lack patient-centred measures. A desirability of outcome ranking for PJI (DOOR-PJI) unifies joint function, infection cure and mortality into one outcome. We aimed to describe the DOOR-PJI distribution in a large patient cohort and use it to compare DAIR and two-stage revision. <b>Methods</b>: Adults with a newly diagnosed hip or knee PJI from the prospective Prosthetic joint Infection in Australia and New Zealand Observational (PIANO) study were analysed. Patients from 27 hospitals were included. PJI was classified as \"early\" or \"late\". The primary outcome was the novel DOOR-PJI at the 2-year follow-up. Results were expressed using win ratio (WR) values. A WR <math><mo>></mo></math> 1.0 indicates that two-stage revision was superior to DAIR. <b>Results</b>: A DOOR was available for 533 patients. The most common treatments were DAIR (297 patients, 56 %) and two-stage revision (139 patients, 26 %). In early PJI, DAIR was superior to two-stage revision (WR 0.51, 95 % confidence interval (CI) [0.30-0.86], <math><mrow><mi>p</mi> <mo>=</mo></mrow> </math> 0.012). In late PJI, two-stage revision was superior to DAIR (WR 1.61, 95 % CI [1.11-2.33], <math><mrow><mi>p</mi> <mo>=</mo></mrow> </math> 0.012). These findings persisted following stratification by comorbidities, affected joint, symptom duration and a sensitivity analysis applying the initial (rather than the main) surgical strategy at day 90. <b>Conclusions</b>: In the first application of a DOOR in orthopaedics, DAIR was superior to two-stage revision for early PJI. Conversely, two-stage revision was superior compared with DAIR for late PJI. These findings were independent of comorbidities and symptom duration.</p>","PeriodicalId":15271,"journal":{"name":"Journal of Bone and Joint Infection","volume":"10 2","pages":"73-84"},"PeriodicalIF":1.8,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12015177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-centre evaluation of Gram stain in the diagnosis of septic arthritis.","authors":"Charlotte Smith, Robert J Maloney, Deborah Wearmouth, Hemant Sharma, Kordo Saeed, Nusreen Ahmad-Saeed, Rachel Annett, Lucinda Barrett, Sara E Boyd, Peter Davies, Harriet Hughes, Gwennan Jones, Laura Leach, Maureen Lynch, Deepa Nayar, Martin Marsh, Shanine Mitchell, Lynn Moffat, Luke S P Moore, Michael E Murphy, Shaan Ashk O'Shea, Teresa Peach, Christina Petridou, Niamh Reidy, Ben Talbot, Catherine Aldridge, Gavin Barlow","doi":"10.5194/jbji-10-61-2025","DOIUrl":"https://doi.org/10.5194/jbji-10-61-2025","url":null,"abstract":"<p><p><b>Introduction</b>: Gram stain of synovial fluid is a rapid test for the diagnosis of native joint septic arthritis. Single-centre studies have suggested Gram stain will miss a considerable proportion of patients who are subsequently synovial-fluid-culture-positive or polymerase chain reaction (PCR)-positive. The object of this study was to reassess Gram stain in a large, multi-centre cohort of patients from the United Kingdom (UK) and Ireland. <b>Methods</b>: The study was a retrospective analysis combining two large datasets. We defined septic arthritis microbiologically as at least one positive joint aspirate culture and/or PCR test. \"Best case\" and \"worst case\" definitions were applied depending on the likelihood organisms were true infecting pathogens. <b>Results</b>: Gram stain missed a high proportion of culture-/PCR-positive patients using both the best (74 % missed) and worst (81 % missed) case definitions. Using the best case definition, the sensitivity of Gram stain was 0.26, specificity 0.99, positive predictive value 0.84, negative predictive value 0.87, accuracy 0.87, and area under the receiver operator curve 0.62 (95 % CI 0.57 to 0.68, <math><mrow><mi>p</mi> <mo><</mo> <mn>0.001</mn></mrow> </math> ). False positive Gram stains were infrequent (1 %). Age, joint involved, and other synovial fluid characteristics were less predictive of a positive culture/PCR than Gram stain. <b>Conclusions</b>: While a positive synovial fluid Gram stain should always be considered to indicate potential septic arthritis, a negative Gram stain, regardless of synovial fluid crystals or white cell count, should not be used to rule out septic arthritis. The value of Gram stain as an urgent out-of-hours test for septic arthritis is open to considerable debate.</p>","PeriodicalId":15271,"journal":{"name":"Journal of Bone and Joint Infection","volume":"10 2","pages":"61-71"},"PeriodicalIF":1.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12050984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative antibiotic treatment does not lower re-revision rate in presumed aseptic hip and knee revision arthroplasties with unexpected positive intraoperative cultures - a matched cohort study.","authors":"Sebastian Simon, Marjan Wouthuyzen-Bakker, Susana Gardete Hartmann, Jennyfer A Mitterer, Sujeesh Sebastian, Stephanie Huber, Bernhard J H Frank, Jochen G Hofstaetter","doi":"10.5194/jbji-10-51-2025","DOIUrl":"10.5194/jbji-10-51-2025","url":null,"abstract":"<p><p><b>Aims</b>: It remains unclear if postoperative antibiotic (AB) treatment is advantageous in presumed aseptic revision arthroplasties of the hip (rTHA) and knee (rTKA) with unexpected positive intraoperative cultures (UPIC). The aim of this study is to evaluate if there is a difference in the re-revision rate in patients with UPIC when treated with postoperative AB or when postoperative AB is withheld. <b>Methods</b>: In this retrospective matched cohort study we compared the re-revision rates in rTHA and rTKA with (AB group: 45 rTHA, 25 rTKA) and without (non-AB group: 45 rTHA, 25 rTKA) AB treatment in patients with UPIC. Baseline covariates for matching were the microorganism (likely or not likely to be a contaminant), patient demographics, joint, revision type, surgical site infection score, American Society of Anesthesiologists classification, serum C-reactive protein (CRP). <b>Results</b>: After a median follow-up of 4.1 (inter-quartile range, IQR: 2.9-5.5) years after rTHA and rTKA, the re-revision rate between the AB group and the non-AB group was 14.3 % versus 15.7 % (<i>P</i>=0.81). In the AB group, 4.3 % (3/70) of patients underwent revision due to septic complications compared to 5.7 % (4/70) in the non-AB group (<i>P</i>=0.69). None of the patients were diagnosed with a confirmed periprosthetic joint infection (PJI) according to the PJI diagnostic criteria of European Bone and Joint Infection Society (EBJIS). In 22/70 (31.4 %) of the patients in the AB group and in 15/70 (21.4 %) of the patients in the non-AB group, a diagnosis of \"infection likely\" was made according to the EBJIS criteria (<i>P</i>=0.18). All UPICs with low virulent microorganisms were considered to be contamination (coagulase-negative <i>Staphylococci</i>; <i>Corynebacterium</i>; anaerobic Gram-positive bacilli and cocci, e.g., <i>Finegoldia magna</i>, <i>Cutibacterium acnes</i>). <b>Conclusion</b>: Postoperative AB treatment did not result in a decreased re-revision rate in patients with UPIC in presumed aseptic rTHA and rTKA. Patients diagnosed with pathogens classified as a likely contaminant can be safely ignored.</p>","PeriodicalId":15271,"journal":{"name":"Journal of Bone and Joint Infection","volume":"10 2","pages":"51-59"},"PeriodicalIF":1.8,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synovial glucose and serum-to-synovial-glucose ratio perform better than other biomarkers for the diagnosis of acute postoperative prosthetic knee infection.","authors":"Marta Sabater-Martos, Oscar Garcia, Laia Boadas, Laura Morata, Alex Soriano, Juan Carlos Martínez-Pastor","doi":"10.5194/jbji-10-41-2025","DOIUrl":"10.5194/jbji-10-41-2025","url":null,"abstract":"<p><p><b>Introduction</b>: In native septic arthritis, synovial glucose is a well-established diagnostic marker. However, its diagnostic utility in periprosthetic joint infection (PJI) remains unexplored. Given the diagnostic challenges of acute postoperative PJI, we hypothesized that synovial glucose could serve as a valuable biomarker and aimed to evaluate its diagnostic accuracy. <b>Material and methods</b>:  This is a retrospective diagnostic study in acute postoperative PJI in total knee arthroplasty (TKA). We reviewed all TKA surgeries performed in the past 10 years and cross-checked those patients that consulted to our emergency room during the first 90 d after TKA surgery for knee-related symptoms. We calculated the serum-to-synovial-glucose ratio for each patient (serum-to-synovial-glucose ratio = [(serological glucose - synovial glucose) / serological glucose]), and we formed the receiver operating characteristic (ROC) curves for synovial glucose, serum-to-synovial-glucose ratio, serum C-reactive protein (CRP), synovial white blood cell (s-WBC) count, and polymorphonuclear cell percentage (PMN%); then we extracted the optimal cutoff values. <b>Results</b>: The optimal cutoffs for diagnosing acute postoperative PJI were < 44 mg dL^-1 for synovial glucose and > 0.69 for serum-to-synovial-glucose ratio. The area under the curve (AUC) values were 0.861 and 0.889, respectively. ROC curves for serum CRP, s-WBC count, and PMN% showed AUC values of 0.69, 0.714, and 0.66, respectively. The combined ROC curve analysis for serum CRP, s-WBC count, and PMN% showed an AUC of 0.722. When adding synovial glucose, the AUC was 0.859 and with serum-to-synovial-glucose ratio we achieved an AUC of 0.876. <b>Conclusion</b>: Synovial glucose and serum-to-synovial-glucose ratio demonstrated good diagnostic potential for acute postoperative PJI following TKA. These biomarkers exhibited superior accuracy compared to the combination of serum CRP, s-WBC count, and PMN%.</p>","PeriodicalId":15271,"journal":{"name":"Journal of Bone and Joint Infection","volume":"10 2","pages":"41-49"},"PeriodicalIF":1.8,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rethinking antibiotic prophylaxis in orthopaedic oncology: insights from a cohort study of endoprosthetic infections.","authors":"Tariq Azamgarhi, Craig Gerrand, Simon Warren","doi":"10.5194/jbji-10-33-2025","DOIUrl":"https://doi.org/10.5194/jbji-10-33-2025","url":null,"abstract":"<p><p><b>Introduction</b>: Endoprosthetic replacement (EPR) is the preferred limb salvage method for musculoskeletal tumours involving bone; however, infection rates range from 8 % to 12 %. We investigated the impact of antibiotic prophylaxis at primary implantation on the development of prosthetic joint infection (PJI). <b>Methods</b>: We conducted a retrospective analysis of patients who underwent primary EPRs between 2010 and 2021. Prosthetic joint infections were identified and classified according to criteria from the European Bone and Joint Infection Society (EBJIS). The follow-up period extended until an infection was identified, subsequent surgery for non-infectious reasons occurred or the last known follow-up was conducted. For all primary procedures, we collected details of postoperative complications at the surgical site, including superficial wound infections, delayed wound healing and wound dehiscence. PJIs were divided into two groups. The first group included patients with an uncomplicated postoperative course, while the second comprised those with either postoperative wound problems or infections from an identifiable source. <b>Results</b>: Out of 1064 patients, 73 (6.9 %) developed PJI within a median follow-up of 25.6 months (IQR 8.8-52.7). A total of 26 % of PJIs were attributed to primary implantation, while 74 % of PJIs were due to secondary causes, with 47 % having wound complications and 27 % presenting acutely. The microbiological profiles between groups differed significantly, with infections from skin flora related to primary implantation and a high proportion of other bacteria (Gram-negatives and enterococci) linked to secondary infections. <b>Conclusions</b>: Skin flora are likely responsible for infections related to the primary procedure, and antibiotic prophylaxis should be optimised accordingly. Additional measures are needed to prevent secondary infections.</p>","PeriodicalId":15271,"journal":{"name":"Journal of Bone and Joint Infection","volume":"10 1","pages":"33-39"},"PeriodicalIF":1.8,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12050981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ten years of experience with elbow native joint arthritis: a multicenter retrospective cohort study.","authors":"Pansachee Damronglerd, Ryan Bijan Khodadadi, Said El Zein, Jack William McHugh, Omar M Abu Saleh, Mark Edward Morrey, Aaron Joseph Tande, Gina Ann Suh","doi":"10.5194/jbji-10-25-2025","DOIUrl":"10.5194/jbji-10-25-2025","url":null,"abstract":"<p><p><b>Background</b>: Elbow native joint septic arthritis (NJSA) is a rare condition, constituting 6 %-9 % of all native septic arthritis cases. It is associated with elevated mortality and morbidity. This study aims to clarify the characteristics, management, and outcomes of elbow NJSA. <b>Methods</b>: We retrospectively analyzed adults diagnosed with elbow NJSA who underwent surgical intervention at Mayo Clinic facilities from January 2012 to December 2021. Diagnosis relied on clinical presentation, synovial fluid white blood cell (WBC) count, and aspiration or operative cultures. <b>Results</b>: Among 557 patients with NJSA during the study time frame, 19 (3.4 %) were found to have elbow NJSA. The median age of these patients was 64 years. Joint aspirations were conducted in 16 cases (84.2 %). The median synovial fluid WBC count was 43 139 cells mm^-3. Crystals were observed in three patients (15.8 %). Synovial fluid and operative tissue samples revealed 12.5 % and 20 % positive Gram stains, mostly indicating Gram-positive cocci clusters. Open arthrotomy (72.2 %) was the predominant surgical approach, and three patients (16.7 %) required reoperation within 90 d. The median antimicrobial therapy duration was 30 d (interquartile range: 22-44 d). Non-tuberculosis mycobacterium (NTM) was detected in two patients, with a treatment duration of 274 and 374 d, respectively. Complications included joint contracture and joint resection. <b>Conclusions</b>: Elbow NJSA is an infrequent condition associated with significant complications, such as the necessity for reoperation. Although the synovial fluid WBC count, crystals, and Gram stain positivity were less helpful for diagnosis in this study, positive Gram stain and culture results from operative tissue specimens demonstrated greater effectiveness in diagnosing elbow NJSA.</p>","PeriodicalId":15271,"journal":{"name":"Journal of Bone and Joint Infection","volume":"10 1","pages":"25-31"},"PeriodicalIF":1.8,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11911934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mid-term to long-term outcome and risk factors for failure of 158 hips with two-stage revision for periprosthetic hip joint infection.","authors":"Moatasem Abuelnour, Conor McNamee, Abdul Basit Rafi, Wolf Hohlbein, Peter Keogh, James Cashman","doi":"10.5194/jbji-10-15-2025","DOIUrl":"https://doi.org/10.5194/jbji-10-15-2025","url":null,"abstract":"<p><p><b>Introduction</b>: This study aimed to evaluate infection-free survival and outcomes after two-stage revision surgery for hip periprosthetic joint infection (PJI) performed in a specialised arthroplasty unit over 20 years. <b>Methods</b>: We retrospectively identified 158 hips (154 patients) treated with two-stage revision surgery for hip PJI between 2001 and 2021. We analysed their data and presented their infection-free survival, re-operation rate, mortality, risk factors and complications. <b>Results</b>: The mean follow-up time was 9 (2 to 21.7) years. A total of 22 hips (13.9 %) were re-infected. The infection-free survival was 94.4 % at 2 years, 89.3 % at 5 years, 84.2 % at 10 years, and 82.6 % at 15 and 20 years. The re-operation rate for aseptic causes was 12 %, and the most common cause of re-operation was dislocation (7 %). The cumulative survival for re-operation for aseptic causes was 93.6 % at 2 years, 89.7 % at 5 years, 88.8 % at 10 years, and 82.8 % at 15 and 20 years. The cumulative survival for all-cause re-revision was 88.8 % at 2 years, 80.8 % at 5 years, 74.9 % at 10 years, and 68 % at 15 and 20 years. The mean Western Ontario and McMaster Universities Arthritis Index (WOMAC) hip score significantly improved from 68.3 at the pre-operative stage to 35.9 at 2.1 (2 to 3.3) years, 35.3 at 5.3 (5 to 8.4) years, 38.3 at 11.3 (10-15) years and 43.8 at 18.7 (16.5 to 21.7) years ( <math><mrow><mi>p</mi> <mo><</mo> <mn>0.01</mn></mrow> </math> ). Duration of antibiotics and gram-negative infection were the only predictive risk factors for re-infection. <b>Conclusion</b>: Our results of the two-stage revision protocol for hip PJI were satisfactory and comparable with the best reported outcomes.</p>","PeriodicalId":15271,"journal":{"name":"Journal of Bone and Joint Infection","volume":"10 1","pages":"15-24"},"PeriodicalIF":1.8,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12050983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of oral antibiotics after two-stage revision for periprosthetic joint infection on subsequent antibiotic resistance within a national cohort of United States veterans.","authors":"Judd Payne, Jesse D Sutton, Brenna E Blackburn, Snehal Bansod, Hannah Imlay, Emily S Spivak, Jakrapun Pupaibool, Jeremy M Gililland, Laura K Certain","doi":"10.5194/jbji-10-7-2025","DOIUrl":"10.5194/jbji-10-7-2025","url":null,"abstract":"<p><p><b>Background</b>: Prior studies have indicated that administration of prolonged courses of oral antibiotics after Stage 2 reimplantation surgery for periprosthetic joint infection (PJI) results in a lower rate of recurrent PJI. However, there is concern that this antibiotic usage results in an increased risk of antibiotic resistance in any subsequent PJI that does occur. <b>Methods</b>: We retrospectively reviewed patients who underwent Stage 2 reimplantation surgery for PJI within the national Veterans Affairs hospital system of the United States. We compared those who received at least 2 weeks of oral antibiotics after Stage 2 reimplantation to those who did not. The primary outcome was the proportion of organisms resistant to four classes of antibiotics (tetracyclines, fluoroquinolones, oral beta-lactams, and sulfonamides) in recurrent PJI. Secondary outcomes included recurrent PJI and death. <b>Results</b>: Of the 605 patients who underwent Stage 2 reimplantation for PJI, 154 patients received at least 14 d of antibiotics after surgery and 451 patients did not. Bacteria causing recurrent PJI in patients who received prolonged antibiotics were more likely to be resistant to tetracyclines and trimethoprim-sulfamethoxazole but not oral beta-lactams or fluoroquinolones. There was no difference in risk of recurrent PJI or death between the two groups. <b>Conclusions</b>: Prolonged oral antibiotic treatment after Stage 2 reimplantation increases the risk of antibiotic resistance to some antibiotics in subsequent PJI. We recommend further research to identify the best choice of antibiotic and duration after Stage 2 reimplantation, to maximize benefits while minimizing risks.</p>","PeriodicalId":15271,"journal":{"name":"Journal of Bone and Joint Infection","volume":"10 1","pages":"7-14"},"PeriodicalIF":1.8,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing cross-disciplinarity in bone and joint infection science using the COMBINE approach: an example from Denmark.","authors":"Louise Kruse Jensen, Thomas Bjarnsholt, Hans Gottlieb, Mats Bue","doi":"10.5194/jbji-10-1-2025","DOIUrl":"10.5194/jbji-10-1-2025","url":null,"abstract":"<p><p>In 2018, the Centrum fOr translational Medicine on Bone and joint INfEctions (COMBINE) was created to facilitate collaboration among Danish scientists and researchers dedicated to bone and joint infection research. The COMBINE approach was developed to ensure successful collaboration, and this publication aims to share this successful approach.</p>","PeriodicalId":15271,"journal":{"name":"Journal of Bone and Joint Infection","volume":"10 1","pages":"1-5"},"PeriodicalIF":1.8,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case report of fracture-related infection with <i>Metamycoplasma hominis</i> in an immunocompetent patient.","authors":"Karishma Gokani, Prabu Balasubramanian, Edward Matthews, Dunisha Samarasinghe","doi":"10.5194/jbji-9-271-2024","DOIUrl":"10.5194/jbji-9-271-2024","url":null,"abstract":"<p><p>We report a case of post-traumatic <i>Metamycoplasma hominis</i> fracture-related infection of the right femur in a young male with no identified immunodeficiency. Treatment required multiple washouts and femoral nail revision, combined with 10 weeks of treatment with doxycycline and clindamycin.</p>","PeriodicalId":15271,"journal":{"name":"Journal of Bone and Joint Infection","volume":"9 6","pages":"271-275"},"PeriodicalIF":1.8,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11799765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}