Journal of Cardiovascular Magnetic Resonance最新文献

{"title":"Factors influencing image quality in fetal cardiovascular magnetic resonance cine imaging using Doppler ultrasound gating: A multicenter study.","authors":"Thomas M Vollbrecht, Luis F Goncalves, Dianna M E Bardo, Christopher Hart, Heide Boeth, Alex J Barker, Richard M Friesen, Julian A Luetkens","doi":"10.1016/j.jocmr.2025.101875","DOIUrl":"10.1016/j.jocmr.2025.101875","url":null,"abstract":"<p><strong>Background: </strong>Fetal cine cardiovascularmagnetic resonance (CMR) is an emerging technique for evaluating the fetal heart in conditions such as congenital heart disease, but limited evidence on factors affecting image quality restricts its clinical potential. This study investigated key determinants of image quality in a multicenter cohort.</p><p><strong>Methods: </strong>This study analyzed fetal CMR scans from April 2021 to July 2023 at three centers (University Hospital Bonn, Children's Hospital Colorado, Phoenix Children's Hospital). Cine image quality was assessed using a 5-point Likert scale (1=non-diagnostic to 5=excellent) across three criteria as follows: contour sharpness, blood-to-structure contrast, and artifacts. Overall image quality scores were calculated by the average of all criteria. Apparent signal-to-noise (aSNR) and contrast-to-noise ratios (aCNR) were measured. Nine parameters were evaluated for their impact on image quality, namely: gestational age, body mass index (BMI), fetal motion, patient positioning, gating signal stability, breathing technique, field strength, slice thickness, and flip angle. Comparisons were conducted using the Mann-Whitney U test.</p><p><strong>Results: </strong>A total of 98 scans were analyzed. Higher overall image quality, aSNR, and aCNR were observed in participants with BMI <30 kg/m², gestational age ≥32 weeks, low fetal motion severity, and stable gating signals (e.g., overall image quality for BMI <30 kg/m² vs ≥30 kg/m²: 4.4±0.7 vs. 4.1±0.7, p<0.001). Supine positioning resulted in better overall image quality compared to the left lateral position (4.5±0.5 vs. 4.2±0.8, p=0.001). Breath-holds provided similar overall image quality but improved contour sharpness and reduced artifacts compared to free breathing (5 [4,5] vs. 4 [4,5], p=0.042; and 4 [3-5] vs. 4 [3-5], p=0.014, respectively). At 1.5T field strength, higher contrast and fewer artifacts were observed compared to 3T (5 [4,5] vs. 5 [4,5], p=0.041; and 4 [4,5] vs. 4 [3-5], p=0.010, respectively). Slice thickness showed no significant impact on image quality.</p><p><strong>Conclusion: </strong>Various factors (e.g. BMI) influence fetal cardiac cine MRI image quality. Understanding these factors may help achieving reliable examinations and better exploit the potential of fetal cardiac MRI in clinical routine.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101875"},"PeriodicalIF":4.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12053712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid slice-to-volume four-dimensional flow in pediatric congenital heart disease: a feasibility study.","authors":"Valérie Béland, Datta Singh Goolaub, Sharon Portnoy, Shi-Joon Yoo, Christopher Z Lam, Christopher K Macgowan","doi":"10.1016/j.jocmr.2025.101887","DOIUrl":"10.1016/j.jocmr.2025.101887","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular magnetic resonance (CMR) allows cardiac hemodynamic assessment in patients with congenital heart disease (CHD). However, conventional techniques are time-consuming and may require blood contrast agents. Slice-to-volume reconstruction (SVR) four-dimensional (4D) flow is an innovative imaging technique that may overcome these limitations. This study aimed to assess the feasibility of SVR 4D flow in pediatric CHD.</p><p><strong>Methods: </strong>Patients with CHD (n=7, age=12.9±2.8years) underwent CMR with conventional two-dimensional (2D) phase-contrast magnetic resonance imaging (2D PCMRI) and SVR 4D flow. SVR 4D flow datasets were reconstructed from multi-slice 2D spiral PCMRI acquisitions, which were combined via slice-to-volume reconstruction. Mean flows in major thoracic vessels were measured and compared between the two techniques. Signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were calculated for each participant and compared between imaging techniques.</p><p><strong>Results: </strong>Linear regression for SVR 4D flow against 2D PCMRI showed good agreement for mean flows (slope=1.03, intercept=-5.31 mL/s, r²=0.95). The SNR and CNR did not differ significantly between 2D PCMRI and SVR 4D flow data (SNR: p=0.85, CNR: p=0.90).</p><p><strong>Conclusion: </strong>Our results suggest that SVR 4D flow CMR is a feasible 5-minute scan (relative to multiple 2D PCMRI prescriptions and scans) in pediatric patients with CHD. SVR 4D flow showed good agreement with 2D PCMRI for mean flow measurements. The advantages of SVR 4D flow support further research such as its comparison with conventional 4D flow.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101887"},"PeriodicalIF":4.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12182821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automatic flow planning for fetal cardiovascular magnetic resonance imaging.","authors":"Sara Neves Silva, Tomas Woodgate, Sarah McElroy, Michela Cleri, Kamilah St Clair, Jordina Aviles Verdera, Kelly Payette, Alena Uus, Lisa Story, David Lloyd, Mary A Rutherford, Joseph V Hajnal, Kuberan Pushparajah, Jana Hutter","doi":"10.1016/j.jocmr.2025.101888","DOIUrl":"10.1016/j.jocmr.2025.101888","url":null,"abstract":"<p><strong>Background: </strong>Widening access to fetal flow imaging by automating real-time planning of two-dimensional (2D) phase-contrast flow imaging (OWL).</p><p><strong>Methods: </strong>Two subsequent deep learning networks for fetal body localization and cardiac landmark detection on a coronal whole-uterus scan were trained on 167 and 71 fetal datasets, respectively, and implemented for real-time automatic planning of phase-contrast sequences. OWL was evaluated retrospectively in ten datasets and prospectively in seven fetal subjects (36+3-39+3 gestational weeks), with qualitative and quantitative comparisons to manual planning.</p><p><strong>Results: </strong>OWL was successfully implemented in 6/7 prospective cases. Fetal body localization achieved a Dice score of 0.94±0.05, and cardiac landmark detection accuracies were 5.77±2.91 mm (descending aorta), 4.32±2.44 mm (spine), and 4.94±3.82 mm (umbilical vein). Planning quality was 2.73/4 (automatic) and 3.0/4 (manual). Indexed flow measurements differed by -1.8% (range -14.2% to 14.9%) between OWL and manual planning.</p><p><strong>Conclusion: </strong>OWL achieved real-time automated planning of 2D phase-contrast cardiovascular magnetic resonance (CMR) for two major vessels, demonstrating feasibility at 0.55T with potential generalization across field strengths, extending access to this modality beyond specialized centers.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101888"},"PeriodicalIF":4.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12182827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Segmental redistribution of myocardial blood flow after coronary sinus reducer implantation demonstrated by quantitative perfusion cardiovascular magnetic resonance.","authors":"Kevin Cheng, Francisco Alpendurada, Chiara Bucciarelli-Ducci, Jose Almeida, Peter Kellman, Jonathan M Hill, Dudley J Pennell, Ranil de Silva","doi":"10.1016/j.jocmr.2025.101868","DOIUrl":"10.1016/j.jocmr.2025.101868","url":null,"abstract":"<p><strong>Background: </strong>The coronary sinus reducer (CSR) is a novel percutaneous treatment for patients with refractory angina. Increasing evidence supports its clinical efficacy in patients with advanced epicardial coronary artery disease. However, its mechanism of action and its effects on myocardial perfusion remain undefined. Using quantitative stress perfusion cardiovascular magnetic resonance (CMR), this study assessed changes in myocardial perfusion in patients with refractory angina undergoing CSR implantation.</p><p><strong>Methods: </strong>This single-center retrospective observational cohort study included 16 patients. Rest and adenosine stress perfusion CMR was performed before and at median 5 months after CSR implantation. Perfusion images were acquired using a dual-sequence quantitative protocol with automated generation of myocardial blood flow (MBF; mL/min/g). In addition to visual assessment of ischemic segments, changes in absolute MBF across myocardial segments and between myocardial layers were analyzed.</p><p><strong>Results: </strong>A high proportion of myocardial segments had visually adjudicated ischemia at baseline (208 out of 254: 81.9%), which significantly reduced after CSR implantation (175 out of 254: 68.9%; P = 0.001). There were no changes in global MBF or strain values. Changes in myocardial perfusion reserve (MPR) correlated with baseline MPR with more ischemic segments at baseline improving to a greater extent at follow-up. Similar patterns were observed in both the left and right coronary artery territories. Changes in endocardial/epicardial MBF ratio at stress were similarly dependent on baseline values.</p><p><strong>Conclusion: </strong>In patients with refractory angina undergoing CSR implantation, quantitative stress perfusion CMR demonstrated redistribution of myocardial perfusion across segments, from less ischemic to more ischemic myocardium, and across myocardial layers with greatest improvements in endocardial perfusion observed in the most ischemic myocardium. Further studies are needed to validate the different patterns of MBF redistribution that may occur after CSR implantation and correlate with clinical outcomes.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101868"},"PeriodicalIF":4.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences and determinants of coronary microvascular function in asymptomatic adults with type 2 diabetes.","authors":"Jian L Yeo, Abhishek Dattani, Joanna M Bilak, Alice L Wood, Lavanya Athithan, Aparna Deshpande, Anvesha Singh, J Ranjit Arnold, Emer M Brady, David Adlam, John D Biglands, Peter Kellman, Hui Xue, Thomas Yates, Melanie J Davies, Gaurav S Gulsin, Gerry P McCann","doi":"10.1016/j.jocmr.2024.101132","DOIUrl":"10.1016/j.jocmr.2024.101132","url":null,"abstract":"<p><strong>Background: </strong>Coronary microvascular dysfunction (CMD) is a significant complication in type 2 diabetes (T2D) and may be more common in women. We aimed to evaluate the sex differences and sex-specific clinical determinants of CMD in adults with T2D without prevalent cardiovascular disease.</p><p><strong>Methods: </strong>Single center pooled analysis of four prospective studies comparing asymptomatic people with T2D and controls. All subjects underwent comprehensive cardiovascular phenotyping with myocardial perfusion reserve (MPR) quantified with perfusion cardiovascular magnetic resonance (CMR). Participants with silent coronary disease were excluded. Multivariable linear regression was performed to identify determinants of MPR with an interaction term for sex.</p><p><strong>Results: </strong>Four hundred and seventy-nine T2D (age 57 ± 11 years, 42% [202/479] women) were compared with 116 controls (age 53 ± 11 years, 41% [48/116] women). Men with T2D, but not women, demonstrated worse systolic function and higher extracellular volume fraction than controls. MPR was significantly lower in T2D than controls (women, 2.6 ± 0.9 vs 3.3 ± 1.0, p < 0.001; men, 3.1 ± 0.9 vs 3.5 ± 1.0, p = 0.004), and lower in women than men with T2D (p < 0.001). More women than men with T2D had MPR <2.5 (46% [79/202] vs 26% [64/277], p < 0.001). There was a significant interaction between sex and body mass index (BMI) for MPR (p interaction <0.001). Following adjustment for clinical risk factors, inverse association with MPR were BMI in women (β = -0.17, p = 0.045) and systolic blood pressure in men (β = -0.14, p = 0.049).</p><p><strong>Conclusion: </strong>Among asymptomatic adults with T2D, women had a greater prevalence of CMD than men. Risk factors modestly but significantly associated with CMD in asymptomatic people with T2D were BMI among women and systolic blood pressure among men.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101132"},"PeriodicalIF":4.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11761338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive prognosis assessment of cardiovascular magnetic resonance parametric mapping in light chain amyloidosis.","authors":"Xiao Li, Yubo Guo, Kaini Shen, Sisi Huang, Yajuan Gao, Lu Lin, Jian Wang, Jian Cao, Xinxin Cao, Zhengyu Jin, Zhuoli Zhang, Akos Varga-Szemes, U Joseph Schoepf, Jian Li, Yining Wang","doi":"10.1016/j.jocmr.2024.101135","DOIUrl":"10.1016/j.jocmr.2024.101135","url":null,"abstract":"<p><strong>Background: </strong>Recent evidence underscores the importance of cardiovascular magnetic resonance (CMR) in light chain amyloidosis (AL amyloidosis). We aimed to comprehensively assess the prognostic significance of CMR parametric mapping in AL amyloidosis.</p><p><strong>Methods: </strong>This prospective study consecutively included AL amyloidosis patients who underwent CMR imaging before therapy. The statistical analyses included T2, extracellular volume, and native T1 as variates under investigation, adjusted for well-established prognostic markers. The outcome was death from any cause.</p><p><strong>Results: </strong>In total, 195 patients (age, 57.2 ± 9.1 years; male/female, 123/72) were recruited. At the median follow-up time (19 months), the survival probability was approximately 67.2% (131/195). T >44 ms, extracellular volume fraction (ECV) >47%, and native T1 >1468 ms were significantly prognostic (all, P < 0.05) but non-significant after adjustment for N-terminal pro-B-type natriuretic peptide (all, P > 0.05) in AL amyloidosis. T2 >44 ms was independently prognostic after correcting for left ventricle (LV) late gadolinium enhancement, LV ejection fraction, LV longitudinal strain, and therapeutic response (all, P < 0.05). In patients achieving deep hematologic response, T2 >44 ms (hazard ratios [HR] 6.611, 95% confidence interval [CI] 1.723-25.361, P = 0.006) was significantly prognostic for mortality after adjustment for cardiac response. Accordingly, T2 >44 ms was significantly associated with mortality (HR 5.734, 95% CI 1.189-27.656, P = 0.030) and remained independently prognostic after correcting for LV late gadolinium enhancement and LV longitudinal strain (both, P < 0.05) in patients who achieved both deep hematologic response and cardiac response.</p><p><strong>Conclusion: </strong>This study highlights that T2 is a valuable independent predictor of mortality in an AL amyloidosis population, additive to common CMR risk factors. Moreover, myocardial edema assessment identified patients in need of adjunctive therapies, which is of particular prognostic significance in patients with deep therapeutic response.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101135"},"PeriodicalIF":4.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11773017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Joint image reconstruction and segmentation of real-time cardiovascular magnetic resonance imaging in free-breathing using a model based on disentangled representation learning.","authors":"Tobias Wech, Oliver Schad, Simon Sauer, Jonas Kleineisel, Nils Petri, Peter Nordbeck, Thorsten A Bley, Bettina Baeßler, Bernhard Petritsch, Julius F Heidenreich","doi":"10.1016/j.jocmr.2025.101844","DOIUrl":"10.1016/j.jocmr.2025.101844","url":null,"abstract":"<p><strong>Background: </strong>To investigate image quality and agreement of derived cardiac function parameters in a novel joint image reconstruction and segmentation approach based on disentangled representation learning, enabling real-time cardiac cine imaging during free-breathing.</p><p><strong>Methods: </strong>A multi-tasking neural network architecture, incorporating disentangled representation learning, was trained using simulated examinations based on data from a public repository along with cardiovascular magnetic resonance (CMR) scans specifically acquired for model development. An exploratory feasibility study evaluated the method on undersampled real-time acquisitions using an in-house developed spiral balanced steady-state free precession pulse sequence in eight healthy participants and five patients with intermittent atrial fibrillation. Images and predicted left ventricle segmentations were compared to the reference standard of electrocardiography (ECG)-gated segmented Cartesian cine with repeated breath-holds and corresponding manual segmentation.</p><p><strong>Results: </strong>On a 5-point Likert scale, image quality of the real-time breath-hold approach and Cartesian cine was comparable in healthy participants (RT-BH: 1.99 ± 0.98, Cartesian: 1.94 ± 0.86, p = 0.052), but slightly inferior in free-breathing (RT-FB: 2.40 ± 0.98, p < 0.001). In patients with arrhythmia, both real-time approaches demonstrated favorable image quality (RT-BH: 2.10 ± 1.28, p < 0.001, RT-FB: 2.40 ± 1.13, p < 0.01, Cartesian: 2.68 ± 1.13). Intra-observer reliability was good (intraclass correlation coefficient = 0.77, 95% confidence interval [0.75, 0.79], p < 0.001). In functional analysis, a positive bias was observed for ejection fractions derived from the proposed model compared to the clinical reference standard (RT-BH mean: 58.5 ± 5.6%, bias: +3.47%, 95% confidence interval [-0.86, 7.79%], RT-FB mean: 57.9 ± 10.6%, bias: +1.45%, [-3.02, 5.91%], Cartesian mean: 54.9 ± 6.7%).</p><p><strong>Conclusion: </strong>The introduced real-time CMR imaging technique enables high-quality cardiac cine data acquisitions in 1-2 min, eliminating the need for ECG gating and breath-holds. This approach offers a promising alternative to the current clinical practice of segmented acquisition, with shorter scan times, improved patient comfort, and increased robustness to arrhythmia and patient non-compliance.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101844"},"PeriodicalIF":4.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11874730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Doppler ultrasound gating for adult cardiovascular magnetic resonance: Initial experience.","authors":"Lucia D Beissel, Fabian Kording, Christian Ruprecht, Alexander Isaak, Thomas M Vollbrecht, Claus C Pieper, Daniel Kuetting, Abdulamir Ali, Pia Wölfl, Christopher Hart, Julian A Luetkens","doi":"10.1016/j.jocmr.2025.101862","DOIUrl":"10.1016/j.jocmr.2025.101862","url":null,"abstract":"<p><strong>Background: </strong>Despite being a common gating method for cardiovascular magnetic resonance (CMR), electrocardiogram (ECG) gating has its disadvantages, and new gating strategies are desirable. An alternative CMR gating method is Doppler ultrasound (DUS) gating, which detects blood flow and ventricular movement. The aim of this study was to prove the feasibility of DUS gating as a novel CMR gating method in a clinical patient population.</p><p><strong>Methods: </strong>In this prospective study, patients underwent clinically indicated CMR. Balanced steady-state free precession two-dimensional cine sequences in short-axis and 4-chamber views were acquired using ECG and DUS gating. DUS and ECG signal were recorded simultaneously. Time difference between R-wave and DUS systolic trigger detection was defined as trigger delay, the standard deviation of trigger delays as trigger jitter. Left and right ventricular parameters were assessed: left and right ventricular ejection fraction (LVEF, RVEF) and left and right ventricular end-diastolic volume index (LVEDVI, RVEDVI). Overall image quality was assessed using a 5-point Likert scale (5 = excellent to 1 = non-diagnostic). For statistical analysis, paired t-test, Wilcoxon test, Pearson correlation, and intraclass correlation coefficient (ICC) were employed.</p><p><strong>Results: </strong>Twenty-one patients (7 female) were included (age: 45.4 ± 19.7 years; body mass index: 27.6 ± 5.5 kg/m²). DUS mean trigger delay was 128 ± 28 ms. DUS mean trigger jitter was 23 ± 13 ms. Overall image quality showed no difference between ECG and DUS gating (e.g., short axis: 5 [interquartile range (IQR) 3-5] vs 4 [IQR 3.5-5]; P = 0.21). Quantitative analysis revealed no differences between ECG and DUS gating: LVEF (53.2 ± 9.2% vs 52.3 ± 9.1%; P = 0.18; ICC 0.97 [95% confidence interval [CI] 0.93-0.99]), LVEDVI (84.5 ± 15.8 mL/m² vs 83.3 ± 15.8 mL/m²; P = 0.06; ICC 0.99 [95% CI 0.98-1.00]), RVEF (52.8 ± 8.0% vs 51.6 ± 7.2%; P = 0.06; ICC 0.96 [95% CI 0.89-0.99]), and RVEDVI (80.8 ± 17.6 mL/m² vs 80.9 ± 16.5 mL/m²; P = 0.91; ICC 0.98 [95% CI 0.96-0.99]). In one patient with a prominent lingula of the lung image quality was non-diagnostic with DUS gating.</p><p><strong>Conclusion: </strong>CMR gating with DUS is feasible and can offer an equivalent performance to ECG regarding image quality and quantitative parameter assessment.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101862"},"PeriodicalIF":4.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12019829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coprime dual-velocity encoding for extended velocity dynamic range in 4D flow magnetic resonance imaging.","authors":"Marta Beghella Bartoli, Sara Boccalini, David Chechin, Loic Boussel, Philippe Douek, Damien Garcia, Monica Sigovan","doi":"10.1016/j.jocmr.2025.101871","DOIUrl":"10.1016/j.jocmr.2025.101871","url":null,"abstract":"<p><strong>Background: </strong>In the field of cardiovascular imaging, four-dimensional (4D) flow cardiovascular magnetic resonance (CMR) provides non-invasive assessment of blood flow. Dual velocity encoding (dual-VENC) strategies have emerged to obtain quantitative information on both low and high blood flow velocities simultaneously. However, these strategies often encounter difficulties in coping with large velocity ranges. This work presents a dual-VENC 4D flow CMR sequence that utilizes the coprime rule to define the VENC ratio.</p><p><strong>Methods: </strong>A dual-VENC 4D flow CMR sequence and reconstruction algorithm were developed and validated in vitro at two different field strengths, using a flow phantom generating realistic complex flow patterns. A digital twin of the phantom allowed comparison of the MRI measurements with computational fluid dynamics (CFD) simulations. Three patients with different cardiac pathologies were scanned in order to evaluate the in vivo feasibility of the proposed method.</p><p><strong>Results: </strong>The results of the in vitro acquisitions demonstrated significant improvement in velocity-to-noise ratio (VNR) with respect to single-VENC acquisitions (110±3%) and conventional dual-VENC de-aliasing approach (75±3%). Furthermore, the effectiveness of aliasing correction was demonstrated even when both sets of images from the dual-VENC acquisition presented velocity aliasing artifacts. We observed a high degree of agreement between the measured and simulated velocity fields.</p><p><strong>Conclusion: </strong>The strength of this approach lies in the fact that, unlike the conventional de-aliasing method, no data is discarded. The final image is obtained by a weighted average of the VENC_low and VENC_high datasets. Consequently, setting the value of the VENC_high to prevent aliasing is no longer necessary, and higher VNR gains are possible.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101871"},"PeriodicalIF":4.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12032882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic handgrip exercise for the detection of myocardial ischemia using fast Strain-ENCoded cardiovascular magnetic resonance.","authors":"Andreas Ochs, Michael Nippes, Janek Salatzki, Lukas D Weberling, Nael Osman, Johannes Riffel, Hugo A Katus, Matthias G Friedrich, Norbert Frey, Marco M Ochs, Florian André","doi":"10.1016/j.jocmr.2025.101879","DOIUrl":"10.1016/j.jocmr.2025.101879","url":null,"abstract":"<p><strong>Background: </strong>Previous data suggest dynamic handgrip exercise (DHE) as a potential physiological, needle-free stressor feasible for cardiovascular magnetic resonance (CMR) examinations. DHE-fast Strain-ENCoded imaging (fSENC) is potentially cost-saving, ultra-fast and avoids pharmacological side effects thereby targeting the drawbacks of conventional pharmacological stress CMR.</p><p><strong>Objectives: </strong>To assess the diagnostic accuracy of DHE-fSENC for detecting ischemia-related wall motion abnormalities in suspected obstructive coronary artery disease (CAD).</p><p><strong>Methods: </strong>Patients with known or suspected obstructive CAD referred for CMR stress testing were prospectively enrolled. Diagnostic accuracy was assessed in comparison to pharmacological stress CMR and in a subgroup, compared to invasive coronary angiography (ICA). The CMR protocol was extended by both-handed DHE with 80 repetitions per minute over 2 min followed by fSENC short-axis acquisition before pharmacological stress testing. Stress-induced impairment of regional longitudinal strain was graded suspicious for obstructive CAD.</p><p><strong>Results: </strong>Two-hundred sixty individuals with cardiovascular high-risk profile (64±13years, 75% male) were enrolled. DHE-fSENC provided a sensitivity of 79% (95% CI: 64-89) and specificity of 87% (95% CI 82-91) compared to pharmacological stress CMR. In a subgroup of 105 patients with recent ICA, high diagnostic accuracy was found for the detection of obstructive CAD (sensitivity 82% [95% CI: 67-92], specificity 89% [95% CI: 78-95]). Exam duration of DHE-fSENC was significantly reduced compared to conventional CMR stress protocols (DHE-fSENC 207±69 s vs. adenosine-perfusion 287±82 s vs. dobutamine-cine 1132±294 s, all p<0.001).</p><p><strong>Conclusion: </strong>DHE-fSENC allows for a reliable and fast detection of obstructive CAD, thereby expanding the applicability of needle-free CMR stress testing.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101879"},"PeriodicalIF":4.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076776/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}