Journal of Cardiovascular Magnetic Resonance最新文献

{"title":"Transformer networks enable fast and robust dictionary generation for multiparametric cardiac mapping with variable timing.","authors":"Pauline Calarnou, Amaury George, Costa Georgantas, Angela Rocca, Gabriel Paffi, Augustin C Ogier, Roger Hullin, Jonas Richiardi, Ruud B van Heeswijk","doi":"10.1016/j.jocmr.2026.102757","DOIUrl":"10.1016/j.jocmr.2026.102757","url":null,"abstract":"<p><strong>Background: </strong>Cardiac multiparametric mapping often relies on dictionary matching. When the acquisition timing varies due to electrocardiographic or navigator gating, dictionaries must be simulated for each acquisition, which is time-consuming and limits their in-line clinical utility. Deep learning can be used to accelerate this dictionary generation. In this work, we implement and evaluate a transformer network that leverages self-attention to capture long-range dependencies and compare its performance against a previously proposed fully connected multi-layer perceptron (FC-MLP).</p><p><strong>Methods: </strong>Transformer (6 layers, 700,674 trainable parameters) and FC-MLP (3 hidden layers, 300-300-75 units) networks were implemented, optimized, and trained on synthetic timing intervals generated through extended phase graph (EPG) simulation. Network performance was quantified as mean average percent error (MAPE) versus EPG simulations in silico, as a correlation in a mapping phantom and through Bland-Atman analysis in 138 patients (age 67±13 y, 50 F) at 3T. Inference time was recorded. Finally, the full mapping pipeline was integrated directly on the MR (magnetic resonance) scanner.</p><p><strong>Results: </strong>EPG dictionary simulations required 30±2 minutes per subject, whereas the transformer completed inference in 13.2±0.4 s on CPU and 89.2±0.4 ms on GPU, representing a >100-fold acceleration. In the phantom experiments, the transformer achieved near-ideal correlation with the EPG dictionary (slope 1.00 vs 1.02 for FC-MLP) and demonstrated superior accuracy in Bland-Altman analysis, with smaller bias (1.8 ms vs 13.6 ms) and narrower limits of agreement. Across patient datasets, the transformer exhibited tighter error distributions for T₁ and T₂ (median MAPE [IQR]: 0.37%[0.09%-0.76%] and 0.50%[0.25%-0.91%] compared to FC-MLP (2.04%[1.61%-2.55%] and 3.03%[2.40%-3.92%], p<3×10⁻¹⁷² for both), respectively. Correlation between navigator skips and MAPE was also lower for the transformer, indicating greater robustness. In vivo transformer-dictionary maps were visually indistinguishable from EPG-dictionary maps. Bland-Altman analysis in the myocardium confirmed very small biases for the transformer-dictionary maps (-1.70ms for T₁, 0.23 ms for T₂) versus substantially larger errors for FC-MLP-dictionary maps (18.41 ms for T₁, 1.16 ms for T₂).</p><p><strong>Conclusions: </strong>The transformer network significantly accelerates cardiac multiparametric map reconstruction while maintaining accuracy comparable to EPG simulations and superior to the FC‑MLP. Its robustness to variable acquisition timing and minimal bias support clinical feasibility, and successful on‑scanner integration demonstrates the potential for routine in‑line deployment of quantitative T₁-T₂ mapping.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"102757"},"PeriodicalIF":5.0,"publicationDate":"2026-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13311263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148211289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Method-Dependent Variability in Late Gadolinium Enhancement Quantification Before and After Left Atrial Ablation.","authors":"Nikki van Pouderoijen, Luuk H G A Hopman, Michiel J B Kemme, Cornelis P Allaart, Marco J W Götte","doi":"10.1016/j.jocmr.2026.102759","DOIUrl":"https://doi.org/10.1016/j.jocmr.2026.102759","url":null,"abstract":"","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"102759"},"PeriodicalIF":6.1,"publicationDate":"2026-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148211332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Field strength dependence, physiologic correlates, and prognostic significance of ventricular blood pool T2 mapping on cardiovascular magnetic resonance imaging.","authors":"Moran Drucker Iarovich, Fadi Ibrahim, Joao Francisco Matos, Nilushi de Silva, William Holden Lowes, Yasbanoo Moayedi, Paaladinesh Thavendiranathan, Tilman Emrich, Akos Varga-Szemes, Kate Hanneman","doi":"10.1016/j.jocmr.2026.102760","DOIUrl":"10.1016/j.jocmr.2026.102760","url":null,"abstract":"<p><strong>Background and purpose: </strong>Cardiovascular magnetic resonance (CMR) T2 mapping is sensitive to blood oxygenation. The purpose was to evaluate determinants of the right-to-left ventricular (RV/LV) blood pool (BP) T2 ratio, determine field strength-specific cut-points for prediction of major adverse cardiac events (MACE), and assess physiologic correlates.</p><p><strong>Methods: </strong>Adults undergoing CMR (at 1.5T or 3T) for evaluation of cardiomyopathy between 2018 and 2020 were retrospectively evaluated along with healthy controls. RV and LV BP T2 values were measured on a mid-ventricular short-axis T2 map with calculation of the RV/LV BP T2 ratio. Reproducibility was assessed in a random subset of 100 patients. Associations with cardiopulmonary exercise testing (CPET) parameters and major adverse cardiac events (MACE) were evaluated using Spearman correlation, Cox regression, and receiver operating characteristic analysis.</p><p><strong>Results: </strong>A total of 718 subjects were included: 678 with cardiomyopathy (mean age 50±16 years; 58% men) and 40 controls (mean age 45±15 years; 55% men). Over a median follow-up of 3.2 years (IQR 2.3-3.8), 53 patients experienced MACE. RV/LV BP T2 ratios were 18%-31% higher at 1.5T versus 3T (cardiomyopathy: 0.77±0.14 vs 0.59±0.13, p<0.001; controls: 0.79±0.11 vs 0.67±0.09, p<0.001) with excellent reproducibility (intra-observer ICC 0.96 and inter-observer ICC 0.95). Each 0.1-unit decrease in RV/LV BP T2 ratio was associated with 41%-42% increased hazard of MACE in multivariable analysis (HR 0.59, 95%CI 0.45, 0.78, p<0.001 at 1.5T and HR 0.58, 95%CI 0.40, 0.85, p=0.005 at 3T). Optimal cut-points for prediction of MACE were <0.70 at 1.5T (AUC 0.727) and <0.55 at 3T (AUC 0.689). Absolute RV BP T2 demonstrated similar prognostic performance. Among patients with CPET (n=150), lower RV/LV BP T2 ratios correlated significantly with reduced percent-predicted oxygen uptake (VO₂), impaired heart rate recovery, and worse ventilatory efficiency (VE/VCO₂) at anaerobic threshold.</p><p><strong>Conclusions: </strong>The RV/LV BP T2 ratio reflects clinically meaningful cardiopulmonary physiology and independently predicts MACE, but is strongly influenced by MRI field strength, challenging assumptions of inherent field-independence and necessitating field strength-specific thresholds. Absolute RV BP T2 demonstrated comparable prognostic performance and may serve as a practical complementary metric. These findings establish RV BP T2 metrics as promising biomarkers for improved risk stratification in clinical CMR.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"102760"},"PeriodicalIF":5.0,"publicationDate":"2026-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13292778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148199013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circumferential strain recovery after human cardiomyocyte transplantation in minipigs using a novel frequency-based method for myocardial tagging quantification.","authors":"Anna V Naumova, Kenta Nakamura, Silvia Marchiano, Lauren E Neidig, Leslie P Blakely, Hiroshi Tsuchida, Charles E Murry, William S Kerwin","doi":"10.1016/j.jocmr.2026.102756","DOIUrl":"10.1016/j.jocmr.2026.102756","url":null,"abstract":"<p><strong>Background: </strong>Transplantation of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) is a promising new method for heart remuscularization after infarction. We hypothesized that hPSC-CMs affect heart function by improving local contractility in the infarcted zones. However, there is a need for a precise noninvasive assessment of regional contractile function in the infarcted segments.</p><p><strong>Methods: </strong>We describe here a novel approach for rapid and robust quantification of myocardial end-systolic circumferential strain (CS). Linear tags are placed in 60-degree pattern offsets and analyzed via optimized post-processing based on local Fourier transformation of standardized American Heart Association (AHA) myocardial segmentation. This method has been implemented for the first time to evaluate transendocardial hPSC-CMs transplantation in a minipig model of myocardial infarction. Validation of the new frequency-based calculation of myocardial strain was done using two independent approaches as follows: (1) a tag tracking, and (2) feature tracking technique.</p><p><strong>Results: </strong>In the cell-treated hearts (n=4), mean end-systolic CS in the infarcted segments (anterior and anteroseptal areas combined) at the mid-wall region decreased from -6.69 ± 1.56% (pre-MI) to -1.13 ± 1.96% at 2 weeks post-MI (pre-treatment), with subsequent improvement to -4.00 ± 0.76% by 8 weeks after cell transplantation. Conversely, CS in the infarcted segments in vehicle-control group (n=5) decreased from -5.18 ± 0.97% (pre-MI) to -1.39 ± 1.23% at 2 weeks post-MI and worsened further to 0.33 ± 1.93% by 8 weeks post-vehicle. There was no improvement in the global ejection fraction in the cell-treated group in comparison with control. It was a high correlation of the new method of myocardial strain calculation with the standard tag tracking approach and feature tracking strain analysis across the experimental conditions (normal heart, infarcted, cell/vehicle treated).</p><p><strong>Conclusions: </strong>A novel frequency-based technique for assessment of local circumferential strain does not require specialized acquisition protocols, access to k-space data, nor highly optimized reconstruction algorithms or commercial software. It can quickly and precisely assess regional myocardial injury and recovery. Our findings support our hypothesis that transplantation of hPSC-CMs improves regional myocardial strain in infarcted minipig hearts.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"102756"},"PeriodicalIF":5.0,"publicationDate":"2026-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13311266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148194706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of 3D fetal cardiac MRI in the late second trimester.","authors":"Milou Pm van Poppel, Alena Uus, Johannes K Steinweg, Jacqueline Matthew, Irina Grigorescu, Sujeev Mathur, Hannah Bellsham-Revell, Tomas Woodgate, Alexander Gonzalez-Lamberth, Aminah Hussan, Mary Rutherford, Reza Razavi, John M Simpson, Trisha V Vigneswaran, Maria Deprez, David Fa Lloyd, Kuberan Pushparajah","doi":"10.1016/j.jocmr.2026.102754","DOIUrl":"https://doi.org/10.1016/j.jocmr.2026.102754","url":null,"abstract":"<p><strong>Background: </strong>Fetal cardiovascular magnetic resonance imaging (CMR) is restricted to late gestation due to fetal movement and vessel size while initial clinical assessment of the fetal heart is conducted mid-trimester. This study aimed to assess feasibility and diagnostic potential of automated motion-correction tools for 3D fetal CMR of late second trimester fetuses.</p><p><strong>Methods: </strong>Black-blood fetal CMR datasets of controls and fetuses with congenital heart disease (CHD) (20 - 27⁺⁶ weeks' gestation) were collected and reconstructed to 3D volumes. Image quality, nineteen cardiovascular structures and sequential segmental analysis were assessed. Correlation with gestational age, fetal body volume and maternal BMI was investigated.</p><p><strong>Results: </strong>142 controls were included (median gestation 24.4 weeks, IQR 23.4 - 25.7). Image quality was adequate or high in 119/142 (84%), poor in 22/142 (16%), and inadequate in one. In total, 48/2679 (2%) cardiac structures were not visualised. Completion of vascular segmental assessment was high across all four areas (84-98%). Maternal girth and BMI showed a weak negative correlation with image quality. Number of input stacks had a weak positive correlation with vessel visualisation. Six CHD cases were assessed; pathognomonic vascular features were identified in 5/6 by at least one blinded observer.</p><p><strong>Conclusions: </strong>This study demonstrates feasibility of 3D fetal cardiac MRI for detailed assessment of the fetal cardiovascular system before 28 weeks' gestation. Overall performance, image quality and visualisation of vascular structures was high, and visualisation of vascular anomalies was demonstrated. This creates new potential for improving antenatal diagnosis of major vascular anomalies in second trimester fetuses.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"102754"},"PeriodicalIF":6.1,"publicationDate":"2026-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148194640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fully automated free-breathing cardiac magnetic resonance imaging at 3T: A prospective randomized study of image quality, efficiency, and workflow burden.","authors":"Keyi Li, Wenli Zhou, Xinling Yang, Lin Chen, Xuan Qin, Chen Cui, Kai Yang, Weipeng Yan, Wenhao Dong, Lele Liu, Jialin Song, Jing An, Jens Wetzl, Michaela Schmidt, Shihua Zhao, Gang Yin, Minjie Lu","doi":"10.1016/j.jocmr.2026.102755","DOIUrl":"10.1016/j.jocmr.2026.102755","url":null,"abstract":"<p><strong>Background: </strong>Automation in cardiovascular magnetic resonance (CMR) scans holds the potential to improve examination efficiency and workflow consistency. Prospective clinical evidence validating automated scan workflows in routine CMR practice remains limited.</p><p><strong>Methods: </strong>In this prospective randomized study, consecutive patients referred for non-stress CMR were assigned to either an automated or a manual free-breathing scanning workflow. The fully automated workflow integrated automated plane prescription of multiple steps required for successful image acquisition. The primary endpoint was total examination time; secondary endpoints included plane prescription accuracy, image quality scores, scanner idle time, and technologist workload.</p><p><strong>Results: </strong>Of 255 screened patients, 221 were included (automated, n = 109; manual, n = 112). All examinations were diagnostically adequate. The automated and manual workflows showed a similarly low incidence of plane prescription misalignment, corresponding to 19.3% (21/109) and 17.9% (20/112) misalignment events per examination, respectively, with no significant difference between groups (0.19 vs. 0.18 events per examination, P = 0.780). No significant differences were observed across imaging planes or technologist experience levels, and image quality scores were comparable between workflows (2.74 ± 0.67 vs. 2.69 ± 0.70, P = 0.547). However, the automated scanning workflow significantly reduced total examination time (19.16 ± 2.32 vs. 21.25 ± 2.25 min, P < 0.001) and scanner idle time (7.80 ± 1.80 vs. 10.12 ± 2.03 min, P < 0.001), with consistent savings across all experience levels. Operator workload was also substantially lower with automated scanning, evidenced by fewer mouse clicks and keystrokes (both P < 0.01).</p><p><strong>Conclusions: </strong>An automated CMR scanning workflow improves examination efficiency and reduces operator workload without compromising image quality or plane prescription accuracy, supporting its integration in routine clinical CMR practice.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"102755"},"PeriodicalIF":5.0,"publicationDate":"2026-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13292677/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148194697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular magnetic resonance-derived left atrial parameters for assessing diastolic dysfunction and prognosis in hypertrophic cardiomyopathy.","authors":"Weiwei Liao, Jianping Zhong, Wenjian Tang, Daoxiong Xiao, Yongming Tan, Xiangqiang Liu, Youlin Fu","doi":"10.1016/j.jocmr.2026.102752","DOIUrl":"10.1016/j.jocmr.2026.102752","url":null,"abstract":"<p><strong>Background: </strong>Echocardiography is the mainstay for assessing left ventricular diastolic dysfunction (LVDD) in hypertrophic cardiomyopathy (HCM). Given that routine cardiovascular magnetic resonance (CMR) lacks guideline-recommended valvular hemodynamic parameters, this study aimed to evaluate the diagnostic and prognostic value of CMR left atrial (LA) parameters for guideline-defined LVDD.</p><p><strong>Methods: </strong>This dual-center study included 248 HCM patients and 70 controls, all of whom underwent both echocardiography and CMR. Patients were categorized into normal left atrial pressure (LAP) (normal or Grade I LVDD) and elevated LAP (Grade ≥ II LVDD) groups per echocardiographic guidelines. Volumetric and CMR-FT strain analyses quantified left heart function. LA parameters' diagnostic ability for elevated LAP and their prognostic value were assessed.</p><p><strong>Results: </strong>Compared with controls, HCM patients showed significantly impaired LA reservoir (εs), conduit (εe), and booster pump (εa) strains, which progressively deteriorated with LAP elevation (LVDD progression), while LA volumes progressively increased. LA parameters diagnosed elevated LAP superior to LV indices, with εs showing the highest efficacy [AUC=0.903, cutoff=27.95%]; combining εs with LAVImin improved the AUC to 0.929. Multivariable Cox analysis showed εs (HR: 0.867), LAVImin (HR: 1.025), and LV-LGE burden (HR: 1.103) were independent predictors of heart failure-related composite events, and the combined model demonstrated a C-index of 0.852. Furthermore, both εs and the HCM-AF score independently predicted incident atrial fibrillation, with εs outperforming the HCM-AF score (C-index: 0.802 vs 0.734).</p><p><strong>Conclusion: </strong>CMR LA parameters are sensitive markers for LVDD with elevated LAP in HCM, providing significant clinical value for risk stratification and prognostic assessment.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"102752"},"PeriodicalIF":5.0,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13288509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148176168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reference ranges for myocardial native T1, T2, and extracellular volume at 5.0T cardiac magnetic resonance imaging in healthy adults.","authors":"Shiyu Wang, Xianling Qian, Yali Wu, Xiyin Miao, Ziyun Guan, Dong Wang, Rui Wang, Yinyin Chen, Ling Chen, Zhuolin Liu, Shaofeng Duan, Lin Tian, Hang Jin, Mengsu Zeng","doi":"10.1016/j.jocmr.2026.102753","DOIUrl":"10.1016/j.jocmr.2026.102753","url":null,"abstract":"<p><strong>Background: </strong>A 5.0T Cardiovascular magnetic resonance (CMR) offers potential advantages over 3.0T systems, including improved signal-to-noise ratio and spatial resolution. Although myocardial T1 and T2 mapping techniques are increasingly applied in clinical practice, reference ranges for these parameters at 5.0T have not yet been established. The aim of this study is to determine normal reference values for myocardial native T1, T2 relaxation times, and extracellular volume fraction (ECV) in healthy adults using 5.0T CMR.</p><p><strong>Methods: </strong>This prospective study enrolled 181 healthy Chinese adults aged 20-80 years who underwent 5.0T CMR. T1 and T2 mapping of the left ventricle were performed using a motion-corrected modified Look-Locker inversion recovery sequence and a T2-prepared single-shot sequence, respectively. Global and segmental myocardial T1, T2, and ECV values were quantified. Associations with sex, age, body mass index (BMI), and myocardial thickness were analyzed.</p><p><strong>Results: </strong>The mean global myocardial T1, T2, and ECV values were 1496 ± 37 ms, 35 ± 3 ms and 27 ± 2 %, respectively. Females showed significantly higher T1 and T2 values than males (T1: 1509 ± 35 ms vs 1483 ± 35 ms, p<.001; T2: 36 ± 2 ms vs 34 ± 2 ms, p<.001). No significant age-related differences were observed. T1, T2, and ECV values were inversely associated with BMI (T1: r=-0.16, p=.034; T2: r=-0.35, p<.001; ECV: r=-0.31, p=.015). T1 values positively correlated with myocardial thickness (r=0.19, p<.001), whereas T2 and ECV values negatively correlated with thickness (r=-0.21 and -0.19, respectively; both p<.001). Segmental analysis showed lower T1 but higher T2 and ECV values at the apex compared with the mid and basal myocardium (all p<.001).</p><p><strong>Conclusion: </strong>This study establishes normative myocardial T1, T2, and ECV values at 5.0T CMR in healthy adults. Myocardial tissue characteristics were influenced by sex, BMI, and myocardial thickness, with regional variations observed across myocardial segments.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"102753"},"PeriodicalIF":5.0,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13292681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148176173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monitoring myocardial oxygenation response to respiratory maneuvers using real-time magnetic resonance imaging.","authors":"Nora Vogt, Sonia Lebza, Jacques Felblinger, Gilles Bosser, Freddy Odille","doi":"10.1016/j.jocmr.2026.102751","DOIUrl":"10.1016/j.jocmr.2026.102751","url":null,"abstract":"<p><strong>Background: </strong>Oxygenation-sensitive (OS) cardiovascular magnetic resonance (CMR), using breathing maneuver-induced stress and blood oxygen level-dependent contrast, is a well-tolerated, non-invasive approach for assessing myocardial oxygenation. This study evaluated two real-time CMR sequences and a semi-automated analysis workflow to enable continuous, motion-robust assessment of myocardial oxygenation dynamics, aiming to overcome limitations of electrocardiogram (ECG)-triggered acquisitions and reduce manual evaluation requirements.</p><p><strong>Methods: </strong>Signal intensity dynamics of ten young healthy female volunteers were analyzed from images acquired on a 3T scanner using an ECG-triggered balanced steady-state free precession (bSSFP) sequence, a real-time (RT) bSSFP sequence, and a RT fast low-angle short (FLASH) sequence. Images were obtained in a mid-ventricular slice while participants performed a breathing maneuver consisting of normal breathing, paced hyperventilation, and a prolonged breath hold. A semi-automated processing pipeline was implemented to generate motion-resolved oxygenation maps using retrospective cardiac phase binning, deformable image registration, and automated segmentation.</p><p><strong>Results: </strong>The RT sequences captured end-systolic global myocardial signal intensity change (ΔSI, relative to reference frames at breath-hold start) with dynamics comparable to those of the ECG-triggered bSSFP sequence. As expected in healthy volunteers, ΔSI decreased during hyperventilation and recovered during the prolonged breath-hold. At 20-30s, oxygenation responses at end-systole were 3.95%[3.36, 7.50] for ECG-triggered bSSFP, 5.47%[3.31, 9.08] for RT bSSFP, and 3.24%[1.99, 4.80] for RT FLASH. RT FLASH showed fewer artifacts but lower contrast and smaller ΔSI than the bSSFP sequences, with inter-sequence differences appearing modest in mixed-effects analysis.</p><p><strong>Conclusions: </strong>This exploratory study demonstrates the feasibility of combining real-time MR sequences with a semi-automated processing pipeline for continuous assessment of T2∕T2*-related myocardial oxygenation dynamics. Potential confounders, including through-plane motion and physiological drift, warrant further investigation.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"102751"},"PeriodicalIF":5.0,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13288510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148163262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fully self-gated dual-venc five-dimensional flow magnetic resonance imaging for simultaneous imaging of the cardiovascular and portal venous systems: A feasibility study.","authors":"Yuyang Ren, Wen Ye, Wenchao Yang, Wenjian Liu, Haotian Hong, Junpu Hu, Jiayu Zhu, Haikun Qi, Fei Shan, Peng Hu, Zijian Zhou","doi":"10.1016/j.jocmr.2026.102750","DOIUrl":"10.1016/j.jocmr.2026.102750","url":null,"abstract":"<p><strong>Purpose: </strong>To develop and evaluate a fully self-gated dual-venc five-dimensional (5D) flow cardiovascular magnetic resonance (CMR) technique for joint assessment of cardiovascular and portal venous hemodynamics under free breathing.</p><p><strong>Methods: </strong>A dual-venc 5D flow sequence using a spiral-in Cartesian sampling trajectory was implemented. Cardiac and respiratory motion were retrospectively resolved using principal component analysis of self-gating signals, followed by total variation regularized reconstruction. The technique was first tested in a custom-built phantom with steady flow and stationary parts, and compared with conventional four-dimensional (4D) flow. It was then evaluated in healthy volunteers and in patients with cirrhosis or portal hypertension, including post-transjugular intrahepatic portosystemic shunt (TIPS) cases. No contrast agent was administered for either the phantom or in vivo scans, with an in vivo 5D flow scan time of approximately 15 min per subject. Hemodynamic parameters in both the cardiovascular and portal venous systems were quantified and compared with conventional breath-held, ECG-triggered two-dimensional (2D) phase-contrast (PC) MRI. For each subject, flow internal consistency (IC) across vessel planes and respiration-resolved flow variations were also computed.</p><p><strong>Results: </strong>Phantom experiments demonstrated an average 67% improvement in velocity-to-noise ratio (VNR) and similar flow quantification compared with fully sampled 4D flow MRI. In vivo evaluation included 12 healthy volunteers, 8 cirrhosis patients, and 9 post-TIPS patients. Across all cohorts, dual-venc 5D flow achieved substantial VNR enhancement (approximately 200% on average), high flow IC (>82%), and strong agreement with 2D PC MRI for both peak and net flow (bias <10%). Respiration-resolved analysis revealed a consistent increase in net flow in the main pulmonary artery (MPA), right pulmonary artery (RPA), and superior vena cava (SVC) during inspiration, along with elevated SVC peak flow.</p><p><strong>Conclusions: </strong>Fully self-gated dual-venc 5D flow MRI enables simultaneous, respiration-resolved quantification of cardiovascular and portal venous hemodynamics within a clinically feasible scan time and with high VNR. This technique provides a promising tool for characterizing systemic hemodynamics in cirrhosis and for evaluating portal-systemic circulatory interactions following TIPS.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"102750"},"PeriodicalIF":5.0,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13292760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148163327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}